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A J Fornace

Author PubWeight™ 228.88‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992 19.87
2 An information-intensive approach to the molecular pharmacology of cancer. Science 1997 11.43
3 p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol Cell Biol 2000 6.23
4 Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 1994 6.11
5 Repair of gamma-ray-induced DNA base damage in xeroderma pigmentosum cells. Radiat Res 1986 5.08
6 Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res 1997 4.34
7 The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol Cell Biol 1994 4.15
8 Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 1999 3.46
9 Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol Cell Biol 1994 3.30
10 Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 2001 3.25
11 Genomic instability in Gadd45a-deficient mice. Nat Genet 1999 3.01
12 GADD45 induction of a G2/M cell cycle checkpoint. Proc Natl Acad Sci U S A 1999 2.80
13 Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Mol Cell Biol 1993 2.77
14 An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res 2000 2.47
15 The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Res 1994 2.41
16 Induction of B2 RNA polymerase III transcription by heat shock: enrichment for heat shock induced sequences in rodent cells by hybridization subtraction. Nucleic Acids Res 1986 2.31
17 Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 1999 2.29
18 Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 1999 2.12
19 Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionizing radiation. Radiat Res 2000 2.11
20 p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha. Cancer Res 1998 2.02
21 Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Res 1995 2.00
22 Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage. Oncogene 1995 2.00
23 Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol 1999 1.97
24 p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res 1994 1.94
25 Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene 1994 1.88
26 Myc represses the growth arrest gene gadd45. Oncogene 1997 1.86
27 Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. J Biol Chem 1997 1.85
28 T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells. Proc Natl Acad Sci U S A 1984 1.77
29 Response to adversity: molecular control of gene activation following genotoxic stress. New Biol 1991 1.72
30 Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene 1998 1.71
31 Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. Mol Cell Biol 1991 1.69
32 Induction of gene expression as a monitor of exposure to ionizing radiation. Radiat Res 2001 1.69
33 A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes. Cancer Biol Ther 2002 1.64
34 Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins. Mol Cell Biol 1999 1.62
35 The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. J Biol Chem 2000 1.62
36 Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem 1993 1.58
37 Isolation, characterization and chromosomal localization of the human GADD153 gene. Gene 1992 1.55
38 Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. Proc Natl Acad Sci U S A 1994 1.53
39 Regulation of translation initiation following stress. Oncogene 1999 1.51
40 The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. Oncogene 1996 1.51
41 Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats. Proc Natl Acad Sci U S A 1990 1.51
42 Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion. Proc Natl Acad Sci U S A 1985 1.49
43 Evolution and structure of the fibrinogen genes. Random insertion of introns or selective loss? J Mol Biol 1985 1.47
44 DNA single-strand breaks during repair of UV damage in human fibroblasts and abnormalities of repair in xeroderma pigmentosum. Proc Natl Acad Sci U S A 1976 1.42
45 Induction of fos RNA by DNA-damaging agents. Cancer Res 1989 1.41
46 Induction of stress genes by low doses of gamma rays. Radiat Res 1999 1.41
47 The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis. Oncogene 2006 1.40
48 Death and decoy receptors and p53-mediated apoptosis. Leukemia 2000 1.36
49 Metallothionein gene expression and resistance to cisplatin in human ovarian cancer. Int J Cancer 1990 1.35
50 Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding. Mol Cell Biol 1998 1.35
51 Biological indicators for the identification of ionizing radiation exposure in humans. Expert Rev Mol Diagn 2001 1.34
52 Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells. Nature 1983 1.33
53 Role of p53 family members in apoptosis. J Cell Physiol 2000 1.31
54 Low-ratio hybridization subtraction. Anal Biochem 1990 1.31
55 Structure of the human gamma-fibrinogen gene. Alternate mRNA splicing near the 3' end of the gene produces gamma A and gamma B forms of gamma-fibrinogen. J Biol Chem 1984 1.30
56 Altered cell cycle control at the G(2)/M phases in aryl hydrocarbon receptor-null embryo fibroblast. Mol Pharmacol 2000 1.28
57 Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes. Cancer Res 1994 1.26
58 Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein. J Biol Chem 1997 1.26
59 The p53-dependent gamma-ray response of GADD45. Cancer Res 1994 1.25
