A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

PubWeight™: 2.46‹?› | Rank: Top 2%

🔗 View Article (PMC 3864571)

Published in Cancer Discov on September 26, 2013

Authors

Nadine S Jahchan1, Joel T Dudley, Pawel K Mazur, Natasha Flores, Dian Yang, Alec Palmerton, Anne-Flore Zmoos, Dedeepya Vaka, Kim Q T Tran, Margaret Zhou, Karolina Krasinska, Jonathan W Riess, Joel W Neal, Purvesh Khatri, Kwon S Park, Atul J Butte, Julien Sage

Author Affiliations

1: Departments of 1Pediatrics, 2Genetics, and 5Medicine-Oncology, 3Vincent Coates Mass Spectrometry Laboratory, Stanford University, Stanford; and 4Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis Cancer Center, University of California Davis School of Medicine, Sacramento, California.

Associated clinical trials:

Phase IIa Desipramine in Small Cell Lung Cancer and Other High-Grade Neuroendocrine Tumors | NCT01719861

Articles citing this

Comprehensive genomic profiles of small cell lung cancer. Nature (2015) 2.20

The roles of K(+) channels in cancer. Nat Rev Cancer (2013) 1.46

Identification of tumorigenic cells and therapeutic targets in pancreatic neuroendocrine tumors. Proc Natl Acad Sci U S A (2016) 1.42

Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respir Med (2015) 1.40

Cancer Mortality in People Treated with Antidepressants before Cancer Diagnosis: A Population Based Cohort Study. PLoS One (2015) 1.38

Drug repurposing in oncology-patient and health systems opportunities. Nat Rev Clin Oncol (2015) 1.25

Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. J Am Coll Cardiol (2015) 1.19

A survey of current trends in computational drug repositioning. Brief Bioinform (2015) 1.18

Molecular pathways and therapeutic targets in lung cancer. Oncotarget (2014) 1.16

Origins, genetic landscape, and emerging therapies of small cell lung cancer. Genes Dev (2015) 1.11

Cancer systems biology: embracing complexity to develop better anticancer therapeutic strategies. Oncogene (2014) 1.00

Genomic analysis of fibrolamellar hepatocellular carcinoma. Hum Mol Genet (2014) 0.99

A weighted and integrated drug-target interactome: drug repurposing for schizophrenia as a use case. BMC Syst Biol (2015) 0.99

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues. Nat Nanotechnol (2016) 0.95

Small cell lung cancer: will recent progress lead to improved outcomes? Clin Cancer Res (2015) 0.94

Common mechanisms of pain and depression: are antidepressants also analgesics? Front Behav Neurosci (2014) 0.92

Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget (2016) 0.90

Relating hepatocellular carcinoma tumor samples and cell lines using gene expression data in translational research. BMC Med Genomics (2015) 0.90

Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. Nat Rev Cancer (2015) 0.89

Voltage-gated ion channels in cancer cell proliferation. Cancers (Basel) (2015) 0.89

A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood. Cancer Prev Res (Phila) (2014) 0.86

Towards precision medicine-based therapies for glioblastoma: interrogating human disease genomics and mouse phenotypes. BMC Genomics (2016) 0.85

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. Oncotarget (2014) 0.85

Mapping the effects of drugs on the immune system. Nat Biotechnol (2015) 0.84

Combining Human Disease Genetics and Mouse Model Phenotypes towards Drug Repositioning for Parkinson's disease. AMIA Annu Symp Proc (2015) 0.84

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish. PLoS Genet (2015) 0.84

Leveraging big data to transform target selection and drug discovery. Clin Pharmacol Ther (2016) 0.84

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders. Front Pharmacol (2014) 0.83

Surveying Recent Themes in Translational Bioinformatics: Big Data in EHRs, Omics for Drugs, and Personal Genomics. Yearb Med Inform (2014) 0.83

Pharmacogenomic approach to identify drug sensitivity in small-cell lung cancer. PLoS One (2014) 0.80

Kv10.1 K(+) channel: from physiology to cancer. Pflugers Arch (2016) 0.80

Pathway analysis for drug repositioning based on public database mining. J Chem Inf Model (2014) 0.80

Teaching an old dog new tricks: drug repositioning in small cell lung cancer. Cancer Discov (2013) 0.80

