Sorting within the regulated secretory pathway occurs in the trans-Golgi network.

PubWeight™: 1.21‹?› | Rank: Top 10%

🔗 View Article (PMC 2115992)

Published in J Cell Biol on January 01, 1990

Authors

W S Sossin1, J M Fisher, R H Scheller

Author Affiliations

1: Department of Biological Sciences, Stanford University, California 94305.

Articles citing this

Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin. EMBO J (1995) 2.76

Sorting and storage during secretory granule biogenesis: looking backward and looking forward. Biochem J (1998) 2.61

A tyrosine-based motif and a casein kinase II phosphorylation site regulate the intracellular trafficking of the varicella-zoster virus glycoprotein I, a protein localized in the trans-Golgi network. EMBO J (1996) 2.42

Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network. J Cell Biol (1991) 2.07

Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells. J Cell Biol (1993) 1.52

Insulin granule biogenesis, trafficking and exocytosis. Vitam Horm (2009) 1.32

N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes. Proc Natl Acad Sci U S A (1994) 1.26

Expression of individual forms of peptidylglycine alpha-amidating monooxygenase in AtT-20 cells: endoproteolytic processing and routing to secretory granules. J Cell Biol (1992) 1.26

Assembly and disassembly of the Golgi complex: two processes arranged in a cis-trans direction. J Cell Biol (1992) 1.15

Polymorphism and structural maturation of bunyamwera virus in Golgi and post-Golgi compartments. J Virol (2003) 1.13

Structural maturation of the transmissible gastroenteritis coronavirus. J Virol (1999) 1.13

Not all secretory granules are created equal: Partitioning of soluble content proteins. Mol Biol Cell (2006) 1.12

Differential trafficking of soluble and integral membrane secretory granule-associated proteins. J Cell Biol (1994) 1.06

Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells. Mol Biol Cell (2011) 0.98

Evidence for defects in membrane traffic in Paramecium secretory mutants unable to produce functional storage granules. J Cell Biol (1994) 0.95

Secretory protein traffic. Chromogranin A contains a dominant targeting signal for the regulated pathway. J Clin Invest (1993) 0.95

Proinsulin endoproteolysis confers enhanced targeting of processed insulin to the regulated secretory pathway. Mol Biol Cell (2000) 0.94

Dale's hypothesis revisited: different neuropeptides derived from a common prohormone are targeted to different processes. Proc Natl Acad Sci U S A (1990) 0.93

Passive sorting in maturing granules of AtT-20 cells: the entry and exit of salivary amylase and proline-rich protein. J Cell Biol (1997) 0.93

Expression of mutant ELH prohormones in AtT-20 cells: the relationship between prohormone processing and sorting. J Cell Biol (1993) 0.84

Regulated and constitutive protein targeting can be distinguished by secretory polarity in thyroid epithelial cells. J Cell Biol (1991) 0.84

Prothyrotropin-releasing hormone targets its processing products to different vesicles of the secretory pathway. J Biol Chem (2008) 0.83

Calcitonin and calcitonin receptors. Clin Cases Miner Bone Metab (2007) 0.81

Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3. PLoS Genet (2013) 0.80

Expression and processing of procholecystokinin in a rat medullary thyroid carcinoma cell line. Biochem J (1990) 0.80

Heterologous in vivo processing of human preproendothelin 1 into bioactive peptides. Proc Natl Acad Sci U S A (1991) 0.80

Articles cited by this

High-resolution autoradiography. I. Methods. J Cell Biol (1962) 19.73

Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi. Annu Rev Biochem (1987) 10.25

The trans Golgi network: sorting at the exit site of the Golgi complex. Science (1986) 10.08

The mannose 6-phosphate receptor and the biogenesis of lysosomes. Cell (1988) 7.22

Golgi apparatus, GERL, and lysosomes of neurons in rat dorsal root ganglia, studied by thick section and thin section cytochemistry. J Cell Biol (1971) 5.94

Perturbation of vesicular traffic with the carboxylic ionophore monensin. Cell (1983) 5.71