60 p53-mediated protective responses to UV irradiation. Proc Natl Acad Sci U S A 1997 1.24
61 Single-strand scission and repair of DNA in mammalian cells by bleomycin. Cancer Res 1976 1.23
62 Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation or cisplatin. Oncogene 1996 1.23
63 Isolation and characterization of the hamster gadd153 gene. Activation of promoter activity by agents that damage DNA. J Biol Chem 1990 1.22
64 Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. Int J Cancer 2001 1.19
65 Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation. DNA Cell Biol 1996 1.18
66 Oligomerization of human Gadd45a protein. J Biol Chem 2001 1.18
67 Genomic instability and the role of p53 mutations in cancer cells. Curr Opin Oncol 1995 1.18
68 The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis. Mol Pharmacol 1998 1.17
69 Estimation of relative mRNA content by filter hybridization to a polythymidylate probe. Biotechniques 1990 1.14
70 Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction. Oncogene 1996 1.14
71 Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard. Oncogene 1997 1.12
72 Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells. Science 1983 1.10
73 Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency. Cancer Res 2001 1.08
74 DNA crosslinking induced by x-rays and chemical agents. Biochim Biophys Acta 1977 1.08
75 Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis. Cancer Res 1996 1.07
76 p21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate. Cell Cycle 2010 1.07
77 Enhancement of X ray induced DNA damage by pre-treatment with halogenated pyrimidine analogs. Int J Radiat Oncol Biol Phys 1987 1.04
78 Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents. Oncogene 1998 1.04
79 Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA. Oncogene 1995 1.04
80 BRCA1 activation of the GADD45 promoter. Oncogene 2000 1.03
81 Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. Oncogene 1997 1.03
82 Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1. Oncogene 1998 1.03
83 Gene expression profiles for monitoring radiation exposure. Radiat Prot Dosimetry 2001 1.02
84 Measurement of M. luteus endonuclease-sensitive lesions by alkaline elution. Mutat Res 1982 1.02
85 The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. Mol Ther 2000 1.01
86 Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following gamma-irradiation of human lymphoma cells. Cancer Res 1995 1.01
87 An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines. Cancer Res 1996 1.00
88 Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm. Environ Health Perspect 1990 0.96
89 DNA repair and its pathogenetic implications. Lab Invest 1989 0.96
90 p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells. DNA Cell Biol 1998 0.96
91 Quantitation of mitochondrial DNA in human lymphoblasts by a competitive polymerase chain reaction method: application to the study of inhibitors of mitochondrial DNA content. Mol Pharmacol 1994 0.96
92 Induction of BCL2 family member MCL1 as an early response to DNA damage. Oncogene 1997 0.96
93 DNA-protein cross-linking by chromium salts. Chem Biol Interact 1981 0.94
94 Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents. Proc Natl Acad Sci U S A 1994 0.94
95 The ATF/CREB transcription factor-binding site in the polymerase beta promoter mediates the positive effect of N-methyl-N'-nitro-N-nitrosoguanidine on transcription. Proc Natl Acad Sci U S A 1991 0.94
96 The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract. Oncogene 1999 0.94
97 Signaling events controlling the molecular response to genotoxic stress. EXS 1996 0.94
98 Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis. Mutat Res 1996 0.92
99 Chromatin relaxation by overexpression of mutant p53, HPV16-E6, or cyclin G transgenes. Exp Cell Res 1998 0.92
100 Identification of an additional p53-responsive site in the human epidermal growth factor receptor gene promotor. Oncogene 1997 0.92
101 Detection of DNA single-strand breaks produced during the repair of damage by DNA-protein cross-linking agents. Cancer Res 1982 0.91
102 Normal repair of DNA single-strand breaks in patients with ataxia telangiectasia. Biochim Biophys Acta 1980 0.90
103 The central region of Gadd45 is required for its interaction with p21/WAF1. Exp Cell Res 2000 0.90
104 Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1)). J Biol Chem 1999 0.90
105 The p53-regulated cyclin G gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity. Exp Cell Res 1997 0.89
106 Repair of trans-Pt(II) diamminedichloride DNA-protein crosslinks in normal and excision-deficient human cells. Mutat Res 1982 0.88
107 UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation. Oncogene 1995 0.88
108 The two faces of tumor suppressor p53. Am J Pathol 1996 0.88
109 Presetting of chromatin structure and transcription factor binding poise the human GADD45 gene for rapid transcriptional up-regulation. Nucleic Acids Res 1999 0.88
110 A novel DNA damage-inducible transcript, gadd7, inhibits cell growth, but lacks a protein product. Nucleic Acids Res 1996 0.88
111 Inhibitory effect of Bcl-2 on p53-mediated transactivation following genotoxic stress. Oncogene 1999 0.87
