Published in J Immunol on February 01, 2005
A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med (2006) 2.61
Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc (2011) 1.48
Role of innate host defenses in susceptibility to early-onset neonatal sepsis. Clin Perinatol (2010) 1.39
Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid. J Immunol (2008) 1.22
Host defense peptides in the oral cavity and the lung: similarities and differences. J Dent Res (2008) 1.19
Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity. Antimicrob Agents Chemother (2010) 1.14
Developmental switch of intestinal antimicrobial peptide expression. J Exp Med (2008) 1.11
Human respiratory syncytial virus A2 strain replicates and induces innate immune responses by respiratory epithelia of neonatal lambs. Int J Exp Pathol (2009) 1.08
LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs. PLoS One (2011) 1.08
Ocular surface expression and in vitro activity of antimicrobial peptides. Curr Eye Res (2007) 1.06
Toll-like receptor activation modulates antimicrobial peptide expression by ocular surface cells. Exp Eye Res (2010) 1.00
Effect of corticosteroids and neuropeptides on the expression of defensins in bovine tracheal epithelial cells. Infect Immun (2006) 0.93
Preterm birth, intrauterine infection, and fetal inflammation. Front Immunol (2014) 0.91
A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media. Mol Immunol (2006) 0.89
The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets. Infect Immun (2006) 0.89
Fusobacterium nucleatum-associated beta-defensin inducer (FAD-I): identification, isolation, and functional evaluation. J Biol Chem (2010) 0.88
Changes in salivary antimicrobial peptides, immunoglobulin A and cortisol after prolonged strenuous exercise. Eur J Appl Physiol (2011) 0.87
Silencing airway epithelial cell-derived hepcidin exacerbates sepsis induced acute lung injury. Crit Care (2014) 0.82
Antimicrobial peptide response to group B Streptococcus in human extraplacental membranes in culture. Placenta (2013) 0.82
Immune vulnerability of infants to tuberculosis. Clin Dev Immunol (2013) 0.82
Endotoxin-directed innate immunity in tracheal aspirates of mechanically ventilated human neonates. Pediatr Res (2009) 0.81
Lamb model of respiratory syncytial virus-associated lung disease: insights to pathogenesis and novel treatments. ILAR J (2014) 0.80
Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells. Virology (2015) 0.80
Cathelicidin impact on inflammatory cells. Cent Eur J Immunol (2015) 0.79
Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation. Pediatr Res (2012) 0.78
Neonatal mucosal immunology. Mucosal Immunol (2016) 0.77
Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities. Front Immunol (2016) 0.77
Defensins and sepsis. Biomed Res Int (2014) 0.76
FAD-I, a Fusobacterium nucleatum Cell Wall-Associated Diacylated Lipoprotein That Mediates Human Beta Defensin 2 Induction through Toll-Like Receptor-1/2 (TLR-1/2) and TLR-2/6. Infect Immun (2016) 0.75
Effects of yoga exercise on salivary beta-defensin 2. Eur J Appl Physiol (2013) 0.75
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell (2008) 11.24
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (2008) 6.28
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med (2006) 5.20
Current prospects for RNA interference-based therapies. Nat Rev Genet (2011) 3.63
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36
Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nat Med (2012) 3.27
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature (2012) 2.94
Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature (2011) 2.94
A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med (2006) 2.61
Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A (2002) 2.56
The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53
Cytokine-mediated regulation of antimicrobial proteins. Nat Rev Immunol (2008) 2.46
Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. J Clin Invest (2008) 2.21
The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. J Biol Chem (2001) 2.20
Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A (2014) 2.17
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A (2011) 2.12
The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med (2011) 2.01
Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. Am J Respir Crit Care Med (2010) 1.94
Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events. J Virol (2007) 1.93
Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms. J Clin Microbiol (2004) 1.91
Correlation between beta-defensin expression and induction profiles in gingival keratinocytes. Mol Immunol (2004) 1.90
Antimicrobial polypeptides of human vernix caseosa and amniotic fluid: implications for newborn innate defense. Pediatr Res (2003) 1.86
Neutrophil-derived cathelicidin protects from neointimal hyperplasia. Sci Transl Med (2011) 1.84
CD46 in meningococcal disease. Science (2003) 1.84
Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents (2003) 1.84
[beta]-defensins in lung host defense. Annu Rev Physiol (2002) 1.80
Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc Natl Acad Sci U S A (2006) 1.75
Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2. Am J Physiol Lung Cell Mol Physiol (2004) 1.64
The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol Lung Cell Mol Physiol (2010) 1.61
Innate immune functions of the airway epithelium. Contrib Microbiol (2008) 1.57