Pathways of protein secretion in eukaryotes. Science (1985) 5.70

Constitutive and regulated secretion of proteins. Annu Rev Cell Biol (1987) 5.29

Lysosomal enzymes and their receptors. Annu Rev Biochem (1986) 5.09

Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus. J Cell Biol (1983) 4.20

Vesicular stomatitis virus and sindbis virus glycoprotein transport to the cell surface is inhibited by ionophores. Virology (1980) 3.13

Clathrin-coated vesicular transport of secretory proteins during the formation of ACTH-containing secretory granules in AtT20 cells. J Cell Biol (1986) 2.40

A view of acidic intracellular compartments. J Cell Biol (1988) 2.35

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles. Cell (1987) 2.33

OSMIUM IMPREGNATION OF THE GOLGI APPARATUS. Am J Anat (1965) 2.18

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases. Nature (1988) 2.07

The trans-most cisternae of the Golgi complex: a compartment for sorting of secretory and plasma membrane proteins. Cell (1987) 2.00

A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin. Cell (1984) 1.99

Relationship between the Golgi apparatus, GERL, and secretory granules in acinar cells of the rat exorbital lacrimal gland. J Cell Biol (1977) 1.76

A single gene encodes multiple neuropeptides mediating a stereotyped behavior. Cell (1983) 1.75

Sorting of progeny coronavirus from condensed secretory proteins at the exit from the trans-Golgi network of AtT20 cells. J Cell Biol (1987) 1.66

Cellular and molecular biology of neuropeptide processing and packaging. Neuron (1989) 1.66

Proteolysis in neuropeptide processing and other neural functions. Annu Rev Neurosci (1984) 1.56

Coated vesicles from rat liver and calf brain contain lysosomal enzymes bound to mannose 6-phosphate receptors. J Biol Chem (1983) 1.54

Stimulation of egg laying: possible neuroendocrine function of bag cells of abdominal ganglion of Aplysia californica. Nature (1967) 1.40

Multiple neuropeptides derived from a common precursor are differentially packaged and transported. Cell (1988) 1.35

An antibody specific for an endoproteolytic cleavage site provides evidence that pro-opiomelanocortin is packaged into secretory granules in AtT20 cells before its cleavage. J Cell Biol (1987) 1.22

Neurophysin biosynthesis: conversion of a putative precursor during axonal transport. Science (1977) 1.16

In situ hybridization to study the origin and fate of identified neurons. Science (1983) 1.14

Molecular sorting in the secretory pathway. Science (1989) 1.13

High resolution analysis of the secretory pathway in mammotrophs of the rat anterior pituitary. J Cell Biol (1981) 1.13

A common source of difficulty in high-resolution radioautography. J Cell Biol (1969) 1.12

Sorting of three secretory proteins to distinct secretory granules in acidophilic cells of cow anterior pituitary. J Cell Biol (1987) 1.09

In cow anterior pituitary, growth hormone and prolactin can be packed in separate granules of the same cell. J Cell Biol (1985) 1.07

Egg-laying hormone: direct action on the ovotestis of Aplysia. Gen Comp Endocrinol (1983) 1.06

Activation of neurosecretory cells enhances their synthesis of secretory protein. Brain Res (1981) 0.98

Proteolytic processing of the Aplysia egg-laying hormone and R3-14 neuropeptide precursors. J Neurosci (1987) 0.97

Processing of the egg-laying hormone (ELH) precursor in the bag cell neurons of Aplysia. J Biol Chem (1988) 0.93

Localization of Aplysia neurosecretory peptides to multiple populations of dense core vesicles. J Cell Biol (1986) 0.92

Primary structure and neuronal effects of alpha-bag cell peptide, a second candidate neurotransmitter encoded by a single gene in bag cell neurons of Aplysia. Proc Natl Acad Sci U S A (1983) 0.89

Two neuronal populations in the head ganglia of Aplysia californica with egg-laying hormone-like immunoreactivity. Brain Res (1984) 0.86

Nonsynaptic characteristics of neurotransmission mediated by egg-laying hormone in the abdominal ganglion of Aplysia. J Neurosci (1985) 0.85

Effects of monensin on the processing of pro-opiomelanocortin in the intermediate lobe of the rat pituitary. Biochem Biophys Res Commun (1982) 0.84

Alpha bag cell peptide directly modulates the excitability of the neurons that release it. J Neurosci (1987) 0.84

