Published in Intensive Care Med on February 12, 2004
Ulinastatin Treatment in Adult Patients With Sepsis and Septic Shock in China | NCT02647554
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med (2008) 4.21
Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care (2008) 2.65
Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther (2012) 2.34
Severe sepsis epidemiology: sampling, selection, and society. Crit Care (2004) 2.28
Epidemiology of severe sepsis. Virulence (2013) 2.26
The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care (2006) 2.21
Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality. J Glob Health (2012) 1.74
Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study. BMJ (2011) 1.64
Epidemiology of sepsis in Norway in 1999. Crit Care (2004) 1.48
The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study. Crit Care (2013) 1.46
The influence of volume and intensive care unit organization on hospital mortality in patients admitted with severe sepsis: a retrospective multicentre cohort study. Crit Care (2007) 1.43
Prevalence and incidence of severe sepsis in Dutch intensive care units. Crit Care (2004) 1.33
Estimating long-term survival of critically ill patients: the PREDICT model. PLoS One (2008) 1.32
Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis. Crit Care (2011) 1.26
Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China. PLoS One (2014) 1.25
Vancomycin dosing in critically ill patients: robust methods for improved continuous-infusion regimens. Antimicrob Agents Chemother (2011) 1.21
Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med (2014) 1.17
Clinical applications of intravenous immunoglobulins (IVIg)--beyond immunodeficiencies and neurology. Clin Exp Immunol (2009) 1.16
Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response. Recent Pat Inflamm Allergy Drug Discov (2009) 1.14
A global perspective on the epidemiology of sepsis. Intensive Care Med (2004) 1.11
Clinical sepsis and septic shock--definition, diagnosis and management principles. Langenbecks Arch Surg (2008) 1.08
Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Crit Care (2016) 1.04
The predisposition, infection, response and organ failure (Piro) sepsis classification system: results of hospital mortality using a novel concept and methodological approach. PLoS One (2013) 1.04
Impact of invasive fungal infection on outcomes of severe sepsis: a multicenter matched cohort study in critically ill surgical patients. Crit Care (2008) 1.04
Epidemiology of severe sepsis in the emergency department and difficulties in the initial assistance. Clinics (Sao Paulo) (2008) 1.04
Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients. Crit Care (2014) 1.04
The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study. Scand J Trauma Resusc Emerg Med (2009) 1.02
Hypothermia predicts mortality in critically ill elderly patients with sepsis. BMC Geriatr (2010) 0.98
Antibiotic dosing in the 'at risk' critically ill patient: Linking pathophysiology with pharmacokinetics/pharmacodynamics in sepsis and trauma patients. BMC Anesthesiol (2011) 0.97
An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function. PLoS One (2011) 0.97
The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial. Crit Care (2013) 0.96
Monitoring of endothelial dysfunction in critically ill patients: the role of endothelial progenitor cells. Curr Opin Crit Care (2008) 0.92
Interplay between inflammation, immune system and neuronal pathways: effect on gastrointestinal motility. World J Gastroenterol (2010) 0.91
Treatment of complicated intra-abdominal infections in the era of multi-drug resistant bacteria. Eur J Med Res (2010) 0.91
Aetiology, antimicrobial therapy and outcome of patients with community acquired severe sepsis: a prospective study in a Norwegian university hospital. BMC Infect Dis (2014) 0.91
Is severe sepsis associated with new-onset atrial fibrillation and stroke? JAMA (2011) 0.91
Population structure of gut Escherichia coli and its role in development of extra-intestinal infections. Iran J Microbiol (2010) 0.91
Infections of respiratory or abdominal origin in ICU patients: what are the differences? Crit Care (2010) 0.91
Sepsis in the pediatric cardiac intensive care unit. World J Pediatr Congenit Heart Surg (2011) 0.90
Bench-to-bedside review: Bacterial virulence and subversion of host defences. Crit Care (2008) 0.90
Statins in the critically ill. Ann Intensive Care (2012) 0.90
Stem cells in sepsis and acute lung injury. Crit Care Med (2010) 0.90
Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome. BMC Infect Dis (2014) 0.89
Epidemiology and Outcome of Severe Sepsis and Septic Shock in Surgical Intensive Care Units in Northern Taiwan. Medicine (Baltimore) (2015) 0.85
Skin and soft tissue infections in hospitalized and critically ill patients: a nationwide population-based study. BMC Infect Dis (2010) 0.84
Meropenem dosing in critically ill patients with sepsis receiving high-volume continuous venovenous hemofiltration. Antimicrob Agents Chemother (2010) 0.83
Epidemiology studies in critical care. Crit Care (2006) 0.82
Clinical evaluation of commercial nucleic acid amplification tests in patients with suspected sepsis. BMC Infect Dis (2015) 0.81
Epidemiology of critically ill patients in intensive care units: a population-based observational study. Crit Care (2013) 0.80
Stem cells in sepsis and acute lung injury. Am J Med Sci (2011) 0.80
The Changing Epidemiology and Definitions of Sepsis. Clin Chest Med (2016) 0.79
Incidence and outcome of sepsis in Japanese intensive care units: The Japanese nosocomial infection surveillance system. Environ Health Prev Med (2006) 0.79
Gram-negative infections in adult intensive care units of latin america and the Caribbean. Crit Care Res Pract (2014) 0.79
The Nature and Variability of Automated Practice Alerts Derived from Electronic Health Records in a U.S. Nationwide Critical Care Research Network. Ann Am Thorac Soc (2016) 0.78
Is Drotrecogin alfa (activated) for adults with severe sepsis, cost-effective in routine clinical practice? Crit Care (2011) 0.78
Host species-specific translocation of Escherichia coli. Eur J Clin Microbiol Infect Dis (2009) 0.78
Community-onset sepsis and its public health burden: protocol of a systematic review. Syst Rev (2015) 0.78
The microbiology and outcome of sepsis in Victoria, Australia. Epidemiol Infect (2006) 0.77
Prevention of sepsis in children: a new paradigm for public policy. Crit Care Res Pract (2011) 0.77
Antihypertensive agents acting on the renin-angiotensin system and the risk of sepsis. Br J Clin Pharmacol (2014) 0.77
Renal transplantation: relationship between hospital/surgeon volume and postoperative severe sepsis/graft-failure. a nationwide population-based study. Int J Med Sci (2014) 0.77
Eritoran: the evidence of its therapeutic potential in sepsis. Core Evid (2008) 0.76
Hospital staff education on severe sepsis/septic shock and hospital mortality: an original hypothesis. BMC Anesthesiol (2012) 0.76
Blood transfusions in septic shock: is 7.0 g/dL really the appropriate threshold? Rev Bras Ter Intensiva (2015) 0.76
Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis Patients. Biomed Res Int (2016) 0.75
Analysis of elevated liver enzymes in an acute medical setting: jaundice may indicate increased survival in elderly patients with bacterial sepsis. Saudi J Gastroenterol (2010) 0.75
Efficacy of measuring procalcitonin levels in determination of prognosis and early diagnosis of bacterial resistance in sepsis. Niger Med J (2015) 0.75
Sepsis in Buraidah Central Hospital, Qassim, Kingdom of Saudi Arabia. Int J Health Sci (Qassim) (2016) 0.75
Effect of antiplatelet therapy on mortality and acute lung injury in critically ill patients: A systematic review and meta-analysis. Ann Card Anaesth (2016) 0.75
Introduction to Pediatric Sepsis. Open Inflamm J (2011) 0.75
Community-onset sepsis and its public health burden: a systematic review. Syst Rev (2016) 0.75
Risk factors for new-onset delirium in patients with bloodstream infections: independent and quantitative effect of catheters and drainages-a four-year cohort study. Ann Intensive Care (2016) 0.75
Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting. Ann Intensive Care (2017) 0.75
Epidemiologic trends of sepsis in western countries. Ann Transl Med (2016) 0.75
Comparative Study of Plasma Endotoxin with Procalcitonin Levels in Diagnosis of Bacteremia in Intensive Care Unit Patients. Chin Med J (Engl) (2016) 0.75
Epidemiological Study of Sepsis in China: Protocol of a Cross-sectional Survey. Chin Med J (Engl) (2016) 0.75
A specially tailored vancomycin continuous infusion regimen for renally impaired critically ill patients. SAGE Open Med (2013) 0.75
Genomic Comparison of Translocating and Non-Translocating Escherichia coli. PLoS One (2015) 0.75
Differences in reported sepsis incidence according to study design: a literature review. BMC Med Res Methodol (2016) 0.75
Epidemiology of Adult-population Sepsis in India: A Single Center 5 Year Experience. Indian J Crit Care Med (2017) 0.75
