Published in Arch Biochem Biophys on October 01, 1979
Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites. J Biol Chem (2011) 1.52
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi. J Exp Med (2002) 1.41
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Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. J Med Chem (2001) 2.26
Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion. J Exp Med (1994) 1.64
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Ca2+/H+ exchange in acidic vacuoles of Trypanosoma brucei. Biochem J (1994) 1.53
Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation, and environmental stress in Trypanosoma cruzi. J Biol Chem (2001) 1.51
Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem (2001) 1.42
The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and are similar to acidocalcisomes. J Biol Chem (2001) 1.41
Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi. Mol Biochem Parasitol (1981) 1.41
Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs. J Biol Chem (1999) 1.39
Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisomes of Trypanosoma cruzi. J Biol Chem (1998) 1.38
Regulatory volume decrease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium. Mol Biochem Parasitol (2003) 1.32
Digitonin permeabilization does not affect mitochondrial function and allows the determination of the mitochondrial membrane potential of Trypanosoma cruzi in situ. J Biol Chem (1991) 1.32
Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in beta-lapachone-treated Trypanosoma cruzi epimastigotes. Arch Biochem Biophys (1978) 1.29
Ca2+ transport by digitonin-permeabilized Leishmania donovani. Effects of Ca2+, pentamidine and WR-6026 on mitochondrial membrane potential in situ. Biochem J (1992) 1.26
In situ compositional analysis of acidocalcisomes in Trypanosoma cruzi. J Biol Chem (1997) 1.16
31P NMR spectroscopy of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Evidence for high levels of condensed inorganic phosphates. J Biol Chem (2000) 1.15
Ca2+ content and expression of an acidocalcisomal calcium pump are elevated in intracellular forms of Trypanosoma cruzi. Mol Cell Biol (1998) 1.14
Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites. Biochem J (2000) 1.14
Presence of a vacuolar H+-pyrophosphatase in promastigotes of Leishmania donovani and its localization to a different compartment from the vacuolar H+-ATPase. Biochem J (1999) 1.13
Characterization of a vacuolar pyrophosphatase in Trypanosoma brucei and its localization to acidocalcisomes. Mol Cell Biol (1999) 1.13
Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii. Antimicrob Agents Chemother (1997) 1.13
Reduction of nifurtimox and nitrofurantoin to free radical metabolites by rat liver mitochondria. Evidence of an outer membrane-located nitroreductase. J Biol Chem (1984) 1.12
Free radical metabolism of antiparasitic agents. Fed Proc (1986) 1.12
Calcium homeostasis in procyclic and bloodstream forms of Trypanosoma brucei. Lack of inositol 1,4,5-trisphosphate-sensitive Ca2+ release. J Biol Chem (1992) 1.11
A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation. J Biol Chem (2000) 1.09
Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria. J Biol Chem (1993) 1.08
Effect of beta-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi. Biochem J (1978) 1.08
Ca2+ storage in Trypanosoma brucei: the influence of cytoplasmic pH and importance of vacuolar acidity. Biochem J (1995) 1.07
Presence of a Na(+)/H(+) exchanger in acidocalcisomes of Leishmania donovani and their alkalization by anti-leishmanial drugs. FEBS Lett (2000) 1.07
Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi. Comp Biochem Physiol C (1978) 1.07
The regulation of yeast pyruvate carboxylase by acetyl-coenzyme A and L-aspartate. Arch Biochem Biophys (1968) 1.07
Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis. Environ Health Perspect (1985) 1.06
Sodium-proton exchange stimulates Ca2+ release from acidocalcisomes of Trypanosoma brucei. Biochem J (1996) 1.05
A calmodulin-stimulated Ca2+ pump in plasma-membrane vesicles from Trypanosoma brucei; selective inhibition by pentamidine. Biochem J (1993) 1.04
Calcium homeostasis in Trypanosoma cruzi amastigotes: presence of inositol phosphates and lack of an inositol 1,4,5-trisphosphate-sensitive calcium pool. Mol Biochem Parasitol (1992) 1.03
Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages. Mol Biochem Parasitol (1993) 1.03
Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi. Biochem J (1980) 1.03
Localization of peroxidase activity in Trypanosoma cruzi microbodies. Experientia (1976) 1.03
Intracellular Ca2+ pool content and signaling and expression of a calcium pump are linked to virulence in Leishmania mexicana amazonesis amastigotes. J Biol Chem (1997) 1.03
Energization-dependent Ca2+ accumulation in Trypanosoma brucei bloodstream and procyclic trypomastigotes mitochondria. Mol Biochem Parasitol (1992) 1.02
Free radical metabolites in the mode of action of chemotherapeutic agents and phagocytic cells on Trypanosoma cruzi. Rev Infect Dis (1984) 1.02
Generation of free radicals induced by nifurtimox in mammalian tissues. J Biol Chem (1981) 1.01
A plant-like vacuolar H(+)-pyrophosphatase in Plasmodium falciparum. FEBS Lett (1999) 1.01
Purification and properties of pyruvate carboxylase from baker's yeast. Arch Biochem Biophys (1967) 1.01
Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet). Science (1983) 1.01
Trypanosoma cruzi: ultrastructural and metabolic alterations of epimastigotes by beta-lapachone. Exp Parasitol (1977) 1.01
