Published in J Biol Chem on November 10, 1981
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc Natl Acad Sci U S A (2008) 2.54
Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites. J Biol Chem (2011) 1.52
CYP51: A major drug target in the cytochrome P450 superfamily. Lipids (2008) 1.19
Trypanocidal activity of aziridinyl nitrobenzamide prodrugs. Antimicrob Agents Chemother (2010) 1.11
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase. Antimicrob Agents Chemother (2009) 1.11
Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population. J Infect Dis (2012) 1.07
Some reactions and properties of nitro radical-anions important in biology and medicine. Environ Health Perspect (1985) 0.89
Drug Resistance in the Microaerophilic Parasite Giardia lamblia. Curr Trop Med Rep (2015) 0.87
Heme-induced ROS in Trypanosoma cruzi activates CaMKII-like that triggers epimastigote proliferation. One helpful effect of ROS. PLoS One (2011) 0.84
Biochemical mechanism of oxidative damage by redox-cycling drugs. Environ Health Perspect (1985) 0.79
Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids. Bioorg Med Chem Lett (2017) 0.75
Effects of treatment with the anti-parasitic drug diminazene aceturate on antioxidant enzymes in rat liver and kidney. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest (2000) 2.67
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. J Med Chem (2001) 2.26
Quantifying amyloid by congo red spectral shift assay. Methods Enzymol (1999) 2.09
Oxygen-sensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes. J Biol Chem (1979) 2.03
The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med (2001) 1.69
In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle. Chem Res Toxicol (1997) 1.68
The horseradish peroxidase-catalyzed oxidation of 3,5,3',5'-tetramethylbenzidine. Free radical and charge-transfer complex intermediates. J Biol Chem (1982) 1.66
Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion. J Exp Med (1994) 1.64
Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. Mol Pharmacol (2001) 1.64
Evidence for free radical formation during the oxidation of 2'-7'-dichlorofluorescin to the fluorescent dye 2'-7'-dichlorofluorescein by horseradish peroxidase: possible implications for oxidative stress measurements. Free Radic Biol Med (1999) 1.58
Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay. Anal Biochem (1999) 1.55
Ca2+/H+ exchange in acidic vacuoles of Trypanosoma brucei. Biochem J (1994) 1.53
Attenuation of channel kinetics and conductance by cholesterol: an interpretation using structural stress as a unifying concept. J Membr Biol (1995) 1.52
Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation, and environmental stress in Trypanosoma cruzi. J Biol Chem (2001) 1.51
The influence of sulfide on solid-phase mercury bioavailability for methylation by pure cultures of Desulfobulbus propionicus (1pr3). Environ Sci Technol (2001) 1.50
Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging. Trends Neurosci (1995) 1.50
The role of catalytic superoxide formation in the O2 inhibition of nitroreductase. Biochem Biophys Res Commun (1975) 1.43
Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radic Biol Med (2005) 1.42
Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem (2001) 1.42
The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and are similar to acidocalcisomes. J Biol Chem (2001) 1.41
Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi. Mol Biochem Parasitol (1981) 1.41
The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol (1998) 1.40
Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs. J Biol Chem (1999) 1.39
Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisomes of Trypanosoma cruzi. J Biol Chem (1998) 1.38
The mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates. Biochemistry (1975) 1.36
Mercury methylation by dissimilatory iron-reducing bacteria. Appl Environ Microbiol (2006) 1.33
Digitonin permeabilization does not affect mitochondrial function and allows the determination of the mitochondrial membrane potential of Trypanosoma cruzi in situ. J Biol Chem (1991) 1.32
