Published in Rev Infect Dis on February 06, 1987
Chagas' disease. Clin Microbiol Rev (1992) 2.30
Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob Agents Chemother (1993) 1.43
Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrob Agents Chemother (1988) 1.33
Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease. Antimicrob Agents Chemother (1993) 1.16
"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease. Proc Natl Acad Sci U S A (1988) 1.09
NK-lysin and its shortened analog NK-2 exhibit potent activities against Trypanosoma cruzi. Antimicrob Agents Chemother (2003) 0.99
Changing Epidemiology and Approaches to Therapy for Chagas Disease. Curr Infect Dis Rep (2003) 0.89
Benznidazole, a drug employed in the treatment of Chagas' disease, down-regulates the synthesis of nitrite and cytokines by murine stimulated macrophages. Clin Exp Immunol (1999) 0.88
Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation. Bioorg Med Chem Lett (2007) 0.86
Immunization with Trypanosoma cruzi epimastigote antigens incorporated into iscoms protects against lethal challenge in mice. Infect Immun (1991) 0.83
Allopurinol is effective to modify the evolution of Trypanosoma cruzi infection in mice. Parasitol Res (2007) 0.83
Association of clomipramine and allopurinol for the treatment of the experimental infection with Trypanosoma cruzi. Parasitol Res (2010) 0.78
Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms. Parasitol Res (2006) 0.78
Tropical medicine. Postgrad Med J (1991) 0.77
Variation in the susceptibility of strains of Staphylococcus aureus to oxacillin, cephalothin, and gentamicin. Antimicrob Agents Chemother (1976) 6.26
Rapid drug-susceptibility testing of Mycobacterium tuberculosis. Am Rev Respir Dis (1981) 4.77
Decreasing reliability of acid-fast smear techniques for detection of tuberculosis. Ann Intern Med (1975) 3.31
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. J Med Chem (2001) 2.26
Bacterial studies of Clindamycin-associated colitis. A preliminary report. Gastroenterology (1975) 2.13
Allopurinol in the treatment of American cutaneous leishmaniasis. N Engl J Med (1992) 1.89
Detection of pneumococci in respiratory secretions: clinical evaluation of gentamicin blood agar. J Clin Microbiol (1977) 1.83
Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion. J Exp Med (1994) 1.64
Purine metabolism in Leishmania donovani and Leishmania braziliensis. Biochim Biophys Acta (1978) 1.60
Ca2+/H+ exchange in acidic vacuoles of Trypanosoma brucei. Biochem J (1994) 1.53
Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation, and environmental stress in Trypanosoma cruzi. J Biol Chem (2001) 1.51
Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation. J Biol Chem (1979) 1.49
A tissue culture system for the growth of several species of Leishmania: growth kinetics and drug sensitivities. Am J Trop Med Hyg (1988) 1.47
Fastidious mycobacteria grown from porcine prosthetic-heart-valve cultures. N Engl J Med (1977) 1.44
An easily prepared defined medium for cultivation of Leishmania donovani promastigotes. J Parasitol (1978) 1.44
Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem (2001) 1.42
The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and are similar to acidocalcisomes. J Biol Chem (2001) 1.41
Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi. Mol Biochem Parasitol (1981) 1.41
Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae. Mol Biochem Parasitol (1983) 1.41
Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs. J Biol Chem (1999) 1.39
Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisomes of Trypanosoma cruzi. J Biol Chem (1998) 1.38
Ribozymes as human therapeutic agents. J Med Chem (1995) 1.36
Digitonin permeabilization does not affect mitochondrial function and allows the determination of the mitochondrial membrane potential of Trypanosoma cruzi in situ. J Biol Chem (1991) 1.32
Regulatory volume decrease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium. Mol Biochem Parasitol (2003) 1.32
Anaerobic infections in surgery: clinical review. Surgery (1976) 1.29
Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in beta-lapachone-treated Trypanosoma cruzi epimastigotes. Arch Biochem Biophys (1978) 1.29
Purine metabolism in Toxoplasma gondii. J Biol Chem (1989) 1.28
Ca2+ transport by digitonin-permeabilized Leishmania donovani. Effects of Ca2+, pentamidine and WR-6026 on mitochondrial membrane potential in situ. Biochem J (1992) 1.26
