Published in EMBO J on May 12, 2005
Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin. Mol Cell Biol (2011) 1.70
The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice. Blood (2008) 1.63
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity. J Exp Med (2011) 1.36
Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR. Blood (2005) 1.34
Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice. J Clin Invest (2007) 1.30
Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS One (2008) 1.28
A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression. Cancer Cell (2014) 1.27
Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Blood (2009) 1.23
PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood (2011) 1.21
Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator. Mol Ther (2009) 1.13
Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media. PLoS Genet (2006) 1.11
Point mutations in two EVI1 Zn fingers abolish EVI1-GATA1 interaction and allow erythroid differentiation of murine bone marrow cells. Mol Cell Biol (2006) 1.09
Significant increase of self-renewal in hematopoietic cells after forced expression of EVI1. Blood Cells Mol Dis (2007) 1.04
Two types of precursor cells in a multipotential hematopoietic cell line. Proc Natl Acad Sci U S A (2005) 1.02
Molecular biology of myelodysplastic syndromes. Semin Oncol (2011) 1.01
The increased expression of integrin α6 (ITGA6) enhances drug resistance in EVI1(high) leukemia. PLoS One (2012) 1.01
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs. Blood (2012) 1.01
Common features of megakaryocytes and hematopoietic stem cells: what's the connection? J Cell Biochem (2009) 0.99
Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. J Leukoc Biol (2009) 0.99
Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. Proc Natl Acad Sci U S A (2012) 0.96
Overexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0/1 phase. Cell Cycle (2012) 0.92
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry (2011) 0.91
Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Oncogene (2014) 0.89
Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation. Mol Ther (2010) 0.89
EVI1 controls proliferation in acute myeloid leukaemia through modulation of miR-1-2. Br J Cancer (2010) 0.88
High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML. Leukemia (2015) 0.87
Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2. J Biol Chem (2010) 0.87
Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells. PLoS One (2012) 0.87
EVI1 promotes tumor growth via transcriptional repression of MS4A3. J Hematol Oncol (2015) 0.85
Intra-aortic clusters undergo endothelial to hematopoietic phenotypic transition during early embryogenesis. PLoS One (2012) 0.85
Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation. Drug Des Devel Ther (2015) 0.85
Evi1 forms a bridge between the epigenetic machinery and signaling pathways. Oncotarget (2011) 0.84
The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia. PLoS Genet (2016) 0.83
EVI1 and MDS1/EVI1 expression during primary human hematopoietic progenitor cell differentiation into various myeloid lineages. Anticancer Res (2012) 0.82
Expression of MECOM is associated with unfavorable prognosis in glioblastoma multiforme. Onco Targets Ther (2016) 0.82
Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia. PLoS One (2013) 0.81
Acetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosis. PLoS One (2011) 0.81
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One (2014) 0.80
Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they? Haematologica (2012) 0.80
Disease-specific motifs can be identified in circulating nucleic acids from live elk and cattle infected with transmissible spongiform encephalopathies. Nucleic Acids Res (2008) 0.79
Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia. Bone (2013) 0.78
Arsenic trioxide induces apoptosis in the THP1 cell line by downregulating EVI-1. Exp Ther Med (2014) 0.78
RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study. BMC Cancer (2015) 0.78
Monitoring Response and Resistance to the Novel Arsenical Darinaparsin in an AML Patient. Front Pharmacol (2013) 0.78
Zinc finger transcription factor ecotropic viral integration site 1 is induced by all-trans retinoic acid (ATRA) and acts as a dual modulator of the ATRA response. FEBS J (2009) 0.78
Gene profiling of the erythro- and megakaryoblastic leukaemias induced by the Graffi murine retrovirus. BMC Med Genomics (2010) 0.76
The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans retinoic acid. Cell Cycle (2014) 0.76
Embryonic Hematopoietic Progenitor Cells Reside in Muscle before Bone Marrow Hematopoiesis. PLoS One (2015) 0.76
Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence. EMBO J (2016) 0.75
Bridges between Cell Cycle Regulation and Self-Renewal Maintenance. Genes Cancer (2012) 0.75
Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls. PLoS One (2017) 0.75
Functional features of EVI1 and EVI1Δ324 isoforms of MECOM gene in genome-wide transcription regulation and oncogenicity. Oncogene (2015) 0.75
lncRNA requirements for mouse acute myeloid leukemia and normal differentiation. Elife (2017) 0.75
'Green mice' as a source of ubiquitous green cells. FEBS Lett (1997) 17.06
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell (1996) 9.74
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell (1991) 6.14
Definitive hematopoiesis is autonomously initiated by the AGM region. Cell (1996) 5.75
Use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol Cell Biol (2001) 5.61
Erythroid colony formation in cultures of mouse and human bone marrow: analysis of the requirement for erythropoietin by gel filtration and affinity chromatography on agarose-concanavalin A. J Cell Physiol (1974) 4.92
HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression. Science (1982) 4.07
Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell (1988) 3.75
A role for hematopoietic stem cells in promoting angiogenesis. Cell (2000) 3.25
The genetic program of hematopoietic stem cells. Science (2000) 2.85
Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity (1998) 2.46
Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity (1997) 2.27
The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3. Nature (1998) 2.18
Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev (1998) 2.16
Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J (1994) 2.12
Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors. Mol Cell Biol (1988) 1.95
Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26. Proc Natl Acad Sci U S A (1992) 1.90
Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus. Proc Natl Acad Sci U S A (1995) 1.89
Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis. Blood (1999) 1.77
Differential gene expression profiling of adult murine hematopoietic stem cells. Blood (2002) 1.69
Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor. Mol Cell Biol (1992) 1.61
Alternative promoters regulate transcription of the mouse GATA-2 gene. J Biol Chem (1998) 1.53
The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development. Mech Dev (1997) 1.49
The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region. Blood (1999) 1.44
Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis. Proc Natl Acad Sci U S A (2003) 1.42
Patterns of Evi-1 expression in embryonic and adult tissues suggest that Evi-1 plays an important regulatory role in mouse development. Development (1991) 1.35
Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos. Blood (2003) 1.34
Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene. Proc Natl Acad Sci U S A (1993) 1.31
Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene. Mol Cell Biol (1990) 1.20
The Evi-1 zinc finger myeloid transforming gene is normally expressed in the kidney and in developing oocytes. Oncogene (1990) 1.15
Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain. J Biol Chem (1994) 1.13
EVI-1 zinc finger protein works as a transcriptional activator via binding to a consensus sequence of GACAAGATAAGATAAN1-28 CTCATCTTC. Oncogene (1995) 0.97
EVI1 is expressed in megakaryocyte cell lineage and enforced expression of EVI1 in UT-7/GM cells induces megakaryocyte differentiation. Biochem Biophys Res Commun (2002) 0.94
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell (2004) 12.67
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med (2006) 7.62
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature (2004) 7.21
Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med (2007) 6.98
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 5.94
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell (2010) 4.90
Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology (2006) 4.61
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab (2006) 4.33
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell (2007) 4.31
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature (2010) 4.12
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell (2011) 4.04
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med (2009) 4.03
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med (2005) 4.02
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med (2006) 3.78
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature (2004) 3.77
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med (2012) 3.33
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell (2008) 2.69
Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med (2009) 2.66
A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med (2009) 2.65
TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood (2008) 2.64
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem (2003) 2.59
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell (2013) 2.58
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. Cell Stem Cell (2011) 2.58
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab (2011) 2.42
Human placenta-derived cells have mesenchymal stem/progenitor cell potential. Stem Cells (2004) 2.38
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell (2012) 2.36
M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med (2009) 2.29
Identification and characterization of stem cells in prepubertal spermatogenesis in mice. Dev Biol (2003) 2.24
Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res (2007) 2.22
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J (2006) 2.18
Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest. Cell Stem Cell (2008) 2.14
The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends Cardiovasc Med (2008) 2.14
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab (2009) 2.13
Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Dev Biol (2004) 2.13
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev (2008) 2.12
The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity. Cancer Cell (2006) 2.09
The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage. Development (2006) 2.07
Essential and instructive roles of GATA factors in eosinophil development. J Exp Med (2002) 1.98
Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells. Proc Natl Acad Sci U S A (2006) 1.96
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med (2006) 1.94
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment. Arterioscler Thromb Vasc Biol (2008) 1.90
The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential. Development (2006) 1.88
Role of SOX17 in hematopoietic development from human embryonic stem cells. Blood (2012) 1.86
The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med (2005) 1.85
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med (2011) 1.79
Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells. Blood (2010) 1.78
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell (2009) 1.78
Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann N Y Acad Sci (2007) 1.78
Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4. Cancer Res (2003) 1.78
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood (2005) 1.75
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis. J Exp Med (2005) 1.72
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood (2005) 1.71
Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Biochem Biophys Res Commun (2007) 1.66
Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells. Blood (2011) 1.66
R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development (2008) 1.66
Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J Exp Med (2002) 1.63
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes. J Immunol (2007) 1.62
Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med (2005) 1.61
The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases. Cell Rep (2013) 1.61
Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway. Invest Ophthalmol Vis Sci (2007) 1.59
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med (2010) 1.59
MOZ is essential for maintenance of hematopoietic stem cells. Genes Dev (2006) 1.56
The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques. Arterioscler Thromb Vasc Biol (2010) 1.56
The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. Cancer Res (2008) 1.56
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood (2012) 1.56
Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B. Atherosclerosis (2011) 1.55
Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood (2002) 1.53
A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation. Blood (2003) 1.49
Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell (2010) 1.48
Angiopoietin-like protein 2 is a potent hemangiogenic and lymphangiogenic factor in corneal inflammation. Invest Ophthalmol Vis Sci (2013) 1.47
Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochem Biophys Res Commun (2007) 1.45
Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. J Exp Med (2005) 1.44
Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. Mol Biol Cell (2007) 1.44
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat Genet (2002) 1.44
Hematopoietic cells regulate the angiogenic switch during tumorigenesis. Blood (2004) 1.44
Plasma platelet-derived microparticles in patients with connective tissue diseases. J Rheumatol (2011) 1.44
Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation. Gastroenterology (2007) 1.42
Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status. Am J Physiol Endocrinol Metab (2002) 1.41
Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ Res (2004) 1.40
Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy. Trends Mol Med (2005) 1.40
Cancer stem cells and their niche. Cancer Sci (2009) 1.39
Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood (2002) 1.39
Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J Biol Chem (2009) 1.39
Nifedipine increases energy expenditure by increasing PGC-1α expression in skeletal muscle. Hypertens Res (2011) 1.38