Regulatory volume decrease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium. Mol Biochem Parasitol (2003) 1.32
Spin-trapping methods for detecting superoxide and hydroxyl free radicals in vitro and in vivo. Methods Enzymol (1990) 1.32
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol Gastrointest Liver Physiol (2001) 1.32
Aspects of bioavailability of mercury for methylation in pure cultures of Desulfobulbus propionicus (1pr3). Appl Environ Microbiol (2001) 1.32
CYP2E1 is not involved in early alcohol-induced liver injury. Am J Physiol (1999) 1.29
Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in beta-lapachone-treated Trypanosoma cruzi epimastigotes. Arch Biochem Biophys (1978) 1.29
Ca2+ transport by digitonin-permeabilized Leishmania donovani. Effects of Ca2+, pentamidine and WR-6026 on mitochondrial membrane potential in situ. Biochem J (1992) 1.26
Tumor oximetry: demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor. Int J Radiat Oncol Biol Phys (2001) 1.26
Free radicals in pharmacology and toxicology--selected topics. Pharmacol Rev (1981) 1.25
Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine. Am J Physiol (1998) 1.24
Formaldehyde metabolism by Escherichia coli. Detection by in vivo 13C NMR spectroscopy of S-(hydroxymethyl)glutathione as a transient intracellular intermediate. Biochemistry (1986) 1.24
Direct detection of the sulfur trioxide radical anion during the horseradish peroxidase-hydrogen peroxide oxidation of sulfite (aqueous sulfur dioxide). Mol Pharmacol (1982) 1.23
Photoreduction of the fluorescent dye 2'-7'-dichlorofluorescein: a spin trapping and direct electron spin resonance study with implications for oxidative stress measurements. Free Radic Biol Med (1999) 1.23
ESR spin-trapping of a protein-derived tyrosyl radical from the reaction of cytochrome c with hydrogen peroxide. J Biol Chem (1996) 1.22
The origin of the hydroxyl radical oxygen in the Fenton reaction. Free Radic Biol Med (1997) 1.21
Factors controlling the bioaccumulation of mercury and methylmercury by the estuarine amphipod Leptocheirus plumulosus. Environ Pollut (2001) 1.21
Free radical metabolites of L-cysteine oxidation. J Biol Chem (1984) 1.21
The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes. Mol Pharmacol (1980) 1.21
In vivo production of nitric oxide in rats after administration of hydroxyurea. Mol Pharmacol (1997) 1.20
Crystallization of free cholesterol in model macrophage foam cells. Arterioscler Thromb Vasc Biol (1999) 1.19
Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl(4) poisoning? Free Radic Biol Med (2000) 1.19
A direct electron spin resonance and spin-trapping investigation of peroxyl free radical formation by hematin/hydroperoxide systems. J Biol Chem (1983) 1.18
When are metal ion-dependent hydroxyl and alkoxyl radical adducts of 5,5-dimethyl-1-pyrroline N-oxide artifacts? Arch Biochem Biophys (1992) 1.17
Direct evidence for in vivo hydroxyl-radical generation in experimental iron overload: an ESR spin-trapping investigation. Proc Natl Acad Sci U S A (1991) 1.16
Redox cycling and sulphydryl arylation; their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes. Chem Biol Interact (1988) 1.16
In situ compositional analysis of acidocalcisomes in Trypanosoma cruzi. J Biol Chem (1997) 1.16
Direct evidence for immiscible cholesterol domains in human ocular lens fiber cell plasma membranes. J Biol Chem (1999) 1.16
31P NMR spectroscopy of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Evidence for high levels of condensed inorganic phosphates. J Biol Chem (2000) 1.15
Speciation and fate of arsenic in three lakes of the aberjona watershed. Environ Sci Technol (1994) 1.15
Free radical metabolite of uric acid. J Biol Chem (1988) 1.15
A new method for radiochemical separation of arsenic from irradiated germanium oxide. Appl Radiat Isot (2005) 1.15
Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi. Arch Biochem Biophys (1979) 1.14
Ca2+ content and expression of an acidocalcisomal calcium pump are elevated in intracellular forms of Trypanosoma cruzi. Mol Cell Biol (1998) 1.14
Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites. Biochem J (2000) 1.14
Physical effects of cholesterol on arterial smooth muscle membranes: evidence of immiscible cholesterol domains and alterations in bilayer width during atherogenesis. J Lipid Res (1998) 1.13
Phenoxyl free radical formation during the oxidation of the fluorescent dye 2',7'-dichlorofluorescein by horseradish peroxidase. Possible consequences for oxidative stress measurements. J Biol Chem (1999) 1.13
Characterization of a vacuolar pyrophosphatase in Trypanosoma brucei and its localization to acidocalcisomes. Mol Cell Biol (1999) 1.13
Presence of a vacuolar H+-pyrophosphatase in promastigotes of Leishmania donovani and its localization to a different compartment from the vacuolar H+-ATPase. Biochem J (1999) 1.13
Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii. Antimicrob Agents Chemother (1997) 1.13
Reduction of nifurtimox and nitrofurantoin to free radical metabolites by rat liver mitochondria. Evidence of an outer membrane-located nitroreductase. J Biol Chem (1984) 1.12
Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs. Biochim Biophys Acta (1980) 1.12
Free radical metabolism of antiparasitic agents. Fed Proc (1986) 1.12
Sulfate anion free radical formation by the peroxidation of (Bi)sulfite and its reaction with hydroxyl radical scavengers. Arch Biochem Biophys (1988) 1.11
Nitrobenzyl radical metabolites from microsomal reduction of nitrobenzyl chlorides. J Biol Chem (1986) 1.11
Calcium homeostasis in procyclic and bloodstream forms of Trypanosoma brucei. Lack of inositol 1,4,5-trisphosphate-sensitive Ca2+ release. J Biol Chem (1992) 1.11
The formation of sulfur trioxide radical anion during the prostaglandin hydroperoxidase-catalyzed oxidation of bisulfite (hydrated sulfur dioxide). J Biol Chem (1982) 1.10
Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation. J Clin Invest (1995) 1.10
Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death. Oncogene (2011) 1.10
A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation. J Biol Chem (2000) 1.09
Detection of nitrosyl hemoglobin in venous blood in the treatment of sickle cell anemia with hydroxyurea. Mol Pharmacol (1999) 1.09
Assay of in situ radicals by electron spin resonance. Methods Enzymol (1984) 1.09
Evidence for distinct cholesterol domains in fiber cell membranes from cataractous human lenses. J Biol Chem (2001) 1.08
Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria. J Biol Chem (1993) 1.08
Direct evidence for inhibition of free radical formation from Cu(I) and hydrogen peroxide by glutathione and other potential ligands using the EPR spin-trapping technique. Arch Biochem Biophys (1992) 1.08
Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J Biol Chem (2001) 1.08
Correlation of kinetic parameters of nitroreductase enzymes with redox properties of nitroaromatic compounds. J Biol Chem (1989) 1.08
Effect of beta-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi. Biochem J (1978) 1.08
Ca2+ storage in Trypanosoma brucei: the influence of cytoplasmic pH and importance of vacuolar acidity. Biochem J (1995) 1.07
Presence of a Na(+)/H(+) exchanger in acidocalcisomes of Leishmania donovani and their alkalization by anti-leishmanial drugs. FEBS Lett (2000) 1.07
Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi. Comp Biochem Physiol C (1978) 1.07
Mechanism of radical production from the reaction of cytochrome c with organic hydroperoxides. An ESR spin trapping investigation. J Biol Chem (1995) 1.07
Can altering serum cholesterol affect neurologic function? J Mol Cell Cardiol (1991) 1.06
Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis. Environ Health Perspect (1985) 1.06
Primary nonfunction of fatty livers produced by alcohol is associated with a new, antioxidant-insensitive free radical species. Transplantation (1995) 1.05
Mechanisms of alcohol-induced hepatotoxicity: studies in rats. Front Biosci (1999) 1.05
Oxidation of p-aminophenol catalyzed by horseradish peroxidase and prostaglandin synthase. Mol Pharmacol (1983) 1.05