Published in Immunology on February 01, 1990
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med (2005) 7.87
Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes. J Clin Invest (1996) 0.97
Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases. Clin Exp Immunol (2017) 0.75
T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol (1978) 28.92
The diabetic syndrome of the 'BB' Wistar rat: possible relevance to type 1 (insulin-dependent) diabetes in man. Diabetologia (1982) 1.76
Nonspecific inhibitor released by T acceptor cells reduces the production of interleukin-2. Nature (1982) 1.75
The BB rat. Diabetes Metab Rev (1987) 1.65
Lyt-23+ cyclophosphamide-sensitive T cells regulate the activity of an interleukin 2 inhibitor in vivo. J Exp Med (1981) 1.59
Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat. J Immunol (1983) 1.58
The BB diabetic rat. Profound T-cell lymphocytopenia. Diabetes (1981) 1.55
In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2. J Immunol (1985) 1.50
Acquired defect in interleukin-2 production in patients with type I diabetes mellitus. N Engl J Med (1986) 1.25
Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus. Diabetes (1984) 1.25
Immunochemical studies on thymosin: radioimmunoassay of thymosin alpha 1. J Immunol (1982) 1.21
Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice. Diabetes Metab Rev (1987) 1.15
Serum IL-2 inhibitor in mice. I. Increase during infection. Immunology (1985) 1.14
Induction and upregulation by interleukin 2 of high-affinity interleukin 2 receptors on thymocytes and T cells. Proc Natl Acad Sci U S A (1985) 1.13
T cell-specific suppressor factor(s) with regulatory influence on interleukin 2 production and function. J Immunol (1982) 1.12
Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages. J Exp Med (1984) 1.10
Islet cell surface antibodies and lymphocyte antibodies in the spontaneously diabetic BB Wistar rat. Diabetes (1982) 1.07
Characterization and partial purification of a specific interleukin 2 inhibitor. J Immunol (1985) 1.05
Thymosin alpha 1 and thymosin beta 4 in serum: comparison of normal, cord, homosexual and AIDS serum. Int J Immunopharmacol (1986) 1.01
Modulation of human natural killer cell cytotoxic activity, lymphokine production, and interleukin 2 receptor expression by thymic hormones. J Immunol (1987) 1.01
T-lymphocyte subpopulations in insulin-dependent (type I) diabetes mellitus. Clin Exp Immunol (1986) 0.98
Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients. Diabetes (1989) 0.97
Serum IL-2 inhibitor in mice. II. Molecular characteristics. Immunology (1985) 0.96
Increased soluble interleukin-2 receptor levels in the sera of type 1 diabetic patients. Diabetes Res (1988) 0.92
Contra-IL 2; a suppressor lymphokine that inhibits IL 2 activity. J Immunol (1986) 0.92
Modulation of interleukin 2 receptor expression on normal human lymphocytes by thymic hormones. Proc Natl Acad Sci U S A (1986) 0.89
Mechanism of action of thymosin. I. Thymosin fraction 5 increases lymphokine production by mature murine T cells responding in a mixed lymphocyte reaction. J Immunol (1985) 0.86
Decreased interleukin 2 inhibitor in sera of patients with autoimmune disorders. Clin Exp Immunol (1986) 0.86
Genetic heterogeneity in the major histocompatibility complex of various BB rat sublines. Diabetologia (1986) 0.84
Thymosin increases production of T-cell growth factor by normal human peripheral blood lymphocytes. Proc Natl Acad Sci U S A (1984) 0.84
Curing BB rats of freshly manifested diabetes by short-term treatment with a combination of a monoclonal anti-interleukin 2 receptor antibody and a subtherapeutic dose of cyclosporin A. Eur J Immunol (1987) 0.83
Inhibition of interleukin 2 by serum in healthy individuals and in patients with autoimmune disease. Int Arch Allergy Appl Immunol (1987) 0.80
IL-2 normalizes defective suppressor T cell function of patients with systemic lupus erythematosus in vitro. Clin Exp Immunol (1986) 0.80
Recombinant interleukin 2 enhances spontaneous insulin-dependent diabetes in BB rats. Eur J Immunol (1986) 0.79
Reconstitution of T cell functions in aging mice by thymosin alpha 1. Immunopharmacology (1986) 0.79
Improved ELISA to measure thymosin alpha 1: comparison of whole and absorbed antisera. Int J Immunopharmacol (1988) 0.79
Detection of activated lymphocytes in endocrine pancreas of BB/W rats by injection of 123I-interleukin-2: an early sign of type 1 diabetes. Lancet (1987) 0.79
In vivo administration of interleukin 2 stimulates mitosis in thymus and bone marrow. Eur J Immunol (1986) 0.77
Interleukin 2 activates BB/W diabetic rat lymphoid cells cytotoxic to islet cells. Diabetes (1987) 0.77
Decreased level of thymidine in the serum of obese strain (OS) chickens with spontaneous autoimmune thyroiditis. Immunol Invest (1988) 0.77
In vitro T cell hyperreactivity in Obese strain (OS) chickens is due to a defect in nonspecific suppressor mechanism(s). J Immunol (1985) 0.77
Experimental autoimmune thyroiditis: modulation of the disease level in high and low responder mice by thymosin. Clin Exp Immunol (1984) 0.77
