Published in J Natl Cancer Inst on November 21, 2012
Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med (2013) 7.72
Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication. J Natl Cancer Inst (2013) 4.37
Aspirin use and risk of colorectal cancer according to BRAF mutation status. JAMA (2013) 2.26
Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int J Mol Sci (2013) 2.00
Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Mod Pathol (2013) 1.95
Epigenetics and colorectal cancer pathogenesis. Cancers (Basel) (2013) 1.33
Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression. Mod Pathol (2014) 1.16
Promoter hypermethylation of tumour suppressor genes as potential biomarkers in colorectal cancer. Int J Mol Sci (2015) 1.09
Family history of colorectal cancer in BRAF p.V600E-mutated colorectal cancer cases. Cancer Epidemiol Biomarkers Prev (2013) 1.05
Familial colorectal cancer, beyond Lynch syndrome. Clin Gastroenterol Hepatol (2013) 1.03
Epigenetic status of LINE-1 predicts clinical outcome in early-stage rectal cancer. Br J Cancer (2013) 1.01
Statistical methods for studying disease subtype heterogeneity. Stat Med (2015) 1.01
Tumor LINE-1 methylation level and microsatellite instability in relation to colorectal cancer prognosis. J Natl Cancer Inst (2014) 1.00
Differences in DNA methylation by extent of breast cancer family history in unaffected women. Epigenetics (2013) 0.92
Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer. PLoS One (2014) 0.83
Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region. Am J Clin Nutr (2014) 0.81
Tumor LINE-1 methylation level and colorectal cancer location in relation to patient survival. Oncotarget (2016) 0.81
Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives. Gut (2014) 0.80
IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. World J Gastroenterol (2014) 0.80
LINE-1 in cancer: multifaceted functions and potential clinical implications. Genet Med (2015) 0.79
Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer. BMC Cancer (2016) 0.76
DNA Methylation Identifies Loci Distinguishing Hereditary Nonpolyposis Colorectal Cancer Without Germ-Line MLH1/MSH2 Mutation from Sporadic Colorectal Cancer. Clin Transl Gastroenterol (2016) 0.75
Genomics, Telomere Length, Epigenetics, and Metabolomics in the Nurses' Health Studies. Am J Public Health (2016) 0.75
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet (2006) 13.63
Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med (2007) 9.04
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
The impact of retrotransposons on human genome evolution. Nat Rev Genet (2009) 8.08
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res (2004) 7.92
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut (2008) 6.26
A prospective study of family history and the risk of colorectal cancer. N Engl J Med (1994) 6.12
Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes. Nature (2004) 5.15
Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome. JAMA (2011) 4.84
Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn (2006) 4.68
A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol (2001) 4.61
Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut (2010) 4.01
Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA (2005) 3.99
Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review. J Natl Cancer Inst (2012) 3.87
A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer. J Natl Cancer Inst (2008) 3.54
Clinically relevant changes in family history of cancer over time. JAMA (2011) 3.18
Epigenetics and colorectal cancer. Nat Rev Gastroenterol Hepatol (2011) 3.15
Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer. J Natl Cancer Inst (2006) 3.08
Does this patient have a family history of cancer? An evidence-based analysis of the accuracy of family cancer history. JAMA (2004) 2.99
LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS One (2007) 2.99
Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PLoS One (2008) 2.92
Cancer immunology--analysis of host and tumor factors for personalized medicine. Nat Rev Clin Oncol (2011) 2.90
LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Int J Cancer (2008) 2.87
Colorectal cancer: a tale of two sides or a continuum? Gut (2012) 2.85
Cancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear family. PLoS Med (2004) 2.67
Risks of Lynch syndrome cancers for MSH6 mutation carriers. J Natl Cancer Inst (2009) 2.56
A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. Gastroenterology (2009) 2.56
Cigarette smoking and colorectal cancer risk by molecularly defined subtypes. J Natl Cancer Inst (2010) 2.38
Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology. J Natl Cancer Inst (2010) 2.35
Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer. JAMA (2011) 2.28
NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology. J Natl Compr Canc Netw (2011) 2.24
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice. Oncogene (2007) 2.22
Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis. Eur J Cancer (2005) 2.16
Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells. J Mol Diagn (2010) 2.15
Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res (2006) 2.15
Family history of cancer and colon cancer risk: the Utah Population Database. J Natl Cancer Inst (1994) 2.14
Confirmation of family cancer history reported in a population-based survey. J Natl Cancer Inst (2011) 2.13
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci U S A (2005) 2.11
Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status. J Natl Cancer Inst (2010) 1.99
Reliability of self-reported family history of cancer in a large case-control study of lymphoma. J Natl Cancer Inst (2006) 1.68
How many molecular subtypes? Implications of the unique tumor principle in personalized medicine. Expert Rev Mol Diagn (2012) 1.66
CpG island methylation in colorectal cancer: past, present and future. Patholog Res Int (2011) 1.62
DNA methylation predicts recurrence from resected stage III proximal colon cancer. Cancer (2010) 1.55
Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer. Gut (2009) 1.54
Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. Mol Cancer (2010) 1.50
Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology (2010) 1.46
The CpG island methylator phenotype in colorectal cancer: progress and problems. Biochim Biophys Acta (2011) 1.43
Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer. Cancer Res (2003) 1.36
