Published in Hum Mol Genet on September 21, 2012
Sticking together the Crumbs - an unexpected function for an old friend. Nat Rev Mol Cell Biol (2013) 1.07
Defects of CRB2 cause steroid-resistant nephrotic syndrome. Am J Hum Genet (2014) 0.96
CRB2 mutations produce a phenotype resembling congenital nephrosis, Finnish type, with cerebral ventriculomegaly and raised alpha-fetoprotein. Am J Hum Genet (2014) 0.94
Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis. PLoS Genet (2013) 0.89
Transgenic expression of constitutively active RAC1 disrupts mouse rod morphogenesis. Invest Ophthalmol Vis Sci (2014) 0.85
Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background. PLoS One (2013) 0.82
Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. PLoS Genet (2015) 0.81
CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium. Sci Rep (2015) 0.80
Epithelial cell polarity determinant CRB3 in cancer development. Int J Biol Sci (2015) 0.79
Neurite Mistargeting and Inverse Order of Intraretinal Vascular Plexus Formation Precede Subretinal Vascularization in Vldlr Mutant Mice. PLoS One (2015) 0.77
Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. Nat Cell Biol (2016) 0.77
Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye. Gene Expr Patterns (2015) 0.77
Polarity transitions during neurogenesis and germinal zone exit in the developing central nervous system. Front Cell Neurosci (2015) 0.77
CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling. Mol Cell Biol (2015) 0.77
Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo. Sci Rep (2015) 0.77
The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy. Front Neurosci (2017) 0.75
Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model. BMC Ophthalmol (2016) 0.75
Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye. Dev Biol (2016) 0.75
The C. elegans Crumbs family contains a CRB3 homolog and is not essential for viability. Biol Open (2015) 0.75
Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes. Cell Mol Life Sci (2017) 0.75
Photoreceptor oxidative stress in hyperoxia-induced proliferative retinopathy accelerates rd8 degeneration. PLoS One (2017) 0.75
Standard for clinical electroretinography (2004 update). Doc Ophthalmol (2004) 6.97
Guidelines for basic multifocal electroretinography (mfERG). Doc Ophthalmol (2003) 4.53
CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells. Mol Biol Cell (2004) 2.61
hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. J Biol Chem (2002) 2.51
Polarity complex proteins. Biochim Biophys Acta (2007) 2.42
Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum. Hum Mol Genet (2005) 2.36
TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci (2009) 2.19
Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography. PLoS One (2009) 2.18
Spectral domain optical coherence tomography in mouse models of retinal degeneration. Invest Ophthalmol Vis Sci (2009) 2.08
In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy. Vision Res (2005) 2.02
Elimination of inhibitory synapses is a major component of adult ocular dominance plasticity. Neuron (2012) 1.97
Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal. Invest Ophthalmol Vis Sci (2005) 1.95
Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission. Neuron (2006) 1.91
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A (2003) 1.90
A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Brain (2007) 1.82
Prolonged recovery of retinal structure/function after gene therapy in an Rs1h-deficient mouse model of x-linked juvenile retinoschisis. Mol Ther (2005) 1.79
MRP6 (ABCC6) detection in normal human tissues and tumors. Lab Invest (2002) 1.79
Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci (2004) 1.77
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol (2003) 1.73
Junctional recruitment of mammalian Scribble relies on E-cadherin engagement. Oncogene (2005) 1.73
Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosis. PLoS Med (2006) 1.67
Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure. Proc Natl Acad Sci U S A (2002) 1.65
Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. J Biol Chem (2003) 1.63
Pseudoxanthoma elasticum: a clinical, histopathological, and molecular update. Surv Ophthalmol (2003) 1.54
Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila. J Cell Biol (2002) 1.50
Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function. Mol Ther (2010) 1.46
Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells. J Cell Biol (2005) 1.43
Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors. Development (2002) 1.42
RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice. Invest Ophthalmol Vis Sci (2007) 1.39
Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration. J Neurosci (2009) 1.39
Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol (2007) 1.37
Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6. Hum Mol Genet (2009) 1.37
R91W mutation in Rpe65 leads to milder early-onset retinal dystrophy due to the generation of low levels of 11-cis-retinal. Hum Mol Genet (2007) 1.36
Towards understanding CRUMBS function in retinal dystrophies. Hum Mol Genet (2006) 1.34
Role of the Norrie disease pseudoglioma gene in sprouting angiogenesis during development of the retinal vasculature. Invest Ophthalmol Vis Sci (2005) 1.33
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. Mol Biol Cell (2004) 1.30
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. J Clin Invest (2006) 1.29
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol (2005) 1.29
The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes. J Neurochem (2006) 1.28
Synaptic plasticity in CNGA3(-/-) mice: cone bipolar cells react on the missing cone input and form ectopic synapses with rods. J Neurosci (2006) 1.24
The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron (2010) 1.22
The retinal G protein-coupled receptor (RGR) enhances isomerohydrolase activity independent of light. J Biol Chem (2005) 1.22
Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells. Hum Mol Genet (2006) 1.21
Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. FASEB J (2001) 1.21
Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus. Proc Natl Acad Sci U S A (2006) 1.20
Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev (2002) 1.20
The C. elegans P4-ATPase TAT-1 regulates lysosome biogenesis and endocytosis. Traffic (2008) 1.19
PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. J Cell Sci (2005) 1.19
Oxidative modification of peroxiredoxin is associated with drug-induced apoptotic signaling in experimental models of Parkinson disease. J Biol Chem (2008) 1.18
Screening mouse vision with intrinsic signal optical imaging. Eur J Neurosci (2007) 1.18
Effect of late-stage therapy on disease progression in AAV-mediated rescue of photoreceptor cells in the retinoschisin-deficient mouse. Mol Ther (2008) 1.17
Characterization of the Crumbs homolog 2 (CRB2) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis. Mol Vis (2005) 1.16
Computer modelling in combination with in vitro studies reveals similar binding affinities of Drosophila Crumbs for the PDZ domains of Stardust and DmPar-6. Eur J Cell Biol (2006) 1.15
Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol (2013) 1.13
Crb1 is a determinant of retinal apical Müller glia cell features. Glia (2007) 1.13
A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Hum Mol Genet (2010) 1.13
Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy. J Gene Med (2003) 1.12
PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS One (2010) 1.10
CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype. Int J Neuropsychopharmacol (2009) 1.10
Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice. J Neurosci (2005) 1.10
MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. Invest Ophthalmol Vis Sci (2005) 1.09
Hook2 is involved in the morphogenesis of the primary cilium. Mol Biol Cell (2011) 1.08
A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1. J Neurosci (2007) 1.08
Vision tests in the mouse: Functional phenotyping with electroretinography. Front Biosci (Landmark Ed) (2009) 1.08
CD146 and its soluble form regulate monocyte transendothelial migration. Arterioscler Thromb Vasc Biol (2009) 1.08
Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP. FASEB J (2005) 1.07
Flow of energy in the outer retina in darkness and in light. Proc Natl Acad Sci U S A (2010) 1.07
EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement. Mol Biol Cell (2003) 1.07
Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Hum Mol Genet (2012) 1.07