Published in JAMA on October 17, 2012
Saline Against Lactated Ringers or Plasmalyte in the Emergency Department (SaLt-ED) | NCT02614040
Normal Saline Versus Balance Salt Solution Resuscitation on Kidney Function | NCT02520804
Isotonic Solution Administration Logistical Testing (SALT) | NCT02345486
Plasmalyte Versus Saline in Trauma Patients (ASTRAU) | NCT03630224
Septic Shock: Advances in Diagnosis and Treatment. JAMA (2015) 2.37
Association of Hyperchloremia With Hospital Mortality in Critically Ill Septic Patients. Crit Care Med (2015) 1.93
Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS. Intensive Care Med (2014) 1.90
Albumin administration is associated with acute kidney injury in cardiac surgery: a propensity score analysis. Crit Care (2014) 1.88
The growth of acute kidney injury: a rising tide or just closer attention to detail? Kidney Int (2014) 1.80
Effects of fluid resuscitation with 0.9% saline versus a balanced electrolyte solution on acute kidney injury in a rat model of sepsis*. Crit Care Med (2014) 1.66
Higher serum chloride concentrations are associated with acute kidney injury in unselected critically ill patients. BMC Nephrol (2013) 1.56
Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome. Crit Care (2015) 1.48
The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care (2016) 1.43
Volume Overload: Prevalence, Risk Factors, and Functional Outcome in Survivors of Septic Shock. Ann Am Thorac Soc (2015) 1.41
Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice. Acta Anaesthesiol Scand (2015) 1.37
Relationship between a perioperative intravenous fluid administration strategy and acute kidney injury following off-pump coronary artery bypass surgery: an observational study. Crit Care (2015) 1.31
Meta-analysis of high- versus low-chloride content in perioperative and critical care fluid resuscitation. Br J Surg (2014) 1.30
Iatrogenic salt water drowning and the hazards of a high central venous pressure. Ann Intensive Care (2014) 1.13
Hemolytic uremic syndrome. Semin Immunopathol (2014) 1.12
Urinary strong ion difference is a major determinant of plasma chloride concentration changes in postoperative patients. Rev Bras Ter Intensiva (2013) 1.09
Saving the kidneys by sparing intravenous chloride? JAMA (2012) 1.07
Pathophysiology and management of septic acute kidney injury. Pediatr Nephrol (2013) 1.05
Acute kidney injury following cardiac surgery: current understanding and future directions. Crit Care (2016) 0.99
Prehospital intravenous access and fluid resuscitation in severe sepsis: an observational cohort study. Crit Care (2014) 0.98
Association of serum chloride concentration with outcomes in postoperative critically ill patients: a retrospective observational study. J Intensive Care (2014) 0.95
Prevention and treatment of sepsis-induced acute kidney injury: an update. Ann Intensive Care (2015) 0.95
Chloride-restrictive fluid administration and incidence of acute kidney injury. JAMA (2013) 0.95
Should chloride-rich crystalloids remain the mainstay of fluid resuscitation to prevent 'pre-renal' acute kidney injury?: con. Kidney Int (2014) 0.95
Choices in fluid type and volume during resuscitation: impact on patient outcomes. Ann Intensive Care (2014) 0.94
Perioperative fluid therapy: a statement from the international Fluid Optimization Group. Perioper Med (Lond) (2015) 0.94
Albumin administration in the acutely ill: what is new and where next? Crit Care (2014) 0.92
Why is saline so acidic (and does it really matter?). Int J Med Sci (2013) 0.92
Chloride-restrictive fluid administration and incidence of acute kidney injury. JAMA (2013) 0.91
Chloride-restrictive fluid administration and incidence of acute kidney injury. JAMA (2013) 0.91
Hypertonic sodium lactate improves fluid balance and hemodynamics in porcine endotoxic shock. Crit Care (2014) 0.91
Is it AKI or nonrecovery of renal function that is important for long-term outcomes? Clin J Am Soc Nephrol (2013) 0.90
Fluid and electrolyte overload in critically ill patients: An overview. World J Crit Care Med (2015) 0.89
Balanced versus chloride-rich solutions for fluid resuscitation in brain-injured patients: a randomised double-blind pilot study. Crit Care (2013) 0.89
Three feasible strategies to minimize kidney injury in 'incipient AKI'. Nat Rev Nephrol (2013) 0.88
Controversies in fluid therapy: Type, dose and toxicity. World J Crit Care Med (2014) 0.87
Balanced Crystalloids versus Saline in the Intensive Care Unit: The SALT Randomized Trial. Am J Respir Crit Care Med (2016) 0.84
Crystalloid fluid therapy. Crit Care (2016) 0.84
Acute kidney injury after cardiac arrest. Crit Care (2015) 0.83
Chloride-liberal fluids are associated with acute kidney injury after liver transplantation. Crit Care (2014) 0.82
Dose and type of crystalloid fluid therapy in adult hospitalized patients. Perioper Med (Lond) (2013) 0.82
