Published in PLoS Pathog on October 25, 2012
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med (2016) 1.43
Increasing the Content of High-Content Screening: An Overview. J Biomol Screen (2014) 1.36
Innate immunity to adenovirus. Hum Gene Ther (2014) 1.15
How cells tune viral mechanics--insights from biophysical measurements of influenza virus. Biophys J (2014) 0.87
A direct and versatile assay measuring membrane penetration of adenovirus in single cells. J Virol (2013) 0.86
NEMix: single-cell nested effects models for probabilistic pathway stimulation. PLoS Comput Biol (2015) 0.86
Simultaneous analysis of large-scale RNAi screens for pathogen entry. BMC Genomics (2014) 0.83
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors. Int J Mol Sci (2015) 0.82
The Rhinovirus subviral a-particle exposes 3'-terminal sequences of its genomic RNA. J Virol (2014) 0.81
Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part II: Future compounds against influenza virus. J Prev Med Hyg (2014) 0.81
Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure. Bioorg Med Chem (2015) 0.80
Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments. Antimicrob Agents Chemother (2017) 0.78
Chemical induction of unfolded protein response enhances cancer cell killing through lytic virus infection. J Virol (2014) 0.78
Plaque2.0-A High-Throughput Analysis Framework to Score Virus-Cell Transmission and Clonal Cell Expansion. PLoS One (2015) 0.76
Altered Gene Expression in the Schistosome-Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide. PLoS Negl Trop Dis (2015) 0.76
Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis. Bioorg Med Chem (2017) 0.75
Viral entry pathways: the example of common cold viruses. Wien Med Wochenschr (2016) 0.75
Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide. PLoS One (2016) 0.75
Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction. Cell Res (2017) 0.75
Niclosamide: Beyond an antihelminthic drug. Cell Signal (2017) 0.75
Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc Natl Acad Sci U S A (1978) 18.85
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Nat Rev Mol Cell Biol (2007) 6.86
A three-dimensional model to analyze drug-drug interactions. Antiviral Res (1991) 6.58
Infectious entry pathway of influenza virus in a canine kidney cell line. J Cell Biol (1981) 6.46
Stepwise dismantling of adenovirus 2 during entry into cells. Cell (1993) 6.34
Endosome maturation. EMBO J (2011) 5.22
Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver. J Biol Chem (1980) 5.00
Acidification of macrophage and fibroblast endocytic vesicles in vitro. Proc Natl Acad Sci U S A (1983) 4.65
The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch Intern Med (2003) 4.37
Sensors and regulators of intracellular pH. Nat Rev Mol Cell Biol (2009) 4.30
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nat Cell Biol (2006) 3.93
Hepatitis C virus entry depends on clathrin-mediated endocytosis. J Virol (2006) 3.33
Inhibition of Semliki forest virus penetration by lysosomotropic weak bases. J Gen Virol (1982) 3.10
Effect of bafilomycin A1 and nocodazole on endocytic transport in HeLa cells: implications for viral uncoating and infection. J Virol (1998) 2.93
Rhinovirus and the lower respiratory tract. Rev Med Virol (2004) 2.26
Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: randomised double-blind placebo-controlled trial. Lancet (2006) 2.21
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One (2009) 2.20
Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res (2007) 2.14
A cation counterflux supports lysosomal acidification. J Cell Biol (2010) 2.02
Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nat Med (2011) 1.96
Activity of pleconaril against enteroviruses. Antimicrob Agents Chemother (1999) 1.83
Picornavirales, a proposed order of positive-sense single-stranded RNA viruses with a pseudo-T = 3 virion architecture. Arch Virol (2008) 1.80
Mechanism of action of reagents that uncouple oxidative phosphorylation. Nature (1969) 1.68
The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry (2009) 1.58
Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. Cancer Res (2011) 1.58
Acridine orange as a probe for measuring pH gradients across membranes: mechanism and limitations. Anal Biochem (1991) 1.52
Selective optimization of side activities: another way for drug discovery. J Med Chem (2004) 1.37
Combating enterovirus replication: state-of-the-art on antiviral research. Biochem Pharmacol (2011) 1.37
Uncoating of human rhinoviruses. Rev Med Virol (2010) 1.36
The biology and toxicology of molluscicides, Bayluscide. Pharmacol Ther (1982) 1.29
Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level. J Biol Chem (2009) 1.28
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem (2012) 1.20
Conformational changes, plasma membrane penetration, and infection by human rhinovirus type 2: role of receptors and low pH. J Virol (2003) 1.20
Functional entry of dengue virus into Aedes albopictus mosquito cells is dependent on clathrin-mediated endocytosis. J Gen Virol (2008) 1.18
