Published in Mitochondrion on November 16, 2012
Synergistic cytotoxicity of gemcitabine, clofarabine and edelfosine in lymphoma cell lines. Blood Cancer J (2014) 0.81
Lipid analogues as potential drugs for the regulation of mitochondrial cell death. Br J Pharmacol (2014) 0.77
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood (2004) 2.61
Doxorubicin: the good, the bad and the ugly effect. Curr Med Chem (2009) 1.95
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts. Blood (2006) 1.49
Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis. J Exp Med (2004) 1.46
The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins. Eur J Immunol (2011) 1.45
Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species. Curr Diabetes Rev (2008) 1.40
Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization. J Biochem Mol Toxicol (2007) 1.39
Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells. Curr Drug Metab (2002) 1.17
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem (2005) 1.16
Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis. J Biol Chem (2002) 1.15
Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition. J Biol Chem (2005) 1.12
Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. J Immunol (2007) 1.11
Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo. Cancer Res (2008) 1.11
Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy. Med Res Rev (2013) 1.10
Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets. Cell Biol Toxicol (2008) 1.08
Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions. J Pharmacol Exp Ther (2007) 1.08
Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells. Cancer Res (2007) 1.06
Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells. PLoS One (2009) 1.05
Role of mitochondria in nonalcoholic fatty liver disease--from origin to propagation. Clin Biochem (2012) 1.03
Mitochondrial involvement in cardiac apoptosis during ischemia and reperfusion: can we close the box? Cardiovasc Toxicol (2009) 1.02
Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line. Cancer Chemother Pharmacol (2007) 1.02
Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis. Am J Physiol Heart Circ Physiol (2005) 1.01
Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency. PLoS One (2013) 1.00
Parabens in male infertility-is there a mitochondrial connection? Reprod Toxicol (2008) 1.00
Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism. Clin Cancer Res (2003) 0.99
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety? Curr Drug Saf (2009) 0.99
Lipid raft connection between extrinsic and intrinsic apoptotic pathways. Biochem Biophys Res Commun (2009) 0.98
Evaluation of respiration with clark type electrode in isolated mitochondria and permeabilized animal cells. Methods Mol Biol (2012) 0.97
Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids. Cell Cycle (2014) 0.96
Rapid human melanoma cell death induced by sanguinarine through oxidative stress. Eur J Pharmacol (2013) 0.95
DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin. Chem Biol (2005) 0.94
Mitochondria in chronic liver disease. Curr Drug Targets (2011) 0.93
Differential immuno-reactivity to genomic DNA, RNA and mitochondrial DNA is associated with auto-immunity. Cell Physiol Biochem (2014) 0.93
Drug-induced cardiac mitochondrial toxicity and protection: from doxorubicin to carvedilol. Curr Pharm Des (2011) 0.92
Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells. Chem Res Toxicol (2011) 0.92
Berberine as a promising safe anti-cancer agent - is there a role for mitochondria? Curr Drug Targets (2011) 0.91
Rab27a regulates exocytosis of tertiary and specific granules in human neutrophils. J Immunol (2008) 0.91
Differentiation-dependent doxorubicin toxicity on H9c2 cardiomyoblasts. Cardiovasc Toxicol (2012) 0.91
Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast. J Biol Chem (2013) 0.90
Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage. Free Radic Biol Med (2008) 0.90
Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells. J Biol Chem (2006) 0.90
Edelfosine is incorporated into rafts and alters their organization. J Phys Chem B (2008) 0.89
Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats. Clin Sci (Lond) (2011) 0.89
Lipid rafts and Fas/CD95 signaling in cancer chemotherapy. Recent Pat Anticancer Drug Discov (2011) 0.89
Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts. Cancer Chemother Pharmacol (2009) 0.89
Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death. BMC Cell Biol (2007) 0.89
Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents. Biochim Biophys Acta (2003) 0.88
Mitochondrial membrane lipid remodeling in pathophysiology: a new target for diet and therapeutic interventions. Prog Lipid Res (2013) 0.87