Thymosin modulates immune and endocrine events. Prog Clin Biol Res (1988) 0.76
Effect of thymic hormones on interleukin 2 synthesis by lymphocytes from HIV-positive pre-AIDS subjects. Immunol Invest (1988) 0.76
The ontogeny of the interleukin 2 receptor expression and of the interleukin 2 responsiveness in the rat thymus. Immunobiology (1987) 0.76
Interleukin induction of non-specific suppressor cells. Ann Inst Pasteur Immunol (1986) 0.76
Effect of interleukin-2 on diabetes in the BB/Wor rat. Diabetes Res (1987) 0.76
Thymosin and the spontaneously diabetic BB rat. Autoimmunity (1988) 0.76
Serum inhibitors of interleukin-2. Life Sci (1988) 0.76
Beta-D-fructofuranoside fructohydrolase from yeast. Methods Enzymol (1975) 9.19
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol (2000) 6.57
Self-monitoring of blood glucose in type 2 diabetes and long-term outcome: an epidemiological cohort study. Diabetologia (2005) 5.47
Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet (2000) 3.92
Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency. N Engl J Med (2001) 3.85
Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science (1982) 3.80
Morphine-tolerant longitudinal muscle strip from guinea-pig ileum. Br J Pharmacol (1973) 2.93
Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain. Proc Natl Acad Sci U S A (1971) 2.82
Dynorphin-(1-13), an extraordinarily potent opioid peptide. Proc Natl Acad Sci U S A (1979) 2.66
Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer. Br J Cancer (1999) 2.66
Specific receptor for the opioid peptide dynorphin: structure--activity relationships. Proc Natl Acad Sci U S A (1981) 2.53
A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties. Life Sci (1975) 2.34
Intracellular staining reveals different levels of stratification for on- and off-center ganglion cells in cat retina. J Neurophysiol (1978) 2.19
Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin. Proc Natl Acad Sci U S A (1976) 2.16
Rod and cone pathways in the inner plexiform layer of cat retina. Science (1974) 2.12
Human 60-kDa heat-shock protein: a danger signal to the innate immune system. J Immunol (1999) 2.01
Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nat Med (1999) 1.98
Structural basis for ON-and OFF-center responses in retinal ganglion cells. Science (1976) 1.98
Forced expiratory flows and volumes in infants. Normative data and lung growth. Am J Respir Crit Care Med (2000) 1.95
A bistratified amacrine cell and synaptic cirucitry in the inner plexiform layer of the retina. Brain Res (1975) 1.80
Opioid peptides and opioid receptors in cells of the immune system. Annu Rev Immunol (1988) 1.76
Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide. Proc Natl Acad Sci U S A (1981) 1.74
Tolerance to opioid narcotics. I. Tolerance to the "running fit" caused by levorphanol in the mouse. J Pharmacol Exp Ther (1969) 1.73
Psychotropic effects of caffeine in man. IV. Quantitative and qualitative differences associated with habituation to coffee. Clin Pharmacol Ther (1969) 1.72
Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the Fourth International Workshop on the Standardization of Insulin Autoantibody Measurement. J Clin Endocrinol Metab (1992) 1.70
Antimalarial therapy and early retinal changes in patients with rheumatoid arthritis. Br Med J (1966) 1.68
Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation. Lancet (1993) 1.68
A specific radioimmunoassay for the novel opioid peptide dynorphin. Life Sci (1980) 1.67
Chloroquine retinopathy in the rhesus monkey. Invest Ophthalmol Vis Sci (1978) 1.66
The inner plexiform layer in the retina of the cat: electron microscopic observations. J Neurocytol (1979) 1.58
Malignant thymoma associated with T-cell lymphocytosis. A case report with immunophenotypic and gene rearrangement analysis. Arch Pathol Lab Med (1993) 1.58
Allogeneic bone marrow transplantation for secondary leukaemia and myelodysplastic syndrome: a survey by the Leukaemia Working Party of the European Bone Marrow Transplantation Group (EBMTG) Br J Haematol (1990) 1.56
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem (1995) 1.56
Multiple organ failure due to 5-fluorouracil chemotherapy in a patient with a rare dihydropyrimidine dehydrogenase gene variant. Onkologie (2004) 1.54
Limited capacity for protein synthesis at zero degrees centigrade in Escherichia coli. J Mol Biol (1968) 1.51
Increased urinary nitrite excretion in children with minimal change nephrotic syndrome. J Pediatr (1996) 1.51
Amacrine cells, bipolar cells and ganglion cells of the cat retina: a Golgi study. Vision Res (1981) 1.50
Opioid peptides endorphins in pituitary and brain. Science (1976) 1.50
Diabetes classification: grey zones, sound and smoke: Action LADA 1. Diabetes Metab Res Rev (2008) 1.50
Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors. Diabetologia (2002) 1.49
The mammalian photoreceptor mosaic-adaptive design. Prog Retin Eye Res (2000) 1.48
Cloning and pharmacological characterization of a rat kappa opioid receptor. Proc Natl Acad Sci U S A (1993) 1.47
