Published in Proc Natl Acad Sci U S A on March 30, 1999
p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol Cell Biol (2000) 6.23
BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood (2005) 2.54
miR-301a as an NF-κB activator in pancreatic cancer cells. EMBO J (2010) 2.47
Human cyclin A is required for mitosis until mid prophase. J Cell Biol (1999) 2.31
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci U S A (2002) 2.04
Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Mol Biol Cell (2001) 2.00
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95
Activation and activities of the p53 tumour suppressor protein. Br J Cancer (2001) 1.90
Molecular mechanism of endothelial growth arrest by laminar shear stress. Proc Natl Acad Sci U S A (2000) 1.83
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry (2011) 1.81
Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene (2010) 1.78
Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts. PLoS One (2009) 1.58
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor. Proc Natl Acad Sci U S A (2001) 1.56
p53 accumulates but is functionally impaired when DNA synthesis is blocked. Proc Natl Acad Sci U S A (2001) 1.55
Anti-tumour activity of two novel compounds in cisplatin-resistant testicular germ cell cancer. Br J Cancer (2012) 1.48
The exosome complex establishes a barricade to erythroid maturation. Blood (2014) 1.48
IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response. J Cell Biol (2006) 1.46
MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M. Mol Cell Biol (2000) 1.44
Gadd45 in stress signaling. J Mol Signal (2008) 1.42
Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Mol Cell Biol (2003) 1.38
The tumour suppressor protein p53 can repress transcription of cyclin B. Nucleic Acids Res (2000) 1.36
Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity. Hematol Oncol (2009) 1.29
Gadd45 in the response of hematopoietic cells to genotoxic stress. Blood Cells Mol Dis (2007) 1.28
Gadd45 stress sensors in malignancy and leukemia. Crit Rev Oncog (2011) 1.27
GADD45 proteins: central players in tumorigenesis. Curr Mol Med (2012) 1.26
Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA. Nucleic Acids Res (2006) 1.23
Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs. J Clin Invest (2000) 1.22
C/EBPalpha is a DNA damage-inducible p53-regulated mediator of the G1 checkpoint in keratinocytes. Mol Cell Biol (2004) 1.21
Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus 1. Proc Natl Acad Sci U S A (1999) 1.20
Gadd45 proteins: relevance to aging, longevity and age-related pathologies. Ageing Res Rev (2011) 1.19
Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells. Blood (2006) 1.19
Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria. Mol Cell Biol (2005) 1.16
Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress. Cancer Res (2010) 1.12
The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis. Front Biosci (Landmark Ed) (2012) 1.12
Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling. J Biol Chem (2009) 1.11
Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells. J Neurooncol (2010) 1.11
Stress sensor Gadd45 genes as therapeutic targets in cancer. Cancer Ther (2009) 1.09
Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells. Proc Natl Acad Sci U S A (2005) 1.09
Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response? Cell Cycle (2011) 1.08
Reovirus-induced alterations in gene expression related to cell cycle regulation. J Virol (2002) 1.03
Posttranscriptional regulation of p53 and its targets by RNA-binding proteins. Curr Mol Med (2008) 1.03
HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication. Proc Natl Acad Sci U S A (2010) 1.03
UV irradiation induces a postreplication DNA damage checkpoint. Proc Natl Acad Sci U S A (2006) 1.02
Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades. Curr Cancer Drug Targets (2009) 1.00
Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage. Mol Cell Biol (2003) 1.00
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B (2007) 0.99
Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction. Oncotarget (2010) 0.98
The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage. Oncogene (2012) 0.97
The crystal structure and dimerization interface of GADD45gamma. Proc Natl Acad Sci U S A (2008) 0.97
Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses. J Biol Chem (2008) 0.97
Role of gadd45 in myeloid cells in response to hematopoietic stress. Blood Cells Mol Dis (2007) 0.96
c-Myc alters the DNA damage-induced G2/M arrest in human mammary epithelial cells. Br J Cancer (2003) 0.94
A critical function of Mad2l2 in primordial germ cell development of mice. PLoS Genet (2013) 0.93
Age-related gene response of human corneal endothelium to oxidative stress and DNA damage. Invest Ophthalmol Vis Sci (2011) 0.92
Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1. Cell Cycle (2005) 0.91
Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells. NMR Biomed (2011) 0.90
Tumor suppressors and cell-cycle proteins in lung cancer. Patholog Res Int (2011) 0.89
Contribution of GADD45 family members to cell death suppression by cellular Bcl-xL and cytomegalovirus vMIA. J Virol (2005) 0.89
Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9-mediated EMT. Neuro Oncol (2011) 0.89
Wip1 contributes to cell homeostasis maintained by the steady-state level of Wtp53. Cell Cycle (2011) 0.89
Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest. Toxicol Appl Pharmacol (2008) 0.88
Transcriptional Control of Vascular Smooth Muscle Cell Proliferation by Peroxisome Proliferator-Activated Receptor-gamma: Therapeutic Implications for Cardiovascular Diseases. PPAR Res (2008) 0.88
Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis. Neuro Oncol (2008) 0.88
Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways. Toxicol Appl Pharmacol (2008) 0.88
Posttranscriptional regulation of gene expression-adding another layer of complexity to the DNA damage response. Front Genet (2012) 0.87
Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45α-dependent manner. Carcinogenesis (2011) 0.87
Development and progression of colorectal neoplasia. Cancer Biomark (2010) 0.85
Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase. Oncotarget (2016) 0.85
Cell cycle perturbations and radiosensitization effects in a human prostate cancer cell line. J Cancer Res Clin Oncol (2003) 0.84
Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy. Curr Pharm Des (2013) 0.84
RB·E2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1. J Biol Chem (2010) 0.84
A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45α mRNA stability. J Biol Chem (2015) 0.84
p53-Dependent but ATM-independent inhibition of DNA synthesis and G2 arrest in cadmium-treated human fibroblasts. Toxicol Appl Pharmacol (2006) 0.83
Integrin-dependent amplification of the G2 arrest induced by ionizing radiation. Prostate (2006) 0.83
Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair. Br J Cancer (2013) 0.83
Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation. Mol Cell Neurosci (2010) 0.82
Different cell cycle modulation following treatment of human ovarian carcinoma cells with a new platinum(IV) complex vs cisplatin. Invest New Drugs (2007) 0.82
Udu deficiency activates DNA damage checkpoint. Mol Biol Cell (2009) 0.82
Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatin. PLoS One (2008) 0.82
Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells. Cell Death Dis (2015) 0.82
Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proc Natl Acad Sci U S A (2013) 0.82
GADD45γ induces G2/M arrest in human pharynx and nasopharyngeal carcinoma cells by cucurbitacin E. Sci Rep (2014) 0.81
Hyperosmotic stress induces cell cycle arrest in retinal pigmented epithelial cells. Cell Death Dis (2013) 0.81
p53 Promotes cell survival due to the reversibility of its cell-cycle checkpoints. Mol Cancer Res (2014) 0.81
1α,25-dihydroxyvitamin D3 inhibits C4-2 prostate cancer cell growth via a retinoblastoma protein (Rb)-independent G1 arrest. Prostate (2011) 0.81
Rebamipide, a gastro-protective drug, inhibits indomethacin-induced apoptosis in cultured rat gastric mucosal cells: association with the inhibition of growth arrest and DNA damage-induced 45 alpha expression. Dig Dis Sci (2005) 0.80
Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation. Nucleic Acids Res (2013) 0.80
Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival. Cancer Res (2008) 0.80
Transcriptional repression by p53 promotes a Bcl-2-insensitive and mitochondria-independent pathway of apoptosis. Nucleic Acids Res (2004) 0.79
Octyl methoxycinnamate modulates gene expression and prevents cyclobutane pyrimidine dimer formation but not oxidative DNA damage in UV-exposed human cell lines. Toxicol Sci (2010) 0.79
Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1. Oncotarget (2016) 0.78
Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor. BMC Cancer (2008) 0.78
Characterization of growth suppressive functions of a splice variant of cyclin D2. PLoS One (2013) 0.78
Census and evaluation of p53 target genes. Oncogene (2017) 0.77
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival. Stem Cells (2016) 0.77
Temporal changes in rat liver gene expression after acute cadmium and chromium exposure. PLoS One (2015) 0.77
BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo. Drug Des Devel Ther (2015) 0.77
Mutation analysis of the Gadd45 gene at exon 4 in atypical fibroxanthoma. BMC Dermatol (2009) 0.76
Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G₁ phase and protects them from UV light-induced apoptosis. J Neural Transm (Vienna) (2014) 0.76
Controlling the response to DNA damage by the APC/C-Cdh1. Cell Mol Life Sci (2015) 0.76
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