Physical exercise as a possible strategy for brain protection: evidence from mitochondrial-mediated mechanisms. Prog Neurobiol (2012) 0.87
Mitochondrial remodeling in cancer metabolism and survival: potential for new therapies. Biochim Biophys Acta (2012) 0.87
Endurance training reverts heart mitochondrial dysfunction, permeability transition and apoptotic signaling in long-term severe hyperglycemia. Mitochondrion (2010) 0.87
Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety. J Med Chem (2005) 0.86
Mechanisms of berberine (natural yellow 18)-induced mitochondrial dysfunction: interaction with the adenine nucleotide translocator. Toxicol Sci (2008) 0.86
Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults. Neurotox Res (2008) 0.86
Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine). Biochim Biophys Acta (2007) 0.86
Isoproterenol cytotoxicity is dependent on the differentiation state of the cardiomyoblast H9c2 cell line. Cardiovasc Toxicol (2011) 0.86
Mitochondria from distinct tissues are differently affected by 17β-estradiol and tamoxifen. J Steroid Biochem Mol Biol (2010) 0.86
Metabolic remodeling during H9c2 myoblast differentiation: relevance for in vitro toxicity studies. Cardiovasc Toxicol (2011) 0.85
The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo. Expert Opin Drug Metab Toxicol (2012) 0.85
Regulation and protection of mitochondrial physiology by sirtuins. Mitochondrion (2011) 0.85
In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites. PLoS Negl Trop Dis (2012) 0.85
Mitochondria in cancer stem cells: a target for therapy. Recent Pat Endocr Metab Immune Drug Discov (2013) 0.85
Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin. J Med Chem (2004) 0.84
Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes. Autophagy (2012) 0.84
The role of hexokinase in cardioprotection - mechanism and potential for translation. Br J Pharmacol (2014) 0.84
Expression and subcellular localization of syntaxin 11 in human neutrophils. Inflamm Res (2009) 0.84
Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis. BMC Syst Biol (2010) 0.83
Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast. J Biol Chem (2013) 0.83
Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: development and in vitro characterization. Eur J Pharm Biopharm (2007) 0.83
Beneficial effects of exercise on muscle mitochondrial function in diabetes mellitus. Sports Med (2008) 0.83
Mitochondrial-derived ROS in edelfosine-induced apoptosis in yeasts and tumor cells. Acta Pharmacol Sin (2007) 0.83
Vitamin E prevents hypobaric hypoxia-induced mitochondrial dysfunction in skeletal muscle. Clin Sci (Lond) (2007) 0.83
Mitochondria as a target for exercise-induced cardioprotection. Curr Drug Targets (2011) 0.82
Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities. J Med Chem (2010) 0.82
Combination of the anti-tumour cell ether lipid edelfosine with sterols abolishes haemolytic side effects of the drug. J Chem Biol (2008) 0.82
Targeting mitochondrial function for the treatment of breast cancer. Future Med Chem (2014) 0.82
Endurance training limits the functional alterations of rat heart mitochondria submitted to in vitro anoxia-reoxygenation. Int J Cardiol (2005) 0.82
Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells--nuclear vs. mitochondrial effects. Biochem Pharmacol (2008) 0.82
Melatonin modulates autophagy through a redox-mediated action in female Syrian hamster Harderian gland controlling cell types and gland activity. J Pineal Res (2011) 0.82
Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells. Anticancer Drugs (2011) 0.82
Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling. J Bioenerg Biomembr (2011) 0.82
Cytotoxic oxasqualenoids from the red alga Laurencia viridis. Eur J Med Chem (2011) 0.81
Cardiac mitochondrial dysfunction during hyperglycemia--the role of oxidative stress and p66Shc signaling. Int J Biochem Cell Biol (2012) 0.81
Toxicity evaluation of some traditional African spices on breast cancer cells and isolated rat hepatic mitochondria. Food Chem Toxicol (2012) 0.81
Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes. Int J Pharm (2006) 0.81
Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice. Clin Cancer Res (2009) 0.81
Bisphenol A as epigenetic modulator: setting the stage for carcinogenesis? Eur J Clin Invest (2015) 0.81
Inhibition of mitochondrial bioenergetics by carbaryl is only evident for higher concentrations -- Relevance for carbaryl toxicity mechanisms. Chemosphere (2006) 0.80
Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak. FEBS Lett (2008) 0.80
Endurance training improves gastrocnemius mitochondrial function despite increased susceptibility to permeability transition. Mitochondrion (2009) 0.80
Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk. Antimicrob Agents Chemother (2008) 0.80