Incidence and characteristics of acute kidney injury in severe diabetic ketoacidosis. PLoS One (2014) 0.82
Saline Is Not the First Choice for Crystalloid Resuscitation Fluids. Crit Care Med (2016) 0.81
Evaluation of Short-Term Changes in Serum Creatinine Level as a Meaningful End Point in Randomized Clinical Trials. J Am Soc Nephrol (2015) 0.81
Treatment of acute non-anion gap metabolic acidosis. Clin Kidney J (2014) 0.81
Prediction and Prevention of Acute Kidney Injury after Cardiac Surgery. Biomed Res Int (2016) 0.81
Response to Fluid Boluses in the Fluid and Catheter Treatment Trial. Chest (2015) 0.80
From the nephrologist's point of view: diversity of causes and clinical features of acute kidney injury. Clin Kidney J (2015) 0.80
Effects of atrial natriuretic peptide on inter-organ crosstalk among the kidney, lung, and heart in a rat model of renal ischemia-reperfusion injury. Intensive Care Med Exp (2014) 0.80
Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant (2013) 0.80
Dyschloremia Is a Risk Factor for the Development of Acute Kidney Injury in Critically Ill Patients. PLoS One (2016) 0.80
Clinical controversies in the management of critically ill patients with severe sepsis: resuscitation fluids and glucose control. Virulence (2013) 0.80
Impact of chloride and strong ion difference on ICU and hospital mortality in a mixed intensive care population. Ann Intensive Care (2016) 0.79
Acute kidney injury: Restriction of intravenous chloride intake may reduce the incidence of AKI in critically ill patients. Nat Rev Nephrol (2012) 0.79
Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies). Ann Intensive Care (2016) 0.78
Intravascular volume therapy in adults: Guidelines from the Association of the Scientific Medical Societies in Germany. Eur J Anaesthesiol (2016) 0.78
Fluid therapy for septic shock resuscitation: which fluid should be used? Einstein (Sao Paulo) (2015) 0.78
Multicountry survey of emergency and critical care medicine physicians' fluid resuscitation practices for adult patients with early septic shock. BMJ Open (2016) 0.77
Ebola virus disease: an update for anesthesiologists and intensivists. Can J Anaesth (2014) 0.77
Fluid overload is an independent risk factor for acute kidney injury in critically Ill patients: results of a cohort study. BMC Nephrol (2017) 0.77
Perioperative intravenous fluid therapy for adults. Ulster Med J (2013) 0.77
The great fluid debate: saline or so-called "balanced" salt solutions? Ital J Pediatr (2015) 0.77
Choice of Fluids in Severe Septic Patients - A Cost-effectiveness Analysis Informed by Recent Clinical Trials. Rev Recent Clin Trials (2014) 0.77
Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome. Crit Care Med (2016) 0.77
Review of Evidence for Adult Diabetic Ketoacidosis Management Protocols. Front Endocrinol (Lausanne) (2017) 0.77
Hydroxyethyl starch 130/0.4 or hypertonic saline solution to decrease inflammatory response in hemorrhagic shock? Crit Care (2013) 0.76
Should hydroxyethyl starch solutions be totally banned? Crit Care (2013) 0.76
Overview of progresses in critical care medicine 2012. J Thorac Dis (2013) 0.76
Unilateral Renal Ischemia-Reperfusion as a Robust Model for Acute to Chronic Kidney Injury in Mice. PLoS One (2016) 0.76
Fluid therapy and outcome: balance is best. J Extra Corpor Technol (2014) 0.76
Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients. Crit Care (2016) 0.76
Variable change in renal function by hypertonic saline. World J Crit Care Med (2014) 0.76
Acute Kidney Injury Subsequent to Cardiac Surgery. J Extra Corpor Technol (2015) 0.76
Acute kidney injury: quoi de neuf? Ochsner J (2014) 0.76
Chloride-restrictive fluid administration and incidence of acute kidney injury--reply. JAMA (2013) 0.76
Fluid Therapy: Double-Edged Sword during Critical Care? Biomed Res Int (2015) 0.76
Fluid Management for Critically Ill Patients: A Review of the Current State of Fluid Therapy in the Intensive Care Unit. Kidney Dis (Basel) (2016) 0.75
Sepsis Resuscitation: Fluid Choice and Dose. Clin Chest Med (2016) 0.75
Making a pragmatic choice for fluid resuscitation in critically ill patients. JAMA (2013) 0.75
Fluid loading in abdominal surgery - saline versus hydroxyethyl starch (FLASH Trial): study protocol for a randomized controlled trial. Trials (2015) 0.75
Serum hyperchloremia as a risk factor for acute kidney injury in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. Proc (Bayl Univ Med Cent) (2016) 0.75
Key Controversies in Colloid and Crystalloid Fluid Utilization. Hosp Pharm (2015) 0.75
Intraoperative and Postoperative Blood Glucose Concentrations in Diabetic Surgical Patients Receiving Lactated Ringer's Versus Normal Saline: A Retrospective Review of Medical Records. Ochsner J (2014) 0.75
Saline versus balanced crystalloids for intravenous fluid therapy in the emergency department: study protocol for a cluster-randomized, multiple-crossover trial. Trials (2017) 0.75
