Published in Nat Struct Mol Biol on October 07, 2012
Regulation of PCNA-protein interactions for genome stability. Nat Rev Mol Cell Biol (2013) 1.88
Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication. Science (2014) 1.69
Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nat Genet (2014) 1.68
DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. Nat Struct Mol Biol (2012) 1.38
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis. J Cell Sci (2014) 1.32
Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage. Mol Cell (2014) 1.15
Repair of a DNA-protein crosslink by replication-coupled proteolysis. Cell (2014) 1.12
Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity. Nat Commun (2014) 1.08
A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks. Nucleic Acids Res (2013) 1.05
Ubiquitylation, neddylation and the DNA damage response. Open Biol (2015) 1.04
What is the DNA repair defect underlying Fanconi anemia? Curr Opin Cell Biol (2015) 1.03
Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Mol Cell (2014) 0.97
Spartan deficiency causes genomic instability and progeroid phenotypes. Nat Commun (2014) 0.95
Structure and function of the AAA+ ATPase p97/Cdc48p. Gene (2016) 0.94
Role of p97/VCP (Cdc48) in genome stability. Front Genet (2013) 0.94
Activation of the ATR kinase by the RPA-binding protein ETAA1. Nat Cell Biol (2016) 0.94
Readers of PCNA modifications. Chromosoma (2013) 0.93
Regulation of error-prone translesion synthesis by Spartan/C1orf124. Nucleic Acids Res (2012) 0.92
Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates. Elife (2015) 0.89
RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner. Cell Cycle (2016) 0.86
The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance. J Biol Chem (2014) 0.85
Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin. Nat Commun (2014) 0.83
USP7 is a SUMO deubiquitinase essential for DNA replication. Nat Struct Mol Biol (2016) 0.83
Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN. Mol Cell (2016) 0.81
Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication. Chromosoma (2016) 0.81
The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. Cell Cycle (2014) 0.81
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress. J Cell Biol (2015) 0.81
Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin. Front Genet (2016) 0.81
Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress. Front Genet (2016) 0.80
The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight. DNA Repair (Amst) (2015) 0.80
Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork. Mol Cell (2017) 0.80
Relevance of simultaneous mono-ubiquitinations of multiple units of PCNA homo-trimers in DNA damage tolerance. PLoS One (2015) 0.78
SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination. J Cell Biol (2014) 0.78
Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA. Nat Commun (2016) 0.77
SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Elife (2016) 0.77
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair. Mol Cell (2016) 0.77
The Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like Modifiers. Front Genet (2016) 0.76
DNA-dependent protease activity of human Spartan facilitates replication of DNA-protein crosslink-containing DNA. Nucleic Acids Res (2017) 0.76
Mechanisms of Post-Replication DNA Repair. Genes (Basel) (2017) 0.75
Illuminating Spatial and Temporal Organization of Protein Interaction Networks by Mass Spectrometry-Based Proteomics. Front Genet (2015) 0.75
Using ultra-sensitive next generation sequencing to dissect DNA damage-induced mutagenesis. Sci Rep (2016) 0.75
Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA. Sci Rep (2016) 0.75
Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis. Nucleic Acids Res (2017) 0.75
A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. Elife (2016) 0.75
PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress. PLoS Genet (2016) 0.75
Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing. PLoS One (2015) 0.75
Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication. Cell Rep (2017) 0.75
The role of WRNIP1 in genome maintenance. Cell Cycle (2017) 0.75
Ubiquitin regulates dissociation of DNA repair factors from chromatin. Oncotarget (2015) 0.75
Structural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated Degradation. PLoS One (2016) 0.75
A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase. Front Mol Biosci (2017) 0.75
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol (2008) 38.00
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics (2002) 30.58
The DNA-damage response in human biology and disease. Nature (2009) 17.86
Genome maintenance mechanisms for preventing cancer. Nature (2001) 16.17
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
Specific interference by ingested dsRNA. Nature (1998) 11.82
The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol (2006) 10.76
PCNA, the maestro of the replication fork. Cell (2007) 10.43
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol (2003) 4.77
Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol (2006) 4.67
Principles of ubiquitin and SUMO modifications in DNA repair. Nature (2009) 4.10
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol (2012) 3.90
Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer. Mol Cell Proteomics (2011) 3.75
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J Cell Biol (2005) 3.69
Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nat Rev Mol Cell Biol (2012) 3.43
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell (2005) 3.29
Translesion synthesis: Y-family polymerases and the polymerase switch. DNA Repair (Amst) (2007) 3.27
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20
Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells. Genes Dev (2001) 2.53
Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Repair (Amst) (2010) 2.51
