Published in Nat Rev Mol Cell Biol on December 09, 2009
Impact of seawater acidification on pH at the tissue-skeleton interface and calcification in reef corals. Proc Natl Acad Sci U S A (2012) 2.64
Molecular aspects of bacterial pH sensing and homeostasis. Nat Rev Microbiol (2011) 2.46
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Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer (2013) 1.93
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Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development. Neuron (2013) 1.79
Widespread and enzyme-independent Nε-acetylation and Nε-succinylation of proteins in the chemical conditions of the mitochondrial matrix. J Biol Chem (2013) 1.78
Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase. EMBO J (2010) 1.76
Dynamic regulation of the mitochondrial proton gradient during cytosolic calcium elevations. J Biol Chem (2011) 1.66
Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases. Mol Cell (2014) 1.56
Imaging intracellular pH in live cells with a genetically encoded red fluorescent protein sensor. J Am Chem Soc (2011) 1.49
Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation. Am J Transplant (2014) 1.48
Conserved gene expression in sperm reservoirs between birds and mammals in response to mating. BMC Genomics (2017) 1.38
Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells. Angew Chem Int Ed Engl (2011) 1.37
Histone acetylation regulates intracellular pH. Mol Cell (2012) 1.30
Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio. Nat Commun (2013) 1.29
Ion channels, phosphorylation and mammalian sperm capacitation. Asian J Androl (2011) 1.21
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem (2012) 1.20
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Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA delivery. ACS Nano (2011) 1.17
Quantitative tissue pH measurement during cerebral ischemia using amine and amide concentration-independent detection (AACID) with MRI. J Cereb Blood Flow Metab (2014) 1.15
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Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells. Proc Natl Acad Sci U S A (2010) 1.14
Multicolored pH-tunable and activatable fluorescence nanoplatform responsive to physiologic pH stimuli. J Am Chem Soc (2012) 1.13
Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA. Nat Commun (2014) 1.12
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Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae. Genome Biol (2012) 1.09
The metabolically-modulated stem cell niche: a dynamic scenario regulating cancer cell phenotype and resistance to therapy. Cell Cycle (2014) 1.09
Putting the pH into phosphatidic acid signaling. BMC Biol (2011) 1.05
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Ultra-pH-sensitive nanoprobe library with broad pH tunability and fluorescence emissions. J Am Chem Soc (2014) 1.04
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Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate. Plant Cell (2013) 1.01
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X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction. Brain (2011) 1.01
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Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing. J Am Chem Soc (2012) 0.99
In vivo intracellular pH measurements in tobacco and Arabidopsis reveal an unexpected pH gradient in the endomembrane system. Plant Cell (2013) 0.99
Considering protonation as a posttranslational modification regulating protein structure and function. Annu Rev Biophys (2013) 0.98
Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release. Angew Chem Int Ed Engl (2010) 0.98
An inside job: how endosomal Na(+)/H(+) exchangers link to autism and neurological disease. Front Cell Neurosci (2014) 0.96
Acidic pH via NF-κB favours VEGF-C expression in human melanoma cells. Clin Exp Metastasis (2013) 0.96
Proteomic study of the mucin granulae in an intestinal goblet cell model. J Proteome Res (2012) 0.95
Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects. PLoS Pathog (2012) 0.95
Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes. Free Radic Biol Med (2012) 0.94
Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy. J Am Chem Soc (2010) 0.94
The intracellular Ca²⁺ channels of membrane traffic. Channels (Austin) (2012) 0.93
Illumination of the spatial order of intracellular pH by genetically encoded pH-sensitive sensors. Sensors (Basel) (2013) 0.93
Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger. J Biol Chem (2011) 0.93
Functional evaluation of autism-associated mutations in NHE9. Nat Commun (2013) 0.93
Genetically encoded pH-indicators reveal activity-dependent cytosolic acidification of Drosophila motor nerve termini in vivo. J Physiol (2013) 0.92
Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels. Physiol Rev (2015) 0.92
Polymeric nanoparticle technologies for oral drug delivery. Clin Gastroenterol Hepatol (2014) 0.92
Rapid analysis of glycolytic and oxidative substrate flux of cancer cells in a microplate. PLoS One (2014) 0.91
Sources of protons and a role for bicarbonate in inhibitory feedback from horizontal cells to cones in Ambystoma tigrinum retina. J Physiol (2016) 0.91
Effects of hypercapnia on the lung. J Physiol (2017) 0.91
Calcineurin homologous protein: a multifunctional Ca2+-binding protein family. Am J Physiol Renal Physiol (2011) 0.91
Multiparametric analyses reveal the pH-dependence of silicon biomineralization in diatoms. PLoS One (2012) 0.91
pH dependent transfer of nano-pores into membrane of cancer cells to induce apoptosis. Sci Rep (2013) 0.91
A pH-independent DNA nanodevice for quantifying chloride transport in organelles of living cells. Nat Nanotechnol (2015) 0.90
SorLA complement-type repeat domains protect the amyloid precursor protein against processing. J Biol Chem (2014) 0.89
Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells. Clin Exp Metastasis (2014) 0.89
The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation. J Neurosci (2013) 0.89
pH Regulation by NHX-Type Antiporters Is Required for Receptor-Mediated Protein Trafficking to the Vacuole in Arabidopsis. Plant Cell (2015) 0.89
Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J (2013) 0.89
Lysosomal storage causes cellular dysfunction in mucolipidosis II skin fibroblasts. J Biol Chem (2011) 0.89
