Published in J Immunol on June 01, 1978
T cell growth factor receptors. Quantitation, specificity, and biological relevance. J Exp Med (1981) 10.66
HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J (1990) 9.34
Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med (1997) 8.59
The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med (1992) 7.80
Continuous proliferation of murine antigen-specific helper T lymphocytes in culture. J Exp Med (1979) 7.20
Macrophage deactivation by interleukin 10. J Exp Med (1991) 6.94
Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen. J Exp Med (1984) 6.45
Transient expression of interleukin 2 receptors. Consequences for T cell growth. J Exp Med (1983) 5.82
The functional relationship of the interleukins. J Exp Med (1980) 5.62
Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas. Proc Natl Acad Sci U S A (1986) 5.60
Monoclonal cytolytic T-cell lines. J Exp Med (1979) 5.28
Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines. J Exp Med (1979) 5.22
Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media. Proc Natl Acad Sci U S A (1980) 4.91
Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex. Proc Natl Acad Sci U S A (1983) 4.83
Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line. J Exp Med (1980) 4.32
Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J Exp Med (1983) 4.10
Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. Proc Natl Acad Sci U S A (1985) 3.95
Long-term culture of human antigen-specific cytotoxic T-cell lines. J Exp Med (1978) 3.80
Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J (1990) 3.62
Structure of the human interleukin 2 gene. Proc Natl Acad Sci U S A (1983) 3.45
Molecular cloning of human interleukin 2 cDNA and its expression in E. coli. Nucleic Acids Res (1983) 3.44
Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis. J Clin Invest (1985) 3.41
Selection of a human T helper type 1-like T cell subset by mycobacteria. J Exp Med (1991) 3.41
B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells. Proc Natl Acad Sci U S A (1987) 3.33
Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor. J Exp Med (1981) 3.30
Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen. Proc Natl Acad Sci U S A (1981) 3.28
Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2. J Exp Med (1981) 3.27
Self-regulation of procoagulant events on the endothelial cell surface. J Exp Med (1985) 3.16
The in vitro generation and sustained culture of nude mouse cytolytic T-lymphocytes. J Exp Med (1979) 3.15
Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus. J Clin Invest (1982) 3.10
Fas transduces activation signals in normal human T lymphocytes. J Exp Med (1993) 3.04
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A (1992) 2.98
Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. Am J Pathol (1986) 2.95
Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J Exp Med (1991) 2.78
Dendritic cells initiate a two-stage mechanism for T lymphocyte proliferation. J Exp Med (1983) 2.76
Characterization of the human receptor for T-cell growth factor. Proc Natl Acad Sci U S A (1983) 2.76
Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells. Mol Cell Biol (1986) 2.76
Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas. J Exp Med (1987) 2.74
Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells. J Exp Med (1985) 2.65
B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors. J Exp Med (1988) 2.64
Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and gamma interferon. J Exp Med (1988) 2.61
Voltage-gated potassium channels are required for human T lymphocyte activation. J Exp Med (1984) 2.54
Chronic chlamydial genital infection in congenitally athymic nude mice. Infect Immun (1985) 2.54
T-Cell lymphoma model for the analysis of interleukin 1-mediated T-cell activation. Proc Natl Acad Sci U S A (1981) 2.51
Spleen cell cytokine secretion in Mycobacterium bovis BCG-infected mice. Infect Immun (1992) 2.50
Modification and secretion of human interleukin 2 produced in insect cells by a baculovirus expression vector. Proc Natl Acad Sci U S A (1985) 2.46
Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene. J Exp Med (1981) 2.46
Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity. Proc Natl Acad Sci U S A (1988) 2.45
Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J Clin Invest (1984) 2.43
Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor. J Virol (1989) 2.42
Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann Surg (1995) 2.38
Quantitative hybridization-arrest of mRNA in Xenopus oocytes using single-stranded complementary DNA or oligonucleotide probes. Nucleic Acids Res (1985) 2.38
A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. J Exp Med (1987) 2.37
Human alveolar macrophage growth factor for fibroblasts. Regulation and partial characterization. J Clin Invest (1982) 2.33
Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis. J Exp Med (1991) 2.29
Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders. J Clin Invest (1983) 2.27
Interleukin 2 regulates the expression of Tac antigen on peripheral blood T lymphocytes. J Exp Med (1984) 2.26
Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells. J Exp Med (1989) 2.22
Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures. J Exp Med (1985) 2.22
Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes. Proc Natl Acad Sci U S A (1984) 2.17
Modification of T-cell proliferation and interleukin 2 production in mice infected with Trypanosoma cruzi. Proc Natl Acad Sci U S A (1983) 2.17
Multiple biological activities of human recombinant interleukin 1. J Clin Invest (1986) 2.16
Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype. J Exp Med (1983) 2.15
Definition of T cell idiotypes using anti-idiotypic antisera produced by immunization with T cell clones. J Exp Med (1982) 2.14