Haemophilus influenzae forms biofilms on airway epithelia: implications in cystic fibrosis. Am J Respir Crit Care Med (2006) 1.56
The antimicrobial peptide LL-37 inhibits HIV-1 replication. Curr HIV Res (2007) 1.50
Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc (2011) 1.48
miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production. Am J Respir Crit Care Med (2014) 1.45
Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha. J Virol (2003) 1.45
PLUNC is a novel airway surfactant protein with anti-biofilm activity. PLoS One (2010) 1.44
Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection. Infect Immun (2006) 1.41
Uropathogenic Escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide LL-37. PLoS Pathog (2010) 1.41
Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation. Infect Immun (2002) 1.40
piggyBac transposase tools for genome engineering. Proc Natl Acad Sci U S A (2013) 1.35
Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open (2012) 1.34
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest (2013) 1.30
Antimicrobial peptides important in innate immunity. FEBS J (2011) 1.30
CCL20 is an inducible product of human airway epithelia with innate immune properties. Am J Respir Cell Mol Biol (2003) 1.28
Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection. J Virol (2014) 1.25
Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages. J Clin Invest (2008) 1.25
Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins. J Immunol (2003) 1.24
Antimicrobial peptides in the first line defence of human colon mucosa. Peptides (2003) 1.24
The role of the multifunctional peptide LL-37 in host defense. Front Biosci (2008) 1.23
Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology (2011) 1.22
Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37. Cell Microbiol (2005) 1.22
Cathelicidin LL-37 in severe Streptococcus pyogenes soft tissue infections in humans. Infect Immun (2008) 1.21
Phenylbutyrate induces antimicrobial peptide expression. Antimicrob Agents Chemother (2009) 1.21
Integration site choice of a feline immunodeficiency virus vector. J Virol (2006) 1.20
Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors. J Virol (2009) 1.20
Measles virus preferentially transduces the basolateral surface of well-differentiated human airway epithelia. J Virol (2002) 1.18
Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer. J Virol (2005) 1.18
In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins. J Virol (2002) 1.16
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol (2009) 1.15
Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer. Blood (2005) 1.14
ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol (2005) 1.14
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides. Protein Eng (2002) 1.14
PLUNC is a secreted product of neutrophil granules. J Leukoc Biol (2008) 1.13
Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth. Proc Natl Acad Sci U S A (2010) 1.12
Expression of beta-defensins in gingival health and in periodontal disease. J Oral Pathol Med (2004) 1.12
MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state. Am J Respir Cell Mol Biol (2008) 1.11
A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A. Mol Ther (2011) 1.11
CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia. Am J Physiol Lung Cell Mol Physiol (2005) 1.09
Involvement of the antimicrobial peptide LL-37 in human atherosclerosis. Arterioscler Thromb Vasc Biol (2006) 1.09
SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection. Am J Pathol (2013) 1.08
Advances in cell and gene-based therapies for cystic fibrosis lung disease. Mol Ther (2012) 1.08
A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A (2012) 1.07
Lentivirus vector can be readministered to nasal epithelia without blocking immune responses. J Virol (2008) 1.07
Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1. FASEB J (2011) 1.07
Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. Am J Physiol Lung Cell Mol Physiol (2009) 1.06
Viral vector-mediated and cell-based therapies for treatment of cystic fibrosis. Mol Ther (2007) 1.05
Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy. PLoS One (2011) 1.04
Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis. Laryngoscope (2012) 1.02
Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia. Respir Res (2009) 1.02
Person-to-person spread of the MERS coronavirus--an evolving picture. N Engl J Med (2013) 1.02
Antibacterial peptides in stimulated human granulocytes: characterization of ubiquitinated histone H1A. Eur J Biochem (2002) 1.02
PLUNC: a multifunctional surfactant of the airways. Biochem Soc Trans (2011) 1.01
Large-scale gene discovery in human airway epithelia reveals novel transcripts. Physiol Genomics (2004) 1.01
Human-like immune responses in CD46 transgenic mice. J Immunol (2005) 1.00
Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections. J Leukoc Biol (2012) 0.99
Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. Am J Respir Cell Mol Biol (2011) 0.97
Antimicrobial components of the neonatal gut affected upon colonization. Pediatr Res (2007) 0.96
Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. J Virol (2009) 0.96
Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections. J Virol (2012) 0.95
Viscoelastic gel formulations enhance airway epithelial gene transfer with viral vectors. Am J Respir Cell Mol Biol (2005) 0.95
Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. Am J Respir Crit Care Med (2012) 0.94