Published in Intensive Care Med on August 30, 2013
Protocolized Care for Early Septic Shock (ProCESS) | NCT00510835
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Septic Shock: Advances in Diagnosis and Treatment. JAMA (2015) 2.37
Protocolized Care for Early Septic Shock (ProCESS) statistical analysis plan. Crit Care Resusc (2013) 1.45
The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: a meta-analysis of randomized controlled trials. Crit Care (2014) 1.35
Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment. Crit Care (2014) 1.26
Prehospital intravenous access and fluid resuscitation in severe sepsis: an observational cohort study. Crit Care (2014) 0.98
Early goal-directed resuscitation of patients with septic shock: current evidence and future directions. Crit Care (2015) 0.95
Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria. Crit Care Med (2016) 0.91
Did they just prove that a diagnosis of "septic shock" is meaningless? Am J Respir Crit Care Med (2014) 0.80
Conservative fluid therapy in septic shock: an example of targeted therapeutic minimization. Crit Care (2014) 0.79
The new trials of early goal-directed resuscitation: three-part harmony or disharmony? Intensive Care Med (2013) 0.77
Critical care medicine 2013: a review and prospect. J Thorac Dis (2013) 0.75
Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med (2001) 51.99
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med (2000) 48.03
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med (2001) 27.70
A multiple testing procedure for clinical trials. Biometrics (1979) 26.80
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med (1999) 20.31
The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA (2001) 19.20
Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration. Ann Intern Med (2008) 13.87
Impracticability of informed consent in the Registry of the Canadian Stroke Network. N Engl J Med (2004) 9.85
Randomized trials stopped early for benefit: a systematic review. JAMA (2005) 8.43
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09
Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial. Lancet (2005) 7.81
CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. PLoS Med (2010) 6.88
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med (2004) 5.64
Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med (2005) 4.49
Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med (2007) 4.42
Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med (2006) 4.10
Barriers to implementing protocol-based sepsis resuscitation in the emergency department--results of a national survey. Crit Care Med (2007) 3.28
Prospective meta-analysis using individual patient data in intensive care medicine. Intensive Care Med (2009) 2.93
Long-term mortality and medical care charges in patients with severe sepsis. Crit Care Med (2003) 2.39
The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis. Crit Care Med (2004) 2.24
Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments. Crit Care Med (2005) 2.03
Informed consent in clinical trials in critical care: experience from the PAC-Man Study. Intensive Care Med (2006) 1.98
New strategies for clinical trials in patients with sepsis and septic shock. Crit Care Med (2001) 1.95
Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine. Crit Care Med (1999) 1.91
The incidence and outcome of septic shock patients in the absence of early-goal directed therapy. Crit Care (2006) 1.77
Variability in management of early severe sepsis. Emerg Med J (2010) 1.76
The importance of usual care control groups for safety monitoring and validity during critical care research. Intensive Care Med (2008) 1.62
The outcome of patients with sepsis and septic shock presenting to emergency departments in Australia and New Zealand. Crit Care Resusc (2007) 1.39
Blood lactate as a predictor for in-hospital mortality in patients admitted acutely to hospital: a systematic review. Scand J Trauma Resusc Emerg Med (2011) 1.38
A survey of Canadian intensivists' resuscitation practices in early septic shock. Crit Care (2007) 1.37
Agreement between peripheral venous and arterial lactate levels. Ann Emerg Med (1997) 1.34
Early goal-directed therapy of septic shock: we honestly remain skeptical. Crit Care Med (2007) 1.22
Australasian resuscitation of sepsis evaluation (ARISE): A multi-centre, prospective, inception cohort study. Resuscitation (2009) 1.19
Bench-to-bedside review: avoiding pitfalls in critical care meta-analysis--funnel plots, risk estimates, types of heterogeneity, baseline risk and the ecologic fallacy. Crit Care (2008) 1.10
Delta inflation: a bias in the design of randomized controlled trials in critical care medicine. Crit Care (2010) 1.09
Implementation of early goal-directed therapy for severe sepsis and septic shock: A decision analysis. Crit Care Med (2007) 1.01
Landmark survival as an end-point for trials in critically ill patients--comparison of alternative durations of follow-up: an exploratory analysis. Crit Care (2009) 1.00
Data sharing among data monitoring committees and responsibilities to patients and science. Trials (2013) 0.96
Accuracy of weight and height estimation in an intensive care unit. Anaesth Intensive Care (2010) 0.94
