The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats.

PubWeight™: 0.93‹?›

🔗 View Article (PMID 23172753)

Published in Ann Rheum Dis on November 21, 2012

Authors

Markus H Hoffmann1, Heiko Bruns, Liselotte Bäckdahl, Petra Neregård, Birgit Niederreiter, Martin Herrmann, Anca Irinel Catrina, Birgitta Agerberth, Rikard Holmdahl

Author Affiliations

1: Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. markus.hoffmann@uk-erlangen.de

Articles citing this

Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J Immunol (2013) 1.15

Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity. Semin Immunopathol (2013) 1.09

Role of neutrophils in systemic autoimmune diseases. Arthritis Res Ther (2013) 1.05

The human antimicrobial peptide LL-37, but not the mouse ortholog, mCRAMP, can stimulate signaling by poly(I:C) through a FPRL1-dependent pathway. J Biol Chem (2013) 0.94

Modulation of neutrophil NETosis: interplay between infectious agents and underlying host physiology. Semin Immunopathol (2013) 0.91

Neutrophil crawling in capillaries; a novel immune response to Staphylococcus aureus. PLoS Pathog (2014) 0.85

Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells. J Steroid Biochem Mol Biol (2014) 0.81

No evidence of pathogenic involvement of cathelicidins in patient cohorts and mouse models of lupus and arthritis. PLoS One (2014) 0.80

Inflammatory response and neuronal necrosis in rats with cerebral ischemia. Neural Regen Res (2014) 0.80

Inflammatory etiopathogenesis of systemic lupus erythematosus: an update. J Inflamm Res (2015) 0.80

Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat. PLoS One (2016) 0.78

Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis. J Istanb Univ Fac Dent (2017) 0.75

Characterization of Circulating Low-Density Neutrophils Intrinsic Properties in Healthy and Asthmatic Horses. Sci Rep (2017) 0.75

Gingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis. Clin Oral Investig (2016) 0.75

Articles by these authors

(truncated to the top 100)

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37

Progress and prospects in rat genetics: a community view. Nat Genet (2008) 6.01

The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med (2006) 5.20

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A (2010) 5.05

Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum (2006) 5.03

An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res (2008) 4.84

Rheumatoid arthritis. Lancet (2009) 4.69

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest (2012) 4.31

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nat Med (2012) 3.27

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med (2011) 3.27

Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products. J Immunol (2005) 3.05

Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med (2008) 2.97

The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol (2010) 2.93

Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum (2002) 2.52

Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Res (2007) 2.50

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet (2002) 2.46

Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci U S A (2004) 2.38

Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients. Arthritis Rheum (2010) 2.27

Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice. Proc Natl Acad Sci U S A (2008) 2.07

12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity (2012) 2.06

Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus. Arthritis Rheum (2009) 2.04

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood (2002) 1.90

Clearance deficiency and systemic lupus erythematosus (SLE). J Autoimmun (2007) 1.87

Antimicrobial polypeptides of human vernix caseosa and amniotic fluid: implications for newborn innate defense. Pediatr Res (2003) 1.86

Neutrophil-derived cathelicidin protects from neointimal hyperplasia. Sci Transl Med (2011) 1.84

CD46 in meningococcal disease. Science (2003) 1.84

Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum (2006) 1.83

Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol (2003) 1.81

Early structural changes in cartilage and bone are required for the attachment and invasion of inflamed synovial tissue during destructive inflammatory arthritis. Ann Rheum Dis (2012) 1.81

Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia. Blood (2014) 1.80

Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Res (2005) 1.76

Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc Natl Acad Sci U S A (2006) 1.75

The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans. Eur J Immunol (2005) 1.74

Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species. J Clin Invest (2007) 1.71

Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice. Arthritis Rheum (2011) 1.71

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med (2009) 1.68

IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis. J Immunol (2003) 1.68

Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum (2009) 1.65

Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis. Arthritis Rheum (2006) 1.63

T cell surface redox levels determine T cell reactivity and arthritis susceptibility. Proc Natl Acad Sci U S A (2006) 1.63

SLE--a disease of clearance deficiency? Rheumatology (Oxford) (2005) 1.59

Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces. J Cell Sci (2011) 1.59

Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum. Proc Natl Acad Sci U S A (2006) 1.58

Factors masking HMGB1 in human serum and plasma. J Leukoc Biol (2006) 1.56

Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol (2006) 1.55

Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis. Proc Natl Acad Sci U S A (2002) 1.55

Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile. Ann Rheum Dis (2012) 1.53

