Published in EMBO Rep on November 06, 2012
Organization of the mitotic chromosome. Science (2013) 3.50
ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells. Science (2017) 1.39
Chromatin organization and transcriptional regulation. Curr Opin Genet Dev (2012) 1.31
Chromatin as dynamic 10-nm fibers. Chromosoma (2014) 1.11
DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice. Nucleic Acids Res (2013) 1.09
Organization and function of the 3D genome. Nat Rev Genet (2016) 1.03
Spatial confinement is a major determinant of the folding landscape of human chromosomes. Nucleic Acids Res (2014) 0.90
Nucleosomal arrays self-assemble into supramolecular globular structures lacking 30-nm fibers. EMBO J (2016) 0.87
The variant histone H2A.V of Drosophila--three roles, two guises. Chromosoma (2013) 0.86
Chromatin without the 30-nm fiber: constrained disorder instead of hierarchical folding. Epigenetics (2014) 0.86
Flexible and dynamic nucleosome fiber in living mammalian cells. Nucleus (2013) 0.84
Through thick and thin: the conundrum of chromatin fibre folding in vivo. EMBO Rep (2012) 0.84
Histone variants: the tricksters of the chromatin world. Curr Opin Genet Dev (2014) 0.84
Chromatin in a marine picoeukaryote is a disordered assemblage of nucleosomes. Chromosoma (2013) 0.84
Unraveling the 3D genome: genomics tools for multiscale exploration. Trends Genet (2015) 0.83
Chromatin Dynamics in Vivo: A Game of Musical Chairs. Genes (Basel) (2015) 0.82
Understanding Spatial Genome Organization: Methods and Insights. Genomics Proteomics Bioinformatics (2016) 0.82
Fractal Characterization of Chromatin Decompaction in Live Cells. Biophys J (2015) 0.80
Modulation of Higher Order Chromatin Conformation in Mammalian Cell Nuclei Can Be Mediated by Polyamines and Divalent Cations. PLoS One (2013) 0.80
Coming to terms with chromatin structure. Chromosoma (2015) 0.79
ELCS in ice: cryo-electron microscopy of nuclear envelope-limited chromatin sheets. Chromosoma (2014) 0.79
Inferring 3D chromatin structure using a multiscale approach based on quaternions. BMC Bioinformatics (2015) 0.76
Budding yeast chromatin is dispersed in a crowded nucleoplasm in vivo. Mol Biol Cell (2016) 0.76
The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes. Epigenetics Chromatin (2016) 0.75
Dynamic Nucleosome Movement Provides Structural Information of Topological Chromatin Domains in Living Human Cells. PLoS Comput Biol (2016) 0.75
Atomic force microscopy of chromatin arrays reveal non-monotonic salt dependence of array compaction in solution. PLoS One (2017) 0.75
Soft X-Ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis In Vivo. Cell Rep (2016) 0.75
Inferring the physical properties of yeast chromatin through Bayesian analysis of whole nucleus simulations. Genome Biol (2017) 0.75
Nucleosome-nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity. Mol Biol Cell (2017) 0.75
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83
Computer visualization of three-dimensional image data using IMOD. J Struct Biol (1996) 25.42
Automated electron microscope tomography using robust prediction of specimen movements. J Struct Biol (2005) 9.78
Solenoidal model for superstructure in chromatin. Proc Natl Acad Sci U S A (1976) 6.65
Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers. Cell (2004) 5.84
SPARX, a new environment for Cryo-EM image processing. J Struct Biol (2006) 4.66
Mouse centric and pericentric satellite repeats form distinct functional heterochromatin. J Cell Biol (2004) 3.65
EM measurements define the dimensions of the "30-nm" chromatin fiber: evidence for a compact, interdigitated structure. Proc Natl Acad Sci U S A (2006) 2.94
Visualization of G1 chromosomes: a folded, twisted, supercoiled chromonema model of interphase chromatid structure. J Cell Biol (1994) 2.66
Higher-order structures of chromatin: the elusive 30 nm fiber. Cell (2007) 2.45
Mapping in vivo chromatin interactions in yeast suggests an extended chromatin fiber with regional variation in compaction. J Biol Chem (2008) 2.40
Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure. EMBO J (2012) 2.17
Single-molecule force spectroscopy reveals a highly compliant helical folding for the 30-nm chromatin fiber. Nat Struct Mol Biol (2009) 2.02
Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ. Proc Natl Acad Sci U S A (2008) 1.95
The three-dimensional architecture of chromatin in situ: electron tomography reveals fibers composed of a continuously variable zig-zag nucleosomal ribbon. J Cell Biol (1994) 1.84
Chromatin structure: does the 30-nm fibre exist in vivo? Curr Opin Cell Biol (2010) 1.69
Low angle x-ray diffraction studies of chromatin structure in vivo and in isolated nuclei and metaphase chromosomes. J Cell Biol (1983) 1.63
Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One (2010) 1.60
Living without 30nm chromatin fibers. Trends Biochem Sci (2011) 1.52
The H4 tail domain participates in intra- and internucleosome interactions with protein and DNA during folding and oligomerization of nucleosome arrays. Mol Cell Biol (2008) 1.50
Chromatin fibers observed in situ in frozen hydrated sections. Native fiber diameter is not correlated with nucleosome repeat length. J Cell Biol (1994) 1.30
