Published in Neuron on January 17, 2002
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67
Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci (2006) 2.68
Signaling mechanisms underlying Slit2-induced collapse of Xenopus retinal growth cones. Neuron (2006) 2.45
ClearT: a detergent- and solvent-free clearing method for neuronal and non-neuronal tissue. Development (2013) 2.33
New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron (2010) 2.12
Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling. PLoS Biol (2008) 1.85
Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell (2008) 1.79
A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci U S A (2003) 1.60
VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron (2011) 1.58
MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling. Circ Res (2010) 1.56
Regeneration and maintenance of the planarian midline is regulated by a slit orthologue. Dev Biol (2007) 1.42
Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers. Br J Cancer (2004) 1.42
Wiring the brain: the biology of neuronal guidance. Cold Spring Harb Perspect Biol (2010) 1.33
Cellular strategies of axonal pathfinding. Cold Spring Harb Perspect Biol (2010) 1.33
Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Mol Cell Biol (2005) 1.31
Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Res (2011) 1.24
Dual function of Slit2 in repulsion and enhanced migration of trunk, but not vagal, neural crest cells. J Cell Biol (2003) 1.24
Assembly of lamina-specific neuronal connections by slit bound to type IV collagen. Cell (2011) 1.22
Essential role for Galpha13 in endothelial cells during embryonic development. Proc Natl Acad Sci U S A (2005) 1.22
Sugar codes for axons? Neuron (2005) 1.22
Perturbations of microRNA function in mouse dicer mutants produce retinal defects and lead to aberrant axon pathfinding at the optic chiasm. PLoS One (2010) 1.17
Slit-Robo interactions during cortical development. J Anat (2007) 1.16
Vascular Robo4 restricts proangiogenic VEGF signaling in breast. Proc Natl Acad Sci U S A (2010) 1.15
Development of the retina and optic pathway. Vision Res (2010) 1.11
A roundabout way to cancer. Adv Cancer Res (2012) 1.11
Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm. Development (2009) 1.09
Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. J Neurosci (2011) 1.09
Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing. Neuron (2012) 1.08
A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J Neurosci (2013) 1.08
cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons. J Cell Biol (2002) 1.05
Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation. Development (2007) 1.04
Molecular determinants of the face map development in the trigeminal brainstem. Anat Rec A Discov Mol Cell Evol Biol (2006) 1.02
Expression and roles of Slit/Robo in human ovarian cancer. Histochem Cell Biol (2011) 1.02
Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons. Invest Ophthalmol Vis Sci (2011) 1.02
Slit/Robo signaling modulates the proliferation of central nervous system progenitors. Neuron (2012) 1.01
Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res (2011) 1.01
Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance. BMC Dev Biol (2008) 1.00
Connecting the eye to the brain: the molecular basis of ganglion cell axon guidance. Br J Ophthalmol (2003) 1.00
Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals. Mol Cell Neurosci (2010) 0.99
Slit2, a branching-arborization factor for sensory axons in the Mammalian CNS. J Neurosci (2002) 0.98
Developmental guidance of embryonic corneal innervation: roles of Semaphorin3A and Slit2. Dev Biol (2010) 0.96
Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization. Nat Med (2015) 0.95
Retinal axon guidance: novel mechanisms for steering. Curr Opin Neurobiol (2004) 0.95
PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat Neurosci (2014) 0.95
Involvement of the SLIT/ROBO pathway in follicle development in the fetal ovary. Reproduction (2009) 0.95
Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain. J Comp Neurol (2004) 0.94
A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat Neurosci (2012) 0.91
microRNAs in axon guidance. Front Cell Neurosci (2014) 0.91
Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction. Dev Biol (2014) 0.90
Connecting the retina to the brain. ASN Neuro (2014) 0.90
The Slit receptor Robo1 is predominantly expressed via the Dutt1 alternative promoter in pioneer neurons in the embryonic mouse brain and spinal cord. Gene Expr Patterns (2007) 0.89
Distinguishing between directional guidance and motility regulation in neuronal migration. J Neurosci (2003) 0.89
Uncoupling of EphA/ephrinA signaling and spontaneous activity in neural circuit wiring. J Neurosci (2013) 0.89
Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis. Proc Natl Acad Sci U S A (2014) 0.88
Molecular/genetic manipulation of extrinsic axon guidance factors for CNS repair and regeneration. Exp Neurol (2007) 0.88
RabGDI controls axonal midline crossing by regulating Robo1 surface expression. Neural Dev (2012) 0.88
Analysis of the astray/robo2 zebrafish mutant reveals that degenerating tracts do not provide strong guidance cues for regenerating optic axons. J Neurosci (2010) 0.86
Dendrite self-avoidance requires cell-autonomous slit/robo signaling in cerebellar purkinje cells. Neuron (2014) 0.86
Slit/Robo signaling mediates spatial positioning of spiral ganglion neurons during development of cochlear innervation. J Neurosci (2013) 0.86
Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning. Cereb Cortex (2012) 0.84
Slit-Robo signals regulate pioneer axon pathfinding of the tract of the postoptic commissure in the mammalian forebrain. J Neurosci Res (2011) 0.84
Robo1 and Robo2 have distinct roles in pioneer longitudinal axon guidance. Dev Biol (2011) 0.84
