PubRank

Mischa Machius

Author PubWeight™ 73.01‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Three-dimensional structure of the complexin/SNARE complex. Neuron 2002 3.69
2 Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. Nature 2005 3.31
3 Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana. Proc Natl Acad Sci U S A 2004 2.48
4 Side chain and backbone contributions of Phe508 to CFTR folding. Nat Struct Mol Biol 2004 2.43
5 Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell 2006 2.32
6 Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J 2002 2.27
7 p31comet blocks Mad2 activation through structural mimicry. Cell 2007 2.26
8 Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol Cell 2005 2.16
9 Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci U S A 2009 2.02
10 Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. PLoS Biol 2006 1.88
11 Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol 2007 1.59
12 Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat Struct Mol Biol 2010 1.58
13 Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell 2010 1.51
14 Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry 2007 1.44
15 Changes at the KinA PAS-A dimerization interface influence histidine kinase function. Biochemistry 2008 1.43
16 Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol 2008 1.41
17 The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation. Sci Signal 2011 1.40
18 Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations. J Mol Biol 2005 1.37
19 Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell 2008 1.32
20 Diffraction data analysis in the presence of radiation damage. Acta Crystallogr D Biol Crystallogr 2010 1.27
21 Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4. Nat Struct Mol Biol 2004 1.26
22 Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett 2012 1.22
23 Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K. Structure 2004 1.21
24 Localization and structure of the ankyrin-binding site on beta2-spectrin. J Biol Chem 2008 1.21
25 Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex. Structure 2006 1.19
26 Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer. J Am Chem Soc 2011 1.19
27 Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. Structure 2008 1.12
28 Computational design of a symmetric homodimer using β-strand assembly. Proc Natl Acad Sci U S A 2011 1.12
29 Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin. J Biol Chem 2006 1.10
30 The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum. J Biol Chem 2006 1.09
31 Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases. J Biol Chem 2007 1.08
32 Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation. Structure 2004 0.99
33 Crystal structure of the 47-kDa lipoprotein of Treponema pallidum reveals a novel penicillin-binding protein. J Biol Chem 2002 0.98
34 Crystal structure of the Formin mDia1 in autoinhibited conformation. PLoS One 2010 0.96
35 Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem 2013 0.96
36 Computational design of the sequence and structure of a protein-binding peptide. J Am Chem Soc 2011 0.95
37 Hyperthermostabilization of Bacillus licheniformis alpha-amylase and modulation of its stability over a 50 degrees C temperature range. Protein Eng 2003 0.94
38 Structure and mechanism of a eukaryotic FMN adenylyltransferase. J Mol Biol 2009 0.93
39 Monovalent cation dependence and preference of GHKL ATPases and kinases. FEBS Lett 2003 0.92
40 Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase. J Biol Chem 2004 0.91
41 Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem 2013 0.91
42 Structural evidence that the 32-kilodalton lipoprotein (Tp32) of Treponema pallidum is an L-methionine-binding protein. J Biol Chem 2004 0.90
43 Crystal structure of the RIM2 C2A-domain at 1.4 A resolution. Biochemistry 2005 0.89
44 Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates. Mol Microbiol 2008 0.87
45 Increasing sequence diversity with flexible backbone protein design: the complete redesign of a protein hydrophobic core. Structure 2012 0.87
46 A proximal arginine R206 participates in switching of the Bradyrhizobium japonicum FixL oxygen sensor. J Mol Biol 2006 0.87
47 Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel. Biochemistry 2008 0.86
48 Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants. J Biol Chem 2010 0.86
49 The two active sites in human branched-chain alpha-keto acid dehydrogenase operate independently without an obligatory alternating-site mechanism. J Biol Chem 2007 0.85
50 Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis. J Bacteriol 2012 0.83
51 Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica. PLoS Pathog 2012 0.83
52 Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution. Biochemistry 2007 0.83
53 Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis. Structure 2012 0.79
54 Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site. J Biol Chem 2003 0.79
55 Interactions of substrates at the surface of P450s can greatly enhance substrate potency. Biochemistry 2007 0.79
56 A single active-site mutation of P450BM-3 dramatically enhances substrate binding and rate of product formation. Biochemistry 2011 0.77