Published in Neuron on May 22, 2003
The calpain system and cancer. Nat Rev Cancer (2011) 2.10
Guiding neuronal growth cones using Ca2+ signals. Trends Cell Biol (2004) 1.97
TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J Biol Chem (2006) 1.75
Neurite consolidation is an active process requiring constant repression of protrusive activity. EMBO J (2008) 1.46
Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med (2010) 1.43
Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia. J Neurosci (2010) 1.39
Second messengers and membrane trafficking direct and organize growth cone steering. Nat Rev Neurosci (2011) 1.32
Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration. Mol Biol Cell (2005) 1.30
Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions. Dev Neurobiol (2011) 1.27
A midline switch of receptor processing regulates commissural axon guidance in vertebrates. Genes Dev (2010) 1.25
Spatial and temporal second messenger codes for growth cone turning. Proc Natl Acad Sci U S A (2011) 1.18
Actin dynamics in growth cone motility and navigation. J Neurochem (2013) 1.16
Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3. J Cell Biol (2005) 1.13
Moderation of calpain activity promotes neovascular integration and lumen formation during VEGF-induced pathological angiogenesis. PLoS One (2010) 1.11
Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons. Proc Natl Acad Sci U S A (2005) 1.11
Calpain is required for normal osteoclast function and is down-regulated by calcitonin. J Biol Chem (2006) 1.10
Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion. J Neurosci (2009) 1.06
Membrane depolarization inhibits spiral ganglion neurite growth via activation of multiple types of voltage sensitive calcium channels and calpain. Mol Cell Neurosci (2007) 1.05
Mechanical membrane injury induces axonal beading through localized activation of calpain. Exp Neurol (2009) 1.04
Glutamate controls growth rate and branching of dopaminergic axons. J Neurosci (2009) 0.96
Killer proteases and little strokes--how the things that do not kill you make you stronger. J Cereb Blood Flow Metab (2006) 0.96
Role of calpain-mediated p53 truncation in semaphorin 3A-induced axonal growth regulation. Proc Natl Acad Sci U S A (2010) 0.96
Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration. Proc Natl Acad Sci U S A (2004) 0.95
Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci (2013) 0.95
Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo. Development (2010) 0.94
Calcium-sensing receptor modulates cell adhesion and migration via integrins. J Biol Chem (2011) 0.92
Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits. Front Cell Neurosci (2014) 0.91
Serine phosphorylation regulates paxillin turnover during cell migration. Cell Commun Signal (2006) 0.91
Calpain activation impairs neuromuscular transmission in a mouse model of the slow-channel myasthenic syndrome. J Clin Invest (2007) 0.91
Twigs into branches: how a filopodium becomes a dendrite. Curr Opin Neurobiol (2009) 0.89
Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress. J Biol Chem (2012) 0.89
Role of calpain in apoptosis. Cell J (2011) 0.89
Phosphatidylinositol 3-kinase facilitates microtubule-dependent membrane transport for neuronal growth cone guidance. J Biol Chem (2010) 0.88
An antiangiogenic neurokinin-B/thromboxane A2 regulatory axis. J Cell Biol (2006) 0.86
Learning and memory: an emergent property of cell motility. Neurobiol Learn Mem (2013) 0.84
Skeletal muscle calpain acts through nitric oxide and neural miRNAs to regulate acetylcholine release in motor nerve terminals. J Neurosci (2013) 0.83
Regulation of intrinsic axon growth ability at retinal ganglion cell growth cones. Invest Ophthalmol Vis Sci (2014) 0.83
Microtubule and cell contact dependency of ER-bound PTP1B localization in growth cones. Mol Biol Cell (2009) 0.83
Calpain-1 contributes to IgE-mediated mast cell activation. J Immunol (2014) 0.82
Mechanochemical regulation of growth cone motility. Front Cell Neurosci (2015) 0.80
Kihi-to, a herbal traditional medicine, improves Abeta(25-35)-induced memory impairment and losses of neurites and synapses. BMC Complement Altern Med (2008) 0.79
A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion. J Cell Biol (2016) 0.78
L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling. Nat Commun (2016) 0.78
Varicones and growth cones: two neurite terminals in PC12 cells. PLoS One (2009) 0.78
The Calcium-Sensing Receptor and Integrins in Cellular Differentiation and Migration. Front Physiol (2016) 0.77
Coronin-1 and calcium signaling governs sympathetic final target innervation. J Neurosci (2015) 0.76