T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor. J Exp Med (1988) 2.14
cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci U S A (1989) 2.13
Interleukin-6 induced at mucosal surfaces by gram-negative bacterial infection. Infect Immun (1989) 2.13
Human T-cell growth factor: partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells. Proc Natl Acad Sci U S A (1984) 2.12
Separation of subcellular compartments containing distinct functional forms of MHC class II. J Cell Biol (1994) 2.09
Purification and partial sequence analysis of human T-cell growth factor. Proc Natl Acad Sci U S A (1983) 2.09
Specificity of cytotoxic T cells from athymic mice. J Exp Med (1980) 2.07
Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies. J Clin Invest (1986) 2.05
Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J Clin Invest (1981) 2.04
The persisting (P) cell: histamine content, regulation by a T cell-derived factor, origin from a bone marrow precursor, and relationship to mast cells. Proc Natl Acad Sci U S A (1981) 1.97
Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4. Proc Natl Acad Sci U S A (1991) 1.96
The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters. EMBO J (1985) 1.95
Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats. J Exp Med (1987) 1.93
Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. Evidence of specific competition for accessory cell antigen presentation. J Exp Med (1983) 1.92
Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH. J Exp Med (1991) 1.92
Human Mycobacterium tuberculosis-reactive CD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes. Infect Immun (1991) 1.89
Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis. J Exp Med (1986) 1.88
Candida-specific Th1-type responsiveness in mice with experimental vaginal candidiasis. Infect Immun (1993) 1.84
Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J (1995) 1.84
Stable expression of the tax gene of type I human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth. Proc Natl Acad Sci U S A (1988) 1.83
Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J Exp Med (1989) 1.83
Characterization of the high-affinity cell-surface receptor for murine B-cell-stimulating factor 1. Proc Natl Acad Sci U S A (1987) 1.83
Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes. Proc Natl Acad Sci U S A (1991) 1.81
Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. J Clin Invest (1986) 1.81
Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH-cell subsets in resistant versus susceptible mice. Immunology (1992) 1.77
Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2. J Exp Med (1982) 1.76
CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. J Exp Med (1994) 1.76
Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors. Proc Natl Acad Sci U S A (1985) 1.75
Reduced interferon-gamma mRNA levels in human neonates. Evidence for an intrinsic T cell deficiency independent of other genes involved in T cell activation. J Exp Med (1986) 1.75
Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J Exp Med (1994) 1.74
Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome. J Exp Med (1986) 1.74
Long term culture of tumour-specific cytotoxic T cells. Nature (1977) 14.15
T cell growth factor receptors. Quantitation, specificity, and biological relevance. J Exp Med (1981) 10.66
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature (1985) 9.94
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature (1982) 9.42
T-cell growth factor. Immunol Rev (1980) 8.11
Transient expression of interleukin 2 receptors. Consequences for T cell growth. J Exp Med (1983) 5.82
The interleukin-2 T-cell system: a new cell growth model. Science (1984) 5.81
The functional relationship of the interleukins. J Exp Med (1980) 5.62
Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2. J Immunol (1984) 5.51
Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature (1988) 5.50
Monoclonal cytolytic T-cell lines. J Exp Med (1979) 5.28
Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines. J Exp Med (1979) 5.22
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A (1984) 4.78
Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med (1987) 4.53
Interleukin 2. Annu Rev Immunol (1984) 4.37
Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line. J Exp Med (1980) 4.32
Interleukin 2 regulates its own receptors. Proc Natl Acad Sci U S A (1985) 4.19
Interleukin-2 augments natural killer cell activity. Nature (1981) 4.15
Long-term culture of human antigen-specific cytotoxic T-cell lines. J Exp Med (1978) 3.80
Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver--conditioned medium. Cell (1990) 3.66
The interleukin 2 receptor. Functional consequences of its bimolecular structure. J Exp Med (1987) 3.66
The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science (1992) 3.64
Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation. J Immunol (1979) 3.32
Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med (1993) 3.31
Biochemical characterization of lymphocyte regulatory molecules. II. Purification of a class of rat and human lymphokines. J Immunol (1980) 3.28
T-cell growth factor-mediated T-cell proliferation. Ann N Y Acad Sci (1979) 3.16
The in vitro generation and sustained culture of nude mouse cytolytic T-lymphocytes. J Exp Med (1979) 3.15
The born-again spleen. Return of splenic function after splenectomy for trauma. N Engl J Med (1978) 3.13
In vitro generation of tumor-specific cytotoxic lymphocytes. Secondary allogeneic mixed tumor lymphocyte culture of normal murine spleen cells. J Exp Med (1977) 3.11
Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science (1999) 3.10
