Published in Nat Rev Immunol on December 01, 2002
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity (2009) 9.73
CD4 T cells: fates, functions, and faults. Blood (2008) 7.03
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity (2009) 6.86
Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood (2008) 6.81
Aberrant T cell differentiation in the absence of Dicer. J Exp Med (2005) 6.58
TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med (2005) 5.77
Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol (2009) 5.72
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A (2006) 5.69
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 5.63
Signalling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol (2009) 4.98
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Th17: the third member of the effector T cell trilogy. Curr Opin Immunol (2007) 4.78
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
Th17 cells in human disease. Immunol Rev (2008) 4.27
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 3.97
Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat Immunol (2007) 3.72
Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev (2010) 3.41
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med (2006) 3.36
Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum (2008) 3.35
Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest (2006) 3.25
Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity (2011) 3.24
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol (2010) 3.12
Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2007) 3.09
Engineering lymphocyte subsets: tools, trials and tribulations. Nat Rev Immunol (2009) 3.06
Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum (2007) 3.06
Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology (2009) 2.92
Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity (2007) 2.88
Notch signaling is an important regulator of type 2 immunity. J Exp Med (2005) 2.87
A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo. J Exp Med (2007) 2.82
Th17 cells: effector T cells with inflammatory properties. Semin Immunol (2007) 2.81
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity (2010) 2.70
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation. Nat Rev Immunol (2006) 2.70
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J Exp Med (2006) 2.70
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat Immunol (2009) 2.48
Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis. Hepatology (2010) 2.48
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med (2009) 2.45
IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc Natl Acad Sci U S A (2003) 2.45
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med (2006) 2.38
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity (2010) 2.38
Development and characterization of IL-21-producing CD4+ T cells. J Exp Med (2008) 2.34
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. Nat Immunol (2008) 2.31
Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t. Proc Natl Acad Sci U S A (2009) 2.27
Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease. Blood (2008) 2.24
In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. Blood (2008) 2.24
Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development. EMBO J (2006) 2.21
Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest (2004) 2.20
Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications. J Exp Med (2003) 2.19
A method for the generation of standardized qualitative dynamical systems of regulatory networks. Theor Biol Med Model (2006) 2.14
Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol (2009) 2.12
Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med (2007) 2.08
IL-23 promotes maintenance but not commitment to the Th17 lineage. J Immunol (2008) 2.06
M1 and M2 macrophages: the chicken and the egg of immunity. J Innate Immun (2014) 2.06
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
The transcription factor STAT3 is required for T helper 2 cell development. Immunity (2011) 2.03
T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. Proc Natl Acad Sci U S A (2005) 2.00
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol (2009) 1.99
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev (2007) 1.98
Th9 and allergic disease. Immunology (2009) 1.97
Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy. J Immunol (2006) 1.94
Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J Immunol (2011) 1.93
Follicular helper T cells in immunity and systemic autoimmunity. Nat Rev Rheumatol (2012) 1.89
Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function. Trends Immunol (2009) 1.89
Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol Rev (2008) 1.88
Role of TL1A and its receptor DR3 in two models of chronic murine ileitis. Proc Natl Acad Sci U S A (2006) 1.87
Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proc Natl Acad Sci U S A (2008) 1.87
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol (2007) 1.87
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A (2009) 1.86
Synchronous versus asynchronous modeling of gene regulatory networks. Bioinformatics (2008) 1.85
The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses. Immunity (2012) 1.84
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med (2006) 1.84
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A (2005) 1.82
IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together. J Exp Med (2005) 1.76
High IFN-γ and low SLPI mark severe asthma in mice and humans. J Clin Invest (2015) 1.74
Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues. Proc Natl Acad Sci U S A (2009) 1.74
The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat Immunol (2010) 1.72
Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand J Immunol (2010) 1.70
Pathogenesis and immune responses in gnotobiotic calves after infection with the genogroup II.4-HS66 strain of human norovirus. J Virol (2007) 1.70
From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol Rev (2008) 1.65
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity (2010) 1.64
Helper T cell diversity and plasticity. Curr Opin Immunol (2012) 1.63