The delta neutrophil index is a prognostic factor for postoperative mortality in patients with sepsis caused by peritonitis. PLoS One (2017) 0.75
Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30
Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA (2005) 19.57
A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med (2004) 12.79
Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med (2012) 11.83
International study of the prevalence and outcomes of infection in intensive care units. JAMA (2009) 11.57
Goal-directed resuscitation for patients with early septic shock. N Engl J Med (2014) 11.32
Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med (2009) 10.60
Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med (2009) 9.77
Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. JAMA (2009) 9.47
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA (2012) 8.05
Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial. Lancet (2005) 7.81
Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med (2015) 7.73
Cardiorenal syndrome. J Am Coll Cardiol (2008) 7.09
Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis (2009) 6.99
An assessment of the RIFLE criteria for acute renal failure in hospitalized patients. Crit Care Med (2006) 6.87
Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17
Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology (2006) 5.58
Augmented renal clearance in the ICU: results of a multicenter observational study of renal function in critically ill patients with normal plasma creatinine concentrations*. Crit Care Med (2014) 5.50
Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med (2012) 5.15
Findings of the first consensus conference on medical emergency teams. Crit Care Med (2006) 4.64
The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol (2011) 4.57
Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med (2007) 4.42
Respiratory rate: the neglected vital sign. Med J Aust (2008) 4.38
Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort study. Crit Care Med (2009) 4.30
A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients. Nephrol Dial Transplant (2008) 4.29
A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients. Nephrol Dial Transplant (2007) 4.11
DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients? Clin Infect Dis (2014) 3.99
Rapid-response teams. N Engl J Med (2011) 3.84
Percutaneous versus surgical tracheostomy: A randomized controlled study with long-term follow-up. Crit Care Med (2006) 3.80
Blood glucose concentration and outcome of critical illness: the impact of diabetes. Crit Care Med (2008) 3.73
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. N Engl J Med (2015) 3.57
Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur Heart J (2009) 3.52
Vancomycin-associated nephrotoxicity in the critically ill: a retrospective multivariate regression analysis*. Crit Care Med (2014) 3.45
A comparison of three methods to estimate baseline creatinine for RIFLE classification. Nephrol Dial Transplant (2010) 3.45
A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis. Am J Respir Crit Care Med (2013) 3.44
Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care (2008) 3.32
Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol (2007) 3.17
Pharmacokinetic issues for antibiotics in the critically ill patient. Crit Care Med (2009) 3.09
A new marker of sepsis post burn injury?*. Crit Care Med (2014) 3.05
Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators. Intensive Care Med (2007) 3.03
Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med (2015) 2.97
Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med (2009) 2.94
Prospective meta-analysis using individual patient data in intensive care medicine. Intensive Care Med (2009) 2.93
Measurement of renal blood flow by phase-contrast magnetic resonance imaging during septic acute kidney injury: a pilot investigation. Crit Care Med (2012) 2.91
Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial. Clin Infect Dis (2012) 2.88
Early isovolaemic haemofiltration in oliguric patients with septic shock. Intensive Care Med (2005) 2.85
Routine use of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) by bedside nurses may underdiagnose delirium. Crit Care Resusc (2011) 2.81
Conservative oxygen therapy in mechanically ventilated patients: a pilot before-and-after trial. Crit Care Med (2014) 2.77
The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury. Nephrol Dial Transplant (2009) 2.73
