Published in Nat Commun on January 01, 2012
Neat1 is a p53-inducible lincRNA essential for transformation suppression. Genes Dev (2017) 1.39
Aneuploidy in health, disease, and aging. J Cell Biol (2013) 1.13
Lessons learned about human stem cell responses to ionizing radiation exposures: a long road still ahead of us. Int J Mol Sci (2013) 0.96
Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation. Oncogene (2013) 0.91
Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. J Exp Med (2013) 0.88
E2F inhibition synergizes with paclitaxel in lung cancer cell lines. PLoS One (2014) 0.83
Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D. Genes Dev (2016) 0.83
Skin Tumors Rb(eing) Uncovered. Front Oncol (2013) 0.80
Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies. World J Stem Cells (2016) 0.79
Transcriptional control of stem cell fate by E2Fs and pocket proteins. Front Genet (2015) 0.77
Novel functions for the transcription factor E2F4 in development and disease. Cell Cycle (2016) 0.76
CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency. Cell Death Differ (2016) 0.76
Crosstalk between stem cell and cell cycle machineries. Curr Opin Cell Biol (2015) 0.76
The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency. J Biol Chem (2015) 0.76
Modeling Developmental and Tumorigenic Aspects of Trilateral Retinoblastoma via Human Embryonic Stem Cells. Stem Cell Reports (2017) 0.75
RB controls growth, survival, and neuronal migration in human cerebral organoids. Development (2017) 0.75
p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation. Stem Cell Reports (2016) 0.75
The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage. J Reprod Dev (2015) 0.75
Regional signals in the planarian body guide stem cell fate in the presence of genomic instability. Development (2016) 0.75
Idelalisib induces PUMA-dependent apoptosis in colon cancer cells. Oncotarget (2017) 0.75
Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation. Cancer Sci (2017) 0.75
New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature (2007) 13.54
WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res (2005) 12.88
Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat Rev Genet (2008) 7.30
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev (2000) 5.80
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet (2008) 5.26
Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol (2002) 5.00
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature (2004) 4.41
Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev (2000) 3.74
The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat Rev Cancer (2011) 3.42
Differences between human and mouse embryonic stem cells. Dev Biol (2004) 3.30
A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proc Natl Acad Sci U S A (2006) 3.06
Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell (2009) 3.03
A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Res (2007) 2.97
Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells. Cell Stem Cell (2010) 2.73
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell (2008) 2.67
Cell cycle control of embryonic stem cells. Stem Cell Rev (2005) 2.64
Rb regulates fate choice and lineage commitment in vivo. Nature (2010) 2.60
Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev (2010) 2.50
Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status. J Clin Invest (2010) 2.38
A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol (2010) 2.32
Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev (2010) 2.12
Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell (2009) 2.05
Therapeutic potential of embryonic stem cells. Blood Rev (2005) 1.96
Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol (2012) 1.93
Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen. EMBO J (2001) 1.93
Rb is critical in a mammalian tissue stem cell population. Genes Dev (2007) 1.92
Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling. Genes Dev (2010) 1.88
Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell (2009) 1.73
Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells. Stem Cells (2009) 1.68
A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. J Cell Biol (2009) 1.67
Cell cycle features of primate embryonic stem cells. Stem Cells (2005) 1.64
Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells. Dev Biol (2004) 1.60
Division and apoptosis of E2f-deficient retinal progenitors. Nature (2009) 1.55
Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells. J Cell Physiol (2007) 1.55
Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells. Oncogene (2008) 1.55
Direct reprogramming of fibroblasts into epiblast stem cells. Nat Cell Biol (2010) 1.52
Survival responses of human embryonic stem cells to DNA damage. J Cell Physiol (2009) 1.51
RB: mitotic implications of a tumour suppressor. Nat Rev Cancer (2012) 1.51
G1 to S phase cell cycle transition in somatic and embryonic stem cells. J Anat (2008) 1.48
DiRE: identifying distant regulatory elements of co-expressed genes. Nucleic Acids Res (2008) 1.42
Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.41
RB1, development, and cancer. Curr Top Dev Biol (2011) 1.37
T-antigen mutant activities in vivo: roles of p53 and pRB binding in tumorigenesis of the choroid plexus. Oncogene (1992) 1.36
The retinoblastoma tumor suppressor and stem cell biology. Genes Dev (2012) 1.34
Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F. Oncogene (1998) 1.34
Differentiation is coupled to changes in the cell cycle regulatory apparatus of human embryonic stem cells. Stem Cell Res (2007) 1.31
Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells. Oncogene (2008) 1.30
Isolation and transcriptional profiling of purified hepatic cells derived from human embryonic stem cells. Stem Cells (2008) 1.19
Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability. Cancer Res (2002) 1.12
T antigen transgenic mouse models. Semin Cancer Biol (2009) 1.06
Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency. Am J Pathol (2010) 1.06
A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res (2008) 1.05
Keeping an eye on retinoblastoma control of human embryonic stem cells. J Cell Biochem (2009) 1.01
Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genet (2010) 0.99
Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation. Mol Cell Biol (2003) 0.94
RB regulates pancreas development by stabilizing Pdx1. EMBO J (2011) 0.93
Retinal progenitor cells, differentiation, and barriers to cell cycle reentry. Curr Top Dev Biol (2010) 0.80
Factors regulating pluripotency and differentiation in early mammalian embryos and embryo-derived stem cells. Vitam Horm (2011) 0.78
Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med (2011) 5.77
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28
Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer (2008) 5.19
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell (2011) 3.88
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev (2007) 3.31
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell (2008) 2.67
Characterization of the cell of origin for small cell lung cancer. Cell Cycle (2011) 2.62
PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature (2011) 2.53
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov (2013) 2.46
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proc Natl Acad Sci U S A (2002) 2.24
Cell type-specific effects of Rb deletion in the murine retina. Genes Dev (2004) 2.18
A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med (2011) 1.97
Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell (2010) 1.89
The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J Biol Chem (2005) 1.85
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83
Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Res (2010) 1.81
A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle (2011) 1.80
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med (2011) 1.74
Methylation of the retinoblastoma tumor suppressor by SMYD2. J Biol Chem (2010) 1.73
Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol (2011) 1.68
The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J Thorac Oncol (2015) 1.68
Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell (2011) 1.67
An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell (2002) 1.63
C/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence. EMBO J (2005) 1.44
Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo. Mol Cell Biol (2003) 1.43
RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult. Nucleic Acids Res (2004) 1.33
Newly identified aspects of tumor suppression by RB. Dis Model Mech (2011) 1.24
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Epigenetics (2012) 1.19
Isolation and transcriptional profiling of purified hepatic cells derived from human embryonic stem cells. Stem Cells (2008) 1.19
Regulation of RB transcription in vivo by RB family members. Mol Cell Biol (2010) 1.18
MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Res (2011) 1.17
Structure and function of the thymic microenvironment. Front Biosci (Landmark Ed) (2011) 1.14
Perp is a mediator of p53-dependent apoptosis in diverse cell types. Curr Biol (2003) 1.11
Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents. Oncogene (2004) 1.05
Functional interaction of protein kinase Calpha with the tyrosine kinases Syk and Src in human platelets. J Biol Chem (2004) 1.03
G1 arrest and differentiation can occur independently of Rb family function. J Cell Biol (2010) 1.02
Keeping an eye on retinoblastoma control of human embryonic stem cells. J Cell Biochem (2009) 1.01
Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genet (2010) 0.99
p107 in the public eye: an Rb understudy and more. Cell Div (2010) 0.94
Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer. Cancer Res (2012) 0.93
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J Clin Invest (2016) 0.92
Viral infection of human progenitor and liver-derived cells encapsulated in three-dimensional PEG-based hydrogel. Biomed Mater (2008) 0.90
RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo. Mol Biol Cell (2011) 0.89
Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. J Exp Med (2013) 0.88
Obligatory Broca's area modulation associated with passive speech perception. Neuroreport (2009) 0.87
The role of the retinoblastoma/E2F1 tumor suppressor pathway in the lesion recognition step of nucleotide excision repair. DNA Repair (Amst) (2009) 0.87
JMJD5 regulates cell cycle and pluripotency in human embryonic stem cells. Stem Cells (2014) 0.83
Late afternoon dosing of plerixafor for stem cell mobilization: a practical solution. Clin Lymphoma Myeloma Leuk (2011) 0.81
GFP reporter mice for the retinoblastoma-related cell cycle regulator p107. Cell Cycle (2008) 0.81
Distinguishing human cell types based on housekeeping gene signatures. Stem Cells (2012) 0.81
Are parents in the UK equipped to provide adequate burns first aid? Burns (2011) 0.80
How safe is telenursing from home? Collegian (2009) 0.80
RB goes mitochondrial. Genes Dev (2013) 0.80
Derivation of human embryonic stem cells in standard and chemically defined conditions. Methods Cell Biol (2008) 0.79
Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma. PLoS One (2011) 0.79
Hope in sight for retinoblastoma. Nat Med (2007) 0.78
Genomics: The path to retinoblastoma. Nature (2012) 0.77
Correction: Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation. Oncotarget (2017) 0.75
Complex transcriptional regulatory networks around the retinoblastoma tumor suppressor gene. Cell Cycle (2010) 0.75