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Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 for HIV (Zinc-Finger)
Clinical Trial ID NCT00842634
PubWeight™ 114.69
‹?›
🔗 Visit the ClinicalTrials.gov page for NCT00842634
Top papers
Rank
Title
Journal
Year
PubWeight™
‹?›
1
Genome editing with engineered zinc finger nucleases.
Nat Rev Genet
2010
18.88
2
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.
Trends Biotechnol
2013
11.58
3
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity.
Nat Biotechnol
2013
8.40
4
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.
Nucleic Acids Res
2011
7.93
5
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.
N Engl J Med
2014
7.64
6
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection.
Nat Methods
2011
6.90
7
Engineering lymphocyte subsets: tools, trials and tribulations.
Nat Rev Immunol
2009
3.06
8
Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy.
Nat Commun
2015
2.56
9
Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs.
Lancet
2013
2.11
10
Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme.
Genome Res
2012
2.02
11
Advances in targeted genome editing.
Curr Opin Chem Biol
2012
1.97
12
Prospects for treatment of latent HIV.
Clin Pharmacol Ther
2012
1.91
13
Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.
PLoS Pathog
2011
1.50
14
HIV-1 transcription and latency: an update.
Retrovirology
2013
1.49
15
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells.
Nucleic Acids Res
2013
1.48
16
Repurposing CRISPR/Cas9 for in situ functional assays.
Genes Dev
2013
1.41
17
Developing strategies for HIV-1 eradication.
Trends Immunol
2012
1.38
18
Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering.
PLoS One
2014
1.24
19
Chemokine receptor 5 knockout strategies.
Curr Opin HIV AIDS
2011
1.22
20
Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5.
Hum Gene Ther
2013
1.14
21
Zinc-finger nucleases for somatic gene therapy: the next frontier.
Hum Gene Ther
2011
1.11
22
Targeted gene disruption to cure HIV.
Curr Opin HIV AIDS
2013
1.09
23
Newer gene editing technologies toward HIV gene therapy.
Viruses
2013
1.07
24
Novel cell and gene therapies for HIV.
Cold Spring Harb Perspect Med
2012
1.07
25
Gene correction by homologous recombination with zinc finger nucleases in primary cells from a mouse model of a generic recessive genetic disease.
Mol Ther
2010
1.04
26
Novel approaches to inhibit HIV entry.
Viruses
2012
1.00
27
T-cell therapies for HIV.
Immunotherapy
2013
0.99
28
Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9.
Mol Cells
2015
0.97
29
Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation.
Nucleic Acids Res
2014
0.95
30
Creating genetic resistance to HIV.
Curr Opin Immunol
2012
0.93
31
A cure for AIDS: a matter of timing?
Retrovirology
2013
0.92
32
Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches.
Front Immunol
2013
0.92
33
Eradication of HIV and Cure of AIDS, Now and How?
Front Immunol
2013
0.92
34
Native homing endonucleases can target conserved genes in humans and in animal models.
Nucleic Acids Res
2011
0.90
35
Emerging gene editing strategies for Duchenne muscular dystrophy targeting stem cells.
Front Physiol
2014
0.86
36
CD4 T-cell immunotherapy for chronic viral infections and cancer.
Immunotherapy
2013
0.85
37
Clinical development of gene therapy: results and lessons from recent successes.
Mol Ther Methods Clin Dev
2016
0.85
38
Adoptive immunotherapy for hematological malignancies using T cells gene-modified to express tumor antigen-specific receptors.
Pharmaceuticals (Basel)
2014
0.84
39
HIV-1 functional cure: will the dream come true?
BMC Med
2015
0.84
40
State-of-the-art human gene therapy: part II. Gene therapy strategies and clinical applications.
Discov Med
2014
0.84
41
Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation.
Mol Ther Nucleic Acids
2013
0.84
42
RNA interference approaches for treatment of HIV-1 infection.
Genome Med
2015
0.81
43
Engineering T Cells to Functionally Cure HIV-1 Infection.
Mol Ther
2015
0.81
44
Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice.
Viruses
2013
0.80
45
Non-integrating gamma-retroviral vectors as a versatile tool for transient zinc-finger nuclease delivery.
Sci Rep
2014
0.79
46
Zinc Finger Nucleases: Tailor-made for Gene Therapy.
Drugs Future
2012
0.79
47
The clinical applications of genome editing in HIV.
Blood
2016
0.79
48
Genetic rearrangements of variable di-residue (RVD)-containing repeat arrays in a baculoviral TALEN system.
Mol Ther Methods Clin Dev
2014
0.79
49
Gene therapy targeting HIV entry.
Viruses
2014
0.79
50
Progress toward curing HIV infection with hematopoietic cell transplantation.
Stem Cells Cloning
2015
0.78
51
Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells.
Mol Ther Methods Clin Dev
2016
0.78
52
Stem cell-based therapies for HIV/AIDS.
Adv Drug Deliv Rev
2016
0.77
53
TALENs targeting HBV: designer endonuclease therapies for viral infections.
Mol Ther
2013
0.76
54
In Vivo Delivery Systems for Therapeutic Genome Editing.
Int J Mol Sci
2016
0.75
55
From hacking the human genome to editing organs.
Organogenesis
2015
0.75
56
T-cell therapies for HIV: Preclinical successes and current clinical strategies.
Cytotherapy
2016
0.75
57
Advances in homology directed genetic engineering of human pluripotent and adult stem cells.
World J Stem Cells
2013
0.75
58
Bone marrow transplant muffles HIV.
Nat Med
2009
0.75
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