Published in Mol Biol Cell on January 12, 2004
The PAR proteins: fundamental players in animal cell polarization. Dev Cell (2007) 4.92
Coordinated protein sorting, targeting and distribution in polarized cells. Nat Rev Mol Cell Biol (2008) 3.63
Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity. Cold Spring Harb Perspect Biol (2009) 2.01
aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. Cell (2010) 1.94
DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol (2004) 1.87
Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis. Biochim Biophys Acta (2007) 1.74
Trafficking of Crumbs3 during cytokinesis is crucial for lumen formation. Mol Biol Cell (2009) 1.70
Synapses: sites of cell recognition, adhesion, and functional specification. Annu Rev Biochem (2007) 1.65
Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex. Nat Struct Mol Biol (2004) 1.53
A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions. J Cell Biol (2007) 1.53
Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. J Cell Biol (2007) 1.51
Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6. Hum Mol Genet (2009) 1.37
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep (2006) 1.35
Organization of multiprotein complexes at cell-cell junctions. Histochem Cell Biol (2008) 1.33
Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression. Cancer Res (2008) 1.30
aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development. Dev Cell (2007) 1.30
Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol (2009) 1.28
Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene (2008) 1.27
PATJ regulates directional migration of mammalian epithelial cells. EMBO Rep (2007) 1.22
Protein complexes that control renal epithelial polarity. Am J Physiol Renal Physiol (2011) 1.22
What drives cell morphogenesis: a look inside the vertebrate photoreceptor. Dev Dyn (2009) 1.21
Fractionation of the epithelial apical junctional complex: reassessment of protein distributions in different substructures. Mol Biol Cell (2004) 1.21
Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size. Development (2006) 1.15
PALS1 regulates E-cadherin trafficking in mammalian epithelial cells. Mol Biol Cell (2006) 1.15
Cell polarity as a regulator of cancer cell behavior plasticity. Annu Rev Cell Dev Biol (2012) 1.15
Polarity in mammalian epithelial morphogenesis. Cold Spring Harb Perspect Biol (2013) 1.14
Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity. Cold Spring Harb Perspect Biol (2009) 1.09
Vimentin regulates scribble activity by protecting it from proteasomal degradation. Mol Biol Cell (2009) 1.04
Antagonistic functions of Par-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila. Dev Biol (2007) 1.04
Extensions of PDZ domains as important structural and functional elements. Protein Cell (2010) 1.02
The assembly and maintenance of epithelial junctions in C. elegans. Front Biosci (Landmark Ed) (2009) 1.01
Tight junctions: a barrier to the initiation and progression of breast cancer? J Biomed Biotechnol (2009) 1.01
Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins. Mol Cell Biol (2009) 1.00
Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype. PLoS One (2014) 0.97
Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex. Proc Natl Acad Sci U S A (2014) 0.95
Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Dev Cell (2011) 0.93
New aspects of the molecular constituents of tissue barriers. J Neural Transm (Vienna) (2010) 0.93
IBD candidate genes and intestinal barrier regulation. Inflamm Bowel Dis (2014) 0.92
Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma. Head Neck Pathol (2012) 0.91
Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. J Cell Biol (2013) 0.88
Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila. Proc Natl Acad Sci U S A (2014) 0.88
Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell (2015) 0.88
The Mammalian Blood-Testis Barrier: Its Biology and Regulation. Endocr Rev (2015) 0.88
Emerging role for epithelial polarity proteins of the Crumbs family as potential tumor suppressors. J Biomed Biotechnol (2011) 0.87
Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegans. Dev Biol (2010) 0.87
Tight junctions: from simple barriers to multifunctional molecular gates. Nat Rev Mol Cell Biol (2016) 0.87
Characterization of mammalian Par 6 as a dual-location protein. Mol Cell Biol (2007) 0.86
Fosmid-based structure-function analysis reveals functionally distinct domains in the cytoplasmic domain of Drosophila crumbs. G3 (Bethesda) (2013) 0.85
A conformational switch in the CRIB-PDZ module of Par-6. Structure (2011) 0.85
Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice. BMC Nephrol (2006) 0.84
Polarity and stratification of the epidermis. Semin Cell Dev Biol (2012) 0.84
Establishment of epithelial polarity--GEF who's minding the GAP? J Cell Sci (2014) 0.84
The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells. J Cell Biol (2013) 0.84
