Published in Antimicrob Agents Chemother on February 23, 2017
Characterization of β-d-N(4)-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus. Antimicrob Agents Chemother (2017) 0.75
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A (1988) 10.77
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med (2013) 8.89
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J Biol Chem (1991) 7.04
In vitro mutagenesis of a full-length cDNA clone of Semliki Forest virus: the small 6,000-molecular-weight membrane protein modulates virus release. J Virol (1991) 6.02
Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J Cell Biol (1993) 5.62
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A (2007) 4.92
Fusion of Semliki forest virus with the plasma membrane can be induced by low pH. J Cell Biol (1980) 3.47
Inhibitors of lysosomal function. Methods Enzymol (1983) 3.17
Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles. J Virol (2002) 3.07
Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes. PLoS Biol (2005) 2.95
A stable full-length yellow fever virus cDNA clone and the role of conserved RNA elements in flavivirus replication. J Gen Virol (2003) 2.25
BioImageXD: an open, general-purpose and high-throughput image-processing platform. Nat Methods (2012) 2.22
Assessment of in vitro prophylactic and therapeutic efficacy of chloroquine against Chikungunya virus in vero cells. J Med Virol (2010) 1.74
Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1. Clin Cancer Res (2007) 1.71
Picornaviruses. Curr Top Microbiol Immunol (2010) 1.53
Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures. J Virol (2010) 1.51
Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro. Proc Natl Acad Sci U S A (2012) 1.48
Chikungunya: Evolutionary history and recent epidemic spread. Antiviral Res (2015) 1.45
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol J (2005) 1.43
A systematic screen of FDA-approved drugs for inhibitors of biological threat agents. PLoS One (2013) 1.38
Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays. PLoS One (2011) 1.37
Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma. Clin Cancer Res (2010) 1.35
Alphavirus Entry and Membrane Fusion. Viruses (2010) 1.31
New insights into the antiviral effects of chloroquine. Lancet Infect Dis (2006) 1.21
Understanding the alphaviruses: recent research on important emerging pathogens and progress towards their control. Antiviral Res (2009) 1.17
Flavivirus cell entry and membrane fusion. Viruses (2011) 1.08
Effectiveness of chloroquine and inflammatory cytokine response in patients with early persistent musculoskeletal pain and arthritis following chikungunya virus infection. Arthritis Rheumatol (2014) 1.06
Production and characterization of mouse monoclonal antibodies reactive to Chikungunya envelope E2 glycoprotein. Virology (2007) 1.01
Uncoating of non-enveloped viruses. Curr Opin Virol (2013) 1.01
New dimension in therapeutic targeting of BCL-2 family proteins. Oncotarget (2015) 1.00
Therapeutics and vaccines against chikungunya virus. Vector Borne Zoonotic Dis (2015) 1.00
Obatoclax mesylate : pharmacology and potential for therapy of hematological neoplasms. Expert Opin Investig Drugs (2012) 0.95
Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects. PLoS Pathog (2012) 0.95
Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection. J Biol Chem (2012) 0.94
Construction, properties, and potential application of infectious plasmids containing Semliki Forest virus full-length cDNA with an inserted intron. J Virol Methods (2007) 0.92
An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies. Core Evid (2013) 0.91
Towards antivirals against chikungunya virus. Antiviral Res (2015) 0.91
Mechanisms of Virus Membrane Fusion Proteins. Annu Rev Virol (2014) 0.90
Increased replicative fitness can lead to decreased drug sensitivity of hepatitis C virus. J Virol (2014) 0.90
Enzymatic defects of the nsP2 proteins of Semliki Forest virus temperature-sensitive mutants. J Virol (2007) 0.90
Early Events in Chikungunya Virus Infection-From Virus CellBinding to Membrane Fusion. Viruses (2015) 0.89
Echovirus 7 entry into polarized intestinal epithelial cells requires clathrin and Rab7. MBio (2012) 0.86
Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization. J Virol (2015) 0.86
Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses. Antiviral Res (2016) 0.85
Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis. J Virol (2006) 0.84
Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein. PLoS One (2016) 0.83
Coxsackievirus A9 infects cells via nonacidic multivesicular bodies. J Virol (2014) 0.83
Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget (2016) 0.83
Broad-spectrum antivirals against viral fusion. Nat Rev Microbiol (2015) 0.82
Antiviral activity of chloroquine against dengue virus type 2 replication in Aotus monkeys. Viral Immunol (2015) 0.80
The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. PLoS One (2016) 0.78
Dynamics of Chikungunya Virus Cell Entry Unraveled by Single-Virus Tracking in Living Cells. J Virol (2016) 0.77
Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis. Oncotarget (2016) 0.77
Antiviral activities of niclosamide and nitazoxanide against chikungunya virus entry and transmission. Antiviral Res (2016) 0.76
Wolbachia Blocks Viral Genome Replication Early in Infection without a Transcriptional Response by the Endosymbiont or Host Small RNA Pathways. PLoS Pathog (2016) 1.48
Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development. PLoS One (2014) 0.97
Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Negl Trop Dis (2014) 0.94
Antiviral activity of silymarin against chikungunya virus. Sci Rep (2015) 0.93
Prime-boost immunization strategies against Chikungunya virus. J Virol (2014) 0.92
Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication. J Virol (2015) 0.91
Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells. EMBO J (2016) 0.89
Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection. J Virol (2014) 0.86
Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses. Antiviral Res (2016) 0.85
Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion. J Virol (2015) 0.82
Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen. Lancet Infect Dis (2017) 0.81
Ability of the Encephalitic Arbovirus Semliki Forest Virus To Cross the Blood-Brain Barrier Is Determined by the Charge of the E2 Glycoprotein. J Virol (2015) 0.81
Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response. EMBO Mol Med (2014) 0.80
Differences in Processing Determinants of Nonstructural Polyprotein and in the Sequence of Nonstructural Protein 3 Affect Neurovirulence of Semliki Forest Virus. J Virol (2015) 0.79
Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizations. J Virol (2014) 0.79
RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications. PLoS One (2015) 0.79
Effects of an In-Frame Deletion of the 6k Gene Locus from the Genome of Ross River Virus. J Virol (2016) 0.79
Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus. Clin Cancer Res (2016) 0.78
The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling. J Virol (2016) 0.77
Antigenic Variation of East/Central/South African and Asian Chikungunya Virus Genotypes in Neutralization by Immune Sera. PLoS Negl Trop Dis (2016) 0.76
Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design. MBio (2017) 0.75
Characterization of β-d-N(4)-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus. Antimicrob Agents Chemother (2017) 0.75
Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus. JCI Insight (2017) 0.75
Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue. Sci Rep (2016) 0.75
Integrins are not essential for entry of coxsackievirus A9 into SW480 human colon adenocarcinoma cells. Virol J (2016) 0.75
Human Parechovirus 1 Infection Occurs via αVβ1 Integrin. PLoS One (2016) 0.75
SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy. Sci Rep (2017) 0.75
Partially uncleaved alphavirus replicase forms spherule structures in the presence and absence of RNA template. J Virol (2017) 0.75
Correction for Chen et al., Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection. J Virol (2015) 0.75
Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research. Sci Rep (2017) 0.75
Correction for Utt et al., Mutations Conferring a Noncytotoxic Phenotype on Chikungunya Virus Replicons Compromise Enzymatic Properties of Nonstructural Protein 2. J Virol (2016) 0.75