Published in Cell Stem Cell on March 05, 2010
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell (2010) 4.18
Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis (2011) 1.70
Control of B cell development by the histone H2A deubiquitinase MYSM1. Immunity (2011) 1.63
BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol (2013) 1.26
Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. J Exp Med (2013) 1.23
Epigenetics: judge, jury and executioner of stem cell fate. Epigenetics (2012) 1.17
Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife (2014) 1.15
Hot topics in epigenetic mechanisms of aging: 2011. Aging Cell (2012) 1.09
Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet (2012) 1.07
E proteins and the regulation of early lymphocyte development. Immunol Rev (2010) 1.05
Epigenetic control of immunity. Cold Spring Harb Perspect Biol (2014) 1.05
Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors. PLoS One (2012) 1.01
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes. J Exp Med (2012) 1.00
Superior efficacy of a combined epigenetic therapy against human mantle cell lymphoma cells. Clin Cancer Res (2012) 0.99
Regulation of gene transcription by Polycomb proteins. Sci Adv (2015) 0.99
Bmi-1: At the crossroads of physiological and pathological biology. Genes Dis (2015) 0.95
The establishment of B versus T cell identity. Trends Immunol (2014) 0.92
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells. PLoS One (2012) 0.91
Context-dependent actions of Polycomb repressors in cancer. Oncogene (2015) 0.89
Bmi1 expression in long-term germ stem cells. Sci Rep (2014) 0.89
Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications. Med Res Rev (2015) 0.88
Epigenetic control of adult stem cell function. Nat Rev Mol Cell Biol (2016) 0.88
Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells. Blood (2011) 0.87
BMI-1 suppresses contact inhibition and stabilizes YAP in Ewing sarcoma. Oncogene (2010) 0.87
Polycomb genes, miRNA, and their deregulation in B-cell malignancies. Blood (2015) 0.87
MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells. Cell Rep (2013) 0.86
Regenerating the epigenome. EMBO Rep (2011) 0.86
Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia. Oncogene (2015) 0.86
The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First? Front Immunol (2014) 0.85
Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1. Proc Natl Acad Sci U S A (2013) 0.84
Bmi1 promotes erythroid development through regulating ribosome biogenesis. Stem Cells (2015) 0.84
Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function. Stem Cells Int (2015) 0.84
The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. Blood (2014) 0.84
Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Oncotarget (2015) 0.83
Transcriptional targeting by microRNA-polycomb complexes: a novel route in cell fate determination. Cell Cycle (2012) 0.83
The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function. Proc Natl Acad Sci U S A (2015) 0.81
Genome-wide and cell-specific epigenetic analysis challenges the role of polycomb in Drosophila spermatogenesis. PLoS Genet (2013) 0.81
Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication. J Exp Clin Cancer Res (2016) 0.80
The TIF1β-HP1 system maintains transcriptional integrity of hematopoietic stem cells. Stem Cell Reports (2014) 0.78
Dysregulation of the Bmi-1/p16(Ink⁴a) pathway provokes an aging-associated decline of submandibular gland function. Aging Cell (2015) 0.78
Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation. Oncogene (2014) 0.78
Concise review: hematopoietic stem cell aging and the prospects for rejuvenation. Stem Cells Transl Med (2014) 0.78
Epigenetics of hematopoiesis and hematological malignancies. Genes Dev (2016) 0.77
IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG. Oncogene (2015) 0.77
Role of Polycomb RYBP in Maintaining the B-1-to-B-2 B-Cell Lineage Switch in Adult Hematopoiesis. Mol Cell Biol (2015) 0.75
The putative tumor suppressor gene EphA7 is a novel BMI-1 target. Oncotarget (2016) 0.75
Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome. Leukemia (2016) 0.75
Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo. Development (2016) 0.75
Bridges between Cell Cycle Regulation and Self-Renewal Maintenance. Genes Cancer (2012) 0.75
The altered fate of aging satellite cells is determined by signaling and epigenetic changes. Front Genet (2015) 0.75
Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells. PLoS One (2016) 0.75
Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program. Genes Dev (2016) 0.75
Retrovirus-Mediated Expression of E2A-PBX1 Blocks Lymphoid Fate but Permits Retention of Myeloid Potential in Early Hematopoietic Progenitors. PLoS One (2015) 0.75
Multifaceted Interpretation of Colon Cancer Stem Cells. Int J Mol Sci (2017) 0.75
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
Frequent pathway mutations of splicing machinery in myelodysplasia. Nature (2011) 11.44
Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature (2009) 9.71
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 5.94
Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology (2006) 4.61
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet (2006) 4.43
KIF5B-RET fusions in lung adenocarcinoma. Nat Med (2012) 4.38
Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells. Cell (2010) 4.24
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell (2011) 4.04
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature (2009) 3.80
Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res (2003) 3.50
Adult T-cell progenitors retain myeloid potential. Nature (2008) 3.41
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity (2004) 3.25
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell (2012) 3.21
Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One (2011) 3.10
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med (2010) 2.98
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84
TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood (2008) 2.64
New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell (2008) 2.61
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med (2007) 2.50
Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2. J Immunol (2009) 2.44
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet (2003) 2.42
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Cell (2013) 2.42
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell (2009) 2.40
Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity (2004) 2.37
Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs. J Exp Med (2004) 2.31
Adult mouse hematopoietic stem cells: purification and single-cell assays. Nat Protoc (2006) 2.29
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors. Blood (2008) 2.24
Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity (2007) 2.23
Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J (2006) 2.18
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet (2013) 2.14
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev (2008) 2.12
Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell (2003) 2.11
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev Cell (2005) 2.11
E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J Exp Med (2006) 2.11
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med (2010) 2.08
The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development (2006) 2.04
An essential developmental checkpoint for production of the T cell lineage. Science (2010) 2.01
Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation. Cell Stem Cell (2013) 2.01
Essential and instructive roles of GATA factors in eosinophil development. J Exp Med (2002) 1.98
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med (2006) 1.94
Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). Int Immunol (2004) 1.92
Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli. Mol Microbiol (2004) 1.91
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91
Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol (2008) 1.89
Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver. J Cell Biol (2002) 1.88
Role of SOX17 in hematopoietic development from human embryonic stem cells. Blood (2012) 1.86
Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol (2004) 1.82
CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. J Exp Med (2003) 1.82
Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells. Cell Stem Cell (2013) 1.79
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell (2009) 1.78
Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J (2005) 1.77
Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis. Proc Natl Acad Sci U S A (2008) 1.75
Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics (2007) 1.73
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis. J Exp Med (2005) 1.72
Identification of a gene expression signature associated with pediatric AML prognosis. Blood (2003) 1.71
Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Proc Natl Acad Sci U S A (2013) 1.70
Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells. Blood (2011) 1.66
PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. Cell (2009) 1.65
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med (2008) 1.63
Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers. Hepatology (2013) 1.63
Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting. Diabetes (2004) 1.59
Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming. J Biol Chem (2010) 1.59
Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma. Mod Pathol (2007) 1.56
MOZ is essential for maintenance of hematopoietic stem cells. Genes Dev (2006) 1.56
Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients. Am J Gastroenterol (2006) 1.56
The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. Cancer Res (2008) 1.56
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood (2012) 1.56
In vitro-differentiated T/natural killer-cell progenitors derived from human CD34+ cells mature in the thymus. Blood (2009) 1.56
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction. Proc Natl Acad Sci U S A (2007) 1.55
Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood (2002) 1.53
Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells. Gastroenterology (2008) 1.53
Src activates Abl to augment Robo1 expression in order to promote tumor cell migration. Oncotarget (2010) 1.52