Alzheimer's disease and the amyloid β-protein.

Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression. Antioxid Redox Signal (2013) 1.20

FoxO6 regulates memory consolidation and synaptic function. Genes Dev (2012) 1.14

The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus. J Neurosci (2012) 1.11

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. J Biol Chem (2013) 1.07

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity. Nat Commun (2013) 1.00

Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation. J Biol Chem (2014) 0.99

Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer's disease. Cell Death Dis (2013) 0.96

Fingolimod phosphate attenuates oligomeric amyloid β-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neurons. PLoS One (2013) 0.95

Aging 2.0: health information about dementia on Twitter. PLoS One (2013) 0.92

Mechanism of amyloid β-protein dimerization determined using single-molecule AFM force spectroscopy. Sci Rep (2013) 0.92

Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease. Mol Neurodegener (2013) 0.92

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease. Mediators Inflamm (2015) 0.89

Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels. PLoS One (2013) 0.86

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits. PLoS One (2014) 0.85

Has inhibition of Aβ production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data. Eur J Clin Pharmacol (2013) 0.84

Mammalian prions and their wider relevance in neurodegenerative diseases. Nature (2016) 0.83

Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. J Comp Neurol (2013) 0.83

Protective effects of Borago officinalis extract on amyloid β-peptide(25-35)-induced memory impairment in male rats: a behavioral study. Biomed Res Int (2014) 0.82

Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses. Front Comput Neurosci (2013) 0.82

Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice. Neurobiol Dis (2015) 0.81

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species. Alzheimers Dement (2015) 0.80

Context dependence of protein misfolding and structural strains in neurodegenerative diseases. Biopolymers (2013) 0.80

Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies. Acta Neuropathol Commun (2014) 0.79

N-terminal domain of prion protein directs its oligomeric association. J Biol Chem (2014) 0.78

The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. J Biol Chem (2014) 0.77

Dab2 attenuates brain injury in APP/PS1 mice via targeting transforming growth factor-beta/SMAD signaling. Neural Regen Res (2014) 0.77

The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII. J Thromb Haemost (2016) 0.77

Modeling of age-dependent amyloid accumulation and γ-secretase inhibition of soluble and insoluble Aβ in a transgenic mouse model of amyloid deposition. Pharmacol Res Perspect (2013) 0.76

Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy. ACS Chem Neurosci (2015) 0.76

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype. PLoS One (2016) 0.75

Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. Neuroimage Clin (2017) 0.75

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci U S A (2002) 5.46

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. J Neurosci Res (2002) 3.79

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem (2009) 3.66

Structure-neurotoxicity relationships of amyloid beta-protein oligomers. Proc Natl Acad Sci U S A (2009) 3.06

Amyloid beta-protein assembly and Alzheimer disease. J Biol Chem (2008) 2.90

On the nucleation of amyloid beta-protein monomer folding. Protein Sci (2005) 2.47

Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. J Biol Chem (2003) 2.31

Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp. Microbiology (2004) 2.22

Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. J Am Chem Soc (2005) 2.19

Amyloid beta-protein monomer structure: a computational and experimental study. Protein Sci (2006) 1.99

Neurotoxic protein oligomers--what you see is not always what you get. Amyloid (2005) 1.84

Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. J Neurosci (2008) 1.75

Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Acc Chem Res (2004) 1.75

A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide. FEBS J (2009) 1.71

Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans. Microbiology (2002) 1.65

Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences. J Mol Biol (2008) 1.62

Kinetic studies of amyloid beta-protein fibril assembly. Differential effects of alpha-helix stabilization. J Biol Chem (2002) 1.61

Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus. Proc Natl Acad Sci U S A (2007) 1.55

A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. J Am Chem Soc (2003) 1.55

Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains. J Biol Chem (2009) 1.52

Structure of the 21-30 fragment of amyloid beta-protein. Protein Sci (2006) 1.51

Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico. Proc Natl Acad Sci U S A (2005) 1.43

Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays. J Biol Chem (2003) 1.42

Structure determination of micelle-like intermediates in amyloid beta -protein fibril assembly by using small angle neutron scattering. Proc Natl Acad Sci U S A (2001) 1.41

Solvent and mutation effects on the nucleation of amyloid beta-protein folding. Proc Natl Acad Sci U S A (2005) 1.37