Choice of Fluid Therapy in the Initial Management of Sepsis, Severe Sepsis, and Septic Shock. Shock (2016) 0.75
Pros and cons of tetrastarch solution for critically ill patients. J Intensive Care (2014) 0.75
Optimal Role of the Nephrologist in the Intensive Care Unit. Blood Purif (2016) 0.75
Perioperative restricted fluid therapy preserves immunological function in patients with colorectal cancer. World J Gastroenterol (2014) 0.75
Abnormal saline: the unphysiological bag of brine. Crit Care (2014) 0.75
Initial resuscitation and management of pediatric septic shock. Minerva Pediatr (2015) 0.75
Temporal Trends in AKI: Insights from Big Data. Clin J Am Soc Nephrol (2015) 0.75
What's New in Critical Illness and Injury Science? The ongoing debate on the optimal resuscitative fluid and monitoring parameters. Int J Crit Illn Inj Sci (2013) 0.75
Acute kidney injury in 2012: type of resuscitation fluid-it does matter! Nat Rev Nephrol (2013) 0.75
Sodium lactate for fluid resuscitation: the preferred solution for the coming decades? Crit Care (2014) 0.75
Associations of Hospital and Patient Characteristics with Fluid Resuscitation Volumes in Patients with Severe Sepsis: Post Hoc Analyses of Data from a Multicentre Randomised Clinical Trial. PLoS One (2016) 0.75
Choice of crystalloids in sepsis: a conundrum waiting to be solved. Ann Transl Med (2016) 0.75
The Challenge and the Promise of Studying Mitochondrial Dysfunction in Humans with Sepsis. Ann Am Thorac Soc (2015) 0.75
A randomized trial of Plasma-Lyte A and 0.9 % sodium chloride in acute pediatric gastroenteritis. BMC Pediatr (2016) 0.75
B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS. Chest (2016) 0.75
Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30
Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA (2005) 19.57
Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA (2008) 13.69
A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med (2004) 12.79
Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med (2012) 11.83
Goal-directed resuscitation for patients with early septic shock. N Engl J Med (2014) 11.32
Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med (2009) 10.60
Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med (2009) 9.77
Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. JAMA (2009) 9.47
Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial. Lancet (2005) 7.81
Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med (2015) 7.73
Cardiorenal syndrome. J Am Coll Cardiol (2008) 7.09
Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis (2009) 6.99
An assessment of the RIFLE criteria for acute renal failure in hospitalized patients. Crit Care Med (2006) 6.87
Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17
Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology (2006) 5.58
Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med (2012) 5.15
Findings of the first consensus conference on medical emergency teams. Crit Care Med (2006) 4.64
The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol (2011) 4.57
Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med (2007) 4.42
Respiratory rate: the neglected vital sign. Med J Aust (2008) 4.38
Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort study. Crit Care Med (2009) 4.30
A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients. Nephrol Dial Transplant (2008) 4.29
A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients. Nephrol Dial Transplant (2007) 4.11
Rapid-response teams. N Engl J Med (2011) 3.84
Percutaneous versus surgical tracheostomy: A randomized controlled study with long-term follow-up. Crit Care Med (2006) 3.80
Predicting survival after extracorporeal membrane oxygenation for severe acute respiratory failure. The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) score. Am J Respir Crit Care Med (2014) 3.78
Blood glucose concentration and outcome of critical illness: the impact of diabetes. Crit Care Med (2008) 3.73
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. N Engl J Med (2015) 3.57
Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur Heart J (2009) 3.52
A comparison of three methods to estimate baseline creatinine for RIFLE classification. Nephrol Dial Transplant (2010) 3.45
A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis. Am J Respir Crit Care Med (2013) 3.44
Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care (2008) 3.32
Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units. Intensive Care Med (2004) 3.30
Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol (2007) 3.17
Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators. Intensive Care Med (2007) 3.03
Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med (2015) 2.97
Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med (2009) 2.94
Prospective meta-analysis using individual patient data in intensive care medicine. Intensive Care Med (2009) 2.93
