Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27884780)

Published in Mol Cell Endocrinol on November 22, 2016

Authors

Nicole E Cummings1, Dudley W Lamming2

Author Affiliations

1: Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, USA.
2: Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: dlamming@medicine.wisc.edu.

Articles cited by this

(truncated to the top 100)

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41

AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46

Oxidative stress, caloric restriction, and aging. Science (1996) 11.07

Caloric restriction delays disease onset and mortality in rhesus monkeys. Science (2009) 9.84

Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25

Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53

Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell (2008) 6.88

The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition (1992) 6.77

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (2012) 6.69

Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol (2005) 6.34

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22

2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol (2013) 5.24

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00

The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr (1986) 4.81

Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science (2007) 4.80

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci U S A (2004) 4.60

Lifespan and reproduction in Drosophila: New insights from nutritional geometry. Proc Natl Acad Sci U S A (2008) 4.43

Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol (2005) 4.30

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature (2009) 4.22

Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell (2005) 4.02

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell (2009) 4.01

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science (2013) 3.96

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science (2010) 3.86

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell (2009) 3.78

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell (2012) 3.77

Rapamycin slows aging in mice. Aging Cell (2012) 3.76

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology (2004) 3.50

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2007) 3.32

Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab (2007) 3.30

Long-term caloric restriction ameliorates the decline in diastolic function in humans. J Am Coll Cardiol (2006) 3.29

Calorie restriction and aging: review of the literature and implications for studies in humans. Am J Clin Nutr (2003) 3.11

Low methionine ingestion by rats extends life span. J Nutr (1993) 3.05

The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metab (2014) 2.97

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science (2015) 2.80

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell (2014) 2.68

Sestrin2 is a leucine sensor for the mTORC1 pathway. Science (2015) 2.52

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab (2014) 2.48

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature (2012) 2.28

Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care (2009) 2.26

Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest (2013) 2.23

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes. Diabetes (2003) 2.19

The sulfur-containing amino acids: an overview. J Nutr (2006) 2.16

Low carbohydrate-high protein diet and mortality in a cohort of Swedish women. J Intern Med (2007) 2.12

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis (2007) 2.08

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature (2015) 2.01

Attenuation of sarcopenia by dietary restriction in rhesus monkeys. J Gerontol A Biol Sci Med Sci (2008) 2.00

Does caloric restriction extend life in wild mice? Aging Cell (2006) 1.99

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun (2014) 1.96

Fasting: molecular mechanisms and clinical applications. Cell Metab (2014) 1.94

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell (2014) 1.87

Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci (2013) 1.87

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell (2016) 1.85

Promoting health and longevity through diet: from model organisms to humans. Cell (2015) 1.80

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest (2011) 1.80

FGF21 is an endocrine signal of protein restriction. J Clin Invest (2014) 1.76

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep (2014) 1.72

Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol (2014) 1.71

Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period. J Gerontol A Biol Sci Med Sci (2002) 1.71

The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann N Y Acad Sci (2001) 1.70

Insulin sensitivity as a key mediator of growth hormone actions on longevity. J Gerontol A Biol Sci Med Sci (2009) 1.69

SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One (2010) 1.68

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab (2012) 1.64

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med (2016) 1.63

Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age (Dordr) (2009) 1.57

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell Rep (2013) 1.56

Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab (2014) 1.56

Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes (2011) 1.55

Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice. Carcinogenesis (2002) 1.52

Dietary intake of total, animal, and vegetable protein and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL study. Diabetes Care (2009) 1.51

Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr (2006) 1.50

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell (2013) 1.48

Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev (2011) 1.47

Optimal protein intake in the elderly. Clin Nutr (2008) 1.46

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR. Biochem J (2013) 1.46

Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell (2009) 1.44

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science (2015) 1.44

The influence of dietary protein source on longevity and age-related disease processes of Fischer rats. J Gerontol (1988) 1.43

Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to. Aging (Albany NY) (2012) 1.41

Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice. J Nutr (2001) 1.41

Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? PLoS One (2011) 1.39

Counting the calories: the role of specific nutrients in extension of life span by food restriction. J Gerontol A Biol Sci Med Sci (2005) 1.38

p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metab (2012) 1.35

Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies. J Nutr (2001) 1.31

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9. Mol Cell Biol (2015) 1.27

Calorie restriction and aging in nonhuman primates. ILAR J (2011) 1.23

Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J (1997) 1.19

Influence of the restriction of individual dietary components on longevity and age-related disease of Fischer rats: the fat component and the mineral component. J Gerontol (1988) 1.13

A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci (2013) 1.12

Nonhuman primate calorie restriction. Antioxid Redox Signal (2010) 1.11

Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A (2014) 1.11

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging. Cell Metab (2016) 1.10

mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat. Am J Physiol Endocrinol Metab (2009) 1.08

Metabolic Control of Longevity. Cell (2016) 1.07