Published in Oxid Med Cell Longev on September 23, 2012
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med (2015) 1.17
New insights into molecular mechanisms of diabetic kidney disease. Am J Kidney Dis (2014) 1.02
Zinc is essential for the transcription function of Nrf2 in human renal tubule cells in vitro and mouse kidney in vivo under the diabetic condition. J Cell Mol Med (2014) 0.88
Resveratrol Prevention of Diabetic Nephropathy Is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of Akt/NF-κB Pathway. Int J Endocrinol (2014) 0.88
Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro. PLoS One (2013) 0.86
Preventive and therapeutic effects of MG132 by activating Nrf2-ARE signaling pathway on oxidative stress-induced cardiovascular and renal injury. Oxid Med Cell Longev (2013) 0.86
Diabetic cardiomyopathy and its prevention by nrf2: current status. Diabetes Metab J (2014) 0.86
Magnolia extract (BL153) ameliorates kidney damage in a high fat diet-induced obesity mouse model. Oxid Med Cell Longev (2013) 0.83
Novel Therapies for Diabetic Kidney Disease: Storied Past and Forward Paths. Diabetes Spectr (2015) 0.83
Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation. Oxid Med Cell Longev (2015) 0.81
Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy. Exp Cell Res (2013) 0.81
Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2. Free Radic Biol Med (2015) 0.80
Inhibitory role of the KEAP1-NRF2 pathway in TGFβ1-stimulated renal epithelial transition to fibroblastic cells: a modulatory effect on SMAD signaling. PLoS One (2014) 0.80
Reactive Oxygen Species and Nuclear Factor Erythroid 2-Related Factor 2 Activation in Diabetic Nephropathy: A Hidden Target. J Diabetes Metab (2015) 0.79
Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System. J Diabetes Res (2015) 0.79
Metallothionein is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy. Diabetes (2016) 0.78
New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease. Oxid Med Cell Longev (2016) 0.76
Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice. Sci Rep (2016) 0.76
Mangiferin Upregulates Glyoxalase 1 Through Activation of Nrf2/ARE Signaling in Central Neurons Cultured with High Glucose. Mol Neurobiol (2016) 0.75
Zinc Prevents the Development of Diabetic Cardiomyopathy in db/db Mice. Int J Mol Sci (2017) 0.75
Sulforaphane Prevents Testicular Damage in Kunming Mice Exposed to Cadmium via Activation of Nrf2/ARE Signaling Pathways. Int J Mol Sci (2016) 0.75
Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy. J Diabetes Res (2017) 0.75
Prevention of Streptozotocin-Induced Diabetic Nephropathy by MG132: Possible Roles of Nrf2 and IκB. Oxid Med Cell Longev (2017) 0.75
High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells. Physiol Rep (2016) 0.75
Sulforaphane prevents bleomycin‑induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2‑related factor‑2 activation. Mol Med Rep (2017) 0.75
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem (2003) 5.67
Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. Am J Physiol Renal Physiol (2009) 2.08
Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes (2011) 2.03
The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes (2010) 2.00
Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart. J Am Coll Cardiol (2008) 1.95
Reactive oxygen species-regulated signaling pathways in diabetic nephropathy. J Am Soc Nephrol (2003) 1.92
Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes. J Mol Cell Cardiol (2008) 1.84
Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2008) 1.83
Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. Food Chem Toxicol (1999) 1.77
Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease. Diabetes (2008) 1.75
Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice. Genes Cells (2008) 1.72
Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy. Diabetes (2005) 1.69
Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling. Biochim Biophys Acta (2011) 1.67
Oxidative stress and diabetic cardiomyopathy: a brief review. Cardiovasc Toxicol (2001) 1.59
Protective effect of sulforaphane against oxidative stress: recent advances. Exp Toxicol Pathol (2010) 1.41
Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. Diabetes (2009) 1.37
The role of oxidative stress and NF-kappaB activation in late diabetic complications. Biofactors (1999) 1.33
The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation. Curr Opin Clin Nutr Metab Care (2011) 1.31
Mouse models of diabetic nephropathy. Curr Opin Nephrol Hypertens (2011) 1.24
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res (2011) 1.21
Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. Am J Physiol Renal Physiol (2009) 1.19
Oxidative stress, diabetes, and diabetic complications. Hemoglobin (2009) 1.15
Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy. Exp Diabetes Res (2012) 1.14
Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. Biochem Pharmacol (2008) 1.14
Nrf2 activators as attractive therapeutics for diabetic nephropathy. Diabetes (2011) 1.12