The Ran importin system in cilia trafficking. Organogenesis (2011) 0.83
Snail destabilizes cell surface Crumbs3a. Traffic (2012) 0.83
Mimicking pregnancy as a strategy for breast cancer prevention. Breast Cancer Manag (2013) 0.82
Polarization and myelination in myelinating glia. ISRN Neurol (2012) 0.82
Cell polarity and cystic kidney disease. Pediatr Nephrol (2012) 0.82
Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC. PLoS Biol (2015) 0.81
Ductal barriers in mammary epithelium. Tissue Barriers (2013) 0.80
Apicobasal polarity in the kidney. Exp Cell Res (2012) 0.80
CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium. Sci Rep (2015) 0.80
Par6b regulates the dynamics of apicobasal polarity during development of the stratified Xenopus epidermis. PLoS One (2013) 0.79
Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers. Adv Exp Med Biol (2012) 0.79
Epithelial cell polarity determinant CRB3 in cancer development. Int J Biol Sci (2015) 0.79
Apical localisation of crumbs in the boundary cells of the Drosophila hindgut is independent of its canonical interaction partner stardust. PLoS One (2014) 0.79
Plasticity of the brush border - the yin and yang of intestinal homeostasis. Nat Rev Gastroenterol Hepatol (2016) 0.79
Mechanisms of cell polarity and aquaporin sorting in the nephron. Pflugers Arch (2011) 0.78
An MBoC favorite: CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells. Mol Biol Cell (2012) 0.77
A Cre-inducible fluorescent reporter for observing apical membrane dynamics. Genesis (2015) 0.77
CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling. Mol Cell Biol (2015) 0.77
Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo. Sci Rep (2015) 0.77
Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells. J Mol Cell Biol (2016) 0.76
Localization and Function of Pals1-associated Tight Junction Protein in Drosophila Is Regulated by Two Distinct Apical Complexes. J Biol Chem (2015) 0.76
Immunocytochemical evidence of the localization of the Crumbs homologue 3 protein (CRB3) in the developing and mature mouse retina. PLoS One (2012) 0.76
CCM1 and the second life of proteins in adhesion complexes. Cell Adh Migr (2014) 0.75
Domain-specific functions of Stardust in Drosophila embryonic development. R Soc Open Sci (2016) 0.75
Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42. Biochemistry (2016) 0.75
The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy. Front Neurosci (2017) 0.75
Cell polarity proteins and spermatogenesis. Semin Cell Dev Biol (2016) 0.75
Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration. Sci Rep (2016) 0.75
The Crumbs_C isoform of Drosophila shows tissue- and stage-specific expression and prevents light-dependent retinal degeneration. Biol Open (2017) 0.75
The C. elegans Crumbs family contains a CRB3 homolog and is not essential for viability. Biol Open (2015) 0.75
Cross talk between the Crumbs complex and Hippo signaling in renal epithelial cells. Pflugers Arch (2017) 0.75
Routes and machinery of primary cilium biogenesis. Cell Mol Life Sci (2017) 0.75
Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes. Cell Mol Life Sci (2017) 0.75
Temporal regulation of epithelium formation mediated by FoxA, MKLP1, MgcRacGAP and PAR-6. Mol Biol Cell (2017) 0.75
Opinion: Building epithelial architecture: insights from three-dimensional culture models. Nat Rev Mol Cell Biol (2002) 4.76
Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell (1995) 4.10
crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell (1990) 3.79
Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol (2003) 3.38
Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis. Nature (2002) 3.22
Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet (2001) 3.22
Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization. Nat Cell Biol (2003) 3.13
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Nat Cell Biol (2003) 3.07
Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. Curr Opin Cell Biol (2001) 2.81
Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 (CRB1) gene. Am J Hum Genet (2001) 2.80
Membrane traffic in polarized epithelial cells. Curr Opin Cell Biol (2000) 2.76
Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12). Nat Genet (1999) 2.75
hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. J Biol Chem (2002) 2.51
Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature (2002) 2.48
The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. J Cell Biol (2002) 2.37
Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell (1999) 2.16
Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells. J Cell Biol (1990) 2.12
Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature (2001) 2.12
Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Nature (2001) 2.11
Control of growth and organ size in Drosophila. Bioessays (2002) 1.90
