Tie2-dependent neovascularization of the ischemic hindlimb is mediated by angiopoietin-2.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 3458045)

Published in PLoS One on September 25, 2012

Authors

Michael Lekas1, Poli Lekas, Shirley H J Mei, Yupu Deng, Daniel J Dumont, Duncan J Stewart

Author Affiliations

1: Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, Canada.

Articles cited by this

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (1996) 18.47

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science (1997) 15.48

Vascular-specific growth factors and blood vessel formation. Nature (2000) 14.42

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell (1996) 13.95

Direct gene transfer into mouse muscle in vivo. Science (1990) 10.39

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature (1995) 8.12

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science (1999) 6.96

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell (2002) 6.41

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest (1998) 5.95

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev (1994) 5.90

Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg (1997) 5.88

Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58

Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med (2006) 5.49

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest (1997) 4.92

Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev (2004) 4.12

Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res (1998) 3.79

Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci U S A (2002) 3.25

Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol (2006) 3.21

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene (1992) 2.68

Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ Res (2005) 2.46

Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Oncogene (2000) 2.32

Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc Natl Acad Sci U S A (2002) 2.15

Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2. Cardiovasc Res (2001) 1.95

Factors regulating arteriogenesis. Arterioscler Thromb Vasc Biol (2003) 1.82

Impaired arteriogenic response to acute hindlimb ischemia in CD4-knockout mice. Circulation (2003) 1.63

Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest (1999) 1.42

Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization. Trends Mol Med (2003) 1.40

Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis. Lab Invest (1998) 1.40

Direct intramuscular injection of plasmid DNA encoding angiopoietin-1 but not angiopoietin-2 augments revascularization in the rabbit ischemic hindlimb. Circulation (1998) 1.38

Angiopoietin-2 impairs revascularization after limb ischemia. Circ Res (2007) 1.29

Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. J Cell Physiol (2000) 1.28

Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody. Mol Cancer Ther (2010) 1.27

Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector. Proc Natl Acad Sci U S A (1996) 1.25

Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors. Mol Ther (2003) 1.22

Naked plasmid DNA encoding fibroblast growth factor type 1 for the treatment of end-stage unreconstructible lower extremity ischemia: preliminary results of a phase I trial. J Vasc Surg (2002) 1.21

Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis. Arterioscler Thromb Vasc Biol (2008) 1.19

Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. Circ Res (2009) 1.03

Vascular endothelial growth factor and the angiopoietins: working together to build a better blood vessel. Circ Res (1998) 0.99

Pre-administration of angiopoietin-1 followed by VEGF induces functional and mature vascular formation in a rabbit ischemic model. J Gene Med (2003) 0.88

Transgenic expression of Angiopoietin 1 in the liver leads to changes in lymphatic and blood vessel architecture. Biochem Biophys Res Commun (2006) 0.80

Articles by these authors

Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med (2010) 3.83

Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell (2005) 3.74

Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med (2007) 3.64

A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation (2002) 2.76

Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One (2012) 2.75

Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension. Circ Res (2005) 2.65

Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation (2007) 2.60

Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ Res (2005) 2.46

A role for survivin in chemoresistance of endothelial cells mediated by VEGF. Proc Natl Acad Sci U S A (2002) 2.16

Therapeutic arteriogenesis by ultrasound-mediated VEGF165 plasmid gene delivery to chronically ischemic skeletal muscle. Circ Res (2007) 2.14

Protective role of angiopoietin-1 in experimental pulmonary hypertension. Circ Res (2003) 1.98

C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease. Circulation (2004) 1.94

Endothelial progenitor cells: new hope for a broken heart. Circulation (2003) 1.93

Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia? Circ Res (2004) 1.83

Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth. Cancer Res (2008) 1.78

Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent manner. Blood (2011) 1.73

Overexpression of endothelial NO synthase induces angiogenesis in a co-culture model. Cardiovasc Res (2002) 1.71

Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. J Clin Invest (2002) 1.70

Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure. J Card Fail (2003) 1.64

Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1. Cancer Biol Ther (2004) 1.62

The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2009) 1.51

Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide. Am J Pathol (2003) 1.48

Problems with co-funding in Canada. Science (2005) 1.48

Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am J Physiol Lung Cell Mol Physiol (2008) 1.47

A median sternotomy approach to right extrapleural pneumonectomy for mesothelioma. Ann Thorac Surg (2005) 1.45

The Janus faces of iNOS. Circ Res (2003) 1.43

Pathology and new players in the pathogenesis of brain edema. Acta Neuropathol (2009) 1.39

A first-in-man study of percutaneous myocardial cryotreatment in nonrevascularizable patients with refractory angina. Catheter Cardiovasc Interv (2009) 1.38

Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues. Am J Pathol (2008) 1.38

Cell-based angiopoietin-1 gene therapy for acute lung injury. Am J Respir Crit Care Med (2007) 1.33

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol (2008) 1.32

The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development. Semin Cell Dev Biol (2002) 1.31