Correlative light and electron spectroscopic imaging of chromatin in situ. Methods Enzymol (2004) 1.19
Multifunctionality of the linker histones: an emerging role for protein-protein interactions. Cell Res (2010) 1.15
The facultative heterochromatin of the inactive X chromosome has a distinctive condensed ultrastructure. J Cell Sci (2008) 1.15
Analysis of active and inactive X chromosome architecture reveals the independent organization of 30 nm and large-scale chromatin structures. Mol Cell (2010) 1.14
A view of the chromatin landscape. Micron (2011) 1.03
Phosphorus distribution in the nucleosome. Science (1981) 1.01
Three-dimensional elemental mapping of phosphorus by quantitative electron spectroscopic tomography (QuEST). J Struct Biol (2007) 0.91
Electron spectroscopic imaging of the nuclear landscape. Methods Mol Biol (2009) 0.90
Electron spectroscopic imaging of chromatin and other nucleoprotein complexes. Electron Microsc Rev (1992) 0.89
Changes in chromatin fiber density as a marker for pluripotency. Cold Spring Harb Symp Quant Biol (2011) 0.87
Copy number variation and selection during reprogramming to pluripotency. Nature (2011) 8.24
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell (2011) 6.71
Global transcription in pluripotent embryonic stem cells. Cell Stem Cell (2008) 5.81
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J Cell Biol (2006) 3.63
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol (2011) 3.60
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis. Genome Res (2009) 3.36
A vertebrate Polycomb response element governs segmentation of the posterior hindbrain. Cell (2009) 3.36
Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00
Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat Genet (2006) 2.92
Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat Methods (2009) 2.51
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
GPS: a comprehensive www server for phosphorylation sites prediction. Nucleic Acids Res (2005) 2.44
PML nuclear bodies: dynamic sensors of DNA damage and cellular stress. Bioessays (2004) 2.32
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell (2012) 2.02
ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy. Autophagy (2006) 1.97
Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation. Hum Mol Genet (2011) 1.87
The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry (2002) 1.81
Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol (2012) 1.73
Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states. J Cell Biochem (2008) 1.71
Macromolecular organization of ATP synthase and complex I in whole mitochondria. Proc Natl Acad Sci U S A (2011) 1.70
High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci. Cell Cycle (2009) 1.68
Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One (2010) 1.60
NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling. J Biol Chem (2004) 1.58
Application of quantum dots as probes for correlative fluorescence, conventional, and energy-filtered transmission electron microscopy. J Histochem Cytochem (2004) 1.58
A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin. Mol Biol Cell (2005) 1.56
Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications. Mol Ther (2004) 1.54
Living without 30nm chromatin fibers. Trends Biochem Sci (2011) 1.52
Urolithiasis in rats consuming a dl bitartrate form of choline in a purified diet. Comp Med (2005) 1.45
Size, position and dynamic behavior of PML nuclear bodies following cell stress as a paradigm for supramolecular trafficking and assembly. J Cell Sci (2003) 1.45
Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR. J Cell Biol (2006) 1.43
PML bodies: a meeting place for genomic loci? J Cell Sci (2005) 1.37
Induced pluripotent stem cells and reprogramming: seeing the science through the hype. Nat Rev Genet (2009) 1.36
Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3. Oncogene (2005) 1.33
Organization of chromatin in the interphase mammalian cell. Micron (2005) 1.30
Large-scale field application of RNAi technology reducing Israeli acute paralysis virus disease in honey bees (Apis mellifera, Hymenoptera: Apidae). PLoS Pathog (2010) 1.29
Probing intranuclear environments at the single-molecule level. Biophys J (2007) 1.28
Constitutive heterochromatin reorganization during somatic cell reprogramming. EMBO J (2011) 1.27
CEP120 and SPICE1 cooperate with CPAP in centriole elongation. Curr Biol (2013) 1.22
Mitotic accumulations of PML protein contribute to the re-establishment of PML nuclear bodies in G1. J Cell Sci (2006) 1.22
Correlative light and electron spectroscopic imaging of chromatin in situ. Methods Enzymol (2004) 1.19
EOS lentiviral vector selection system for human induced pluripotent stem cells. Nat Protoc (2009) 1.17
Retrovirus silencer blocking by the cHS4 insulator is CTCF independent. Nucleic Acids Res (2003) 1.16
The number of PML nuclear bodies increases in early S phase by a fission mechanism. J Cell Sci (2006) 1.15
Nuclear matrix association of the human beta-globin locus utilizing a novel approach to quantitative real-time PCR. Nucleic Acids Res (2003) 1.14
Human ING1 proteins differentially regulate histone acetylation. J Biol Chem (2002) 1.14
Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate-shuttle hypothesis. J Neurosci (2008) 1.11
De novo modeling of the F(420)-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. Elife (2013) 1.11
Chromatin contributes to structural integrity of promyelocytic leukemia bodies through a SUMO-1-independent mechanism. J Biol Chem (2003) 1.09
MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy. PLoS One (2009) 1.09
iPS cells to model CDKL5-related disorders. Eur J Hum Genet (2011) 1.08
The promyelocytic leukemia nuclear body: sites of activity? Biochem Cell Biol (2002) 1.07
The RNA-seq approach to discriminate gene expression profiles in response to melatonin on cucumber lateral root formation. J Pineal Res (2013) 1.07
Comparing women of differing sexual orientations using population-based sampling. Women Health (2004) 1.06
Can breast and cervical cancer screening visits be used to enhance colorectal cancer screening? J Am Coll Radiol (2004) 1.06
Transgenic mouse overexpressing syntaxin-1A as a diabetes model. Diabetes (2005) 1.05
Characterization of OP9 as authentic mesenchymal stem cell line. J Genet Genomics (2010) 1.04
NLRP7, a nucleotide oligomerization domain-like receptor protein, is required for normal cytokine secretion and co-localizes with Golgi and the microtubule-organizing center. J Biol Chem (2011) 1.04
Transcriptional regulation is affected by subnuclear targeting of reporter plasmids to PML nuclear bodies. Mol Cell Biol (2006) 1.03
A view of the chromatin landscape. Micron (2011) 1.03
Intracellular angiotensin II fusion protein alters AT1 receptor fusion protein distribution and activates CREB. J Mol Cell Cardiol (2004) 1.01
Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells. Biochem Biophys Res Commun (2011) 1.01
Elucidating chromatin and nuclear domain architecture with electron spectroscopic imaging. Chromosome Res (2008) 1.00
PML nuclear bodies as sites of epigenetic regulation. Front Biosci (Landmark Ed) (2009) 0.97
Beyond repair foci: subnuclear domains and the cellular response to DNA damage. Cell Cycle (2007) 0.97
X-chromosome inactivation in rett syndrome human induced pluripotent stem cells. Front Psychiatry (2012) 0.97
A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity. J Pharmacol Exp Ther (2004) 0.95
The nucleolar channel system of human endometrium is related to endoplasmic reticulum and R-rings. Mol Biol Cell (2007) 0.95
eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides. Mol Ther (2005) 0.94
'Multicopy multivalent' glycopolymer-stabilized gold nanoparticles as potential synthetic cancer vaccines. J Am Chem Soc (2013) 0.94
Outcome of patients with colorectal liver metastasis: analysis of 1,613 consecutive cases. Ann Surg Oncol (2012) 0.94
Exploring self-management characteristics in youths with type 1 diabetes mellitus: does membership in a glycemic control category matter? Pediatr Diabetes (2010) 0.93
Benefits of utilizing gene-modified iPSCs for clinical applications. Cell Stem Cell (2010) 0.92
Modeling and rescue of the vascular phenotype of Williams-Beuren syndrome in patient induced pluripotent stem cells. Stem Cells Transl Med (2012) 0.92
Beta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapy. PLoS Genet (2008) 0.91
Outer membrane continuity and septosome formation between vegetative cells in the filaments of Anabaena sp. PCC 7120. Cell Microbiol (2011) 0.91
Effect of Bcl-2 and Bax on survival of side population cells from hepatocellular carcinoma cells. World J Gastroenterol (2007) 0.90
"Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome (2005) 0.90
Electron spectroscopic imaging of the nuclear landscape. Methods Mol Biol (2009) 0.90
Cardiovascular and autonomic response to environmental noise during sleep in night shift workers. Sleep (2002) 0.89
Same serial section correlative light and energy-filtered transmission electron microscopy. J Histochem Cytochem (2003) 0.89
Reduced functional connectivity of prefrontal regions and amygdala within affect and working memory networks in pediatric bipolar disorder. Brain Connect (2012) 0.88
A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther (2011) 0.88
Preoperative hepatic and regional arterial chemotherapy in the prevention of liver metastasis after colorectal cancer surgery. Ann Surg (2007) 0.87
Enhanced gene expression through temperature profile-induced variations in molecular architecture of thermoresponsive polymer vectors. J Gene Med (2007) 0.86
Kinetics and epigenetics of retroviral silencing in mouse embryonic stem cells defined by deletion of the D4Z4 element. Mol Ther (2013) 0.86
The Sry3 Y chromosome locus elevates blood pressure and renin-angiotensin system indexes. Gend Med (2011) 0.84
Initiation of DNA replication at the human beta-globin 3' enhancer. Nucleic Acids Res (2005) 0.84
Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP. J Cell Biol (2013) 0.84
Real-time fluorescence tracking of dynamic transgene variegation in stem cells. Mol Ther (2007) 0.84
Sodium taurocholate inhibits intestinal adenoma formation in APCMin/+ mice, potentially through activation of the farnesoid X receptor. Carcinogenesis (2010) 0.84
Deviation of islet autoreactivity to cryptic epitopes protects NOD mice from diabetes. Eur J Immunol (2003) 0.84