Novel cell and gene therapies for HIV.

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Published in Cold Spring Harb Perspect Med on October 01, 2012

Authors

James A Hoxie1, Carl H June

Author Affiliations

1: Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. hoxie@mail.med.upenn.edu

Associated clinical trials:

Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 for HIV (Zinc-Finger) | NCT00842634

Phase 1 Dose Escalation Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Patients | NCT01044654

Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Subjects | NCT01252641

Evaluate the Tolerability and Therapeutic Effects of Repeated Doses of Autologous T Cells With VRX496 in HIV | NCT00295477

Redirected High Affinity Gag‐Specific Autologous T Cells for HIV Gene Therapy | NCT00991224

Safety and Efficacy of T Cell Genetic Immunotherapy for HIV | NCT00131560

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