Relevance, pathogenesis, and testing algorithm for mismatch repair-defective colorectal carcinomas: a report of the association for molecular pathology. J Mol Diagn (2012) 1.34
Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications. Clin Epigenetics (2011) 1.26
Population prevalence of familial cancer and common hereditary cancer syndromes. The 2005 California Health Interview Survey. Genet Med (2010) 1.26
A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer. PLoS One (2012) 1.24
Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations. Oncogene (2005) 1.22
Body mass index and risk of colorectal cancer according to fatty acid synthase expression in the nurses' health study. J Natl Cancer Inst (2012) 1.19
Hypomethylation of intragenic LINE-1 represses transcription in cancer cells through AGO2. PLoS One (2011) 1.18
Implications of familial colorectal cancer risk profiles and microsatellite instability status. J Clin Oncol (2009) 1.08
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer. Cancer Causes Control (2010) 1.04
Clinical outcomes of patients with microsatellite-unstable colorectal carcinomas depend on L1 methylation level. Ann Surg Oncol (2012) 1.04
Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X. Mod Pathol (2012) 1.01
The CpG island methylator phenotype is not associated with a personal or family history of cancer. Cancer Res (2004) 0.98
Commentary: Lifestyle factors and colorectal cancer microsatellite instability--molecular pathological epidemiology science, based on unique tumour principle. Int J Epidemiol (2012) 0.98
Recall bias in subjective reports of familial cancer. Epidemiology (1990) 0.96
Recording, interpreting, and updating the family history of cancer: implications for cancer prevention. JAMA (2011) 0.95
Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22. PLoS One (2012) 0.93
Epigenetic biomarkers in colorectal cancer diagnostics. Expert Rev Mol Diagn (2012) 0.92
The association of tumor microsatellite instability phenotype with family history of colorectal cancer. Cancer Epidemiol Biomarkers Prev (2009) 0.91
Associations between family history of colorectal cancer and genetic alterations in tumors. Int J Cancer (2002) 0.90
Family history and risk of colorectal cancer in the multiethnic population of Hawaii. Am J Epidemiol (1996) 0.89
Assessing disease risk in genome-wide association studies using family history. Epidemiology (2012) 0.80
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med (2007) 20.19
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Easy SAS calculations for risk or prevalence ratios and differences. Am J Epidemiol (2005) 17.45
A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol (2003) 12.24
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr (2006) 10.95
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature (2012) 10.39
Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med (2007) 9.04
Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst (2004) 8.77
Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med (2013) 7.72
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med (2012) 7.47
Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst (2006) 7.19
Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension (2007) 6.99
Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr (2002) 6.96
Aspirin use and survival after diagnosis of colorectal cancer. JAMA (2009) 6.93
Weekly paclitaxel in the adjuvant treatment of breast cancer. N Engl J Med (2008) 6.54
Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney Int (2004) 6.32
Insulin-like growth factors and neoplasia. Nat Rev Cancer (2004) 6.29
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut (2008) 6.26
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature (2008) 6.24
A prospective study of sleep duration and mortality risk in women. Sleep (2004) 6.11
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med (2005) 6.04
Sensitive sequencing method for KRAS mutation detection by Pyrosequencing. J Mol Diagn (2005) 6.00
Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA (2005) 5.95
Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr (2009) 5.79
A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med (2004) 5.68
Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199. J Clin Oncol (2014) 5.61
Alternative dietary indices both strongly predict risk of chronic disease. J Nutr (2012) 5.60
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest (2005) 5.48
Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med (2006) 5.24
Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol (2006) 5.22
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst (2009) 4.72
Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn (2006) 4.68
Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet (2013) 4.61
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol (2009) 4.54
Aspirin intake and survival after breast cancer. J Clin Oncol (2010) 4.50
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet (2013) 4.48
Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med (2003) 4.40
Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem (2003) 4.38
Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication. J Natl Cancer Inst (2013) 4.37
Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol (2006) 4.27
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem (2008) 4.16
A prospective study of long-term intake of dietary fiber and risk of Crohn's disease and ulcerative colitis. Gastroenterology (2013) 4.06
Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med (2004) 4.05
Comparison of risk factors for colon and rectal cancer. Int J Cancer (2004) 4.03
Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut (2010) 4.01
High school dietary dairy intake and teenage acne. J Am Acad Dermatol (2005) 4.00
CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. J Mol Diagn (2006) 3.98
Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst (2006) 3.96
Association of nut consumption with total and cause-specific mortality. N Engl J Med (2013) 3.94
Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med (2007) 3.91
Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. PLoS Med (2011) 3.88
Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA (2005) 3.88
Higher predicted vitamin D status is associated with reduced risk of Crohn's disease. Gastroenterology (2011) 3.84