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell (2006) 2.45
Ubiquitin signalling in DNA replication and repair. Nat Rev Mol Cell Biol (2010) 2.41
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat Struct Mol Biol (2011) 2.23
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat Cell Biol (2011) 2.15
Ubiquitin-binding domains and their role in the DNA damage response. DNA Repair (Amst) (2009) 2.02
Suffering in silence: the tolerance of DNA damage. Nat Rev Mol Cell Biol (2005) 2.01
Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes Dev (2011) 1.95
The ubiquitous role of ubiquitin in the DNA damage response. DNA Repair (Amst) (2010) 1.94
Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta. EMBO Rep (2007) 1.91
DNA polymerases and human disease. Nat Rev Genet (2008) 1.88
Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol Cell (2010) 1.84
Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis. Mol Cell Biol (2000) 1.74
Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.73
Insights into adaptor binding to the AAA protein p97. Biochem Soc Trans (2008) 1.66
A signature element distinguishes sibling and independent mutations in a shuttle vector plasmid. Gene (1992) 1.64
Mechanisms of dealing with DNA damage-induced replication problems. Cell Biochem Biophys (2008) 1.59
A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction. Mol Cell (2011) 1.41
C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis. Genes Dev (2008) 1.41
Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks. J Cell Biol (2012) 1.37
Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. Mol Cell (2012) 1.30
Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci U S A (2008) 1.29
Wss1 is a SUMO-dependent isopeptidase that interacts genetically with the Slx5-Slx8 SUMO-targeted ubiquitin ligase. Mol Cell Biol (2010) 1.16
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76
Human CtIP promotes DNA end resection. Nature (2007) 10.63
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol (2005) 8.27
Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell (2003) 7.48
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol (2006) 6.52
DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol (2007) 5.78
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science (2011) 5.46
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol (2006) 5.34
Checking on DNA damage in S phase. Nat Rev Mol Cell Biol (2004) 4.91
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol (2003) 4.77
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol (2011) 4.57
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol (2005) 4.54
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics (2011) 4.40
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nat Cell Biol (2011) 4.23
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J Cell Biol (2005) 3.69
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell (2003) 3.58
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol (2002) 3.46
Regulation of replication fork progression through histone supply and demand. Science (2007) 3.21
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20
ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell (2013) 2.99
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet (2002) 2.97
Loss of Geminin induces rereplication in the presence of functional p53. J Cell Biol (2004) 2.97
Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science (2010) 2.74
Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep (2012) 2.66
Acetyl-phosphate is a critical determinant of lysine acetylation in E. coli. Mol Cell (2013) 2.65
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol (2004) 2.63
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem (2003) 2.54
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell (2012) 2.53
Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Repair (Amst) (2010) 2.51
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. Mol Cell (2012) 2.51
Human Asf1 regulates the flow of S phase histones during replicational stress. Mol Cell (2005) 2.51
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell (2006) 2.45
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Mol Cell Proteomics (2010) 2.43
Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair (Amst) (2004) 2.39
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J (2002) 2.39
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat Cell Biol (2009) 2.37
The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). Genes Dev (2002) 2.33
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle (2011) 2.31
ATM activation in normal human tissues and testicular cancer. Cell Cycle (2005) 2.25
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med (2012) 2.21
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Nat Genet (2008) 2.18
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin. J Cell Biol (2008) 2.18
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat Cell Biol (2011) 2.15
Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep (2013) 2.15
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol (2006) 2.09
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat Cell Biol (2002) 1.99
Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood (2007) 1.99
Regulation of PCNA-protein interactions for genome stability. Nat Rev Mol Cell Biol (2013) 1.88
Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Sci Signal (2011) 1.84
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol (2010) 1.82
Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol Cell Proteomics (2010) 1.81
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response. J Cell Biol (2009) 1.77
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nat Cell Biol (2012) 1.74
Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases. Cancer Res (2006) 1.73
Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation. Cancer Res (2004) 1.70