Published in Chem Biol on October 26, 2012
Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochim Biophys Acta (2013) 1.04
Lipophilic triphenylphosphonium cations inhibit mitochondrial electron transport chain and induce mitochondrial proton leak. PLoS One (2015) 0.90
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Targeted nanoparticles in mitochondrial medicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2014) 0.81
Stroke neuroprotection: targeting mitochondria. Brain Sci (2013) 0.80
Controlling radicals in the powerhouse: development of MitoSOD. Chem Biol (2012) 0.78
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev (2017) 0.76
Mitochondrial Probe Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase. PLoS One (2016) 0.75
Does MitoSOD protect against the toxicity of paraquat toward mitochondria by acting as a superoxide dismutase mimic? Free Radic Biol Med (2013) 0.75
Erectile dysfunction drugs and oxidative stress in the liver of male rats. Toxicol Rep (2015) 0.75
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc Natl Acad Sci U S A (2006) 4.64
Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol (2007) 4.16
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol (2007) 3.47
Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem (2007) 3.31
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell (2013) 3.10
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10
Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing. Nature (2016) 2.98
Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation (2013) 2.94
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81
Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. J Am Coll Cardiol (2007) 2.60
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell (2013) 2.56
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J (2005) 2.33
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension (2009) 2.28
Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem (2003) 2.28
The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents. J Biol Chem (2007) 2.25
Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci U S A (2003) 2.12
Role of marine biology in glacial-interglacial CO2 cycles. Science (2005) 2.11
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes (2004) 2.08
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem (2002) 2.04
Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE. J Biol Chem (2004) 1.99
Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest (2005) 1.96
Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. Biochem J (2009) 1.94
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis (2010) 1.84
Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production. Biochem Soc Symp (2004) 1.82
Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth. Am J Physiol Cell Physiol (2005) 1.82
Glutathionylation of mitochondrial proteins. Antioxid Redox Signal (2005) 1.79
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2009) 1.78
A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov Disord (2010) 1.72
Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte. Blood (2006) 1.72
Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J (2003) 1.70
Neurological deficits caused by tissue hypoxia in neuroinflammatory disease. Ann Neurol (2013) 1.70
Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. J Leukoc Biol (2012) 1.69
Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci (2010) 1.67
Mitochondria-targeted small molecule therapeutics and probes. Antioxid Redox Signal (2011) 1.66
Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria. J Biol Chem (2006) 1.65
Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis. J Transl Med (2009) 1.62
Control of molecular architecture by use of the appropriate ligand isomer: a mononuclear "corner-type" versus a tetranuclear [2 x 2] grid-type cobalt(III) complex. Chem Commun (Camb) (2004) 1.62
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. J Biol Chem (2003) 1.62
Myeloperoxidase: a front-line defender against phagocytosed microorganisms. J Leukoc Biol (2012) 1.60
Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302. Mol Cancer Ther (2011) 1.58
Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide. J Leukoc Biol (2011) 1.57
The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic Biol Med (2008) 1.55
The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int (2010) 1.54
Adhesion of biologically inspired vertical and angled polymer microfiber arrays. Langmuir (2007) 1.54
PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells. Cell Cycle (2009) 1.54
Covariant glacial-interglacial dust fluxes in the equatorial Pacific and Antarctica. Science (2008) 1.53
A complication from neurocranial restructuring: nasal septum fracture. Arch Otolaryngol Head Neck Surg (2003) 1.53
Mitochondrial pharmacology. Trends Pharmacol Sci (2012) 1.51
Mitochondria-derived reactive oxygen species mediate blue light-induced death of retinal pigment epithelial cells. Photochem Photobiol (2004) 1.50
A redox switch in angiotensinogen modulates angiotensin release. Nature (2010) 1.50
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA. Nucleic Acids Res (2008) 1.48
Nuclear factor kappaB activation in pulmonary leukocytes from infants with hyaline membrane disease: associations with chorioamnionitis and Ureaplasma urealyticum colonization. Pediatr Res (2005) 1.47
Estimating the risk of solid organ malignancy in patients undergoing routine computed tomography scans after endovascular aneurysm repair. J Vasc Surg (2012) 1.46
Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus. J Biol Chem (2001) 1.45
Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Dis Assoc Disord (2007) 1.44
Use of animals by NATO countries in military medical training exercises: an international survey. Mil Med (2012) 1.42
Femoral arterial access management for endovascular aortic aneurysm repair: evolution and outcome. Perspect Vasc Surg Endovasc Ther (2009) 1.42
Dimetallic complexes of acyclic pyridine-armed ligands derived from 3,6-diformylpyridazine. Dalton Trans (2004) 1.40
Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J (2010) 1.40
Dialysis access steal syndromes. Perspect Vasc Surg Endovasc Ther (2009) 1.38
Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling. J Biol Chem (2007) 1.38
Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant. FEBS Lett (2004) 1.38
3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome. Pediatr Res (2003) 1.37
A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha. FEBS Lett (2005) 1.36
DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res (2010) 1.36