Increased caveolin-1 expression precedes decreased expression of occludin and claudin-5 during blood-brain barrier breakdown. Acta Neuropathol (2007) 1.31

Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer. Clin Cancer Res (2005) 1.30

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited. Acta Neuropathol (2012) 1.30

Angiopoietin-2 impairs revascularization after limb ischemia. Circ Res (2007) 1.29

Adiponectin and cardiovascular disease: state of the art? Am J Physiol Heart Circ Physiol (2006) 1.27

The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care (2011) 1.25

Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines. Circulation (2003) 1.23

Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice. Circulation (2004) 1.22

Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat. Cardiovasc Res (2004) 1.21

Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization. J Cell Sci (2006) 1.17

Increased angiopoietin2 expression is associated with endothelial apoptosis and blood-brain barrier breakdown. Lab Invest (2005) 1.15

Endothelial progenitor cells promote fracture healing in a segmental bone defect model. J Orthop Res (2010) 1.14

Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism. PLoS One (2010) 1.13

The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis. Blood (2010) 1.12

Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment. Blood (2006) 1.11

Assemblage of signaling DNA enzymes with intriguing metal-ion specificities and pH dependences. J Am Chem Soc (2003) 1.10

Clinician guide to angiogenesis. Circulation (2003) 1.09

Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer. Am J Respir Cell Mol Biol (2006) 1.09

The role of NOS in heart failure: lessons from murine genetic models. Heart Fail Rev (2002) 1.08

Future perspectives for the treatment of pulmonary arterial hypertension. J Am Coll Cardiol (2009) 1.08

Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis. Am J Respir Crit Care Med (2014) 1.08

Altered expression of angiopoietins during blood-brain barrier breakdown and angiogenesis. Lab Invest (2003) 1.07

Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections. J Biomed Opt (2010) 1.04

A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice. Am J Pathol (2005) 1.04

Single-cell hydrogel encapsulation for enhanced survival of human marrow stromal cells. Biomaterials (2009) 1.03

Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats. Am J Physiol Regul Integr Comp Physiol (2006) 1.02

Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol (2008) 1.02

Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk. Mol Cell Biol (2005) 1.02

Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes. J Comp Neurol (2005) 1.01

Effect of cell-based VEGF gene therapy on healing of a segmental bone defect. J Orthop Res (2009) 1.01

Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation. Dev Biol (2012) 1.01

A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function. Mol Cell Biol (2003) 1.00

Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials. Pharmacol Ther (2010) 1.00

WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development. Proc Natl Acad Sci U S A (2002) 0.99

The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice. J Exp Med (2009) 0.98

Vascular gene transfer of SDF-1 promotes endothelial progenitor cell engraftment and enhances angiogenesis in ischemic muscle. Mol Ther (2011) 0.98

Endothelial progenitor cell therapy for the treatment of coronary disease, acute MI, and pulmonary arterial hypertension: current perspectives. Catheter Cardiovasc Interv (2007) 0.98

Rationale and design of Enhanced Angiogenic Cell Therapy in Acute Myocardial Infarction (ENACT-AMI): the first randomized placebo-controlled trial of enhanced progenitor cell therapy for acute myocardial infarction. Am Heart J (2010) 0.97

Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats. BMC Neurol (2010) 0.97

Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy. Am J Pathol (2005) 0.97

Innate immunity in the therapeutic actions of endothelial progenitor cells in pulmonary hypertension. Am J Respir Cell Mol Biol (2009) 0.96

Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2. BMC Cell Biol (2007) 0.96

High glucose-enhanced activation of mesangial cell p38 MAPK by ET-1, ANG II, and platelet-derived growth factor. Am J Physiol Endocrinol Metab (2002) 0.95

Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia. Arterioscler Thromb Vasc Biol (2009) 0.95

Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury. Arterioscler Thromb Vasc Biol (2009) 0.95

Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling. Proc Natl Acad Sci U S A (2012) 0.95

Fluorescent microangiography is a novel and widely applicable technique for delineating the renal microvasculature. PLoS One (2011) 0.94

Role of angiopoietin-1 in experimental and human pulmonary arterial hypertension. Chest (2005) 0.94

Functional inhibition of secreted angiopoietin: a novel role for angiopoietin 1 in coronary vessel patterning. Biochem Biophys Res Commun (2004) 0.94

Network analysis of transcriptional responses induced by mesenchymal stem cell treatment of experimental sepsis. Am J Pathol (2012) 0.94

Angiogenesis of the heart. Microsc Res Tech (2003) 0.94

Downregulation of eNOS mRNA expression by TNFalpha: identification and functional characterization of RNA-protein interactions in the 3'UTR. Cardiovasc Res (2003) 0.93

miR-26a linked to pulmonary hypertension by global assessment of circulating extracellular microRNAs. Am J Respir Crit Care Med (2013) 0.92

Growth factor-induced therapeutic neovascularization for ischaemic vascular disease: time for a re-evaluation? Curr Opin Cardiol (2006) 0.92