In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses. Antiviral Res (2000) 1.18
Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis. ACS Med Chem Lett (2011) 1.17
Intracellular pH and free calcium changes in single cells using quene 1 and quin 2 probes and fluorescence microscopy. FEBS Lett (1983) 1.17
The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem (2009) 1.16
Receptor priming of major group human rhinoviruses for uncoating and entry at mild low-pH environments. J Virol (2003) 1.15
Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger. Biochimie (1988) 1.09
Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother (2004) 1.07
Thiazolides: a new class of antiviral drugs. Expert Opin Drug Metab Toxicol (2009) 1.06
The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation. Gastroenterology (2009) 1.05
Characterization of the functional coupling of bovine brain vacuolar-type H(+)-translocating ATPase. Effect of divalent cations, phospholipids, and subunit H (SFD). J Biol Chem (2003) 0.95
Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorg Med Chem (2009) 0.95
An RNA replication-center assay for high content image-based quantifications of human rhinovirus and coxsackievirus infections. Virol J (2010) 0.93
Pleconaril, a novel antipicornaviral agent. Pharmacotherapy (2003) 0.91
Molecular structure of monovalent metal cation complexes of monensin. J Mol Biol (1970) 0.90
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med Chem (2007) 0.89
Assessment of cell proliferation with resazurin-based fluorescent dye. Methods Mol Biol (2011) 0.89
Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis C virus replication. J Med Chem (2011) 0.87
Old drugs as lead compounds for a new disease? Binding analysis of SARS coronavirus main proteinase with HIV, psychotic and parasite drugs. Bioorg Med Chem (2004) 0.86
Multidrug resistance: a clinical approach. Curr Opin HIV AIDS (2009) 0.82
Nigericin-induced transient changes in rat-liver mitochondria. Biochim Biophys Acta (1984) 0.80
Worm cure without tears. The effect of niclosamide on taeniasis saginata in man. Acta Med Scand (1967) 0.78
Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem (2002) 3.47
Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Sci Transl Med (2014) 3.23
Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake. J Cell Biol (2002) 2.64
Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes (2011) 2.28
Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans. J Biol Chem (2003) 2.23
Single-cell analysis of population context advances RNAi screening at multiple levels. Mol Syst Biol (2012) 2.13
The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3. J Virol (2004) 2.11
Intact microtubules support adenovirus and herpes simplex virus infections. J Virol (2002) 1.84
Functional analysis of the Helicobacter pylori cag pathogenicity island reveals both VirD4-CagA-dependent and VirD4-CagA-independent mechanisms. Infect Immun (2002) 1.84
Adenovirus endocytosis. J Gene Med (2003) 1.66
Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Natl Acad Sci U S A (2002) 1.64
The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation. EMBO J (2003) 1.60
Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3. EMBO J (2008) 1.59
Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo. PLoS Pathog (2008) 1.58
Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2006) 1.56
Adenovirus endocytosis. J Gene Med (2004) 1.52
The CD4+ T cell-mediated IFN-gamma response to Helicobacter infection is essential for clearance and determines gastric cancer risk. J Immunol (2009) 1.49
Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation. J Immunol (2012) 1.48
Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposure. Cell Host Microbe (2011) 1.41
Infectious adenovirus type 2 transport through early but not late endosomes. Traffic (2008) 1.41
Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury. Respir Res (2005) 1.40
Early steps of clathrin-mediated endocytosis involved in phagosomal escape of Fcgamma receptor-targeted adenovirus. J Virol (2005) 1.37
hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels. J Biol Chem (2005) 1.37
Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection. Cell Host Microbe (2011) 1.26
Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-kappa B signaling. J Immunol (2008) 1.24
Myeloid cells contribute to tumor lymphangiogenesis. PLoS One (2009) 1.22
Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35. J Virol (2010) 1.17
Virus movements on the plasma membrane support infection and transmission between cells. PLoS Pathog (2009) 1.17
Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export. Mol Biol Cell (2005) 1.16
Innate immunity to adenovirus. Hum Gene Ther (2014) 1.15
A novel supervised trajectory segmentation algorithm identifies distinct types of human adenovirus motion in host cells. J Struct Biol (2007) 1.15
Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor. J Gen Virol (2007) 1.15
Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury. J Cell Physiol (2008) 1.11
Chemotactic antiviral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells. Nat Commun (2011) 1.11