Primary care physicians' views on access and health care reform: the situation in North Carolina. J Fam Pract (1993) 1.46
Milk and type I diabetes. Diabetes Care (1996) 1.45
Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice. Blood (2001) 1.45
Self-monitoring of blood glucose in type 2 diabetes: a new look at published trials. Diabetologia (2008) 1.45
Imaging of pelvic postpartum complications. AJR Am J Roentgenol (1997) 1.44
A peptide-like substance from pituitary that acts like morphine. I. Isolation. Life Sci (1975) 1.44
Histochemical demonstration of glycogen in neurons of the cat retina. Invest Ophthalmol Vis Sci (1996) 1.43
Inhibition by chlorampenicol of the growth of nascent protein chains in Escherichia coli. Mol Pharmacol (1966) 1.43
Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation. Biochem Biophys Res Commun (1991) 1.42
Hepatitis C screening and prevalence among urban public safety workers. J Occup Environ Med (2001) 1.42
Sequence and expression of the rat prodynorphin gene. Proc Natl Acad Sci U S A (1985) 1.40
Infections from biomaterials and implants: a race for the surface. Med Prog Technol (1989) 1.39
Transcranial sonography through the burr hole for detection of ventriculomegaly. A preliminary report. J Ultrasound Med (1991) 1.39
Fermi observations of high-energy gamma-ray emission from GRB 080916C. Science (2009) 1.37
Ligand dissociation constants from competition binding assays: errors associated with ligand depletion. Mol Pharmacol (1987) 1.36
Electron microscopic observations of human retinitis pigmentosa, dominantly inherited. Invest Ophthalmol (1974) 1.35
Immunoreactive dynorphin in pituitary and brain. Proc Natl Acad Sci U S A (1980) 1.33
Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats. Diabetologia (1989) 1.32
Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2. J Clin Invest (1997) 1.31
Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus. Nature (1981) 1.30
Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study. Diabetologia (2009) 1.30
ZONE BEHAVIOR OF ENZYMES : ILLUSTRATED BY THE EFFECT OF DISSOCIATION CONSTANT AND DILUTION ON THE SYSTEM CHOLINESTERASE-PHYSOSTIGMINE. J Gen Physiol (1943) 1.29
IL-1 and IFN-gamma increase vascular permeability. Immunology (1988) 1.29
Early open reduction and internal fixation of the disrupted pelvic ring. J Trauma (1986) 1.29
Identification of a subtype of cone photoreceptor, likely to be blue sensitive, in the human retina. J Comp Neurol (1987) 1.29
Elevated levels of circulating adhesion molecules in IDDM patients and in subjects at risk for IDDM. Diabetes (1992) 1.28
Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002. Diabetologia (2006) 1.28
Morphine and other opiates from beef brain and adrenal. Proc Natl Acad Sci U S A (1985) 1.26
Site-directed alkylation of multiple opioid receptors. I. Binding selectivity. Mol Pharmacol (1984) 1.25
A17: a broad-field amacrine cell in the rod system of the cat retina. J Neurophysiol (1985) 1.25
Tolerance to opioid narcotics: time course and reversibility of physical dependence in mice. Nature (1971) 1.24
Altered chemokine levels in individuals at risk of Type 1 diabetes mellitus. Diabet Med (2006) 1.23
Administration of silica prevents diabetes in BB-rats. Diabetes (1985) 1.22
Adult thymectomy prevention of the appearance of suppressor T cells which depress contact sensitivity to picryl chloride and reversal of adult thymectomy effect by thymus extract. Eur J Immunol (1976) 1.22
Heat shock protein hsp70 overexpression confers resistance against nitric oxide. FEBS Lett (1996) 1.21
Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator. Mol Cell Biol (1999) 1.21
Stereospecific nicotine receptors on rat brain membranes. Science (1980) 1.21
Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion. Biochem Biophys Res Commun (1994) 1.21
Training the indigenous nonprofessional: the screening technician. J Pediatr (1970) 1.21
Synaptic patterns and response properties of bipolar and ganglion cells in the cat retina. Vision Res (1983) 1.20
Dynorphin immunocytochemical localization in brain and peripheral nervous system: preliminary studies. Proc Natl Acad Sci U S A (1981) 1.19
Low-dose streptozocin-induced diabetes in mice. Electron microscopy reveals single-cell insulitis before diabetes onset. Diabetes (1988) 1.19
The organization of the outer plexiform layer in the retina of the cat: electron microscopic observations. J Neurocytol (1977) 1.19
The localization of guanylyl cyclase-activating proteins in the mammalian retina. Invest Ophthalmol Vis Sci (1998) 1.19
The connections between bipolar cells and photoreceptors in the retina of the domestic cat. J Comp Neurol (1973) 1.18
Chronic granulomatous disease presenting in childhood with Pseudomonas cepacia septicaemia. J Infect (1993) 1.16
Training pediatric residents to prevent tobacco use. Pediatrics (1995) 1.16
Nicotine self-administration in rats. Br J Pharmacol (1984) 1.16
Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice. Diabetes Metab Rev (1987) 1.15