Activity-Dependent Synaptic Refinement: New Insights from Drosophila. Front Syst Neurosci (2017) 0.76
Calpain-mediated proteolysis of Talin and FAK regulates adhesion dynamics necessary for axon guidance. J Neurosci (2017) 0.75
Spatial wavelet analysis of calcium oscillations in developing neurons. PLoS One (2013) 0.75
Intracellular calcium and cyclic nucleotide levels modulate neurite guidance by microtopographical substrate features. J Biomed Mater Res A (2016) 0.75
Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol (2004) 4.29
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. J Leukoc Biol (2006) 3.21
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell (2010) 3.19
Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host Microbe (2007) 3.09
Regulating cell migration: calpains make the cut. J Cell Sci (2005) 3.03
Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature (2011) 2.54
Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish. J Leukoc Biol (2011) 2.22
Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome. Blood (2010) 2.15
Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis. Arthritis Rheumatol (2014) 2.14
Characterization of a membrane-based gradient generator for use in cell-signaling studies. Lab Chip (2006) 2.11
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. J Cell Biol (2009) 1.97
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. J Cell Biol (2008) 1.79
Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain. J Cell Sci (2002) 1.79
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J Biol Chem (2010) 1.75
TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J Biol Chem (2006) 1.75
Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts. J Neurosci (2006) 1.71
RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site. Mol Biol Cell (2003) 1.65
Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment. Clin Immunol (2002) 1.64
Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding. Nat Neurosci (2006) 1.59
Live imaging of chronic inflammation caused by mutation of zebrafish Hai1. J Cell Sci (2007) 1.59
A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab Chip (2008) 1.58
Neutrophil dysfunction in a family with a SAPHO syndrome-like phenotype. Arthritis Rheum (2008) 1.58
The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages. Blood (2014) 1.57
Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos. Cell Microbiol (2009) 1.45
Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. J Cell Biol (2012) 1.41
Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays. Anal Chem (2011) 1.39
Talin1 regulates TCR-mediated LFA-1 function. J Immunol (2006) 1.39
Characterization of zebrafish larval inflammatory macrophages. Dev Comp Immunol (2009) 1.37
Cell polarization mechanisms during directed cell migration. Nat Cell Biol (2005) 1.33
Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration. Mol Biol Cell (2005) 1.30
Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions. Dev Neurobiol (2011) 1.27
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis. Mol Biol Cell (2007) 1.27
Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores. J Neurosci (2006) 1.25
Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration. J Biol Chem (2011) 1.23
An arrayed high-content chemotaxis assay for patient diagnosis. Integr Biol (Camb) (2010) 1.22
Src-dependent tyrosine phosphorylation at the tips of growth cone filopodia promotes extension. J Neurosci (2005) 1.21
TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway. J Leukoc Biol (2005) 1.17
Calpain proteases in cell adhesion and motility. Int Rev Cytol (2005) 1.14
Asymmetric localization of calpain 2 during neutrophil chemotaxis. Mol Biol Cell (2006) 1.14
Natural killer T-cell autoreactivity leads to a specialized activation state. Blood (2008) 1.11
Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood (2012) 1.11
Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue. Dev Cell (2011) 1.11
Rational design of a ligand-controlled protein conformational switch. Proc Natl Acad Sci U S A (2013) 1.08
Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion. J Neurosci (2009) 1.06
Innate immune response to Streptococcus iniae infection in zebrafish larvae. Infect Immun (2012) 1.05
Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury. Cell Microbiol (2012) 1.04
RACK1 regulates Src activity and modulates paxillin dynamics during cell migration. Exp Cell Res (2007) 1.03
Focal adhesion kinase promotes integrin adhesion dynamics necessary for chemotropic turning of nerve growth cones. J Neurosci (2011) 1.03
Hax1 regulates neutrophil adhesion and motility through RhoA. J Cell Biol (2011) 1.02
