Published in PLoS Med on December 01, 2007
Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16
Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? Hum Genet (2007) 3.13
Mendelian randomisation and causal inference in observational epidemiology. PLoS Med (2008) 3.12
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res (2011) 2.83
Point-counterpoint. The triumph of the null hypothesis: epidemiology in an age of change. Int J Epidemiol (2008) 2.67
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Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. PLoS Med (2010) 2.20
Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable. PLoS Med (2008) 2.16
Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. Int J Epidemiol (2012) 2.12
Risk of esophageal adenocarcinoma decreases with height, based on consortium analysis and confirmed by Mendelian randomization. Clin Gastroenterol Hepatol (2014) 2.07
A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Hum Mol Genet (2009) 2.02
Do X-ray-occult fractures play a role in chronic pain following a whiplash injury? Eur Spine J (2014) 1.98
Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet (2011) 1.82
Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study. J Natl Cancer Inst (2014) 1.81
Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study. Eur Heart J (2008) 1.76
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med (2013) 1.70
Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health. Genes Nutr (2010) 1.65
Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. Am J Clin Nutr (2010) 1.61
Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. Int J Epidemiol (2011) 1.61
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). Hum Mol Genet (2014) 1.58
G = E: What GWAS Can Tell Us about the Environment. PLoS Genet (2016) 1.57
C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. Int J Obes (Lond) (2010) 1.53
Dependence of deodorant usage on ABCC11 genotype: scope for personalized genetics in personal hygiene. J Invest Dermatol (2013) 1.51
Mendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancer. Cancer Prev Res (Phila) (2009) 1.51
Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase. J Am Coll Cardiol (2016) 1.49
Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus. Hum Genet (2013) 1.48
The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study. BMJ (2009) 1.43
A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women. Hum Mol Genet (2009) 1.32
The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. PLoS One (2008) 1.28
Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. J Clin Endocrinol Metab (2009) 1.27
Association between a high-risk autism locus on 5p14 and social communication spectrum phenotypes in the general population. Am J Psychiatry (2010) 1.23
Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis. PLoS Med (2014) 1.19
Is replication the gold standard for validating genome-wide association findings? PLoS One (2008) 1.18
Is epidemiology ready for epigenetics? Int J Epidemiol (2012) 1.17
Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. Hum Mol Genet (2009) 1.17
Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effects. Am J Epidemiol (2012) 1.15
Placing epidemiological results in the context of multiplicity and typical correlations of exposures. J Epidemiol Community Health (2014) 1.11
Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study. PLoS One (2012) 1.11
Adipokine genes and prostate cancer risk. Int J Cancer (2009) 1.10
Mendelian randomization in nutritional epidemiology. Nutr Rev (2009) 1.10
Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study. PLoS One (2008) 1.09
Epigenome-wide Association Studies and the Interpretation of Disease -Omics. PLoS Genet (2016) 1.05
Prenatal alcohol exposure and offspring cognition and school performance. A 'Mendelian randomization' natural experiment. Int J Epidemiol (2013) 1.04
Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals. Int J Epidemiol (2013) 1.03
Effects of BMI, fat mass, and lean mass on asthma in childhood: a Mendelian randomization study. PLoS Med (2014) 1.02
Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet (2012) 1.01
Invited commentary: efficient testing of gene-environment interaction. Am J Epidemiol (2008) 1.00
The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities. Genome Biol (2012) 1.00
Maternal and offspring adiposity-related genetic variants and gestational weight gain. Am J Clin Nutr (2011) 1.00
Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans. Int J Epidemiol (2012) 0.99
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun (2016) 0.98
Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies. Am J Clin Nutr (2016) 0.98
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The many weak instruments problem and Mendelian randomization. Stat Med (2014) 0.97
Approaches for drawing causal inferences from epidemiological birth cohorts: a review. Early Hum Dev (2014) 0.95
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. Eur J Epidemiol (2011) 0.94
Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms. Hum Mol Genet (2011) 0.94