The evolution of human anti-double-stranded DNA autoantibodies. Proc Natl Acad Sci U S A (2005) 1.53

Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis. Eur J Immunol (2005) 1.51

The antimicrobial peptide LL-37 inhibits HIV-1 replication. Curr HIV Res (2007) 1.50

NOX2 complex-derived ROS as immune regulators. Antioxid Redox Signal (2011) 1.50

Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat Med (2009) 1.50

The protective role of ROS in autoimmune disease. Trends Immunol (2009) 1.49

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species. Proc Natl Acad Sci U S A (2010) 1.47

Therapeutic cleavage of IgG: new avenues for treating inflammation. Trends Immunol (2008) 1.46

Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum (2013) 1.46

Rheumatoid arthritis and the complement system. Ann Med (2007) 1.42

Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection. Infect Immun (2006) 1.41

Uropathogenic Escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide LL-37. PLoS Pathog (2010) 1.41

Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen-induced arthritis in the mouse. Arthritis Rheum (2002) 1.39

An optimized conditional suicide switch using doxycycline-dependent expression of human tBid. Cancer Biol Ther (2005) 1.39

In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic Biol Med (2009) 1.35

Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open (2012) 1.34

Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB. Eur J Immunol (2003) 1.32

Endoglycosidase treatment abrogates IgG arthritogenicity: importance of IgG glycosylation in arthritis. Eur J Immunol (2007) 1.32

Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis. Arthritis Res Ther (2006) 1.32

Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet (2013) 1.30

Antimicrobial peptides important in innate immunity. FEBS J (2011) 1.30

Association of arthritis with a gene complex encoding C-type lectin-like receptors. Arthritis Rheum (2007) 1.29

Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis. Eur J Immunol (2004) 1.26

Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells. Apoptosis (2010) 1.26

Impaired clearance of dying cells in systemic lupus erythematosus. Autoimmun Rev (2004) 1.25

Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages. J Clin Invest (2008) 1.25

Basal metabolic rate and the evolution of the adaptive immune system. Proc Biol Sci (2002) 1.25

Antimicrobial peptides in the first line defence of human colon mucosa. Peptides (2003) 1.24

The role of the multifunctional peptide LL-37 in host defense. Front Biosci (2008) 1.23

Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37. Cell Microbiol (2005) 1.22

Cathelicidin LL-37 in severe Streptococcus pyogenes soft tissue infections in humans. Infect Immun (2008) 1.21

Phenylbutyrate induces antimicrobial peptide expression. Antimicrob Agents Chemother (2009) 1.21

Sodium overload and water influx activate the NALP3 inflammasome. J Biol Chem (2010) 1.20

Animal models for arthritis: innovative tools for prevention and treatment. Ann Rheum Dis (2011) 1.20

Ethanol prevents development of destructive arthritis. Proc Natl Acad Sci U S A (2006) 1.18

Antibodies to citrullinated proteins: molecular interactions and arthritogenicity. Immunol Rev (2010) 1.17

Expression and activity of beta-defensins and LL-37 in the developing human lung. J Immunol (2005) 1.17

Autoimmunity and chronic inflammation - two clearance-related steps in the etiopathogenesis of SLE. Autoimmun Rev (2010) 1.17

Blocking of experimental arthritis by cleavage of IgG antibodies in vivo. Arthritis Rheum (2007) 1.17

Structural changes and antibody enrichment in the lungs are early features of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol (2014) 1.16

Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels. Arthritis Rheum (2005) 1.15

Pristane, a non-antigenic adjuvant, induces MHC class II-restricted, arthritogenic T cells in the rat. J Immunol (2006) 1.15

Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo. J Exp Med (2004) 1.15

Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. Arthritis Res Ther (2004) 1.15

A functional methylome map of ulcerative colitis. Genome Res (2012) 1.15

Cadaveric study on static medial patellar stabilizers: the dynamizing role of the vastus medialis obliquus on medial patellofemoral ligament. Knee Surg Sports Traumatol Arthrosc (2005) 1.14

Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis. Arthritis Rheum (2010) 1.14

The role of collagen antibodies in mediating arthritis. Mod Rheumatol (2008) 1.13

Efficient promotion of collagen antibody induced arthritis (CAIA) using four monoclonal antibodies specific for the major epitopes recognized in both collagen induced arthritis and rheumatoid arthritis. J Immunol Methods (2005) 1.13

Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients. Arthritis Res Ther (2006) 1.13

Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides. Arthritis Res Ther (2012) 1.13

A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res (2008) 1.13