Published in J Biol Chem on December 13, 2012
Caspases: a molecular switch node in the crosstalk between autophagy and apoptosis. Int J Biol Sci (2014) 1.04
Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cells. Cell Death Dis (2013) 0.95
Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis. J Cancer (2015) 0.79
Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One (2013) 0.79
Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid. Oncotarget (2016) 0.77
Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy. PLoS One (2016) 0.77
The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis. J Exp Clin Cancer Res (2017) 0.75
Caspase involvement in autophagy. Cell Death Differ (2017) 0.75
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell (2001) 9.33
The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem (1999) 8.97
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell (2007) 7.09
Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol Rev (2002) 5.87
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev (2001) 5.66
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration. Nature (1991) 5.30
Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol (2005) 5.21
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell (2009) 5.18
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell (2010) 4.62
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol (2007) 4.45
Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ (2007) 4.12
Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem (2002) 3.18
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell (2012) 2.75
Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy (2007) 2.59
Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett (2009) 2.58
Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron (1999) 2.41
The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans. Nature (1990) 2.17
The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. J Biol Chem (1996) 2.15
Imaging 26S proteasome activity and inhibition in living mice. Nat Med (2003) 2.04
Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature (2002) 1.97
The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy. J Cell Biol (2010) 1.91
Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum. Neuron (2001) 1.90
Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. J Biol Chem (2008) 1.89
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. J Biol Chem (2012) 1.79
The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. J Biol Chem (1997) 1.76
Selective role for superoxide in InsP3 receptor-mediated mitochondrial dysfunction and endothelial apoptosis. J Cell Biol (2005) 1.73
Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Differ (2007) 1.64
Induction of macroautophagy by exogenously introduced calcium. Autophagy (2008) 1.48
A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans. Nat Cell Biol (2000) 1.37
The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation. Nat Neurosci (2004) 1.34
Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes. Mol Cell Biol (2011) 1.29
On the molecular basis of ion permeation in the epithelial Na+ channel. J Gen Physiol (1999) 1.28
Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90. Arch Biochem Biophys (1996) 1.22
Ion channels as targets for cancer therapy. Int J Physiol Pathophysiol Pharmacol (2011) 1.10
Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans. J Cell Sci (2007) 1.07
The inositol 1,4,5-trisphosphate receptor is required to signal autophagic cell death. Mol Biol Cell (2007) 1.05
Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes. Autophagy (2010) 1.03
Modulation of acid-sensing ion channels: molecular mechanisms and therapeutic potential. Int J Physiol Pathophysiol Pharmacol (2011) 0.96
A retroviral expression system based on tetracycline-regulated tricistronic transactivator/repressor vectors for functional analyses of antiproliferative and toxic genes. Mol Cancer Ther (2006) 0.95
Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury. Mol Cell Biol (2011) 0.93
ENaCs and ASICs as therapeutic targets. Am J Physiol Cell Physiol (2012) 0.91
Intracellular calcium mobilization regulates the activity of 26 S proteasome during the metaphase-anaphase transition in the ascidian meiotic cell cycle. Dev Biol (1994) 0.80
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79
The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity (2007) 4.74
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol (2002) 3.58
To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene (2003) 3.37
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R. Nat Cell Biol (2005) 2.94
Autophagy mediates degradation of nuclear lamina. Nature (2015) 2.93
STIM proteins: dynamic calcium signal transducers. Nat Rev Mol Cell Biol (2012) 2.90
Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat Protoc (2007) 2.84
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell (2012) 2.75
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Nat Cell Biol (2012) 2.48
Calcium signaling and apoptosis. Biochem Biophys Res Commun (2003) 2.30
Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell (2009) 2.28
Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci U S A (2012) 2.14
Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proc Natl Acad Sci U S A (2007) 1.96
Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species. Am J Physiol Cell Physiol (2005) 1.95
The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy. J Cell Biol (2010) 1.91
Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells. Prostate (2002) 1.86
The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors. Anesthesiology (2008) 1.79
S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. J Cell Biol (2010) 1.77
Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice. Blood (2011) 1.77
Chemotherapeutic approaches for targeting cell death pathways. Oncologist (2006) 1.70
Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling. Mol Biol Cell (2007) 1.60
Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol Cell (2009) 1.58
Disease-specific, neurosphere-derived cells as models for brain disorders. Dis Model Mech (2010) 1.57
Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart. Sci Transl Med (2013) 1.55
Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies. Anesthesiology (2008) 1.52
Direct evidence of intracrine angiotensin II signaling in neurons. Am J Physiol Cell Physiol (2014) 1.51
Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus. J Biol Chem (2007) 1.51
Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome. J Biol Chem (2006) 1.49
A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players. EMBO J (2006) 1.49
Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition. J Biol Chem (2009) 1.48
ABCA3 is critical for lamellar body biogenesis in vivo. J Biol Chem (2007) 1.41
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest (2013) 1.40
The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. Oncogene (2003) 1.39
Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Mol Cell Biol (2002) 1.36
Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circ Res (2013) 1.33
Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress. Biochim Biophys Acta (2008) 1.33
Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis. Free Radic Biol Med (2009) 1.30
Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes. Mol Cell Biol (2011) 1.29
Menin induces apoptosis in murine embryonic fibroblasts. J Biol Chem (2003) 1.25
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis. Mol Cell Biol (2011) 1.25
Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis. Mol Cell Biol (2011) 1.24
The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool. J Neurosci (2003) 1.22
Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest (2009) 1.19
Defining the role of the Bcl-2 family of proteins in the nervous system. Neuroscientist (2005) 1.18
Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies. Biomaterials (2007) 1.17
Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells. Eur J Haematol (2008) 1.14
Elevated expression of squamous cell carcinoma antigen (SCCA) is associated with human breast carcinoma. PLoS One (2011) 1.13
Targeting the WNT/beta-catenin/TCF/LEF1 axis in solid and haematological cancers: Multiplicity of therapeutic options. Eur J Cancer (2009) 1.12
DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity. J Immunol (2011) 1.12
The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1. Nat Cell Biol (2006) 1.12
PECAM-targeted delivery of SOD inhibits endothelial inflammatory response. FASEB J (2010) 1.11
Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Mol Cell (2013) 1.11
Inflammasomes: sensors of metabolic stresses for vascular inflammation. Front Biosci (Landmark Ed) (2013) 1.09
Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol Cell Biol (2009) 1.09
tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane. EMBO J (2002) 1.08
NF-kappaB: key mediator of inflammation-associated cancer. Cancer Biol Ther (2004) 1.07
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. J Biol Chem (2003) 1.06
c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1. J Biol Chem (2003) 1.04
Chemotherapy induces tumor clearance independent of apoptosis. Cancer Res (2008) 1.03
Fibronectin growth factor-binding domains are required for fibroblast survival. J Invest Dermatol (2010) 1.02
The vascular endothelial growth factor receptor tyrosine kinase inhibitors vatalanib and pazopanib potently induce apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo. Clin Cancer Res (2010) 1.02
Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex. J Biol Chem (2011) 1.02
Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure. J Biol Chem (2010) 1.02
TGF-beta-induced Ca(2+) influx involves the type III IP(3) receptor and regulates actin cytoskeleton. Am J Physiol Renal Physiol (2002) 1.01
Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Nat Commun (2014) 1.01
Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34. J Immunol (2013) 0.99
Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle. FASEB J (2012) 0.97
Histone 3.3 participates in a self-sustaining cascade of apoptosis that contributes to the progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 0.97
Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J Biol Chem (2009) 0.96
Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. Am J Physiol Renal Physiol (2003) 0.96
Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. Sci Signal (2013) 0.94
G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence. Mol Cell Biol (2007) 0.94
TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria. J Biol Chem (2014) 0.94
A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations. Dis Model Mech (2012) 0.94
Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury. Mol Cell Biol (2011) 0.93
Sensing cellular stress through STIM proteins. Nat Chem Biol (2011) 0.93
Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species. J Biol Chem (2014) 0.93
SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death. Mol Biol Cell (2014) 0.92
Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation. Cell Metab (2015) 0.92
Nitric oxide-donating acetylsalicylic acid induces apoptosis in chronic lymphocytic leukemia cells and shows strong antitumor efficacy in vivo. Clin Cancer Res (2010) 0.92
Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88. J Immunol (2012) 0.91
The cellular decision between apoptosis and autophagy. Chin J Cancer (2012) 0.90
The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol (2013) 0.89
Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family. Cancer Res (2009) 0.88
Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins. J Pharmacol Exp Ther (2005) 0.87
Mammalian PIK3C3/VPS34: the key to autophagic processing in liver and heart. Autophagy (2012) 0.87
Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55. J Biol Chem (2013) 0.87
Intracellular endothelin type B receptor-driven Ca2+ signal elicits nitric oxide production in endothelial cells. J Biol Chem (2012) 0.86
Mitochondrial complex II prevents hypoxic but not calcium- and proapoptotic Bcl-2 protein-induced mitochondrial membrane potential loss. J Biol Chem (2010) 0.86
Visualization of vascular Ca2+ signaling triggered by paracrine derived ROS. J Vis Exp (2011) 0.85