Reduction of "callbacks" to the ED due to discrepancies in plain radiograph interpretation. Am J Emerg Med (1998) 1.23
Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere. J Med Chem (1993) 1.23
The activity of ketoconazole and other azoles against Trypanosoma cruzi: biochemistry and chemotherapeutic action in vitro. Mol Biochem Parasitol (1989) 1.23
Purine metabolism in the bloodstream forms of Trypanosoma gambiense and Trypanosoma rhodesiense. Biochim Biophys Acta (1982) 1.19
Antitrypanosomal effect of allopurinol: conversion in vivo to aminopyrazolopyrimidine nucleotides by Trypanosoma curzi. Science (1978) 1.18
Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives. Antimicrob Agents Chemother (1990) 1.17
In situ compositional analysis of acidocalcisomes in Trypanosoma cruzi. J Biol Chem (1997) 1.16
31P NMR spectroscopy of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Evidence for high levels of condensed inorganic phosphates. J Biol Chem (2000) 1.15
Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi. Arch Biochem Biophys (1979) 1.14
Ca2+ content and expression of an acidocalcisomal calcium pump are elevated in intracellular forms of Trypanosoma cruzi. Mol Cell Biol (1998) 1.14
Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites. Biochem J (2000) 1.14
Characterization of a vacuolar pyrophosphatase in Trypanosoma brucei and its localization to acidocalcisomes. Mol Cell Biol (1999) 1.13
Presence of a vacuolar H+-pyrophosphatase in promastigotes of Leishmania donovani and its localization to a different compartment from the vacuolar H+-ATPase. Biochem J (1999) 1.13
Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii. Antimicrob Agents Chemother (1997) 1.13
Reduction of nifurtimox and nitrofurantoin to free radical metabolites by rat liver mitochondria. Evidence of an outer membrane-located nitroreductase. J Biol Chem (1984) 1.12
Free radical metabolism of antiparasitic agents. Fed Proc (1986) 1.12
Antileishmanial effect of allopurinol. II. Relationship of adenine metabolism in Leishmania species to the action of allopurinol. J Infect Dis (1977) 1.11
Biological action of inosine analogs in Leishmania and Trypanosoma spp. Antimicrob Agents Chemother (1984) 1.11
Calcium homeostasis in procyclic and bloodstream forms of Trypanosoma brucei. Lack of inositol 1,4,5-trisphosphate-sensitive Ca2+ release. J Biol Chem (1992) 1.11
Antileishmanial effect of allopurinol. Antimicrob Agents Chemother (1974) 1.10
Purine metabolism in Leishmania donovani amastigotes and promastigotes. Mol Biochem Parasitol (1983) 1.09
A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation. J Biol Chem (2000) 1.09
Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria. J Biol Chem (1993) 1.08
Effect of beta-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi. Biochem J (1978) 1.08
Ca2+ storage in Trypanosoma brucei: the influence of cytoplasmic pH and importance of vacuolar acidity. Biochem J (1995) 1.07
Atypical mycobacteria and the xenograft valve. J Thorac Cardiovasc Surg (1978) 1.07
Presence of a Na(+)/H(+) exchanger in acidocalcisomes of Leishmania donovani and their alkalization by anti-leishmanial drugs. FEBS Lett (2000) 1.07
Effect of allopurinol on Trypanosoma cruzi: metabolism and biological activity in intracellular and bloodstream forms. Antimicrob Agents Chemother (1982) 1.07
Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi. Comp Biochem Physiol C (1978) 1.07
Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis. Environ Health Perspect (1985) 1.06
Sodium-proton exchange stimulates Ca2+ release from acidocalcisomes of Trypanosoma brucei. Biochem J (1996) 1.05
Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats. Diagn Microbiol Infect Dis (1987) 1.05
A calmodulin-stimulated Ca2+ pump in plasma-membrane vesicles from Trypanosoma brucei; selective inhibition by pentamidine. Biochem J (1993) 1.04
Calcium homeostasis in Trypanosoma cruzi amastigotes: presence of inositol phosphates and lack of an inositol 1,4,5-trisphosphate-sensitive calcium pool. Mol Biochem Parasitol (1992) 1.03
Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages. Mol Biochem Parasitol (1993) 1.03
Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi. Biochem J (1980) 1.03