Analysis of the expression of Kv10.1 potassium channel in patients with brain metastases and glioblastoma multiforme: impact on survival. BMC Cancer (2015) 0.80

DT-Web: a web-based application for drug-target interaction and drug combination prediction through domain-tuned network-based inference. BMC Syst Biol (2015) 0.80

Small cell lung cancer (SCLC): no treatment advances in recent years. Transl Lung Cancer Res (2016) 0.79

A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions. PLoS One (2015) 0.79

Update in Lung Cancer 2014. Am J Respir Crit Care Med (2015) 0.79

Is the Canonical RAF/MEK/ERK Signaling Pathway a Therapeutic Target in SCLC? J Thorac Oncol (2016) 0.78

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer. Cell Rep (2016) 0.78

ONE-CLASS DETECTION OF CELL STATES IN TUMOR SUBTYPES. Pac Symp Biocomput (2016) 0.78

From Bench to Bedside: Attempt to Evaluate Repositioning of Drugs in the Treatment of Metastatic Small Cell Lung Cancer (SCLC). PLoS One (2016) 0.78

Translational Bioinformatics: Past, Present, and Future. Genomics Proteomics Bioinformatics (2016) 0.78

IDEA: Integrated Drug Expression Analysis-Integration of Gene Expression and Clinical Data for the Identification of Therapeutic Candidates. CPT Pharmacometrics Syst Pharmacol (2015) 0.78

Prioritizing therapeutics for lung cancer: an integrative meta-analysis of cancer gene signatures and chemogenomic data. PLoS Comput Biol (2015) 0.77

Exploiting large-scale drug-protein interaction information for computational drug repurposing. BMC Bioinformatics (2014) 0.77

Identification and validation of the dopamine agonist bromocriptine as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia. Oncotarget (2016) 0.77

Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening. Drug Des Devel Ther (2016) 0.77

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment. EBioMedicine (2016) 0.77

Recycling existing drugs for cancer therapy: delivering low cost cancer care. Ecancermedicalscience (2014) 0.77

Use of tricyclic antidepressants and risk of glioma: a nationwide case-control study. Br J Cancer (2016) 0.76

A computational method for clinically relevant cancer stratification and driver mutation module discovery using personal genomics profiles. BMC Genomics (2015) 0.76

Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia. Mol Syst Biol (2015) 0.76

Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia. Mol Syst Biol (2015) 0.76

CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib. Cancer Res (2017) 0.75

A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. J Biomol Screen (2016) 0.75

Expression Profiling Identifies Bezafibrate as Potential Therapeutic Drug for Lung Adenocarcinoma. J Cancer (2015) 0.75

Social stress in adolescents induces depression and brain-region-specific modulation of the transcription factor MAX. Transl Psychiatry (2016) 0.75

From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor. Cell Death Dis (2016) 0.75

Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. Gastroenterology (2017) 0.75

Computational Drug Target Screening through Protein Interaction Profiles. Sci Rep (2016) 0.75

Integrative network modeling approaches to personalized cancer medicine. Per Med (2015) 0.75

Optimal drug prediction from personal genomics profiles. IEEE J Biomed Health Inform (2015) 0.75

Discovery and validation of the antimetastatic activity of citalopram in colorectal cancer. Mol Cell Oncol (2015) 0.75

Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets. Nat Commun (2017) 0.75

Relationship between anti-depressant use and lung cancer survival. Cancer Treat Res Commun (2017) 0.75

Drug repurposing in idiopathic pulmonary fibrosis filtered by a bioinformatics-derived composite score. Sci Rep (2017) 0.75

DrugSig: A resource for computational drug repositioning utilizing gene expression signatures. PLoS One (2017) 0.75

MD-Miner: a network-based approach for personalized drug repositioning. BMC Syst Biol (2017) 0.75

Articles cited by this

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A (2001) 24.34

The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol (2000) 19.46

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature (1985) 9.78

Function and regulation of CREB family transcription factors in the nervous system. Neuron (2002) 7.99

Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov (2004) 7.57

Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell (2012) 5.92

Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med (2011) 5.77

Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med (2011) 5.30

Small-cell lung cancer. Lancet (2011) 3.61

Molecular target class is predictive of in vitro response profile. Cancer Res (2010) 3.27