Intraretinal projection of retinal ganglion cell axons as a model system for studying axon navigation. Brain Res (2007) 0.84
Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci (2014) 0.83
The calmodulin-stimulated adenylate cyclase ADCY8 sets the sensitivity of zebrafish retinal axons to midline repellents and is required for normal midline crossing. J Neurosci (2010) 0.83
G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate. Dev Neurosci (2014) 0.83
Midline crossing is not required for subsequent pathfinding decisions in commissural neurons. Neural Dev (2012) 0.83
Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling. Development (2012) 0.83
Robo2 is required for Slit-mediated intraretinal axon guidance. Dev Biol (2009) 0.83
Over-expression of Slit2 induces vessel formation and changes blood vessel permeability in mouse brain. Acta Pharmacol Sin (2011) 0.83
Slit2 overexpression results in increased microvessel density and lesion size in mice with induced endometriosis. Reprod Sci (2012) 0.81
Nerve repulsion by the lens and cornea during cornea innervation is dependent on Robo-Slit signaling and diminishes with neuron age. Dev Biol (2012) 0.81
A hybrid computational method for the discovery of novel reproduction-related genes. PLoS One (2015) 0.81
Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. Nat Commun (2014) 0.81
Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb. J Neurosci (2009) 0.80
Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Nat Neurosci (2013) 0.80
Slit2 and Robo3 modulate the migration of GnRH-secreting neurons. Development (2012) 0.80
The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap. Development (2014) 0.79
Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube. Exp Neurol (2015) 0.79
Prefrontal-enriched SLIT1 expression in Old World monkey cortex established during the postnatal development. Cereb Cortex (2010) 0.79
Massive dysregulation of genes involved in cell signaling and placental development in cloned cattle conceptus and maternal endometrium. Proc Natl Acad Sci U S A (2016) 0.79
Neuropilin2 regulates the guidance of post-crossing spinal commissural axons in a subtype-specific manner. Neural Dev (2013) 0.79
Surrounded by Slit--how forebrain commissural axons can be led astray. Neuron (2002) 0.78
Transient ipsilateral retinal ganglion cell projections to the brain: Extent, targeting, and disappearance. Dev Neurobiol (2015) 0.78
Regulation of retinal axon growth by secreted Vax1 homeodomain protein. Elife (2014) 0.78
Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury. PLoS One (2016) 0.77
Netrin1-DCC-Mediated Attraction Guides Post-Crossing Commissural Axons in the Hindbrain. J Neurosci (2015) 0.77
The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system. PLoS One (2013) 0.77
Neuronal and microglial regulators of cortical wiring: usual and novel guideposts. Front Neurosci (2015) 0.77
Lysophospholipid receptors LPA1-3 are not required for the inhibitory effects of LPA on mouse retinal growth cones. Eye Brain (2016) 0.77
The Caenorhabditis elegans Ephrin EFN-4 Functions Non-cell Autonomously with Heparan Sulfate Proteoglycans to Promote Axon Outgrowth and Branching. Genetics (2015) 0.76
Involvement of Slit-Robo signaling in the development of the posterior commissure and concomitant swimming behavior in Xenopus laevis. Zoological Lett (2015) 0.76
The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Neural Dev (2015) 0.76
Foxn4 is required for retinal ganglion cell distal axon patterning. Mol Cell Neurosci (2011) 0.76
Ebf1 deficiency causes increase of Müller cells in the retina and abnormal topographic projection at the optic chiasm. Biochem Biophys Res Commun (2011) 0.75
Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling. Neural Dev (2016) 0.75
DSCAM promotes axon fasciculation and growth in the developing optic pathway. Proc Natl Acad Sci U S A (2017) 0.75
Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system. PLoS One (2017) 0.75
Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion. Brain Struct Funct (2014) 0.75
Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos. BMC Neurosci (2013) 0.75
Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet (2010) 13.70
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med (2008) 9.05
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature (2009) 6.17
Common mechanisms of nerve and blood vessel wiring. Nature (2005) 5.46
Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling. Science (2003) 4.18
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell (2007) 4.11
New neurons follow the flow of cerebrospinal fluid in the adult brain. Science (2006) 3.98
A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96
PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science (2008) 3.86
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics (2003) 3.84
wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. Neuron (2002) 3.79
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature (2004) 3.77
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science (2012) 3.72
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell (2003) 3.66
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron (2006) 3.51
Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature (2003) 3.42
Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron (2003) 3.39
Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron (2003) 3.22
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell (2004) 3.19
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene (2005) 3.17
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature (2004) 3.10
Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic Biol Med (2006) 3.04
Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron (2004) 2.94
The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. Neuron (2003) 2.86
Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron (2002) 2.84
SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell (2004) 2.74
DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina. Neuron (2009) 2.73
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci (2004) 2.73
Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron (2002) 2.71
Mechanisms and molecules of neuronal wiring: a primer. Cold Spring Harb Perspect Biol (2011) 2.62
Regulation of cortical dendrite development by Slit-Robo interactions. Neuron (2002) 2.55
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell (2003) 2.54
Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. Science (2003) 2.53
EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science (2005) 2.50
Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer Cell (2008) 2.35
The chemokine SDF1 regulates migration of dentate granule cells. Development (2002) 2.34
False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J Comp Neurol (2003) 2.34
Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion. Neuron (2008) 2.33
Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature (2006) 2.29
Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.27
The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell (2008) 2.25
Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning. Nature (2003) 2.18
New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron (2010) 2.12
Regeneration of the adult central nervous system. Curr Biol (2005) 2.11
Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev Cell (2003) 2.08
Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron (2003) 2.06
The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors. J Neurosci (2007) 2.06
Overexpression of Mn superoxide dismutase does not increase life span in mice. J Gerontol A Biol Sci Med Sci (2009) 1.98
DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell (2008) 1.97
The netrin receptor UNC-40/DCC stimulates axon attraction and outgrowth through enabled and, in parallel, Rac and UNC-115/AbLIM. Neuron (2003) 1.95
Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature (2002) 1.94
Bidirectional regulation of hippocampal mossy fiber filopodial motility by kainate receptors: a two-step model of synaptogenesis. Neuron (2003) 1.93
Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family. Cell (2003) 1.92
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol (2004) 1.92
Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron (2004) 1.91
Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins. Neuron (2005) 1.89
Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation. Proc Natl Acad Sci U S A (2009) 1.89
Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance. Development (2005) 1.86
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev (2007) 1.86
Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell (2003) 1.81
Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. Curr Biol (2004) 1.80
A role for Nr-CAM in the patterning of binocular visual pathways. Neuron (2006) 1.79
Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem (2002) 1.79
Netrins and their receptors. Adv Exp Med Biol (2007) 1.78
A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo. Sci Transl Med (2011) 1.75
Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. Nature (2009) 1.75
Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J Biol Chem (2007) 1.73
Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching. Blood (2010) 1.68
Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase. Hum Mol Genet (2006) 1.68
Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mech Ageing Dev (2006) 1.67
Integrins establish dendrite-substrate relationships that promote dendritic self-avoidance and patterning in drosophila sensory neurons. Neuron (2012) 1.67
Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol Endocrinol (2004) 1.66
Slit proteins regulate distinct aspects of retinal ganglion cell axon guidance within dorsal and ventral retina. J Neurosci (2006) 1.65
The stop signal revised: immature cerebellar granule neurons in the external germinal layer arrest pontine mossy fiber growth. J Neurosci (2006) 1.65
MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr Biol (2006) 1.61
Axotomy-induced Smad1 activation promotes axonal growth in adult sensory neurons. J Neurosci (2009) 1.61
Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. J Exp Med (2009) 1.61
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci (2003) 1.59
Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome. Hum Mol Genet (2004) 1.57
A caspase cascade regulating developmental axon degeneration. J Neurosci (2012) 1.57
Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro. Proc Natl Acad Sci U S A (2013) 1.55
The in vivo gene expression signature of oxidative stress. Physiol Genomics (2008) 1.55
Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes. Proc Natl Acad Sci U S A (2005) 1.55
The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons. Neuron (2004) 1.54
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proc Natl Acad Sci U S A (2013) 1.53
Retrograde control of synaptic transmission by postsynaptic CaMKII at the Drosophila neuromuscular junction. Neuron (2003) 1.53
Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain. J Neurosci (2007) 1.52
Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function. Nat Neurosci (2002) 1.52
Spatiotemporal expression patterns of slit and robo genes in the rat brain. J Comp Neurol (2002) 1.52
Genes contributing to prion pathogenesis. J Gen Virol (2008) 1.51
Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord. J Neurosci (2006) 1.51
A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. Cancer Res (2005) 1.48
MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion. Neuron (2002) 1.47
DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am J Hum Genet (2008) 1.45