Chemotherapy for Chagas' disease: a perspective of current therapy and considerations for future research. Rev Infect Dis (1987) 1.00
Kinetics of bovine liver aldehyde dehydrogenase. Effect of coenzyme and aldehyde structure. Enzymologia (1970) 1.00
In vitro and in vivo evaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives against Trypanosoma cruzi. Ann Trop Med Parasitol (1978) 1.00
Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi. Biochem Pharmacol (1981) 1.00
Structure-activity relationship of new growth inhibitors of Trypanosoma cruzi. J Med Chem (1998) 0.98
Oxidative phosphorylation, Ca(2+) transport, and fatty acid-induced uncoupling in malaria parasites mitochondria. J Biol Chem (2000) 0.97
Generation of free radical metabolites and superoxide anion by the calcium indicators arsenazo III, antipyrylazo III, and murexide in rat liver microsomes. J Biol Chem (1983) 0.97
Characterization of isolated acidocalcisomes of Trypanosoma cruzi. J Biol Chem (2000) 0.97
Action of zinc-complexing agents on nicotinamide adenine dinucleotide-linked aldehyde dehydrogenases from yeast and liver. Arch Biochem Biophys (1966) 0.97
Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi. Bioorg Med Chem Lett (2001) 0.97
Metabolism of serine and glycine in baker's yeast. Biochim Biophys Acta (1967) 0.96
Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations. Arch Biochem Biophys (1982) 0.95
Cloning and functional expression of a gene encoding a vacuolar-type proton-translocating pyrophosphatase from Trypanosoma cruzi. Biochem J (2000) 0.95
The role of a H(+)-ATPase in the regulation of cytoplasmic pH in Trypanosoma cruzi epimastigotes. Biochem J (1996) 0.95
Functional expression of a vacuolar-type H+-ATPase in the plasma membrane and intracellular vacuoles of Trypanosoma cruzi. Biochem J (1998) 0.94
Characterization of the plasma-membrane calcium pump from Trypanosoma cruzi. Biochem J (1995) 0.94
Synthesis and antitrypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives. structure-activity relationships. Eur J Med Chem (2000) 0.93
The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in different sensitivity to digitonin-permeabilization. J Eukaryot Microbiol (2001) 0.93
Structural requirements for the action of steroids as inhibitors of electron transfer. Arch Biochem Biophys (1968) 0.93
Ca2+ and Mg2+-enhanced reduction of arsenazo III to its anion free radical metabolite and generation of superoxide anion by an outer mitochondrial membrane azoreductase. J Biol Chem (1984) 0.93
Hydrogen peroxide generation in Trypanosoma cruzi. Experientia (1977) 0.93
Regulation of intracellular calcium homeostasis in Trypanosoma cruzi. Effects of calmidazolium and trifluoperazine. Cell Calcium (1991) 0.93
Free radical intermediates in the reaction of pyruvate:ferredoxin oxidoreductase in Tritrichomonas foetus hydrogenosomes. J Biol Chem (1987) 0.92
Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus. J Biol Chem (1983) 0.92
The fine structure of acidocalcisomes in Trypanosoma cruzi. Parasitol Res (2000) 0.92
Effect of beta-lapachone on hydrogen peroxide production in Trypanosoma cruzi. Acta Trop (1978) 0.92
Subcellular localization of phosphoenolpyruvate carboxykinase in the trypanosomatids Trypanosoma cruzi and Crithidia fasciculata. Mol Biochem Parasitol (1982) 0.90
Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes. J Biol Chem (1984) 0.90
Aerobic glucose fermentation by Trypanosoma cruzi axenic culture amastigote-like forms during growth and differentiation to epimastigotes. Mol Biochem Parasitol (1987) 0.90
Generation of free radicals from phenazine methosulfate in Trypanosoma cruzi epimastigotes. Acta Trop (1978) 0.89
Porphyrin biosynthesis in parasitic hemoflagellates: functional and defective enzymes in Trypanosoma cruzi. Comp Biochem Physiol B (1982) 0.89
A calmodulin-activated (Ca(2+)-Mg2+)-ATPase is involved in Ca2+ transport by plasma membrane vesicles from Trypanosoma cruzi. Biochem J (1991) 0.89
Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria. Antimicrob Agents Chemother (1978) 0.89
Ca2+ transport in digitonin-permeabilized trypanosomatids. Mol Biochem Parasitol (1990) 0.89
Inhibition of Ca2+ release from Trypanosoma brucei acidocalcisomes by 3,5-dibutyl-4-hydroxytoluene: role of the Na+/H+ exchanger. Biochem J (1997) 0.88
(31)P NMR of apicomplexans and the effects of risedronate on Cryptosporidium parvum growth. Biochem Biophys Res Commun (2001) 0.87
Constant and variable regions in DNA mini-circles from Trypanosoma cruzi and Trypanosoma rangeli: application to species and stock differentiation. Mol Biochem Parasitol (1981) 0.87
TcSCA complements yeast mutants defective in Ca2+ pumps and encodes a Ca2+-ATPase that localizes to the endoplasmic reticulum of Trypanosoma cruzi. J Biol Chem (2001) 0.87
Superoxide anion production by lipoamide dehydrogenase redox-cycling: effect of enzyme modifiers. Biochem Int (1991) 0.87
Two types of H+-ATPase are involved in the acidification of internal compartments in Trypanosoma cruzi. Biochem J (1998) 0.86
Decreased rate of ketone-body oxidation and decreased activity of D-3-hydroxybutyrate dehydrogenase and succinyl-CoA:3-oxo-acid CoA-transferase in heart mitochondria of diabetic rats. Biochem J (1986) 0.86
Calcium mobilization by arachidonic acid in trypanosomatids. Mol Biochem Parasitol (2000) 0.85
Reduction of the metallochromic indicators arsenazo III and antipyrylazo III to their free radical metabolites by cytoplasmic enzymes. FEBS Lett (1985) 0.84
Crystal violet as an uncoupler of oxidative phosphorylation in rat liver mitochondria. J Biol Chem (1988) 0.84