Published in Biochem J on January 01, 2013
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol (2013) 3.11
Sestrin2 is a leucine sensor for the mTORC1 pathway. Science (2015) 2.52
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab (2014) 2.48
Interventions to Slow Aging in Humans: Are We Ready? Aging Cell (2015) 1.46
Drugs that modulate aging: the promising yet difficult path ahead. Transl Res (2013) 1.38
Role of amino acid transporters in amino acid sensing. Am J Clin Nutr (2013) 1.11
Aging and energetics' 'Top 40' future research opportunities 2010-2013. F1000Res (2014) 0.98
Protein and amino acid restriction, aging and disease: from yeast to humans. Trends Endocrinol Metab (2014) 0.97
D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging (Albany NY) (2014) 0.96
mTOR Inhibition: From Aging to Autism and Beyond. Scientifica (Cairo) (2013) 0.94
The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo. Cell Rep (2014) 0.92
Sestrin regulation of TORC1: Is Sestrin a leucine sensor? Sci Signal (2016) 0.91
mTORC1 signaling activates NRF1 to increase cellular proteasome levels. Cell Cycle (2015) 0.89
Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy. J Immunol (2015) 0.87
Reviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis. Nutrients (2015) 0.86
ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Mol Cell (2015) 0.85
Effects of nutritional components on aging. Aging Cell (2014) 0.84
Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila. Development (2014) 0.83
Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa: controversies and clinical implications. Curr Opin Clin Nutr Metab Care (2014) 0.82
Protein and Calorie Restriction Contribute Additively to Protection from Renal Ischemia Reperfusion Injury Partly via Leptin Reduction in Male Mice. J Nutr (2015) 0.82
The conserved role of protein restriction in aging and disease. Curr Opin Clin Nutr Metab Care (2016) 0.82
Biochemical Basis of Sestrin Physiological Activities. Trends Biochem Sci (2016) 0.81
Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart. Pflugers Arch (2013) 0.81
Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. J Gerontol A Biol Sci Med Sci (2014) 0.81
Serotonin signaling mediates protein valuation and aging. Elife (2016) 0.79
Circadian clocks govern calorie restriction-mediated life span extension through BMAL1- and IGF-1-dependent mechanisms. FASEB J (2015) 0.79
GATA-Dependent Glutaminolysis Drives Appressorium Formation in Magnaporthe oryzae by Suppressing TOR Inhibition of cAMP/PKA Signaling. PLoS Pathog (2015) 0.79
Metabolic effects of milk protein intake strongly depend on pre-existing metabolic and exercise status. Nutr Metab (Lond) (2013) 0.79
Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing. Cell Rep (2016) 0.79
Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells. Immunology (2015) 0.79
A comprehensive protein-protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1. Mol Biol Cell (2014) 0.78
Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium. Oncotarget (2015) 0.78
Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines. Sci Rep (2015) 0.78
An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly. Age (Dordr) (2015) 0.78
Dietary Restriction and Nutrient Balance in Aging. Oxid Med Cell Longev (2015) 0.77
Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration. Hum Mol Genet (2014) 0.77
p53 and rapamycin are additive. Oncotarget (2015) 0.77
Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis. FEBS Open Bio (2015) 0.77
Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation? J Transl Med (2016) 0.77
Cytoplasmic mRNA turnover and ageing. Mech Ageing Dev (2015) 0.76
Selective amino acid restriction therapy (SAART): a non-pharmacological strategy against all types of cancer cells. Oncoscience (2015) 0.76
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator. J Biol Chem (2016) 0.76
Pulmonary capillary hemangiomatosis: a focus on the EIF2AK4 mutation in onset and pathogenesis. Appl Clin Genet (2015) 0.76
A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction. Sci Rep (2017) 0.76
Signal transduction in inherited metabolic disorders: a model for a possible pathogenetic mechanism. J Inherit Metab Dis (2015) 0.76
GCN2 and TOR converge on aging. Aging (Albany NY) (2013) 0.76
Maintenance of homeostasis in the aging hypothalamus: the central and peripheral roles of succinate. Front Endocrinol (Lausanne) (2015) 0.75
Protein Restriction with Amino Acid-Balanced Diets Shrinks Circulating Pool Size of Amino Acid by Decreasing Expression of Specific Transporters in the Small Intestine. PLoS One (2016) 0.75
A proteomic adaptation of small intestinal mucosa in response to dietary protein limitation. Sci Rep (2016) 0.75
Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition. Oncotarget (2017) 0.75
A human leucyl-tRNA synthetase as an anticancer target. Onco Targets Ther (2015) 0.75
To Excavate Biomarkers Predictive of the Response for Capecitabine plus RAD001 through Nanostring-Based Multigene Assay in Advanced Gastric Cancer Patients. J Cancer (2016) 0.75
