Published in Cell Metab on October 23, 2015
Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Mol Cell (2016) 1.55
Mitochondria and Cancer. Mol Cell (2016) 1.11
Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine. EMBO J (2017) 0.85
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy. Nat Commun (2016) 0.84
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat Cell Biol (2016) 0.83
Metabolic adaptation of skeletal muscle to hyperammonemia drives the beneficial effects of l-leucine in cirrhosis. J Hepatol (2016) 0.79
MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer. EMBO Rep (2017) 0.76
In vivo Reprogramming of Cancer Metabolism by MYC. Front Cell Dev Biol (2017) 0.75
Targeting MYC Dependence by Metabolic Inhibitors in Cancer. Genes (Basel) (2017) 0.75
p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proc Natl Acad Sci U S A (2017) 0.75
Glutamine Metabolism in Cancer: Understanding the Heterogeneity. Trends Cancer (2017) 0.75
Hippo's Q for a big liver. Nat Cell Biol (2016) 0.75
Hopefully devoted to Q: targeting glutamine addiction in cancer. Br J Cancer (2017) 0.75
Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis. Metab Eng (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A (2007) 15.88
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature (2009) 13.28
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A (2008) 11.71
Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell (2008) 11.18
Bidirectional transport of amino acids regulates mTOR and autophagy. Cell (2009) 7.88
Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene (2009) 5.81
Links between metabolism and cancer. Genes Dev (2012) 5.27
Distinct thresholds govern Myc's biological output in vivo. Cancer Cell (2008) 4.16
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab (2012) 3.81
DNA methylation and cancer. Adv Genet (2010) 3.50
Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest (2013) 3.46
Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell (2014) 3.17
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab (2012) 2.86
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature (2014) 2.33
Metabolism of [U-13 C]glucose in human brain tumors in vivo. NMR Biomed (2012) 2.06
Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. PLoS Genet (2011) 1.90
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol (2013) 1.56
Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition. J Biol Chem (2009) 1.48
Determination of glutamine in muscle protein facilitates accurate assessment of proteolysis and de novo synthesis-derived endogenous glutamine production. Am J Clin Nutr (1999) 1.43
Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts. Oncogene (2011) 1.34
Glutamine and glutamate as vital metabolites. Braz J Med Biol Res (2003) 1.26
A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. J Biol Chem (2013) 1.22
Cancer: pathological nuclear reprogramming? Nat Rev Cancer (2014) 1.17
Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification. J Biol Chem (2010) 0.95
Muscle glutamine depletion in the intensive care unit. Int J Biochem Cell Biol (2005) 0.92
Localization and function of glutamine synthetase and glutaminase. Biochem Soc Trans (1987) 0.77
Autophagy mediates degradation of nuclear lamina. Nature (2015) 2.93
Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition. J Biol Chem (2009) 1.48
Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Nat Commun (2014) 1.01
Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis. J Biol Chem (2012) 0.82
Hacking hexokinase halts tumor growth. Cancer Biol Ther (2008) 0.77