Published in Autophagy on October 12, 2012
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci. Nat Commun (2015) 1.32
Regulation of Bim in Health and Disease. Oncotarget (2015) 0.95
Autophagy: a double-edged sword for neuronal survival after cerebral ischemia. Neural Regen Res (2014) 0.95
Dihydroartemisinin is a Hypoxia-Active Anti-Cancer Drug in Colorectal Carcinoma Cells. Front Oncol (2014) 0.89
Small molecules, big effects: the role of microRNAs in regulation of cardiomyocyte death. Cell Death Dis (2014) 0.88
Autophagy and ethanol neurotoxicity. Autophagy (2014) 0.85
The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma. Oncotarget (2015) 0.83
Involvement of autophagy inhibition in Brucea javanica oil emulsion-induced colon cancer cell death. Oncol Lett (2015) 0.81
Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence. Oncotarget (2015) 0.80
The molecular mechanisms between autophagy and apoptosis: potential role in central nervous system disorders. Cell Mol Neurobiol (2014) 0.79
Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer. Protein Cell (2016) 0.78
Chronic heart failure: Ca(2+), catabolism, and catastrophic cell death. Biochim Biophys Acta (2016) 0.77
Simultaneous activation and inhibition of autophagy sensitizes cancer cells to chemotherapy. Oncotarget (2016) 0.77
Pathogenic mechanisms following ischemic stroke. Neurol Sci (2017) 0.76
Global analysis of differential gene expression related to long-term sperm storage in oviduct of Chinese Soft-Shelled Turtle Pelodiscus sinensis. Sci Rep (2016) 0.76
Microarray study of gene expression profile to identify new candidate genes involved in the molecular mechanism of leptin-induced knee joint osteoarthritis in rat. Hereditas (2017) 0.75
Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents. J Stroke (2017) 0.75
BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells. Oncotarget (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
TFEB links autophagy to lysosomal biogenesis. Science (2011) 8.87
Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem (2003) 6.84
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet (2002) 6.56
Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol (2010) 6.41
Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol (2007) 5.78
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem (2006) 5.39
Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol (2005) 5.21
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell (2009) 5.18
Lysosomal positioning coordinates cellular nutrient responses. Nat Cell Biol (2011) 4.96
In search of an "autophagomometer". Autophagy (2009) 4.31
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol (2008) 4.19
α-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol (2010) 3.67
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy (2008) 3.47
Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet (2005) 3.45
Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet (2005) 3.39
A block of autophagy in lysosomal storage disorders. Hum Mol Genet (2007) 3.28
The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic (2008) 3.18
Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications. Curr Top Dev Biol (2006) 3.02
A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am J Hum Genet (2002) 2.98
Transcriptional abnormalities in Huntington disease. Trends Genet (2003) 2.91
Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett (2009) 2.58
Rapamycin pre-treatment protects against apoptosis. Hum Mol Genet (2006) 2.57
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One (2010) 2.57
Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. J Cell Sci (2008) 2.55
Huntington's disease: from pathology and genetics to potential therapies. Biochem J (2008) 2.41
Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. Hum Mol Genet (2002) 2.41
Autophagosome precursor maturation requires homotypic fusion. Cell (2011) 2.39
Control of autophagy as a therapy for neurodegenerative disease. Nat Rev Neurol (2011) 2.38
Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36
Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Hum Mol Genet (2010) 2.22
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci (2006) 2.19
The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites. Cell (2012) 2.14
Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell (2013) 2.07
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum Mol Genet (2007) 2.03
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol (2011) 1.97
Huntington's disease: degradation of mutant huntingtin by autophagy. FEBS J (2008) 1.89
Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection. J Clin Invest (2011) 1.89
Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease. J Nucl Med (2006) 1.83
Cytoprotective roles for autophagy. Curr Opin Cell Biol (2010) 1.81
The Hedgehog signalling pathway regulates autophagy. Nat Commun (2012) 1.80
Mammalian macroautophagy at a glance. J Cell Sci (2009) 1.78
DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Hum Mol Genet (2006) 1.73
Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation. J Biol Chem (2002) 1.70
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3. Brain (2009) 1.66
Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Mol Cell (2012) 1.55
Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. J Neurosci (2004) 1.54
Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem (2010) 1.50
Lysosomal storage diseases as disorders of autophagy. Autophagy (2007) 1.46
Hydrophilic protein associated with desiccation tolerance exhibits broad protein stabilization function. Proc Natl Acad Sci U S A (2007) 1.45
Autophagy, a guardian against neurodegeneration. Semin Cell Dev Biol (2010) 1.45
Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease. Hum Mol Genet (2005) 1.44
Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy (2006) 1.42
Small molecule enhancers of autophagy for neurodegenerative diseases. Mol Biosyst (2008) 1.39
Autophagy in neurodegeneration and development. Biochim Biophys Acta (2008) 1.38
Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet (2010) 1.38
Protein misfolding disorders and macroautophagy. Curr Opin Cell Biol (2010) 1.36
Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates. Autophagy (2009) 1.36
Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Hum Mol Genet (2005) 1.32
Can autophagy protect against neurodegeneration caused by aggregate-prone proteins? Neuroreport (2004) 1.31
Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. Prog Neurobiol (2013) 1.31
Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. PLoS Genet (2010) 1.30
Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice. Nat Med (2005) 1.30
Autophagic clearance of aggregate-prone proteins associated with neurodegeneration. Methods Enzymol (2009) 1.28
Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int J Biochem Cell Biol (2004) 1.28
Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis. J Biol Chem (2003) 1.27
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radic Biol Med (2009) 1.26
Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course. Brain (2003) 1.26
Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity. J Cell Biol (2005) 1.24
Autophagy and neurodegeneration. J Clin Invest (2015) 1.24
Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex. J Cell Sci (2011) 1.23
Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles. Brain (2006) 1.20
Regulation of autophagy by lysosomal positioning. Autophagy (2011) 1.19
Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet (2003) 1.19
Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein. J Biol Chem (2006) 1.18
Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages. Autophagy (2007) 1.17
Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D. J Cell Biol (2012) 1.16
Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease. Hum Mol Genet (2010) 1.15
Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease. J Am Geriatr Soc (2006) 1.15
Modulation of polyglutamine-induced cell death by genes identified by expression profiling. Hum Mol Genet (2002) 1.12
Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion. Neuropsychopharmacology (2006) 1.12
Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin. Exp Cell Res (2006) 1.12
Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. Cell (2010) 1.12
A novel link between autophagy and the ubiquitin-proteasome system. Autophagy (2009) 1.11
Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. J Neurosci (2008) 1.10
Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres. Hum Mol Genet (2010) 1.10
Autophagy and misfolded proteins in neurodegeneration. Exp Neurol (2010) 1.10
Role of autophagy in the clearance of mutant huntingtin: a step towards therapy? Mol Aspects Med (2006) 1.08
Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species. J Cell Sci (2014) 1.06
Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy. J Biol Chem (2002) 1.05
The role of membrane-trafficking small GTPases in the regulation of autophagy. J Cell Sci (2013) 1.04
Connections between SNAREs and autophagy. Trends Biochem Sci (2013) 1.04
Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Hum Mol Genet (2007) 1.03