Regulation of metabolic health and aging by nutrient-sensitive signaling pathways. Mol Cell Endocrinol (2016) 0.75
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08
Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol (2005) 11.48
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem (1998) 9.37
Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol (2008) 8.92
mTOR signaling at a glance. J Cell Sci (2009) 8.66
Hypothalamic mTOR signaling regulates food intake. Science (2006) 8.62
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
Bidirectional transport of amino acids regulates mTOR and autophagy. Cell (2009) 7.88
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80
Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell (2010) 7.61
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (2011) 7.55
Evidence for translational regulation of the activator of general amino acid control in yeast. Proc Natl Acad Sci U S A (1984) 7.23
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition (1992) 6.77
A unifying model for mTORC1-mediated regulation of mRNA translation. Nature (2012) 6.44
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J (2008) 6.32
Regulation of longevity and stress resistance by Sch9 in yeast. Science (2001) 5.93
(p)ppGpp: still magical? Annu Rev Microbiol (2008) 5.88
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A (2001) 5.59
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell (2004) 5.27
Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem (2008) 5.22
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity (2005) 4.53
The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity (2008) 4.44
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem (1995) 4.36
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem (2005) 4.34
Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol (2005) 4.30
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature (2009) 4.22
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell (2009) 4.20
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell (2005) 4.02
The Vam6 GEF controls TORC1 by activating the EGO complex. Mol Cell (2009) 4.01
MSI and MSII made on ribosome in idling step of protein synthesis. Nature (1972) 3.89
Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control. Mol Cell Biol (1991) 3.83
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell (2012) 3.77
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell (2008) 3.58
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (2009) 3.47
SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell (2008) 3.43
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell (2012) 3.38
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol Cell Biol (1995) 3.36
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol (2002) 3.22
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol (2005) 3.06
Low methionine ingestion by rats extends life span. J Nutr (1993) 3.05
Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab (2008) 3.03
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab (2011) 2.91
Glutaminolysis activates Rag-mTORC1 signaling. Mol Cell (2012) 2.82
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab (2007) 2.76
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain. Mol Cell (2000) 2.75
Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem J (1998) 2.65
Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells. J Biol Chem (1999) 2.65
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science (2005) 2.51
ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol Metab (2009) 2.49
Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. Genes Dev (2003) 2.39
Amino acids and mTORC1: from lysosomes to disease. Trends Mol Med (2012) 2.38
mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol Metab (2011) 2.28
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell (2012) 2.22
Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. J Biol Chem (1999) 2.08
Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem (2004) 2.00
Dissection of the mechanism for the stringent factor RelA. Mol Cell (2002) 1.98
The amino acid sensitive TOR pathway from yeast to mammals. FEBS Lett (2006) 1.97
Subfield history: caloric restriction, slowing aging, and extending life. Sci Aging Knowledge Environ (2003) 1.96
SKAR is a specific target of S6 kinase 1 in cell growth control. Curr Biol (2004) 1.90
Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.88
The role of leucine in weight loss diets and glucose homeostasis. J Nutr (2003) 1.86
Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. J Biol Chem (1998) 1.85
Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice. Sci Transl Med (2012) 1.78
Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell (2009) 1.74
Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p. J Biol Chem (2009) 1.64
ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochem Biophys Res Commun (2008) 1.63
ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress. Cell Metab (2008) 1.62
Effects of ingestion of disproportionate amounts of amino acids. Physiol Rev (1970) 1.57
Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes. Genes Dev (2009) 1.56
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes (2011) 1.55
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol (2012) 1.46
Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2. J Biol Chem (2003) 1.41
Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection. Biochim Biophys Acta (2006) 1.39
Translational control of nrf2 protein in activation of antioxidant response by oxidants. Mol Pharmacol (2007) 1.37
Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids. J Biol Chem (2007) 1.36
The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR. Mol Cell Biol (2000) 1.35
Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells. Int J Mol Med (2004) 1.30
GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. J Biol Chem (2009) 1.29
eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiol Genomics (2009) 1.22
Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions. J Biol Chem (2004) 1.20
Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. J Biol Chem (2010) 1.20
Uncharged tRNA, protein synthesis, and the bacterial stringent response. Mol Microbiol (1990) 1.18
Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters. Am J Physiol (1998) 1.17
Methionine restriction effects on 11 -HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue. J Lipid Res (2007) 1.13
Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells. Biochem Biophys Res Commun (2005) 1.12
Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes. Eur J Biochem (2002) 1.12
Length of life and nutrition in the rat. J Nutr (1961) 1.11
Mechanisms of food intake repression in indispensable amino acid deficiency. Annu Rev Nutr (2007) 1.10
IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress. Nucleic Acids Res (2011) 1.10
An internal ribosomal entry site mediates redox-sensitive translation of Nrf2. Nucleic Acids Res (2009) 1.07
mTOR signaling: RAG GTPases transmit the amino acid signal. Trends Biochem Sci (2008) 1.06
L-Asparaginase inhibits the rapamycin-targeted signaling pathway. Biochem Biophys Res Commun (1999) 1.06
Telomerase in the human organism. Oncogene (2002) 3.30
Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol (2007) 2.21
Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice. Sci Transl Med (2012) 1.78
Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration. Liver Transpl (2011) 1.59
Glucose supplementation does not interfere with fasting-induced protection against renal ischemia/reperfusion injury in mice. Transplantation (2011) 1.57
Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles. PLoS Biol (2006) 1.54
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal (2012) 1.50
Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks. EMBO J (2005) 1.48
An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria. Cancer Cell (2006) 1.21
Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice. PLoS Genet (2006) 1.19
Nucleotide excision repair disorders and the balance between cancer and aging. Cell Cycle (2006) 1.19
Benefits of short-term dietary restriction in mammals. Exp Gerontol (2013) 1.16
DNA double-strand breaks: a potential causative factor for mammalian aging? Mech Ageing Dev (2008) 1.10
Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA. Nucleic Acids Res (2010) 1.04
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. Mol Cell Biol (2008) 0.99
NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary Restriction. J Clin Exp Pathol (2012) 0.92
The use of preoperative nutritional interventions to protect against hepatic ischemia-reperfusion injury. Liver Transpl (2009) 0.88
Pre-operative dietary restriction is feasible in live-kidney donors. Clin Transplant (2010) 0.87
Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging. Mech Ageing Dev (2006) 0.87
Dietary restriction modifies certain aspects of the postoperative acute phase response. J Surg Res (2010) 0.86
Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice. Aging Cell (2009) 0.86
Nanodiscs as a therapeutic delivery agent: inhibition of respiratory syncytial virus infection in the lung. Int J Nanomedicine (2013) 0.84
Lifespan extension by dietary intervention in a mouse model of Cockayne syndrome uncouples early postnatal development from segmental progeria. Aging Cell (2013) 0.81
Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice. DNA Repair (Amst) (2005) 0.78
Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models. DNA Repair (Amst) (2012) 0.77
Erythropoietic defect associated with reduced cell proliferation in mice lacking the 26S proteasome shuttling factor Rad23b. Mol Cell Biol (2013) 0.76
Is Overnight Fasting before Surgery Too Much or Not Enough? How Basic Aging Research Can Guide Preoperative Nutritional Recommendations to Improve Surgical Outcomes: A Mini-Review. Gerontology (2017) 0.75