Production and characterization of monoclonal antibodies to human interleukin 2: strategy and tactics. J Immunol (1983) 3.10
Cloning, sequence and expression of human interleukin-2 receptor. Nature (1985) 3.02
Detection and characterization of high affinity plasma membrane receptors for human interleukin 1. J Exp Med (1985) 3.00
Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE). J Immunol (1983) 2.95
Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science (1986) 2.84
Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells. Proc Natl Acad Sci U S A (1983) 2.84
Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors. J Exp Med (1990) 2.79
Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J Exp Med (1991) 2.78
The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. J Biol Chem (1987) 2.78
Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines. J Exp Med (1986) 2.71
The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical. Nature (1987) 2.68
Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming growth factor-beta. J Immunol (1989) 2.64
IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gamma. J Immunol (1989) 2.57
T-Cell lymphoma model for the analysis of interleukin 1-mediated T-cell activation. Proc Natl Acad Sci U S A (1981) 2.51
Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc Natl Acad Sci U S A (1989) 2.46
Relative cerebral blood volume values to differentiate high-grade glioma recurrence from posttreatment radiation effect: direct correlation between image-guided tissue histopathology and localized dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging measurements. AJNR Am J Neuroradiol (2008) 2.34
Heterogeneity of human T-cell growth factor(s) due to variable glycosylation. Mol Immunol (1981) 2.34
Interleukin-2 induction of T-cell G1 progression and c-myb expression. Science (1986) 2.26
Definition of T cell idiotypes using anti-idiotypic antisera produced by immunization with T cell clones. J Exp Med (1982) 2.14
Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function. J Exp Med (1985) 2.14
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood (2000) 2.12
T-cell growth factor and the culture of cloned functional T cells. Adv Immunol (1981) 2.09
Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J Clin Invest (1981) 2.04
Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice. J Immunol (1993) 2.02
Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells. J Immunol (1987) 2.00
Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells. Nature (1980) 1.99
Cloning, sequence and expression of bovine interleukin 1 alpha and interleukin 1 beta complementary DNAs. Mol Immunol (1988) 1.97
In vivo interleukin 2 administration augments the generation of alloreactive cytolytic T lymphocytes and resident natural killer cells. J Immunol (1983) 1.97
The effect of T cell growth factor on the generation of cytolytic T cells. J Immunol (1978) 1.92
Characterization of the cell surface receptor for granulocyte-macrophage colony-stimulating factor. J Biol Chem (1986) 1.90
Interleukin 7 is a T-cell growth factor. Proc Natl Acad Sci U S A (1989) 1.79
Biochemical and biologic characterization of lymphocyte regulatory molecules. III. The isolation and phenotypic characterization of Interleukin-2 producing T cell lymphomas. J Immunol (1980) 1.79
T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells. Proc Natl Acad Sci U S A (1984) 1.77
Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2. J Exp Med (1982) 1.76
In situ identification of cells in human leprosy granulomas with monoclonal antibodies to interleukin 2 and its receptor. J Immunol (1984) 1.74
Interleukin 2 induces gamma-interferon production: participation of macrophages and NK-like cells. J Immunol (1983) 1.72
Similarity between the interleukin 1 receptors on a murine T-lymphoma cell line and on a murine fibroblast cell line. Proc Natl Acad Sci U S A (1986) 1.70
Murine NK cell cultures: effects of interleukin-2 and interferon on cell growth and cytotoxic reactivity. J Immunol (1981) 1.70
Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines. Blood (1996) 1.66
Functional and molecular characteristics of T-cell growth factor. Mol Immunol (1980) 1.66
Covariation of activity in habenula and dorsal raphé nuclei following tryptophan depletion. Neuroimage (1999) 1.65
Glucocorticoids and immune responses. Arthritis Rheum (1979) 1.65
Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor. Proc Natl Acad Sci U S A (1985) 1.62
Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance. Immunol Rev (1995) 1.58
Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand. J Exp Med (1992) 1.56
The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers. Psychopharmacology (Berl) (2002) 1.56
The development of sequence-tagged sites for human chromosome 4. Hum Mol Genet (1993) 1.55
Induction of antigen-specific parasiticidal cytotoxic T cell splenocytes by a major membrane protein (P30) of Toxoplasma gondii. J Immunol (1988) 1.54
Glucocorticoid-induced inhibition of T cell growth factor production. II. The effect on the in vitro generation of cytolytic T cells. J Immunol (1979) 1.53
Molecular characterization of interleukin 2. Immunol Rev (1982) 1.52
Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor. Proc Natl Acad Sci U S A (1992) 1.52
Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis. J Exp Med (1984) 1.51
Brief report: tumor lysis syndrome following treatment with 2-chlorodeoxyadenosine for refractory chronic lymphocytic leukemia. N Engl J Med (1993) 1.51
Lymphokine purification by reversed-phase high-performance liquid chromatography. J Chromatogr (1984) 1.51
Expression, purification and characterization of recombinant murine granulocyte-macrophage colony-stimulating factor and bovine interleukin-2 from yeast. Gene (1987) 1.50