112 Human O6-alkylguanine-DNA alkyltransferase fails to repair O4-methylthymine and methyl phosphotriesters in DNA as efficiently as does the alkyltransferase from Escherichia coli. Carcinogenesis 1985 0.87
113 Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437. Nucleic Acids Res 1999 0.86
114 Genomic instability in Gadd45a-/- cells is coupled with S-phase checkpoint defects. Cell Cycle 2005 0.86
115 DNA repair in human bronchial epithelial cells. Carcinogenesis 1982 0.86
116 Inhibition of the ligase step of excision repair by 2-chloroethyl isocyanate, a decomposition product of 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res 1978 0.85
117 Single-copy inverted repeats associated with regional genetic duplications in gamma fibrinogen and immunoglobulin genes. Science 1984 0.85
118 Analysis of the effect of DNA alkylation on alkaline elution. Carcinogenesis 1986 0.85
119 Detection of DNA single-strand breaks during the repair of UV damage in xeroderma pigmentosum cells. Radiat Res 1983 0.84
120 DNA-protein cross-linking by ultraviolet radiation in normal human and xeroderma pigmentosum fibroblasts. Biochim Biophys Acta 1976 0.84
121 Physiological function as regulation of large transcriptional programs: the cellular response to genotoxic stress. Comp Biochem Physiol B Biochem Mol Biol 2001 0.84
122 The apoptosis-associated gamma-ray response of BCL-X(L) depends on normal p53 function. Oncogene 1996 0.84
123 DNA repair in a Fanconi's anemia fibroblast cell strain. Biochim Biophys Acta 1979 0.83
124 Cell cycle-independent regulation of p21Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells. Cell Growth Differ 1996 0.83
125 Cyclobutane pyrimidine dimers in UV-DNA induce release of soluble mediators that activate the human immunodeficiency virus promoter. J Invest Dermatol 1993 0.83
126 Induction of p53-, MDM2-, and WAF1/CIP1-like molecules in insect cells by DNA-damaging agents. Exp Cell Res 1995 0.82
127 Expression of the poly(ADP-ribose) polymerase gene following natural and induced DNA strand breakage and effect of hyperexpression on DNA repair. Carcinogenesis 1990 0.82
128 Role of retinoblastoma gene product in p53-mediated DNA damage response. Exp Cell Res 1994 0.81
129 DNA-damage inducible genes. Cancer Treat Res 1991 0.81
130 Regulation and characterization of the mRNAs for the A alpha, B beta and gamma chains of fibrinogen. Ann N Y Acad Sci 1983 0.81
131 DNA-protein cross-linking by chemical carcinogens in mammalian cells. Cancer Res 1979 0.81
132 Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells. Oncogene 1999 0.80
133 Alzheimer's disease fibroblasts have normal repair of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage determined by the alkaline elution technique. Biochem Biophys Res Commun 1987 0.79
134 Relationship of DNA repair to chromosome aberrations, sister-chromatid exchanges and survival during liquid-holding recovery in X-irradiated mammalian cells. Mutat Res 1980 0.79
135 Relationship of enhanced survival during confluent holding recovery in ultraviolet-irradiated human and mouse cells to chromosome aberrations, sister chromatid exchanges, and DNA repair. Radiat Res 1982 0.79
136 Detection of messenger RNA from O6-methylguanine-DNA methyltransferase gene MGMT in human normal and tumor tissues. J Natl Cancer Inst 1992 0.78
137 Characterization of the GADD45 response to ionizing radiation in WI-L2-NS cells, a p53 mutant cell line. Mutat Res 1996 0.78
138 Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines. Oncol Res 1996 0.78
139 Evidence for distinct kinase-mediated pathways in gadd gene responses. Biochem Pharmacol 1998 0.78
140 Gadd45a acts as a modifier locus for lymphoblastic lymphoma. Leukemia 2005 0.77
141 The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. Hybridoma 1995 0.77
142 Estimation of relative mRNA content by filter hybridization to a polyuridylic probe. Biotechniques 2000 0.77
143 Correspondence re: J. S. DeFrank et al., p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine. Cancer Res., 56: 5365-5368, 1996. Cancer Res 1997 0.75
144 Evidence of a reduced DNA topoisomerase II mRNA expression after ionizing radiation. Anticancer Res 2000 0.75
145 Recovery of mitomycin C-treated mouse 10T1/2 cells during confluent holding. Mutat Res 1988 0.75
146 Activation of HIV type 1 long terminal repeat by ultraviolet light is serum and strain specific. AIDS Res Hum Retroviruses 1994 0.75
147 Genetic and biochemical characterization of the CHO-UV-1 mutant defective in postreplication recovery of DNA. Cancer Res 1990 0.75
148 Induction of gadd153 gene in G0-specific ts mutant cells at nonpermissive temperature. Exp Cell Res 1995 0.75
149 Modulation of X ray DNA damage by SR-2508 +/- buthionine sulfoximine. Int J Radiat Oncol Biol Phys 1986 0.75
150 Normal repair of ultraviolet-induced DNA damage in a hypersensitive strain of fibroblasts from a patient with Gardner's syndrome. Mutat Res 1983 0.75
151 Relationship of DNA repair and chromosome aberrations to potentially lethal damage repair in X-irradiated mammalian cells. Basic Life Sci 1980 0.75
152 Normal response of fanconi's anemia cells to high concentrations of O2 as determined by alkaline elution. Biochim Biophys Acta 1982 0.75
153 Repair of ionizing radiation DNA base damage in ataxia-telangiectasia cells. Cancer Res 1986 0.75