Role of IL-17 and Th17 cells in liver diseases. Clin Dev Immunol (2010) 1.63
Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity (2008) 1.62
Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2. PLoS Pathog (2011) 1.62
The impact of T cell intrinsic antigen adaptation on peripheral immune tolerance. PLoS Biol (2006) 1.62
The sonic hedgehog signaling system as a bistable genetic switch. Biophys J (2004) 1.61
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nat Immunol (2009) 1.61
Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. J Exp Med (2009) 1.61
Alternative memory in the CD8 T cell lineage. Trends Immunol (2011) 1.60
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med (2011) 1.60
IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells. J Exp Med (2008) 1.58
The Th17 family: flexibility follows function. Immunol Rev (2013) 1.58
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 1.56
ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat Immunol (2011) 1.54
Human eosinophils secrete preformed, granule-stored interleukin-4 through distinct vesicular compartments. Traffic (2005) 1.52
TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol (2008) 1.49
T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent. J Exp Med (2006) 1.49
Covariates of cervical cytokine mRNA expression by real-time PCR in adolescents and young women: effects of Chlamydia trachomatis infection, hormonal contraception, and smoking. J Clin Immunol (2006) 1.48
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol (2005) 8.27
Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science (2003) 7.75
Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science (2007) 7.64
The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity (2012) 4.32
Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science (2008) 4.04
Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. J Immunol (2006) 3.73
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. J Exp Med (2007) 3.67
A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity (2009) 3.66
Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science (2012) 3.39
Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2007) 3.09
KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity (2009) 2.90
Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat Immunol (2002) 2.87
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol (2011) 2.76
Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. J Immunol (2010) 2.63
The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity (2006) 2.55
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity (2012) 2.52
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity (2011) 2.34
Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur J Immunol (2007) 2.10
IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression. J Immunol (2006) 1.86
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med (2009) 1.86
Gene silencing quantitatively controls the function of a developmental trans-activator. Mol Cell (2002) 1.81
Nuclear repositioning marks the selective exclusion of lineage-inappropriate transcription factor loci during T helper cell differentiation. Eur J Immunol (2004) 1.76
The precursors of memory: models and controversies. Nat Rev Immunol (2009) 1.75
CD44 mediates successful interstitial navigation by killer T cells and enables efficient antitumor immunity. Immunity (2008) 1.72
Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. Eur J Immunol (2010) 1.59
STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosis. J Immunol (2004) 1.47
Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms. J Immunol (2010) 1.46
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. J Immunol (2011) 1.36
Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα. Nat Immunol (2012) 1.34
Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin. J Exp Med (2013) 1.29
Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation. J Immunol (2009) 1.20
Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation. J Exp Med (2007) 1.20
Cutting Edge: Innate production of IFN-gamma by NK cells is independent of epigenetic modification of the IFN-gamma promoter. J Immunol (2004) 1.16
Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. J Immunol (2011) 1.16
Asymmetric B cell division in the germinal center reaction. Science (2011) 1.10
Cutting edge: Asymmetric memory T cell division in response to rechallenge. J Immunol (2012) 1.07
Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons. J Neurosci (2012) 1.06
Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression. J Immunol (2005) 1.06
Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. J Immunol (2004) 1.02
Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells. J Immunol (2007) 0.98
Two-photon imaging of effector T-cell behavior: lessons from a tumor model. Immunol Rev (2008) 0.98
The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A (2013) 0.97
CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin. Eur J Immunol (2009) 0.95
Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J Neurosci (2013) 0.94
Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin. J Immunol (2010) 0.93
Decision making during the conception and career of CD4+ T cells. Nat Rev Immunol (2009) 0.92
Not-so-great expectations: re-assessing the essence of T-cell memory. Immunol Rev (2006) 0.92
Antigen-experienced T cells limit the priming of naive T cells during infection with Leishmania major. J Immunol (2006) 0.89
Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes. J Leukoc Biol (2012) 0.87
T-bet down-modulation in tolerized Th1 effector CD4 cells confers a TCR-distal signaling defect that selectively impairs IFN-gamma expression. J Immunol (2006) 0.85
Cutting edge: a critical role for gene silencing in preventing excessive type 1 immunity. J Immunol (2005) 0.84
Specifying helper T cell fates during immunity. J Pediatr Gastroenterol Nutr (2008) 0.82
Sliding doors in the immune response. Nat Immunol (2005) 0.78
Helping and harming have something in common. Nat Immunol (2009) 0.77
Protection one cell thick. Immunity (2007) 0.75