FADS2 polymorphisms modify the effect of breastfeeding on child IQ. PLoS One (2010) 0.94
Assessment of vibration of effects due to model specification can demonstrate the instability of observational associations. J Clin Epidemiol (2015) 0.93
Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis. PLoS One (2012) 0.91
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Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women. Nicotine Tob Res (2010) 0.90
Beyond Mendelian randomization: how to interpret evidence of shared genetic predictors. J Clin Epidemiol (2015) 0.90
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality. Nat Rev Cardiol (2017) 0.90
RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans. J Lipid Res (2009) 0.89
Smoking and body weight: evidence using genetic instruments. Econ Hum Biol (2011) 0.88
Development of exposome correlation globes to map out environment-wide associations. Pac Symp Biocomput (2015) 0.88
Prenatal alcohol exposure and childhood balance ability: findings from a UK birth cohort study. BMJ Open (2013) 0.88
Using Mendelian randomisation to infer causality in depression and anxiety research. Depress Anxiety (2013) 0.88
Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children. PLoS One (2012) 0.86
MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization. Sci Rep (2015) 0.86
Child height, health and human capital: Evidence using genetic markers. Eur Econ Rev (2013) 0.85
Metabolomics of aging requires large-scale longitudinal studies with replication. Proc Natl Acad Sci U S A (2016) 0.83
Association of Body Mass Index with Depression, Anxiety and Suicide-An Instrumental Variable Analysis of the HUNT Study. PLoS One (2015) 0.83
Mendelian Randomization: Using Natural Genetic Variation to Assess the Causal Role of Modifiable Risk Factors in Observational Studies. Circulation (2017) 0.82
Alcohol Exposure In Utero and Child Academic Achievement. Econ J (London) (2014) 0.82
A genetic instrumental variables analysis of the effects of prenatal smoking on birth weight: evidence from two samples. Biodemography Soc Biol (2011) 0.82
Assessing causal relationships in genomics: From Bradford-Hill criteria to complex gene-environment interactions and directed acyclic graphs. Emerg Themes Epidemiol (2011) 0.82
Paradoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization. J Clin Endocrinol Metab (2015) 0.81
Genetic markers as instrumental variables. J Health Econ (2015) 0.80
Mendelian Randomization and Type 2 Diabetes. Cardiovasc Drugs Ther (2016) 0.79
Re-Examining the Association between Vitamin D and Childhood Caries. PLoS One (2015) 0.79
Analytical Complexity in Detection of Gene Variant-by-Environment Exposure Interactions in High-Throughput Genomic and Exposomic Research. Curr Environ Health Rep (2016) 0.79
The case-only independence assumption: associations between genetic polymorphisms and smoking among controls in two population-based studies. Int J Mol Epidemiol Genet (2012) 0.79
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. Eur J Hum Genet (2011) 0.79
Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis. Int J Epidemiol (2016) 0.78
Alcohol consumption and cognitive performance: a Mendelian randomization study. Addiction (2014) 0.78
Genetic instrumental variable studies of effects of prenatal risk factors. Biodemography Soc Biol (2013) 0.78
ADH1B and ADH1C genotype, alcohol consumption and biomarkers of liver function: findings from a Mendelian randomization study in 58,313 European origin Danes. PLoS One (2014) 0.78
Commentary: Two-sample Mendelian randomization: opportunities and challenges. Int J Epidemiol (2016) 0.77
Determining origins and causes of childhood obesity via Mendelian randomization analysis. PLoS Med (2008) 0.77
Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme. Bone (2012) 0.77
Maternal iron levels early in pregnancy are not associated with offspring IQ score at age 8, findings from a Mendelian randomization study. Eur J Clin Nutr (2014) 0.76
Use of the "Exposome" in the Practice of Epidemiology: A Primer on -Omic Technologies. Am J Epidemiol (2016) 0.76
Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study. PLoS Med (2017) 0.76
Analytic Complexity and Challenges in Identifying Mixtures of Exposures Associated with Phenotypes in the Exposome Era. Curr Epidemiol Rep (2017) 0.75
Vitamin C and Infections. Nutrients (2017) 0.75
Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation. Epigenomics (2017) 0.75
Genome-wide association study identifies common and low-frequency variants at the AMH gene locus that strongly predict serum AMH levels in males. Hum Mol Genet (2015) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
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Demonstrating stratification in a European American population. Nat Genet (2005) 9.49
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Gene-environment correlations: a review of the evidence and implications for prevention of mental illness. Mol Psychiatry (2007) 2.85
Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol (2006) 2.70
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