Published in Science on February 17, 2006
Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu Rev Neurosci (2008) 5.12
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. Nat Rev Mol Cell Biol (2010) 4.72
Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron (2008) 3.65
Mechanisms, regulation and consequences of protein SUMOylation. Biochem J (2010) 3.22
Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01
Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J (2009) 2.65
Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol (2006) 2.49
Communication between the synapse and the nucleus in neuronal development, plasticity, and disease. Annu Rev Cell Dev Biol (2008) 2.40
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The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest (2008) 2.24
A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell (2009) 2.21
The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell (2008) 2.19
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A (2008) 2.09
Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol (2006) 2.01
An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development. Neuron (2007) 1.98
Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction. Nat Rev Neurosci (2007) 1.97
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A (2008) 1.87
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MEF2 is an in vivo immune-metabolic switch. Cell (2013) 1.71
Genetics and cell biology of building specific synaptic connectivity. Annu Rev Neurosci (2010) 1.71
An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Mol Cell Biol (2007) 1.69
MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations. J Med Genet (2009) 1.67
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Pias3-dependent SUMOylation directs rod photoreceptor development. Neuron (2009) 1.45
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Targets and consequences of protein SUMOylation in neurons. Brain Res Rev (2010) 1.44
MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers. Neuron (2015) 1.43
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A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science (2009) 1.40
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Cultures of cerebellar granule neurons. CSH Protoc (2008) 1.27
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Sumoylation dynamics during keratinocyte differentiation. J Cell Sci (2006) 1.26
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A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron (2008) 1.21
Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells. PLoS One (2009) 1.20
Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3. Mol Cell Biol (2009) 1.20
Transcriptional regulation of neuronal polarity and morphogenesis in the mammalian brain. Neuron (2011) 1.19
A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w. J Neurosci (2009) 1.19
Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron (2012) 1.18
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SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis. J Cell Biol (2008) 1.14
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A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain. J Neurosci (2009) 1.09
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MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model. PLoS One (2011) 1.09
Homeostatic synaptic scaling is regulated by protein SUMOylation. J Biol Chem (2012) 1.06
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Protein modifications involved in neurotransmitter and gasotransmitter signaling. Trends Neurosci (2010) 1.06
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The role of dopamine in modulating the structure and function of striatal circuits. Prog Brain Res (2010) 1.04
Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation. Proc Natl Acad Sci U S A (2007) 1.03
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Regulation of the oncoprotein KLF8 by a switch between acetylation and sumoylation. Am J Transl Res (2010) 1.02
Normal dendrite growth in Drosophila motor neurons requires the AP-1 transcription factor. Dev Neurobiol (2008) 1.01
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Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment. J Mol Biol (2010) 0.97
Protein SUMOylation in neuropathological conditions. Drug News Perspect (2009) 0.97
The Mef2A transcription factor coordinately regulates a costamere gene program in cardiac muscle. J Biol Chem (2011) 0.96
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An acetylation switch regulates SUMO-dependent protein interaction networks. Mol Cell (2012) 0.95
The transcription factor Mef2 is required for normal circadian behavior in Drosophila. J Neurosci (2010) 0.94
Transcriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase. J Biol Chem (2010) 0.94
Dephosphorylation and caspase processing generate distinct nuclear pools of histone deacetylase 4. Mol Cell Biol (2007) 0.93
Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells. Nucleic Acids Res (2007) 0.93
Protein SUMOylation in spine structure and function. Curr Opin Neurobiol (2011) 0.92
Myocyte enhancer factor 2A is transcriptionally autoregulated. J Biol Chem (2007) 0.92
Sumoylation in gene regulation, human disease, and therapeutic action. F1000Prime Rep (2013) 0.92
S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death. Cell Rep (2014) 0.91
MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease. J Neurosci (2013) 0.91
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mef2 activity levels differentially affect gene expression during Drosophila muscle development. Proc Natl Acad Sci U S A (2008) 0.90
Array based characterization of a terminal deletion involving chromosome subband 15q26.2: an emerging syndrome associated with growth retardation, cardiac defects and developmental delay. BMC Med Genet (2008) 0.89
SUMO and Alzheimer's disease. Neuromolecular Med (2013) 0.89
Dipeptidyl peptidase-like protein 6 is required for normal electrophysiological properties of cerebellar granule cells. J Neurosci (2010) 0.89
Sumoylated MEF2A coordinately eliminates orphan presynaptic sites and promotes maturation of presynaptic boutons. J Neurosci (2013) 0.89
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The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04
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Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell (2009) 5.41
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