Positive feedback by autoexcitatory neuropeptides in neuroendocrine bag cells of Aplysia. J Neurosci (1989) 0.82

A bag cell neuron-specific antigen localizes to a subset of dense core vesicles in Aplysia californica. Brain Res (1989) 0.81

Subcellular sites of processing of precursors to neurosecretory peptides in the bag cells of Aplysia: inferences from the effects of monensin, FCCP, and chloroquine. J Neurobiol (1984) 0.77

Articles by these authors

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell (1993) 10.66

Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature (2000) 6.96

Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science (1992) 6.50

SNARE-mediated membrane fusion. Nat Rev Mol Cell Biol (2001) 5.58

Chemical synthesis of restriction enzyme recognition sites useful for cloning. Science (1977) 4.81

Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Cell (1998) 4.80

A genomic perspective on membrane compartment organization. Nature (2001) 4.80

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci (1988) 4.36

The molecular machinery for secretion is conserved from yeast to neurons. Proc Natl Acad Sci U S A (1993) 4.22

The syntaxin family of vesicular transport receptors. Cell (1993) 4.14

Specificity and regulation of a synaptic vesicle docking complex. Neuron (1994) 4.02

Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell (1996) 3.88

VAMP-1: a synaptic vesicle-associated integral membrane protein. Proc Natl Acad Sci U S A (1988) 3.76

Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking. Science (1994) 3.08

SNARE complex formation is triggered by Ca2+ and drives membrane fusion. Cell (1999) 3.04

n-Sec1: a neural-specific syntaxin-binding protein. Proc Natl Acad Sci U S A (1994) 2.95

Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron (1998) 2.70

Syntaxin 6 functions in trans-Golgi network vesicle trafficking. Mol Biol Cell (1997) 2.70

SNAREs and NSF in targeted membrane fusion. Curr Opin Cell Biol (1997) 2.66

Mechanisms of synaptic vesicle exocytosis. Annu Rev Cell Dev Biol (2000) 2.66

Structural organization of the synaptic exocytosis core complex. Neuron (1997) 2.64

SNARE interactions are not selective. Implications for membrane fusion specificity. J Biol Chem (1999) 2.60

Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. J Cell Biol (1998) 2.59

Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature (1995) 2.46

nSec1 binds a closed conformation of syntaxin1A. J Cell Biol (2000) 2.44

The mammalian brain rsec6/8 complex. Neuron (1996) 2.44

Control of cytochrome P1-450 gene expression by dioxin. Science (1985) 2.37

Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron (1998) 2.36

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. J Pharmacol Exp Ther (1997) 2.33

Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell (1997) 2.26

Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A). Proc Natl Acad Sci U S A (1999) 2.25

Seven novel mammalian SNARE proteins localize to distinct membrane compartments. J Biol Chem (1998) 2.25

Two vesicle-associated membrane protein genes are differentially expressed in the rat central nervous system. J Biol Chem (1989) 2.23

Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc Natl Acad Sci U S A (1999) 2.23

A role for synaptotagmin (p65) in regulated exocytosis. Cell (1993) 2.22

A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. Mol Cell (2000) 2.21

A molecular description of synaptic vesicle membrane trafficking. Annu Rev Biochem (1994) 2.13

Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins. J Biol Chem (1995) 2.06

Translational control in hemoglobin syntheskis. Cold Spring Harb Symp Quant Biol (1969) 2.02

VAMP-7 mediates vesicular transport from endosomes to lysosomes. J Cell Biol (1999) 2.01

Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation. Neuron (1995) 1.94

The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans. Neuron (1993) 1.91

Three SNARE complexes cooperate to mediate membrane fusion. Proc Natl Acad Sci U S A (2001) 1.91

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro. Nature (1996) 1.90

SNAREs contribute to the specificity of membrane fusion. Neuron (2000) 1.88

Subunit structure of the mammalian exocyst complex. Proc Natl Acad Sci U S A (1997) 1.87

Differential expression of synaptic vesicle protein 2 (SV2) isoforms. J Neurosci (1994) 1.84

SV2, a brain synaptic vesicle protein homologous to bacterial transporters. Science (1992) 1.83

