A gender-related action of IFNbeta-therapy was found in multiple sclerosis.

PubWeight™: 0.79‹?›

🔗 View Article (PMC 3566915)

Published in J Transl Med on November 14, 2012

Authors

Ida Contasta1, Rocco Totaro, Patrizia Pellegrini, Tiziana Del Beato, Antonio Carolei, Anna Maria Berghella

Author Affiliations

1: Consiglio Nazionale delle Ricerche, Istituto di Farmacologia Traslazionale, via G Carducci, 32-Rotilio Center, L'Aquila 67100, Italy.

Articles cited by this

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 46.36

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol (1986) 35.41

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol (1989) 31.72

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet (2001) 15.27

IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol (2007) 14.99

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med (2003) 14.60

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol (2006) 14.33

The lineage decisions of helper T cells. Nat Rev Immunol (2002) 10.61

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol (2008) 9.64

Plasticity of CD4+ T cell lineage differentiation. Immunity (2009) 8.08

IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature (2008) 7.00

Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol (2008) 6.76

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol (2008) 6.41

A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol (2008) 6.09

Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol (2007) 5.27

Sex differences in autoimmune disease. Nat Immunol (2001) 5.08

Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem (2001) 4.23

Data-driven modelling of signal-transduction networks. Nat Rev Mol Cell Biol (2006) 3.18

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2008) 3.04

IL-9 as a mediator of Th17-driven inflammatory disease. J Exp Med (2009) 2.78

Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev (1996) 2.77

Regulation of human Th9 differentiation by type I interferons and IL-21. Immunol Cell Biol (2010) 1.99

Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone. FEMS Immunol Med Microbiol (2003) 1.79

The "gender gap" in autoimmune disease. Lancet (2000) 1.77

A biological approach to computational models of proteomic networks. Curr Opin Chem Biol (2006) 1.73

TGF-beta, a 'double agent' in the immune pathology war. Nat Immunol (2006) 1.27

Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms. J Neuroimmunol (2011) 1.27

IL-9 promotes Th17 cell migration into the central nervous system via CC chemokine ligand-20 produced by astrocytes. J Immunol (2011) 1.19

Whole-blood lymphocyte cultures. J Immunol Methods (1989) 1.11

Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network. BMC Syst Biol (2010) 1.03

IL-4 modulation of CD4+CD25+ T regulatory cell-mediated suppression. J Immunol (2005) 1.03

Reasoning for results. Nature (2001) 0.91

Progression mechanisms in colon cancer: soluble interleukin-2 (IL-2) receptor, IL-2 plus anti-CD3 proliferative response and tumour stage correlations. Cancer Immunol Immunother (1994) 0.87

Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity. Metabolomics (2011) 0.86

Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with the husband's mononuclear cells. Fertil Steril (2006) 0.86

Multivariate gene expression analysis reveals functional connectivity changes between normal/tumoral prostates. BMC Syst Biol (2008) 0.85

Converging and diverging properties of human interleukin-4 and interleukin-10. Behring Inst Mitt (1995) 0.84

CD30 antigen and multiple sclerosis: CD30, an important costimulatory molecule and marker of a regulatory subpopulation of dendritic cells, is involved in the maintenance of the physiological balance between TH1/TH2 immune responses and tolerance. The role of IFNbeta-1a in the treatment of multiple sclerosis. Neuroimmunomodulation (2005) 0.83

Interferon beta treatment in relapsing-remitting multiple sclerosis. A review. Clin Neurol Neurosurg (2002) 0.80

Some thoughts on the reproductive autoimmune failure syndrome (RAFS) and Th-1 versus Th-2 immune responses. Am J Reprod Immunol (2002) 0.79

Soluble CD30: a biomarker for evaluating the clinical risk versus benefit of IFNbeta1A treatment in multiple sclerosis patients. Int J Immunopathol Pharmacol (2010) 0.79

Treatment recommendations for interferon-beta in multiple sclerosis. J Neurol Neurosurg Psychiatry (1999) 0.79

IFNbeta-1a treatment and reestablishment of Th1 regulation in MS patients: dose effects. Clin Neuropharmacol (2004) 0.78

The potential role of thioredoxin 1 and CD30 systems as multiple pathway targets and biomarkers in tumor therapy. Cancer Immunol Immunother (2011) 0.77

Articles by these authors

Migraine and hemorrhagic stroke: a meta-analysis. Stroke (2013) 3.08

Contribution of atrial fibrillation to incidence and outcome of ischemic stroke: results from a population-based study. Stroke (2005) 3.07

Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol (2012) 2.77

Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry. Stroke (2008) 1.72

The Italian version of the Coma Recovery Scale-Revised (CRS-R). Funct Neurol (2007) 1.48