Multiple Transport Pathways for Mediating Intracellular pH Homeostasis: The Contribution of H(+)/ion Exchangers. Front Plant Sci (2012) 0.88
Plant-specific cation/H+ exchanger 17 and its homologs are endomembrane K+ transporters with roles in protein sorting. J Biol Chem (2011) 0.88
Cytosolic H+ microdomain developed around AE1 during AE1-mediated Cl-/HCO3- exchange. J Physiol (2011) 0.87
GABAergic transmission and chloride equilibrium potential are not modulated by pyruvate in the developing optic tectum of Xenopus laevis tadpoles. PLoS One (2012) 0.87
Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol (2012) 0.87
Nanoscale metal-organic frameworks for real-time intracellular pH sensing in live cells. J Am Chem Soc (2014) 0.86
Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3. PLoS One (2013) 0.86
Multifunctional polymeric micelles for delivery of drugs and siRNA. Front Pharmacol (2014) 0.86
Acid-degradable polymer-caged lipoplex (PCL) platform for siRNA delivery: facile cellular triggered release of siRNA. J Am Chem Soc (2013) 0.86
Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling. Mol Biol Cell (2013) 0.86
Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells. Proc Natl Acad Sci U S A (2013) 0.85
Hydrogen sulfide and polysulfides as signaling molecules. Proc Jpn Acad Ser B Phys Biol Sci (2015) 0.85
Measurement of vacuolar and cytosolic pH in vivo in yeast cell suspensions. J Vis Exp (2013) 0.85
Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). PLoS One (2012) 0.85
Molecular imaging with SERS-active nanoparticles. Small (2011) 0.85
KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun (2015) 0.85
Overexpression of a pH-sensitive nitrate transporter in rice increases crop yields. Proc Natl Acad Sci U S A (2016) 0.85
A chaperone function of NO CATALASE ACTIVITY1 is required to maintain catalase activity and for multiple stress responses in Arabidopsis. Plant Cell (2015) 0.84
Modelling of pH dynamics in brain cells after stroke. Interface Focus (2011) 0.84
Protein acetylation and acetyl coenzyme a metabolism in budding yeast. Eukaryot Cell (2014) 0.83
General Strategy to Introduce pH-Induced Allostery in DNA-Based Receptors to Achieve Controlled Release of Ligands. Nano Lett (2015) 0.83
Parallel evolution of nitric oxide signaling: diversity of synthesis and memory pathways. Front Biosci (Landmark Ed) (2011) 0.83
Aggregates, crystals, gels, and amyloids: intracellular and extracellular phenotypes at the crossroads of immunoglobulin physicochemical property and cell physiology. Int J Cell Biol (2013) 0.83
Chromatin: a capacitor of acetate for integrated regulation of gene expression and cell physiology. Curr Opin Genet Dev (2014) 0.82
Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes. J Physiol (2015) 0.82
A calcineurin homologous protein is required for sodium-proton exchange events in the C. elegans intestine. Am J Physiol Cell Physiol (2011) 0.82
A substrate access tunnel in the cytosolic domain is not an essential feature of the solute carrier 4 (SLC4) family of bicarbonate transporters. J Biol Chem (2013) 0.82
Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis. Dev Biol (2011) 0.82
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The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia. J Biol Chem (2003) 1.16
Nramp1 modifies the fusion of Salmonella typhimurium-containing vacuoles with cellular endomembranes in macrophages. J Biol Chem (2001) 1.15
Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B. J Gen Physiol (2004) 1.15
Syntaxins 13 and 7 function at distinct steps during phagocytosis. J Immunol (2002) 1.13
Coronin-1 function is required for phagosome formation. Mol Biol Cell (2005) 1.12
Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosis. J Biol Chem (2003) 1.11
Fusion, fission, and secretion during phagocytosis. Physiology (Bethesda) (2007) 1.11
Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants. J Clin Invest (2008) 1.10
Phosphatidylserine dynamics in cellular membranes. Mol Biol Cell (2012) 1.10
Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae. J Biol Chem (2003) 1.09
Evidence for a fence that impedes the diffusion of phosphatidylinositol 4,5-bisphosphate out of the forming phagosomes of macrophages. Mol Biol Cell (2011) 1.09
Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4. Infect Immun (2009) 1.08
An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis. J Cell Biol (2009) 1.08
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase. J Gen Physiol (2007) 1.07
Phagocytosis and the microtubule cytoskeleton. Biochem Cell Biol (2002) 1.07
Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole. Cell Microbiol (2010) 1.07
Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets. J Cell Biol (2010) 1.06
Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor. J Biol Chem (2003) 1.06
Expression and subcellular localization of NRAMP1 in human neutrophil granules. Blood (2002) 1.05
CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria. J Immunol (2009) 1.05
Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis. J Biol Chem (2009) 1.04
Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell (2013) 1.04
Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling. Mol Biol Cell (2011) 1.03
Enteropathogenic Escherichia coli subverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infection. Mol Biol Cell (2008) 1.03
CD44 is a phagocytic receptor. Blood (2006) 1.03
Localized exocytosis of primary (lysosomal) granules during phagocytosis: role of Ca2+-dependent tyrosine phosphorylation and microtubules. J Immunol (2002) 1.02
Cholesterol accumulation by macrophages impairs phagosome maturation. J Biol Chem (2008) 1.02
Carboxyl-terminus determinants of the iron transporter DMT1/SLC11A2 isoform II (-IRE/1B) mediate internalization from the plasma membrane into recycling endosomes. Biochemistry (2005) 1.02
Subversion of phagocytosis for pathogen survival. Cell Host Microbe (2012) 1.02
Role of ubiquitin and proteasomes in phagosome maturation. Mol Biol Cell (2005) 1.01
Golgi-bound Rab34 is a novel member of the secretory pathway. Mol Biol Cell (2007) 1.01
Phagocytosis: receptors, signal integration, and the cytoskeleton. Immunol Rev (2014) 1.01
Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. J Biol Chem (2005) 1.01
Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes. J Cell Biol (2010) 1.00