A comparative study of tuberculous and other mycobacterial infections and their associations with malignancy. Am Rev Respir Dis (1978) 1.03
Intracellular Ca2+ pool content and signaling and expression of a calcium pump are linked to virulence in Leishmania mexicana amazonesis amastigotes. J Biol Chem (1997) 1.03
Localization of peroxidase activity in Trypanosoma cruzi microbodies. Experientia (1976) 1.03
The metabolism of formycin B in Leishmania donovani. Biochem Biophys Res Commun (1982) 1.03
Antileishmanial effect of allopurinol and allopurinol ribonucleoside on intracellular forms of Leishmania donovani. Biochem Pharmacol (1980) 1.02
Anaerobic streptococcal infections simulating gas gangrene. Arch Surg (1972) 1.02
Free radical metabolites in the mode of action of chemotherapeutic agents and phagocytic cells on Trypanosoma cruzi. Rev Infect Dis (1984) 1.02
A new method for cloning Giardia lamblia, with a discussion of the statistical considerations of limiting dilution. J Parasitol (1988) 1.02
Energization-dependent Ca2+ accumulation in Trypanosoma brucei bloodstream and procyclic trypomastigotes mitochondria. Mol Biochem Parasitol (1992) 1.02
Generation of free radicals induced by nifurtimox in mammalian tissues. J Biol Chem (1981) 1.01
Purine and pyrimidine salvage pathways in Leishmania donovani. Biochem Pharmacol (1982) 1.01
Trypanosoma cruzi: ultrastructural and metabolic alterations of epimastigotes by beta-lapachone. Exp Parasitol (1977) 1.01
Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet). Science (1983) 1.01
A plant-like vacuolar H(+)-pyrophosphatase in Plasmodium falciparum. FEBS Lett (1999) 1.01
Activity of inosine analogs against Pneumocystis carinii in culture. Antimicrob Agents Chemother (1986) 1.00
Feedback inhibition of an allosteric triphosphopyridine nucleotide-specific isocitrate dehydrogenase. J Biol Chem (1969) 1.00
In vitro and in vivo evaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives against Trypanosoma cruzi. Ann Trop Med Parasitol (1978) 1.00
Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi. Biochem Pharmacol (1981) 1.00
Structure-activity relationship of new growth inhibitors of Trypanosoma cruzi. J Med Chem (1998) 0.98
Metabolism of pyrazolo(3,4-d)pyrimidines in Leishmania braziliensis and Leishmania donovani. Allopurinol, oxipurinol, and 4-aminopyrazolo(3,4-d)pyrimidine. J Biol Chem (1979) 0.98
Purine metabolism in Trypanosoma cruzi. Mol Biochem Parasitol (1981) 0.98
Oxidative phosphorylation, Ca(2+) transport, and fatty acid-induced uncoupling in malaria parasites mitochondria. J Biol Chem (2000) 0.97
Generation of free radical metabolites and superoxide anion by the calcium indicators arsenazo III, antipyrylazo III, and murexide in rat liver microsomes. J Biol Chem (1983) 0.97
Characterization of isolated acidocalcisomes of Trypanosoma cruzi. J Biol Chem (2000) 0.97
Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi. Bioorg Med Chem Lett (2001) 0.97
Studies on the mechanism of purine nucleotide inhibition of a triphosphopyridine nucleotide-specific isocitrate dehydrogenase. J Biol Chem (1968) 0.96
Cloning and functional expression of a gene encoding a vacuolar-type proton-translocating pyrophosphatase from Trypanosoma cruzi. Biochem J (2000) 0.95
Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations. Arch Biochem Biophys (1982) 0.95
The role of a H(+)-ATPase in the regulation of cytoplasmic pH in Trypanosoma cruzi epimastigotes. Biochem J (1996) 0.95
Functional expression of a vacuolar-type H+-ATPase in the plasma membrane and intracellular vacuoles of Trypanosoma cruzi. Biochem J (1998) 0.94
Characterization of the plasma-membrane calcium pump from Trypanosoma cruzi. Biochem J (1995) 0.94
Therapeutic efficacy of allopurinol in patients with chronic Chagas' disease. Am J Trop Med Hyg (1990) 0.93
The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in different sensitivity to digitonin-permeabilization. J Eukaryot Microbiol (2001) 0.93
Regulation of intracellular calcium homeostasis in Trypanosoma cruzi. Effects of calmidazolium and trifluoperazine. Cell Calcium (1991) 0.93
Ca2+ and Mg2+-enhanced reduction of arsenazo III to its anion free radical metabolite and generation of superoxide anion by an outer mitochondrial membrane azoreductase. J Biol Chem (1984) 0.93
Antileishmanial action of 4-thiopyrazolo (3.4-d) pyrimidine and its ribonucleoside. Biological effects and metabolism. Biochem Pharmacol (1982) 0.93