An internal deletion in the cytoplasmic tail reverses the apical localization of human NGF receptor in transfected MDCK cells. J Cell Biol (1991) 1.87
Assembly of epithelial tight junctions is negatively regulated by Par6. Curr Biol (2002) 1.84
The Drosophila genes crumbs and stardust are involved in the biogenesis of adherens junctions. Development (1996) 1.75
A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila. Curr Biol (2000) 1.73
The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. J Cell Sci (2003) 1.70
Protein trafficking in the exocytic pathway of polarized epithelial cells. Trends Cell Biol (2001) 1.69
Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). Gene (2003) 1.68
Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins. Mol Biol Cell (2000) 1.60
Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila. J Cell Biol (2002) 1.50
The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. J Biol Chem (2002) 1.47
Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila. Development (2003) 1.41
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Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev (2002) 1.20
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Human syntaxin 3 is localized apically in human intestinal cells. J Cell Sci (1997) 1.11
Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells. Biol Cell (2002) 0.98
Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells. J Biol Chem (2001) 0.97
The basolateral localization signal of the follicle-stimulating hormone receptor. J Biol Chem (1998) 0.90
Cell polarity: Nailing Crumbs to the scaffold. Curr Biol (2000) 0.84
hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. J Biol Chem (2002) 2.51
Polarity complex proteins. Biochim Biophys Acta (2007) 2.42
Junctional recruitment of mammalian Scribble relies on E-cadherin engagement. Oncogene (2005) 1.73
Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila. J Cell Biol (2002) 1.50
Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells. J Cell Biol (2005) 1.43
Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6. Hum Mol Genet (2009) 1.37
Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells. Hum Mol Genet (2006) 1.21
PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. J Cell Sci (2005) 1.19
Computer modelling in combination with in vitro studies reveals similar binding affinities of Drosophila Crumbs for the PDZ domains of Stardust and DmPar-6. Eur J Cell Biol (2006) 1.15
Vesicular trafficking and secretion of matrix metalloproteinases-2, -9 and tissue inhibitor of metalloproteinases-1 in neuronal cells. Mol Cell Neurosci (2008) 1.15
Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol (2013) 1.13
Hook2 is involved in the morphogenesis of the primary cilium. Mol Biol Cell (2011) 1.08
CD146 and its soluble form regulate monocyte transendothelial migration. Arterioscler Thromb Vasc Biol (2009) 1.08
Crumbs proteins in epithelial morphogenesis. Front Biosci (Landmark Ed) (2009) 1.07
EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement. Mol Biol Cell (2003) 1.07
Interaction between Erbin and a Catenin-related protein in epithelial cells. J Biol Chem (2001) 1.05
Distinct v-SNAREs regulate direct and indirect apical delivery in polarized epithelial cells. J Cell Sci (2007) 1.05
FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex. Exp Cell Res (2007) 1.02
Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet (2012) 1.00
Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells. Biol Cell (2002) 0.98
The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells. J Cell Sci (2002) 0.96
The type 3 inositol 1,4,5-trisphosphate receptor is concentrated at the tight junction level in polarized MDCK cells. J Cell Sci (2003) 0.96
Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex. Hum Mol Genet (2007) 0.93
PALS1 is essential for retinal pigment epithelium structure and neural retina stratification. J Neurosci (2011) 0.89
Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis. PLoS Genet (2013) 0.89
Role of the membrane-proximal O-glycosylation site in sorting of the human receptor for neurotrophins to the apical membrane of MDCK cells. Exp Cell Res (2002) 0.87
Apico-basal elongation requires a drebrin-E-EB3 complex in columnar human epithelial cells. J Cell Sci (2012) 0.83
Heterogeneity of Raft-type membrane microdomains associated with VP4, the rotavirus spike protein, in Caco-2 and MA 104 cells. J Virol (2006) 0.83
PSD95beta regulates plasma membrane Ca2+ pump localization at the photoreceptor synapse. Mol Cell Neurosci (2009) 0.81
Differential recognition of a tyrosine-dependent signal in the basolateral and endocytic pathways of thyroid epithelial cells. Endocrinology (2002) 0.81
[Role of Crumbs proteins in the control of epithelial cell and photoreceptor morphogenesis]. Med Sci (Paris) (2004) 0.79
Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function. Hum Mol Genet (2014) 0.75