A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis. Proc Natl Acad Sci U S A (2013) 1.44

Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain (2012) 1.40

Restarting oral anticoagulants after intracerebral hemorrhage: cons. Intern Emerg Med (2014) 1.39

Spreading depolarization may link migraine, stroke, and other cardiovascular disease. Headache (2014) 1.16

Comorbid neuropathologies in migraine. J Headache Pain (2006) 1.09

Comorbid neuropathologies in migraine: an update on cerebrovascular and cardiovascular aspects. J Headache Pain (2008) 1.05

Migraine and vascular diseases: a review of the evidence and potential implications for management. Cephalalgia (2012) 1.00

Epidemiology of stroke in Italy. Int J Stroke (2011) 0.99

Risk of recurrent cerebrovascular events in patients with cryptogenic stroke or transient ischemic attack and patent foramen ovale: the FORI (Foramen Ovale Registro Italiano) study. Cerebrovasc Dis (2010) 0.99

Management of pathologic laughter and crying in patients with locked-in syndrome: a report of 4 cases. Arch Phys Med Rehabil (2008) 0.98

Pregnancy and fetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric study. BMC Neurol (2012) 0.94

CADASIL presenting as status migrainosus and persisting aura without infarction. J Headache Pain (2008) 0.93

CD30 antigen: not a physiological marker for TH2 cells but an important costimulator molecule in the regulation of the balance between TH1/TH2 response. Transpl Immunol (2003) 0.93

Heart rate non linear dynamics in patients with persistent vegetative state: a preliminary report. Brain Inj (2008) 0.91

Diagnostic criteria for CADASIL in the International Classification of Headache Disorders (ICHD-II): are they appropriate? J Headache Pain (2010) 0.90

Effect of prior medical treatments on ischemic stroke severity and outcome. Funct Neurol (2011) 0.89

Stroke tracked by administrative coding data: is it fair? Stroke (2013) 0.89

Passage from normal mucosa to adenoma and colon cancer: alteration of normal sCD30 mechanisms regulating TH1/TH2 cell functions. Cancer Biother Radiopharm (2003) 0.86

The prevalence of multiple sclerosis in central Italy. Mult Scler (2010) 0.85

Hypertension and migraine comorbidity: prevalence and risk of cerebrovascular events: evidence from a large, multicenter, cross-sectional survey in Italy (MIRACLES study). J Hypertens (2011) 0.85

ICHD-II criteria for headache attributed to transient ischemic attack: the need for an update. Cephalalgia (2010) 0.85

Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort study. BMC Neurol (2012) 0.84

Migraine attributed to genetic disorder. Funct Neurol (2007) 0.84

Contribution of hematocrit to early mortality after ischemic stroke. Eur Neurol (2007) 0.83

CD30 antigen and multiple sclerosis: CD30, an important costimulatory molecule and marker of a regulatory subpopulation of dendritic cells, is involved in the maintenance of the physiological balance between TH1/TH2 immune responses and tolerance. The role of IFNbeta-1a in the treatment of multiple sclerosis. Neuroimmunomodulation (2005) 0.83

Behavioral therapy for chronic migraine. Curr Pain Headache Rep (2013) 0.83

Peripheral vascular dysfunction in migraine: a review. J Headache Pain (2013) 0.83

Incidence, case-fatalities and 10-year survival of subarachnoid hemorrhage in a population-based registry. Eur Neurol (2009) 0.82

A case of manic episode during treatment with 5-fluorouracil, epirubicin and cyclophosphamide for breast cancer. Gen Hosp Psychiatry (2007) 0.82

Vegetative states and minimally conscious states revisited: a Russian doll approach. Brain Inj (2013) 0.81

The study of a patient's immune system may prove to be a useful noninvasive tool for stage classification in colon cancer. Cancer Biother Radiopharm (2006) 0.81

Are immunological mechanisms involved in colon cancer and are they possible markers for biotherapy improvement? Cancer Biother Radiopharm (2006) 0.81

Evidence of redox unbalance in post-acute ischemic stroke patients. Curr Neurovasc Res (2012) 0.80

Gender-specific cytokine pathways, targets, and biomarkers for the switch from health to adenoma and colorectal cancer. Clin Dev Immunol (2011) 0.80

The discovery of how gender influences age immunological mechanisms in health and disease, and the identification of ageing gender-specific biomarkers, could lead to specifically tailored treatment and ultimately improve therapeutic success rates. Immun Ageing (2012) 0.80

Peripheral blood immunological parameters for use as markers of pre-invasive to invasive colorectal cancer. Cancer Biother Radiopharm (2002) 0.79