The definition of septic shock: implications for treatment. Crit Care Resusc (2007) 0.93
Considering usual medical care in clinical trial design. PLoS Med (2009) 0.91
Management of severe sepsis and septic shock in the emergency department: a survey of current practice in emergency departments in England. Emerg Med J (2007) 0.86
Why is early goal-directed therapy successful - is it the technology? Crit Care (2005) 0.86
Prognostic value of admission serum lactate concentrations in intensive care unit patients. Acta Clin Belg (2010) 0.84
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care (2007) 29.89
Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30
A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med (2003) 21.55
Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA (2005) 19.57
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med (2008) 14.40
A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med (2004) 12.79
Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med (2012) 11.83
Goal-directed resuscitation for patients with early septic shock. N Engl J Med (2014) 11.32
Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med (2009) 10.60
Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA (2002) 9.89
Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med (2009) 9.77
Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. JAMA (2009) 9.47
RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care (2006) 9.29
Use of intensive care at the end of life in the United States: an epidemiologic study. Crit Care Med (2004) 9.06
Reduction in inappropriate therapy and mortality through ICD programming. N Engl J Med (2012) 8.84
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
Trial of early, goal-directed resuscitation for septic shock. N Engl J Med (2015) 8.24
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA (2012) 8.05
Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial. Lancet (2005) 7.81
Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med (2015) 7.73
Cardiorenal syndrome. J Am Coll Cardiol (2008) 7.09
Trial of the route of early nutritional support in critically ill adults. N Engl J Med (2014) 7.06
Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis (2009) 6.99
An assessment of the RIFLE criteria for acute renal failure in hospitalized patients. Crit Care Med (2006) 6.87
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet (2005) 6.33
Outcomes of medical emergencies on commercial airline flights. N Engl J Med (2013) 6.29
Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial. Lancet (2011) 6.25
Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med (2014) 5.70
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology (2006) 5.58
Nighttime intensivist staffing and mortality among critically ill patients. N Engl J Med (2012) 5.22
Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med (2012) 5.15
Variation in critical care services across North America and Western Europe. Crit Care Med (2008) 5.00
Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. Crit Care Med (2004) 4.93
Acute kidney injury. Lancet (2012) 4.90
The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med (2002) 4.72
Findings of the first consensus conference on medical emergency teams. Crit Care Med (2006) 4.64
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol (2011) 4.57
Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med (2007) 4.42
The effect of multidisciplinary care teams on intensive care unit mortality. Arch Intern Med (2010) 4.41
Effect of evidence-based feeding guidelines on mortality of critically ill adults: a cluster randomized controlled trial. JAMA (2008) 4.41
Respiratory rate: the neglected vital sign. Med J Aust (2008) 4.38
Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial. JAMA (2013) 4.35
Out-of-hospital endotracheal intubation and outcome after traumatic brain injury. Ann Emerg Med (2004) 4.33
Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort study. Crit Care Med (2009) 4.30
A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients. Nephrol Dial Transplant (2008) 4.29
Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1). JAMA (2011) 4.24
A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients. Nephrol Dial Transplant (2007) 4.11
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Rapid-response teams. N Engl J Med (2011) 3.84
Percutaneous versus surgical tracheostomy: A randomized controlled study with long-term follow-up. Crit Care Med (2006) 3.80
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Blood glucose concentration and outcome of critical illness: the impact of diabetes. Crit Care Med (2008) 3.73
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. N Engl J Med (2015) 3.57
Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med (2015) 3.55
Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur Heart J (2009) 3.52
Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats. Chest (2007) 3.51
A comparison of three methods to estimate baseline creatinine for RIFLE classification. Nephrol Dial Transplant (2010) 3.45
A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis. Am J Respir Crit Care Med (2013) 3.44
Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia. Ann Emerg Med (2008) 3.44