The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development (2009) 1.00
The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration. Mol Biol Cell (2008) 1.00
Focal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cues. J Cell Sci (2012) 1.00
CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils. J Cell Sci (2013) 1.00
Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation. Mol Biol Cell (2009) 0.98
Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab Chip (2013) 0.98
Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish. J Leukoc Biol (2013) 0.98
Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7. PLoS Pathog (2009) 0.97
Spatiotemporal regulation of Src and its substrates at invadosomes. Eur J Cell Biol (2012) 0.97
Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24. Dev Dyn (2009) 0.96
Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci (2013) 0.95
Contact-dependent T cell activation and T cell stopping require talin1. J Immunol (2011) 0.94
Adjacent pioneer commissural interneuron growth cones switch from contact avoidance to axon fasciculation after midline crossing. Dev Biol (2005) 0.94
The conserved C-terminal I/LWEQ module targets Talin1 to focal adhesions. Cell Motil Cytoskeleton (2006) 0.93
Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS Pathog (2013) 0.92
PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells. J Immunol (2010) 0.92
iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth. Stem Cells Dev (2014) 0.92
The role of microtubules in neutrophil polarity and migration in live zebrafish. J Cell Sci (2012) 0.92
Selective and tunable gradient device for cell culture and chemotaxis study. Lab Chip (2009) 0.92
Analysis of neutrophil chemotaxis. Methods Mol Biol (2007) 0.91
Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia. J Allergy Clin Immunol (2010) 0.91
Citrullination of fibronectin modulates synovial fibroblast behavior. Arthritis Res Ther (2012) 0.91
Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts. J Cell Sci (2012) 0.90
Impaired podosome formation and invasive migration of macrophages from patients with a PSTPIP1 mutation and PAPA syndrome. Arthritis Rheum (2010) 0.90
Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity. Proc Natl Acad Sci U S A (2009) 0.90
Neutrophil migration: moving from zebrafish models to human autoimmunity. Immunol Rev (2013) 0.90
Integrins in cell migration. Methods Enzymol (2007) 0.89
The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish. J Cell Sci (2012) 0.89
Characterizing asthma from a drop of blood using neutrophil chemotaxis. Proc Natl Acad Sci U S A (2014) 0.89
Kit-On-A-Lid-Assays for accessible self-contained cell assays. Lab Chip (2013) 0.88
Imaging adhesion and signaling dynamics in Xenopus laevis growth cones. Dev Neurobiol (2012) 0.88
Neutrophil reverse migration becomes transparent with zebrafish. Adv Hematol (2012) 0.87
PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth. J Cell Sci (2013) 0.87
Leukocyte migration from a fish eye's view. J Cell Sci (2012) 0.87
Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo. Mol Cell Neurosci (2010) 0.87
An antiangiogenic neurokinin-B/thromboxane A2 regulatory axis. J Cell Biol (2006) 0.86
The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration. J Cell Sci (2008) 0.85
Imaging podosome dynamics and matrix degradation. Methods Mol Biol (2011) 0.85
Neutrophil motility in vivo using zebrafish. Methods Mol Biol (2009) 0.85
Thalidomide for severe systemic onset juvenile rheumatoid arthritis: A multicenter study. J Pediatr (2004) 0.85
The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis. J Biol Chem (2012) 0.84
Adhesions ring: a structural comparison between podosomes and the immune synapse. Eur J Cell Biol (2008) 0.84
Calpain inhibition impairs TNF-alpha-mediated neutrophil adhesion, arrest and oxidative burst. Mol Immunol (2009) 0.83
The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation. Biochem Pharmacol (2013) 0.83
Neutrophil chemotaxis in a patient with neonatal-onset multisystem inflammatory disease and Muckle-Wells syndrome. Ann Allergy Asthma Immunol (2005) 0.82
Interstitial leukocyte migration in vivo. Curr Opin Cell Biol (2013) 0.81
A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist. J Immunol (2011) 0.81
Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions. J Biol Chem (2009) 0.81
Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells. PLoS One (2010) 0.80
WRAMPing up calcium in migrating cells by localized ER transport. Dev Cell (2013) 0.79
Determinants of phosphatidylinositol-4-phosphate 5-kinase type Iγ90 uropod location in T-lymphocytes and its role in uropod formation. PeerJ (2013) 0.79