External validation of severity scoring systems for acute renal failure using a multinational database. Crit Care Med (2005) 2.68
Working Party proposal for a revised classification system of renal dysfunction in patients with cirrhosis. Gut (2011) 2.65
The Australasian Resuscitation in Sepsis Evaluation (ARISE) trial statistical analysis plan. Crit Care Resusc (2013) 2.62
Mortality in Multicenter Critical Care Trials: An Analysis of Interventions With a Significant Effect. Crit Care Med (2015) 2.59
Discontinuation of continuous renal replacement therapy: a post hoc analysis of a prospective multicenter observational study. Crit Care Med (2009) 2.58
A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury. Nephrol Dial Transplant (2009) 2.55
Early blood glucose control and mortality in critically ill patients in Australia. Crit Care Med (2009) 2.53
Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: a pilot double-blind, randomized controlled trial. Crit Care Med (2009) 2.45
Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc (2010) 2.44
Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Med (2013) 2.44
Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis. Intensive Care Med (2010) 2.42
The biochemical effects of restricting chloride-rich fluids in intensive care. Crit Care Med (2011) 2.39
Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury. J Crit Care (2008) 2.36
Intensive insulin therapy in postoperative intensive care unit patients: a decision analysis. Am J Respir Crit Care Med (2005) 2.32
Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest. Resuscitation (2013) 2.32
Comparison of point-of-care versus central laboratory measurement of electrolyte concentrations on calculations of the anion gap and the strong ion difference. Anesthesiology (2003) 2.31
Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units. Crit Care (2007) 2.31
An assessment of the accuracy of renal blood flow estimation by Doppler ultrasound. Intensive Care Med (2008) 2.29
An observational study fluid balance and patient outcomes in the Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy trial. Crit Care Med (2012) 2.27
Urinary biochemistry and microscopy in septic acute renal failure: a systematic review. Am J Kidney Dis (2006) 2.26
Radial artery patency and clinical outcomes: five-year interim results of a randomized trial. J Thorac Cardiovasc Surg (2003) 2.26
Continuous versus intermittent renal replacement therapy for critically ill patients with acute kidney injury: a meta-analysis. Crit Care Med (2008) 2.25
Fluid balance and acute kidney injury. Nat Rev Nephrol (2009) 2.23
Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in adults. Ann Thorac Surg (2009) 2.19
The effects of saline or albumin resuscitation on acid-base status and serum electrolytes. Crit Care Med (2006) 2.19
A pilot study of coupled plasma filtration with adsorption in septic shock. Crit Care Med (2002) 2.19
A systematic review on clinical benefits of continuous administration of beta-lactam antibiotics. Crit Care Med (2009) 2.17
The pathogenesis of septic acute renal failure. Curr Opin Crit Care (2003) 2.16
Randomized, double-blind, placebo-controlled crossover pilot study of a potassium channel blocker in patients with septic shock. Crit Care Med (2006) 2.16
Current oxygen management in mechanically ventilated patients: a prospective observational cohort study. J Crit Care (2013) 2.10
Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. Crit Care Med (2015) 2.05
Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study. Crit Care Med (2012) 2.04
Pathophysiology of septic acute kidney injury: what do we really know? Crit Care Med (2008) 2.02
The interaction of chronic and acute glycemia with mortality in critically ill patients with diabetes. Crit Care Med (2011) 2.01
Pre-dilution vs. post-dilution during continuous veno-venous hemofiltration: impact on filter life and azotemic control. Nephron Clin Pract (2003) 2.01
Fluid resuscitation with 6 % hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy. Intensive Care Med (2013) 2.00
Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery -- a systematic literature review. Crit Care (2004) 2.00
Randomized comparison of nasojejunal and nasogastric feeding in critically ill patients. Crit Care Med (2002) 1.99
The relationship between early emergency team calls and serious adverse events. Crit Care Med (2009) 1.98
Unmeasured anions in critically ill patients: can they predict mortality? Crit Care Med (2003) 1.98