Molecular genetics of small cell lung carcinoma. Semin Oncol (2001) 3.02

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov (2012) 2.68

Prediction of drug-target interactions and drug repositioning via network-based inference. PLoS Comput Biol (2012) 2.63

Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell (2011) 2.55

Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol Rev (1990) 2.33

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements. Nat Biotechnol (2010) 2.11

A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med (2011) 1.97

Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Res (2010) 1.81

Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today. Curr Pharm Des (2009) 1.77

Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell (2011) 1.67

Systematic drug repositioning based on clinical side-effects. PLoS One (2011) 1.56

SnapShot: non-small cell lung cancer. Cancer Cell (2012) 1.47

Autocrine and paracrine signaling through neuropeptide receptors in human cancer. Oncogene (2001) 1.46

Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: comradeship and hostility. Cell Signal (2008) 1.40

Tricyclic antidepressants and the incidence of certain cancers: a study using the GPRD. Br J Cancer (2010) 1.24

M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res (2007) 1.23

Signalling specificity in GPCR-dependent Ca2+ signalling. Cell Signal (2003) 1.19

A computational approach to finding novel targets for existing drugs. PLoS Comput Biol (2011) 1.17

Gene expression profiling for molecular distinction and characterization of laser captured primary lung cancers. J Transl Med (2008) 1.15

Neuronal characteristics of small-cell lung cancer. Br J Cancer (2005) 1.05

Neuropeptides as autocrine growth factors in cancer cells. Curr Pharm Des (2003) 1.03

The G protein-coupled receptors: pharmacogenetics and disease. Crit Rev Clin Lab Sci (2005) 1.03

G protein signaling and the molecular basis of antidepressant action. Life Sci (2003) 1.02

Antiallergic anti-inflammatory effects of H1-antihistamines in humans. Clin Allergy Immunol (2002) 0.98

Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion. Cell (2013) 0.98

Role of PKA and PKC in histamine H1 receptor-mediated activation of catecholamine neurotransmitter synthesis. Neurosci Lett (2006) 0.97

Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response. J Clin Psychopharmacol (1994) 0.90

Recent progress in alpha1-adrenergic receptor research. Acta Pharmacol Sin (2005) 0.89

Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants. Psychosom Med (1999) 0.89

Distinct roles of cholinergic receptors in small cell lung cancer cells. Anticancer Res (2010) 0.85

Current management of small cell lung cancer. Clin Chest Med (2011) 0.85

Anticholinergic activity of imipramine and some analogs at muscarinic receptors of cultured mouse neuroblastoma cells. Psychopharmacology (Berl) (1982) 0.84

G protein-mediated signal transduction as a target of antidepressant and antibipolar drug action: evidence from model systems. J Clin Psychiatry (1996) 0.83

G-protein-coupled receptor agonists augment adenylyl cyclase activity induced by forskolin in human corpus cavernosum smooth muscle cells. Recept Signal Transduct (1997) 0.82

m3 muscarinic acetylcholine receptor regulation in the airway. Am J Respir Cell Mol Biol (2002) 0.81

Key amino acids for differential coupling of alpha1-adrenergic receptor subtypes to Gs. Biochem Biophys Res Commun (2002) 0.80

Imipramine distribution among red blood cells, plasma and brain tissue. Gen Physiol Biophys (1996) 0.80

Articles by these authors

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10

Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32

Global functional profiling of gene expression. Genomics (2003) 12.05

Clinical assessment incorporating a personal genome. Lancet (2010) 10.18

Onto-Tools, the toolkit of the modern biologist: Onto-Express, Onto-Compare, Onto-Design and Onto-Translate. Nucleic Acids Res (2003) 9.30

Performance comparison of exome DNA sequencing technologies. Nat Biotechnol (2011) 7.11

Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics (2002) 7.07

A systems biology approach for pathway level analysis. Genome Res (2007) 6.95

Reliability and reproducibility issues in DNA microarray measurements. Trends Genet (2005) 6.79

Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol (2012) 6.38

Ontology-driven indexing of public datasets for translational bioinformatics. BMC Bioinformatics (2009) 6.31

Rociletinib in EGFR-mutated non-small-cell lung cancer. N Engl J Med (2015) 6.28

Performance comparison of whole-genome sequencing platforms. Nat Biotechnol (2011) 5.79

Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med (2011) 5.77

Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med (2011) 5.30

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28

Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer (2008) 5.19

A novel signaling pathway impact analysis. Bioinformatics (2008) 5.06

Cell type-specific gene expression differences in complex tissues. Nat Methods (2010) 4.75

An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. PLoS One (2010) 4.42

Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell (2011) 3.88

FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell (2009) 3.54

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev (2007) 3.31

Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A (2012) 3.27

Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets. PLoS Comput Biol (2010) 3.23

Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet (2011) 3.20

EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell (2012) 3.19

Challenges in the clinical application of whole-genome sequencing. Lancet (2010) 2.92

Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks. BMC Bioinformatics (2005) 2.83

Babel's tower revisited: a universal resource for cross-referencing across annotation databases. Bioinformatics (2006) 2.78

Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol (2005) 2.68

Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell (2008) 2.67

Characterization of the cell of origin for small cell lung cancer. Cell Cycle (2011) 2.62

NetPath: a public resource of curated signal transduction pathways. Genome Biol (2010) 2.62

Computerized recruiting for clinical trials in real time. Ann Emerg Med (2003) 2.59

PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature (2011) 2.53

Exploiting drug-disease relationships for computational drug repositioning. Brief Bioinform (2011) 2.52

Quantifying the relationship between co-expression, co-regulation and gene function. BMC Bioinformatics (2004) 2.51

Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int (2011) 2.50

AILUN: reannotating gene expression data automatically. Nat Methods (2007) 2.47

Spermatozoal RNA profiles of normal fertile men. Lancet (2002) 2.46

MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev (2009) 2.44

Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol (2012) 2.42

Translational bioinformatics: linking knowledge across biological and clinical realms. J Am Med Inform Assoc (2011) 2.36

Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology (2007) 2.26

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. Circ Res (2010) 2.24

Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499. Circ Cardiovasc Genet (2010) 2.24

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proc Natl Acad Sci U S A (2002) 2.24

Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. Hepatology (2008) 2.21

Reproducibility of gene expression across generations of Affymetrix microarrays. BMC Bioinformatics (2003) 2.20

A nutrient-wide association study on blood pressure. Circulation (2012) 2.19

Cell type-specific effects of Rb deletion in the murine retina. Genes Dev (2004) 2.18

Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev (2004) 2.16

Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association. PLoS One (2010) 2.10

Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nat Genet (2012) 2.02

Early requirement of Rac1 in a mouse model of pancreatic cancer. Gastroenterology (2011) 1.98

A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med (2011) 1.97

Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet (2009) 1.96

Disease signatures are robust across tissues and experiments. Mol Syst Biol (2009) 1.93

Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell (2010) 1.89

Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell (2004) 1.87

The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J Biol Chem (2005) 1.85

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83

Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Res (2010) 1.81

In silico research in the era of cloud computing. Nat Biotechnol (2010) 1.81

A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle (2011) 1.80

Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. Am J Hum Genet (2012) 1.75

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med (2011) 1.74

Methylation of the retinoblastoma tumor suppressor by SMYD2. J Biol Chem (2010) 1.73

Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis. Diabetes Care (2013) 1.70

Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients. Kidney Int (2009) 1.68

The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J Thorac Oncol (2015) 1.68

Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell (2011) 1.67

An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell (2002) 1.63

Translational bioinformatics in the cloud: an affordable alternative. Genome Med (2010) 1.61

Enabling integrative genomic analysis of high-impact human diseases through text mining. Pac Symp Biocomput (2008) 1.61

FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease. Genome Biol (2008) 1.58

Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care (2010) 1.55

Predicting environmental chemical factors associated with disease-related gene expression data. BMC Med Genomics (2010) 1.55

Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases. PLoS Genet (2012) 1.55

Assessing the functional bias of commercial microarrays using the onto-compare database. Biotechniques (2003) 1.52

ImmPort: disseminating data to the public for the future of immunology. Immunol Res (2014) 1.48

Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus. Hum Genet (2013) 1.48

Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures. Proc Natl Acad Sci U S A (2009) 1.47

A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation. J Exp Med (2013) 1.47

C/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence. EMBO J (2005) 1.44

Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo. Mol Cell Biol (2003) 1.43