Stroke in Italy: a disease to prevent. Clin Exp Hypertens (2006) 0.79

Ageing gender-specific "Biomarkers of Homeostasis", to protect ourselves against the diseases of the old age. Immun Ageing (2014) 0.79

Morphological variations of the internal carotid artery: Prevalence, characteristics and association with cerebrovascular disease. Int J Angiol (2007) 0.79

Showered cortical infarctions and brain atrophy in Churg-Strauss syndrome. Eur Neurol (2011) 0.79

Oxidative stress in post-acute ischemic stroke patients after intensive neurorehabilitation. Curr Neurovasc Res (2012) 0.79

Atherothrombotic burden and medium-term prognosis in patients with acute ischemic stroke: findings of the SIRIO study. Cerebrovasc Dis (2012) 0.79

Challenges to the management of high-risk stroke patients with multiple-site occlusive vascular disease. Cerebrovasc Dis (2011) 0.79

Intrathecal baclofen: effects on spasticity, pain, and consciousness in disorders of consciousness and locked-in syndrome. Curr Pain Headache Rep (2015) 0.78

Tension-type headache and systemic medical disorders. Curr Pain Headache Rep (2011) 0.78

Prolongation of TCD-enhanced Doppler signal by continuous infusion of levovist. Ultrasound Med Biol (2002) 0.78

Ethical aspects of vegetative and minimally conscious states. Curr Pharm Des (2014) 0.78

IFNbeta-1a treatment and reestablishment of Th1 regulation in MS patients: dose effects. Clin Neuropharmacol (2004) 0.78

MICA polymorphism in a population from north Morocco, Metalsa Berbers, using sequence-based typing. Hum Immunol (2005) 0.78

Validation of the Italian version of a new coma scale: the FOUR score. Intern Emerg Med (2011) 0.78

The perception of pain and its management in disorders of consciousness. Curr Pain Headache Rep (2013) 0.78

Colon cancer and gene alterations: their immunological implications and suggestions for prognostic indices and improvements in biotherapy. Cancer Biother Radiopharm (2006) 0.78

Corticomotor facilitation in vegetative state: results of a pilot study. Arch Phys Med Rehabil (2013) 0.78

Evaluation of neuropsychological functions in patients with Friedreich ataxia before and after cognitive therapy. Funct Neurol (2010) 0.77

Paternal therapy with disease modifying drugs in multiple sclerosis and pregnancy outcomes: a prospective observational multicentric study. BMC Neurol (2014) 0.77

Sequence-Based analysis of the HLA-DRB1 polymorphism in Metalsa Berber and Chaouya Arabic-speaking groups from Morocco. Hum Immunol (2002) 0.77

Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients. J Transl Med (2011) 0.77

The potential role of thioredoxin 1 and CD30 systems as multiple pathway targets and biomarkers in tumor therapy. Cancer Immunol Immunother (2011) 0.77

Preventive non-pharmacological treatment and nitric oxide in chronic migraine. J Headache Pain (2005) 0.77

An unexpected recovery from permanent vegetative state. Brain Inj (2007) 0.77

Brain white matter lesions in an italian family with charcot-marie-tooth disease. Eur Neurol (2004) 0.77

Immunological study of IFNbeta-1a-treated and untreated multiple sclerosis patients: clarifying IFNbeta mechanisms and establishing specific dendritic cell immunotherapy. Neuroimmunomodulation (2005) 0.77

Migraine attributed to genetic disorder: proposal of a new category. Cephalalgia (2011) 0.77

Acute stroke admission and diagnostic procedures according to the hour and day of onset: the SIRIO collaborative data. Eur Neurol (2008) 0.77

Epidemiology of stroke in the young. Stroke (2003) 0.77

Comorbidities: a key issue in patients with disorders of consciousness. J Neurotrauma (2015) 0.76

Migraine and hemorrhagic stroke: data from general practice. J Headache Pain (2015) 0.76

Moderate consumption of red wine and human platelet responsiveness. Thromb Res (2011) 0.76

A practical definition of minor stroke. Neurol Sci (2012) 0.76

Pharmacological modulation of the state of awareness in patients with disorders of consciousness: an overview. Curr Pharm Des (2014) 0.76

The Role of Gender-specific Cytokine Pathways as Drug Targets and Gender- specific Biomarkers in Personalized Cancer Therapy. Curr Drug Targets (2017) 0.76

The Italian Registry of Endovascular Treatment in Acute Stroke: rationale, design and baseline features of patients. Neurol Sci (2015) 0.75

Validation of the Italian version of the Coma Recovery Scale-Revised (CRS-R). Brain Inj (2011) 0.75

The renin-angiotensin system: a possible contributor to migraine pathogenesis and prophylaxis. Expert Rev Neurother (2014) 0.75