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol (2006) 1.36

Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. J Biol Chem (2008) 1.33

Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization. J Am Chem Soc (2009) 1.30

Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein. J Mol Biol (2008) 1.24

The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. J Biol Chem (2006) 1.21

Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence. Biochemistry (2005) 1.17

Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays. Methods Mol Biol (2005) 1.15

Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy. Acta Neuropathol (2009) 1.10

Apical sorting of beta-secretase limits amyloid beta-peptide production. J Biol Chem (2001) 1.10

Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem (2009) 1.10

Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid beta-protein assembly and toxicity. J Biol Chem (2010) 1.07

1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. J Alzheimers Dis (2013) 1.05

Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. J Biol Chem (2012) 1.05

A non-amyloidogenic function of BACE-2 in the secretory pathway. J Neurochem (2002) 1.05

Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization. ACS Chem Neurosci (2012) 1.05

Computer simulations of Alzheimer's amyloid beta-protein folding and assembly. Curr Alzheimer Res (2006) 1.04

C-terminal turn stability determines assembly differences between Aβ40 and Aβ42. J Mol Biol (2012) 1.00

Polyglutamine repeat length-dependent proteolysis of huntingtin. Neurobiol Dis (2002) 1.00

Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses. J Biol Chem (2011) 1.00

Determination of Peptide oligomerization state using rapid photochemical crosslinking. Methods Mol Biol (2005) 0.99

A peptide hairpin inhibitor of amyloid beta-protein oligomerization and fibrillogenesis. Biochemistry (2009) 0.97

Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease. Curr Pharm Des (2008) 0.97

Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment. J Neurosci (2012) 0.97

Munumbicins E-4 and E-5: novel broad-spectrum antibiotics from Streptomyces NRRL 3052. FEMS Microbiol Lett (2006) 0.94

Mechanism of amyloid β-protein dimerization determined using single-molecule AFM force spectroscopy. Sci Rep (2013) 0.92

Amyloid beta-protein: experiment and theory on the 21-30 fragment. J Phys Chem B (2009) 0.91

Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease. J Alzheimers Dis (2010) 0.90

Nanoprobing of the effect of Cu(2+) cations on misfolding, interaction and aggregation of amyloid β peptide. J Neuroimmune Pharmacol (2012) 0.89

Carvedilol as a potential novel agent for the treatment of Alzheimer's disease. Neurobiol Aging (2010) 0.88

Effect of melatonin on α-synuclein self-assembly and cytotoxicity. Neurobiol Aging (2011) 0.88

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. J Biol Chem (2008) 0.88

Structural dynamics of the ΔE22 (Osaka) familial Alzheimer's disease-linked amyloid β-protein. Amyloid (2011) 0.87

Quasielastic light scattering for protein assembly studies. Methods Mol Biol (2005) 0.87

Quasielastic light scattering study of amyloid beta-protein fibril formation. Protein Pept Lett (2006) 0.82

Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization. J Alzheimers Dis (2009) 0.82

Factors that drive peptide assembly and fibril formation: experimental and theoretical analysis of Sup35 NNQQNY mutants. J Phys Chem B (2013) 0.81

Cerebrospinal Fluid from Alzheimer's disease patients promotes amyloid beta-protein oligomerization. J Alzheimers Dis (2010) 0.81

Factors that drive peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants. J Phys Chem B (2014) 0.80

A direct interaction between transforming growth factor (TGF)-betas and amyloid-beta protein affects fibrillogenesis in a TGF-beta receptor-independent manner. J Biol Chem (2003) 0.80

Preparation of stable amyloid β-protein oligomers of defined assembly order. Methods Mol Biol (2012) 0.79

The exception makes the rule: not all Aβ plaques are created equal. Neurology (2012) 0.79

Structural dynamics of the amyloid β-protein monomer folding nucleus. Biochemistry (2012) 0.78

Quasielastic light scattering study of amyloid β-protein fibrillogenesis. Methods Mol Biol (2012) 0.77

Common threads in neurodegenerative disorders of aging. Alzheimers Dement (2006) 0.76

Molecular biology of neurodegenerative diseases. Preface. Prog Mol Biol Transl Sci (2012) 0.75

Continuous flow reactor for the production of stable amyloid protein oligomers. Biochemistry (2012) 0.75