In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis. BMC Microbiol (2010) 1.07
Genetic reconstitution of the human adenovirus type 2 temperature-sensitive 1 mutant defective in endosomal escape. Virol J (2009) 1.07
Virus interactions with endocytic pathways in macrophages and dendritic cells. Trends Microbiol (2013) 1.07
Tracking viral genomes in host cells at single-molecule resolution. Cell Host Microbe (2013) 1.05
The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3. Virology (2005) 1.05
Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau. J Neurosci (2002) 1.04
Cholesterol is required for endocytosis and endosomal escape of adenovirus type 2. J Virol (2004) 1.04
Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages. Exp Neurol (2007) 1.04
Analysis of cell type-specific responses mediated by the type IV secretion system of Helicobacter pylori. Infect Immun (2005) 1.02
Subproteomes of soluble and structure-bound Helicobacter pylori proteins analyzed by two-dimensional gel electrophoresis and mass spectrometry. Proteomics (2005) 1.02
Response of the Italian agile frog (Rana latastei) to a Ranavirus, frog virus 3: a model for viral emergence in naïve populations. J Wildl Dis (2004) 1.02
Uncoating of non-enveloped viruses. Curr Opin Virol (2013) 1.01
Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model. J Biomed Mater Res A (2008) 1.01
The Helicobacter pylori CagA protein induces tyrosine dephosphorylation of ezrin. Proteomics (2004) 1.01
Avidity binding of human adenovirus serotypes 3 and 7 to the membrane cofactor CD46 triggers infection. J Virol (2011) 1.00
A combined proteomic and genetic analysis identifies a role for the lipid desaturase Desat1 in starvation-induced autophagy in Drosophila. Autophagy (2009) 1.00
Inadequate clearance of translocated bacterial products in HIV-infected humanized mice. PLoS Pathog (2010) 1.00
CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors. J Immunol (2010) 0.98
Adenovirus signalling in entry. Cell Microbiol (2012) 0.98
Stepwise loss of fluorescent core protein V from human adenovirus during entry into cells. J Virol (2010) 0.97
A stochastic model for microtubule motors describes the in vivo cytoplasmic transport of human adenovirus. PLoS Comput Biol (2009) 0.95
The dynactin complex enhances the speed of microtubule-dependent motions of adenovirus both towards and away from the nucleus. Viruses (2011) 0.94
An RNA replication-center assay for high content image-based quantifications of human rhinovirus and coxsackievirus infections. Virol J (2010) 0.93
Inhibition of the Kit ligand/c-Kit axis attenuates metastasis in a mouse model mimicking local breast cancer relapse after radiotherapy. Clin Cancer Res (2012) 0.93
Inhibition of colitis by IL-25 associates with induction of alternatively activated macrophages. Inflamm Bowel Dis (2011) 0.92
Non-classical export of an adenovirus structural protein. Traffic (2003) 0.92
Pulmonary aspiration: new therapeutic approaches in the experimental model. Anesthesiology (2005) 0.91
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: I. binding to DNA AND to hexon of the precursor to protein VI, pVI, of human adenovirus. J Biol Chem (2012) 0.90
Suppression of alveolar macrophage apoptosis prolongs survival of rats and mice with pneumocystis pneumonia. J Immunol (2006) 0.90
Cell-free transmission of human adenovirus by passive mass transfer in cell culture simulated in a computer model. J Virol (2012) 0.89
iTRAQ-Based and Label-Free Proteomics Approaches for Studies of Human Adenovirus Infections. Int J Proteomics (2013) 0.88
Macrophages modulate cardiac function in lipotoxic cardiomyopathy. Am J Physiol Heart Circ Physiol (2012) 0.86
A direct and versatile assay measuring membrane penetration of adenovirus in single cells. J Virol (2013) 0.86
Investigating endocytic pathways to the endoplasmic reticulum and to the cytosol using SNAP-trap. Traffic (2012) 0.81
Cell spreading on quartz crystal microbalance elicits positive frequency shifts indicative of viscosity changes. Anal Bioanal Chem (2003) 0.81
Gene transfer may be preventive but not curative for a lysosomal transport disorder. Mol Ther (2008) 0.80
The depletion of donor macrophages reduces ischaemia-reperfusion injury after mouse lung transplantation. Eur J Cardiothorac Surg (2013) 0.79
A GAL4-based yeast three-hybrid system for the identification of small molecule-target protein interactions. Biochem Pharmacol (2002) 0.78
Redox rescues virus from ER trap. Nat Cell Biol (2008) 0.78
Analysis of adenovirus trans-complementation-mediated gene expression controlled by melanoma-specific TETP promoter in vitro. Virol J (2010) 0.78
Heat shock protein-mediated protection against Cisplatin-induced hair cell death. J Assoc Res Otolaryngol (2014) 0.77
Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK 4 (BLP). Cancer Immunol Immunother (2013) 0.77
Genomic and phylogenetic analyses of murine adenovirus 2. Virus Res (2011) 0.76
Too smart to fail-how viruses exploit the complexity of host cells during entry. Curr Opin Virol (2011) 0.76