The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. Free Radic Biol Med (2010) 1.12
Diabetic nephropathy in humans: pathologic diversity. Curr Opin Nephrol Hypertens (2011) 1.10
Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome. Life Sci (2011) 1.08
Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury. Am J Pathol (2005) 1.06
Angiotensin II plays a critical role in diabetic pulmonary fibrosis most likely via activation of NADPH oxidase-mediated nitrosative damage. Am J Physiol Endocrinol Metab (2011) 0.99
Diabetic cardiomyopathy and its prevention by metallothionein: experimental evidence, possible mechanisms and clinical implications. Curr Med Chem (2007) 0.98
Attenuation of glomerular injury in diabetic mice with tert-butylhydroquinone through nuclear factor erythroid 2-related factor 2-dependent antioxidant gene activation. Am J Nephrol (2011) 0.96
Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation. Exp Mol Pathol (2004) 0.88
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 10.34
Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci (2005) 5.42
Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. N Engl J Med (2010) 5.27
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science (2006) 4.42
Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes. Neurology (2012) 3.46
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol (2002) 3.37
Identification of competence pheromone responsive genes in Streptococcus pneumoniae by use of DNA microarrays. Mol Microbiol (2004) 3.29
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Nat Neurosci (2004) 3.26
Know your place: neural processing of social hierarchy in humans. Neuron (2008) 2.92
Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs. J Biol Chem (2002) 2.79
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol (2007) 2.37
China's syphilis epidemic: a systematic review of seroprevalence studies. Sex Transm Dis (2006) 2.23
Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis. Nat Cell Biol (2012) 2.19
Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer. Clin Cancer Res (2009) 2.13
Parallel cylindrical water nanochannels in Nafion fuel-cell membranes. Nat Mater (2007) 2.10
Is C677T polymorphism in methylenetetrahydrofolate reductase gene a risk factor for diabetic nephropathy or diabetes mellitus in a Chinese population? Arch Med Res (2011) 2.10
Multitarget therapy for induction treatment of lupus nephritis: a randomized trial. Ann Intern Med (2015) 1.99
Genome sequences of three agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria. J Bacteriol (2009) 1.96
Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart. J Am Coll Cardiol (2008) 1.95
Visualizing the chemistry and structure dynamics in lithium-ion batteries by in-situ neutron diffraction. Sci Rep (2012) 1.88
Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo. Diabetes (2011) 1.84
Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes. J Mol Cell Cardiol (2008) 1.84
Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory. J Neurosci (2007) 1.81
Canonical Wnt signaling is critical to estrogen-mediated uterine growth. Mol Endocrinol (2004) 1.76
Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability. Arch Gen Psychiatry (2009) 1.75
Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat Neurosci (2005) 1.73
Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. Hypertension (2009) 1.72
Spatial dynamics of human-origin H1 influenza A virus in North American swine. PLoS Pathog (2011) 1.68
Fast photoacoustic imaging system based on 320-element linear transducer array. Phys Med Biol (2004) 1.63
A DNA replicon system for rapid high-level production of virus-like particles in plants. Biotechnol Bioeng (2009) 1.57
Viral vectors for production of recombinant proteins in plants. J Cell Physiol (2008) 1.55
Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. J Neurosci (2003) 1.54
Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol (2003) 1.53
Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function. Proc Natl Acad Sci U S A (2007) 1.53
Enhanced therapeutic effect of cisplatin on the prostate cancer in tumor-bearing mice by transfecting the attenuated Salmonella carrying a plasmid co-expressing p53 gene and mdm2 siRNA. Cancer Lett (2013) 1.53
Attenuation of diabetes-induced renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammation. Am J Physiol Endocrinol Metab (2009) 1.51
Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils. J Immunol (2003) 1.50
Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly chinese. J Clin Endocrinol Metab (2008) 1.50
Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation. Circulation (2006) 1.45
HCV 6a prevalence in Guangdong province had the origin from Vietnam and recent dissemination to other regions of China: phylogeographic analyses. PLoS One (2012) 1.44
High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system. Biotechnol Bioeng (2010) 1.44
Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex. J Biol Chem (2007) 1.43
Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. J Clin Invest (2008) 1.43
An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine (2008) 1.42
Radio frequency identification enabled wireless sensing for intelligent food logistics. Philos Trans A Math Phys Eng Sci (2014) 1.42
Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A. Arch Gen Psychiatry (2011) 1.38
Balloon valvuloplasty through the right ventricle: another treatment of pulmonary atresia with intact ventricular septum. Ann Thorac Surg (2013) 1.37
Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. Diabetes (2009) 1.37
A multicenter application and evaluation of the oxford classification of IgA nephropathy in adult chinese patients. Am J Kidney Dis (2012) 1.32
Diabetes- and angiotensin II-induced cardiac endoplasmic reticulum stress and cell death: metallothionein protection. J Cell Mol Med (2009) 1.31
Formaldehyde in China: production, consumption, exposure levels, and health effects. Environ Int (2009) 1.28
Two gene determinants are differentially involved in the biogenesis of Fap1 precursors in Streptococcus parasanguis. J Bacteriol (2006) 1.27
Bioprocessing of plant-derived virus-like particles of Norwalk virus capsid protein under current Good Manufacture Practice regulations. Plant Cell Rep (2011) 1.26
Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine. Nat Commun (2012) 1.26
Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway. Am J Pathol (2004) 1.26
Risk of syphilis in STI clinic patients: a cross-sectional study of 11,500 cases in Guangxi, China. Sex Transm Infect (2007) 1.25
Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice. Proc Natl Acad Sci U S A (2010) 1.23
Norwalk virus-like particles as vaccines. Expert Rev Vaccines (2010) 1.23
Efficient agroinfiltration of plants for high-level transient expression of recombinant proteins. J Vis Exp (2013) 1.23
Phylogeography of the spring and fall waves of the H1N1/09 pandemic influenza virus in the United States. J Virol (2010) 1.23
Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana. Plant Biotechnol J (2011) 1.21
A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge. Proc Natl Acad Sci U S A (2011) 1.21
Suicide ideation and behaviours after STN and GPi DBS surgery for Parkinson's disease: results from a randomised, controlled trial. J Neurol Neurosurg Psychiatry (2013) 1.20
Differential effects of deep brain stimulation target on motor subtypes in Parkinson's disease. Ann Neurol (2015) 1.20
Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. Am J Physiol Renal Physiol (2009) 1.19
Distribution study of Chlamydia trachomatis serovars among high-risk women in China performed using PCR-restriction fragment length polymorphism genotyping. J Clin Microbiol (2007) 1.19
The low-dose ionizing radiation stimulates cell proliferation via activation of the MAPK/ERK pathway in rat cultured mesenchymal stem cells. J Radiat Res (2011) 1.18
Poly[[diaqua-hemi-μ(4)-oxalato-μ(2)-oxalato-praseodymium(III)] monohydrate]. Acta Crystallogr Sect E Struct Rep Online (2009) 1.18
Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation. Diabetes (2002) 1.17
Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. J Cell Sci (2009) 1.17
Contrasting the epidemiological and evolutionary dynamics of influenza spatial transmission. Philos Trans R Soc Lond B Biol Sci (2013) 1.17
Simple sequence-based kernels do not predict protein-protein interactions. Bioinformatics (2010) 1.16
Epidemiological dynamics and phylogeography of influenza virus in southern China. J Infect Dis (2012) 1.16
The actin cytoskeleton regulates exocytosis of all neutrophil granule subsets. Am J Physiol Cell Physiol (2007) 1.16
CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer. Gastroenterology (2012) 1.16
PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry. J Cell Sci (2013) 1.15
Oxidative stress, diabetes, and diabetic complications. Hemoglobin (2009) 1.15
Polycyclic aromatic hydrocarbons in urban soils of Beijing: status, sources, distribution and potential risk. Environ Pollut (2010) 1.15
Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy. Exp Diabetes Res (2012) 1.14
Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine. Structure (2012) 1.14
Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications. Curr Med Chem (2009) 1.13
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem (2012) 1.13
Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce. Plant Biotechnol J (2011) 1.12
A novel plasmid-encoded serotype conversion mechanism through addition of phosphoethanolamine to the O-antigen of Shigella flexneri. PLoS One (2012) 1.12
Neural correlates of probabilistic category learning in patients with schizophrenia. J Neurosci (2009) 1.12
Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation. J Mol Cell Cardiol (2013) 1.12
PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity. Biochem Biophys Res Commun (2005) 1.11
MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils. Cell Signal (2003) 1.10