PubRank

Atsushi Iwama

Author PubWeight™ 101.40‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 2006 4.61
2 Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell 2011 4.04
3 TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood 2008 2.64
4 Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J 2006 2.18
5 Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev 2008 2.12
6 Essential and instructive roles of GATA factors in eosinophil development. J Exp Med 2002 1.98
7 Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med 2006 1.94
8 Role of SOX17 in hematopoietic development from human embryonic stem cells. Blood 2012 1.86
9 Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell 2009 1.78
10 Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J 2005 1.77
11 Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis. J Exp Med 2005 1.72
12 Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells. Blood 2011 1.66
13 MOZ is essential for maintenance of hematopoietic stem cells. Genes Dev 2006 1.56
14 The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. Cancer Res 2008 1.56
15 Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood 2012 1.56
16 Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood 2002 1.53
17 Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell 2010 1.48
18 Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. J Exp Med 2005 1.44
19 Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation. Gastroenterology 2007 1.42
20 Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status. Am J Physiol Endocrinol Metab 2002 1.41
21 Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood 2002 1.39
22 Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med 2004 1.31
23 Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J Exp Med 2008 1.27
24 Consequence of the loss of Sox2 in the developing brain of the mouse. FEBS Lett 2008 1.26
25 Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. J Exp Med 2013 1.23
26 Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med 2003 1.21
27 Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells. Blood 2011 1.18
28 The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells. J Hepatol 2010 1.16
29 The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis. Blood 2011 1.14
30 Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing. Biochem Biophys Res Commun 2006 1.14
31 The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells. Mol Cell Biol 2004 1.13
32 MicroRNA-27 enhances differentiation of myeloblasts into granulocytes by post-transcriptionally downregulating Runx1. Br J Haematol 2009 1.13
33 Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells. Mol Cell Biol 2006 1.12
34 Cytokine signaling, lipid raft clustering, and HSC hibernation. Ann N Y Acad Sci 2007 1.12
35 The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon. J Biol Chem 2006 1.12
36 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells. Int J Cancer 2011 1.11
37 Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma. Hum Pathol 2009 1.11
38 The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3. Mol Cell Biol 2005 1.08
39 Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells. Development 2003 1.06
40 Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells. PLoS One 2013 1.06
41 Identification and investigation of methylated genes in hepatoma. Eur J Cancer 2005 1.05
42 Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Proc Natl Acad Sci U S A 2007 1.01
43 Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J Biol Chem 2005 1.01
44 Role of the polycomb group proteins in hematopoietic stem cells. Dev Growth Differ 2010 1.00
45 Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. J Biol Chem 2001 1.00
46 Life and death in hematopoietic stem cells. Curr Opin Immunol 2007 1.00
47 Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes. J Exp Med 2012 1.00
48 Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective. Cancer Lett 2009 0.97
49 Morphological and molecular revision of Zoanthus (Anthozoa: Hexacorallia) from southwestern Japan, with descriptions of two new species. Zoolog Sci 2006 0.97
50 Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice. Hepatology 2010 0.96
51 A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. PLoS One 2010 0.95
52 pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1. Blood 2004 0.94
53 Epigenetic regulation of hematopoiesis. Int J Hematol 2012 0.94
54 Bmi1 confers resistance to oxidative stress on hematopoietic stem cells. PLoS One 2012 0.91
55 Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol 2014 0.90
56 Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma. Int J Cancer 2014 0.90
57 Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells. Exp Hematol 2011 0.89
58 Epigenetics of hematopoietic stem cell aging and disease. Int J Hematol 2014 0.89
59 Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood 2006 0.88
60 Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL. Exp Hematol 2009 0.88
61 Antiproliferative action of metformin in human lung cancer cell lines. Oncol Rep 2012 0.87
62 Aldehyde dehydrogenase 1 is associated with recurrence-free survival but not stem cell-like properties in hepatocellular carcinoma. Hepatol Res 2012 0.87
63 FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells. J Biol Chem 2009 0.86
64 Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis. Br J Haematol 2011 0.86
65 RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes. Blood 2013 0.85
66 Parvovirus nonstructural proteins induce an epigenetic modification through histone acetylation in host genes and revert tumor malignancy to benignancy. J Virol 2005 0.85
67 Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing. Int J Hematol 2008 0.85
68 Retroviral expression screening of oncogenes in natural killer cell leukemia. Leuk Res 2005 0.83
69 Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process. Genes Cells 2009 0.82
70 Effect of metformin on residual cells after chemotherapy in a human lung adenocarcinoma cell line. Int J Oncol 2013 0.81
71 Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One 2011 0.81
72 Tumor suppressor function of the polycomb group genes. Cell Cycle 2012 0.81
73 Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells. Int J Hematol 2010 0.81
74 Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem 2014 0.80
75 Unique composition of polycomb repressive complex 1 in hematopoietic stem cells. Int J Hematol 2007 0.80
76 Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias. Clin Chim Acta 2012 0.79
77 Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice. Int J Radiat Biol 2012 0.79
78 Identification of transcripts commonly expressed in both hematopoietic and germ-line stem cells. Stem Cells Dev 2008 0.79
79 [Structure and function of MYST family histone acetyltransferases]. Rinsho Ketsueki 2011 0.78
80 New approaches to expand hematopoietic stem and progenitor cells. Expert Opin Biol Ther 2012 0.78
81 Mutations of epigenetic regulator genes and myeloid malignancies. Rinsho Ketsueki 2015 0.77
82 Sox17 as a candidate regulator of myeloid restricted differentiation potential. Dev Growth Differ 2014 0.77
83 FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells. Exp Hematol 2010 0.77
84 Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice. Int J Radiat Biol 2015 0.76
85 Myelodysplastic syndrome with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice. Leuk Lymphoma 2014 0.76
86 [Epigenetic dysregulation in myelodysplastic syndrome]. Rinsho Ketsueki 2015 0.75
87 [Self-renewal mechanisms of leukemic stem cells]. Rinsho Ketsueki 2008 0.75
88 [The cancer stem cell model in hematological malignancies]. Nihon Rinsho 2015 0.75
89 High levels of morphological variation despite close genetic relatedness between Zoanthus aff. vietnamensis and Zoanthus kuroshio (Anthozoa: Hexacorallia). Zoolog Sci 2006 0.75
90 [Function of role of polycomb group complexes and possibility of novel molecular target in cancer]. Rinsho Ketsueki 2010 0.75
91 Guest editorial: Epigenetics of hematopoiesis and hematological malignancies. Int J Hematol 2012 0.75
92 Manipulation of hematopoietic stem cells for regenerative medicine. Anat Rec (Hoboken) 2013 0.75
93 [Epigenome in hematopoietic malignancies]. Rinsho Ketsueki 2011 0.75
94 [Overview]. Rinsho Ketsueki 2015 0.75
95 [Transcriptional regulation of spermatogonial stem cell self-renewal]. Tanpakushitsu Kakusan Koso 2007 0.75
96 [Role of the polycomb group proteins in the restriction of tumor development in hematological malignancies]. Rinsho Ketsueki 2013 0.75
97 Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells. Eur J Immunol 2011 0.75