The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.

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Published in J Neurosci on November 14, 2012

Authors

Inger Lauritzen1, Raphaëlle Pardossi-Piquard1, Charlotte Bauer1, Elizabeth Brigham2, Jean-Daniel Abraham3, Sébastien Ranaldi3, Paul Fraser4, Peter St-George-Hyslop4, Ophelia Le Thuc1, Vanessa Espin1, Linda Chami1, Julie Dunys1, Frédéric Checler1

Author Affiliations

1: Université de Nice-Sophia-Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR7275, team labelised «Fondation pour la Recherche Médicale» et "Laboratoire d'excellence Distalz", Sophia-Antipolis, France.
2: Elan Pharmaceuticals, South San Francisco, CA, USA.
3: Cap Delta - Parc Euromédecine, CNRS UMR-3145 SysDiag, Montpellier, France.
4: Center for Research in Neurodegenerative Diseases, University of Toronto, Ontario M5S3H2, Canada.

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