PubRank

Jeffrey R O'Connell

Author PubWeight™ 173.30‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010 23.08
2 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010 20.01
3 Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011 13.25
4 Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010 7.94
5 Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA 2009 6.80
6 New loci associated with kidney function and chronic kidney disease. Nat Genet 2010 5.58
7 Genomic inflation factors under polygenic inheritance. Eur J Hum Genet 2011 4.89
8 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet 2012 4.73
9 A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science 2008 4.50
10 From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci U S A 2008 3.39
11 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 2013 3.25
12 NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet 2009 3.18
13 Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 2013 2.92
14 Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet 2013 2.83
15 FTO genotype is associated with phenotypic variability of body mass index. Nature 2012 2.77
16 CUBN is a gene locus for albuminuria. J Am Soc Nephrol 2011 2.70
17 The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study. Am Heart J 2008 2.61
18 Genomic evaluations with many more genotypes. Genet Sel Evol 2011 2.34
19 Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet 2010 2.15
20 Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation 2011 1.96
21 Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 2013 1.72
22 Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet 2012 1.68
23 Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease. Circ Cardiovasc Genet 2010 1.64
24 Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish. Arch Intern Med 2010 1.64
25 Assessment of gene-by-sex interaction effect on bone mineral density. J Bone Miner Res 2012 1.58
26 Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans. J Bone Miner Res 2003 1.25
27 Exploring the genetics of longevity in the Old Order Amish. Mech Ageing Dev 2005 1.24
28 The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response. Pharmacogenet Genomics 2013 1.19
29 Does having children extend life span? A genealogical study of parity and longevity in the Amish. J Gerontol A Biol Sci Med Sci 2006 1.18
30 COL4A1 is associated with arterial stiffness by genome-wide association scan. Circ Cardiovasc Genet 2009 1.16
31 Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. Hypertension 2013 1.14
32 Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet 2012 1.14
33 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet 2013 1.12
34 Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study. Hum Mol Genet 2006 1.06
35 Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish. Diabetes 2004 1.05
36 Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. Diabetes 2006 1.04
37 PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County. BMC Med Genet 2010 1.00
38 Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes. Circ Cardiovasc Genet 2013 0.99
39 Factor V leiden and ischemic stroke risk: the Genetics of Early Onset Stroke (GEOS) study. J Stroke Cerebrovasc Dis 2011 0.97
40 Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish. Hum Hered 2007 0.96
41 Exploiting gene x gene interaction in linkage analysis. BMC Proc 2007 0.95
42 A genome-wide linkage scan of insulin level derived traits: the Amish Family Diabetes Study. Diabetes 2007 0.94
43 A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density. J Bone Miner Res 2012 0.93
44 Rare variants in ischemic stroke: an exome pilot study. PLoS One 2012 0.92
45 Genome-wide association analysis of ischemic stroke in young adults. G3 (Bethesda) 2011 0.92
46 An evaluation of the variance components approach: type I error, power and size of the estimated effect. Eur J Hum Genet 2002 0.91
47 Variation in the lamin A/C gene: associations with metabolic syndrome. Arterioscler Thromb Vasc Biol 2004 0.90
48 A deletion mutation in bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle. BMC Genomics 2010 0.90
49 Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort). J Am Coll Cardiol 2013 0.88
50 Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish. J Clin Endocrinol Metab 2005 0.88
51 Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study. Thromb J 2008 0.86
52 The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin. Curr Vasc Pharmacol 2016 0.86
53 Extent and distribution of linkage disequilibrium in the Old Order Amish. Genet Epidemiol 2010 0.86
54 Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels. Circ Cardiovasc Genet 2009 0.85
55 Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Hum Mol Genet 2013 0.84
56 Common variants in Mendelian kidney disease genes and their association with renal function. J Am Soc Nephrol 2013 0.82
57 Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish. Diabetes 2004 0.82
58 PROX1 gene variant is associated with fasting glucose change after antihypertensive treatment. Pharmacotherapy 2013 0.80
59 Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study. BMC Neurol 2007 0.80
60 Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. Atherosclerosis 2012 0.79
61 Prothrombin G20210A mutation is associated with young-onset stroke: the genetics of early-onset stroke study and meta-analysis. Stroke 2014 0.78
62 Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response. Hum Genet 2014 0.78
63 PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. J Hypertens 2015 0.76
64 Polymorphisms in the SOCS7 gene and glucose homeostasis traits. BMC Res Notes 2013 0.76
65 Polymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study. Springerplus 2013 0.76
66 Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet 2016 0.75
67 Sequence variation in IGF1R is associated with differences in insulin levels in nondiabetic Old Order Amish. Diabetes Metab Res Rev 2009 0.75
68 A polymorphic 3'UTR element in ATP1B1 regulates alternative polyadenylation and is associated with blood pressure. PLoS One 2013 0.75
69 Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet 2016 0.75
70 Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response. Pharmacogenet Genomics 2017 0.75
71 Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish. Mol Genet Metab 2005 0.75
72 Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 2017 0.75