Measurement of renal blood flow by phase-contrast magnetic resonance imaging during septic acute kidney injury: a pilot investigation. Crit Care Med (2012) 2.91
Bedside electronic capture of clinical observations and automated clinical alerts to improve compliance with an Early Warning Score protocol. Crit Care Resusc (2011) 2.89
Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial. Clin Infect Dis (2012) 2.88
Early isovolaemic haemofiltration in oliguric patients with septic shock. Intensive Care Med (2005) 2.85
Routine use of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) by bedside nurses may underdiagnose delirium. Crit Care Resusc (2011) 2.81
Conservative oxygen therapy in mechanically ventilated patients: a pilot before-and-after trial. Crit Care Med (2014) 2.77
The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury. Nephrol Dial Transplant (2009) 2.73
External validation of severity scoring systems for acute renal failure using a multinational database. Crit Care Med (2005) 2.68
Working Party proposal for a revised classification system of renal dysfunction in patients with cirrhosis. Gut (2011) 2.65
The Australasian Resuscitation in Sepsis Evaluation (ARISE) trial statistical analysis plan. Crit Care Resusc (2013) 2.62
Mortality in Multicenter Critical Care Trials: An Analysis of Interventions With a Significant Effect. Crit Care Med (2015) 2.59
Discontinuation of continuous renal replacement therapy: a post hoc analysis of a prospective multicenter observational study. Crit Care Med (2009) 2.58
A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury. Nephrol Dial Transplant (2009) 2.55
Early blood glucose control and mortality in critically ill patients in Australia. Crit Care Med (2009) 2.53
Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: a pilot double-blind, randomized controlled trial. Crit Care Med (2009) 2.45
Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc (2010) 2.44
Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Med (2013) 2.44
Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis. Intensive Care Med (2010) 2.42
The biochemical effects of restricting chloride-rich fluids in intensive care. Crit Care Med (2011) 2.39
Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury. J Crit Care (2008) 2.36
Intensive insulin therapy in postoperative intensive care unit patients: a decision analysis. Am J Respir Crit Care Med (2005) 2.32
Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest. Resuscitation (2013) 2.32
Comparison of point-of-care versus central laboratory measurement of electrolyte concentrations on calculations of the anion gap and the strong ion difference. Anesthesiology (2003) 2.31
Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units. Crit Care (2007) 2.31
An assessment of the accuracy of renal blood flow estimation by Doppler ultrasound. Intensive Care Med (2008) 2.29
An observational study fluid balance and patient outcomes in the Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy trial. Crit Care Med (2012) 2.27
Urinary biochemistry and microscopy in septic acute renal failure: a systematic review. Am J Kidney Dis (2006) 2.26
Radial artery patency and clinical outcomes: five-year interim results of a randomized trial. J Thorac Cardiovasc Surg (2003) 2.26
Continuous versus intermittent renal replacement therapy for critically ill patients with acute kidney injury: a meta-analysis. Crit Care Med (2008) 2.25
Fluid balance and acute kidney injury. Nat Rev Nephrol (2009) 2.23
Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in adults. Ann Thorac Surg (2009) 2.19
The effects of saline or albumin resuscitation on acid-base status and serum electrolytes. Crit Care Med (2006) 2.19
A pilot study of coupled plasma filtration with adsorption in septic shock. Crit Care Med (2002) 2.19
Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus Species. PLoS Pathog (2010) 2.18
The pathogenesis of septic acute renal failure. Curr Opin Crit Care (2003) 2.16
Randomized, double-blind, placebo-controlled crossover pilot study of a potassium channel blocker in patients with septic shock. Crit Care Med (2006) 2.16
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A (2012) 2.14
Current oxygen management in mechanically ventilated patients: a prospective observational cohort study. J Crit Care (2013) 2.10
Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. Crit Care Med (2015) 2.05
Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study. Crit Care Med (2012) 2.04
Carbon dioxide insufflation in open-chamber cardiac surgery: a double-blind, randomized clinical trial of neurocognitive effects. J Thorac Cardiovasc Surg (2012) 2.04
Pathophysiology of septic acute kidney injury: what do we really know? Crit Care Med (2008) 2.02
The interaction of chronic and acute glycemia with mortality in critically ill patients with diabetes. Crit Care Med (2011) 2.01