A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering. Cell (1994) 1.80

Racial discrimination and alcohol-related behavior in urban transit operators: findings from the San Francisco Muni Health and Safety Study. Public Health Rep (1999) 1.80

The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains. J Neurosci (1999) 1.78

Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle. J Biol Chem (1994) 1.77

Generation and maintenance of neuronal polarity: mechanisms of transport and targeting. Neuron (1999) 1.77

Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex. Trends Cell Biol (1999) 1.76

A single gene encodes multiple neuropeptides mediating a stereotyped behavior. Cell (1983) 1.75

Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs. J Cell Biol (1998) 1.74

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis. J Biol Chem (1988) 1.74

Isolation and characterization of a Drosophila neuropeptide gene. Neuron (1988) 1.74

Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. J Biol Chem (2001) 1.70

Workplace discrimination and alcohol consumption: findings from the San Francisco Muni Health and Safety Study. Ethn Dis (1999) 1.70

Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking. Mol Biol Cell (1999) 1.67

Three novel proteins of the syntaxin/SNAP-25 family. J Biol Chem (1998) 1.67

Cellular and molecular biology of neuropeptide processing and packaging. Neuron (1989) 1.66

A new syntaxin family member implicated in targeting of intracellular transport vesicles. J Biol Chem (1996) 1.66

Synaptic vesicle biogenesis, docking, and fusion: a molecular description. Physiol Rev (1996) 1.65

Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin. J Biol Chem (1996) 1.65

Synaptic vesicle membrane proteins interact to form a multimeric complex. J Cell Biol (1992) 1.64

Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Mol Biol Cell (1999) 1.64

The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding. J Biol Chem (2001) 1.57

Hemin control of globin synthesis: effect of a translational repressor on Met-tRNAf binding to the small ribosomal subunit and its relation to the activity and alailability of an initiation factor. Biochim Biophys Acta (1973) 1.52

Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus. J Biol Chem (1996) 1.51

Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer. Proc Natl Acad Sci U S A (1988) 1.50

Structure and expression of a rat agrin. Neuron (1991) 1.49

Dynamics of tubulovesicular recycling endosomes in hippocampal neurons. J Neurosci (1999) 1.49

Two rat homologs of clathrin-associated adaptor proteins. Gene (1994) 1.47

The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res Mol Brain Res (1991) 1.46

Regulation of membrane trafficking: structural insights from a Rab/effector complex. Cell (1999) 1.46

Localization of synaptotagmin-binding domains on syntaxin. J Neurosci (1996) 1.44

RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes. Neuron (1992) 1.44

Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking. J Biol Chem (2000) 1.44

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab Dispos (1997) 1.43

Sequential SNARE assembly underlies priming and triggering of exocytosis. Neuron (2001) 1.41

Identification and characterization of Drosophila genes for synaptic vesicle proteins. J Neurosci (1993) 1.40

Cellular and molecular biology of the presynaptic nerve terminal. Annu Rev Neurosci (1991) 1.38

The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. Proc Natl Acad Sci U S A (2001) 1.38

Developmental regulation of highly active alternatively spliced forms of agrin. Neuron (1993) 1.38

The biochemistry of neurotransmitter secretion. J Biol Chem (1995) 1.37

Brain contains two forms of synaptic vesicle protein 2. Proc Natl Acad Sci U S A (1993) 1.36

Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex. J Biol Chem (1989) 1.36

Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells. Proc Natl Acad Sci U S A (1994) 1.35

Multiple neuropeptides derived from a common precursor are differentially packaged and transported. Cell (1988) 1.35

The cysteine string secretory vesicle protein activates Hsc70 ATPase. J Biol Chem (1996) 1.34

Phosphorylation of synaptic vesicle proteins: modulation of the alpha SNAP interaction with the core complex. Proc Natl Acad Sci U S A (1996) 1.33

Tomosyn binds t-SNARE proteins via a VAMP-like coiled coil. Neuron (1998) 1.33

Quantitative measurement of mast cell degranulation using a novel flow cytometric annexin-V binding assay. Cytometry (1999) 1.32

A family of genes that codes for ELH, a neuropeptide eliciting a stereotyped pattern of behavior in Aplysia. Cell (1982) 1.30