Pleiotropic actions of estrogen: a mitochondrial matter.

PubWeight™: 2.07‹?› | Rank: Top 2%

🔗 View Article (PMC 3568881)

Published in Physiol Genomics on December 18, 2012

Authors

Michael C Velarde1

Author Affiliations

1: Buck Institute for Research on Aging, Novato, California 94945, USA. mvelarde@buckinstitute.org

Articles cited by this

Cancer statistics, 2010. CA Cancer J Clin (2010) 103.28

A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res (1965) 21.61

Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55

Mitochondria, oxidants, and aging. Cell (2005) 16.11

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol (2008) 11.43

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40

Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA (2007) 10.50

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature (2011) 8.45

Combinatorial control of gene expression by nuclear receptors and coregulators. Cell (2002) 8.01

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci U S A (2001) 7.93

Estrogen plus progestin and colorectal cancer in postmenopausal women. N Engl J Med (2004) 5.65

Estrogen receptors: how do they signal and what are their targets. Physiol Rev (2007) 5.27

Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med (2010) 3.79

Mitochondria as sensors and regulators of calcium signalling. Nat Rev Mol Cell Biol (2012) 3.59

Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol (2010) 3.27

Does oxidative damage to DNA increase with age? Proc Natl Acad Sci U S A (2001) 2.91

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol (2007) 2.78

Hormone therapy and coronary heart disease: the role of time since menopause and age at hormone initiation. J Womens Health (Larchmt) (2006) 2.77

Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell (2009) 2.58

The different roles of ER subtypes in cancer biology and therapy. Nat Rev Cancer (2011) 2.56

A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One (2010) 2.38

Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev (2010) 2.32

Postmenopausal hormone therapy: an Endocrine Society scientific statement. J Clin Endocrinol Metab (2010) 2.27

Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol (2003) 2.16

Free radicals and senescence. Exp Cell Res (2008) 1.79

Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions. Vitam Horm (2001) 1.79

Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels. Mol Pharmacol (2005) 1.75

Functional estrogen receptors in the mitochondria of breast cancer cells. Mol Biol Cell (2006) 1.72

Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol (2009) 1.61

Specific binding of estrogen receptor to the estrogen response element. Mol Cell Biol (1989) 1.61

Cell cycle arrest is not senescence. Aging (Albany NY) (2011) 1.57

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) (2012) 1.57

Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. J Cell Sci (2010) 1.47

A repressive role for prohibitin in estrogen signaling. Mol Endocrinol (2007) 1.40

Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Mol Cell Biol (2006) 1.38

Mitochondria as therapeutic targets of estrogen action in the central nervous system. Curr Drug Targets CNS Neurol Disord (2004) 1.38

Estrogenic control of mitochondrial function and biogenesis. J Cell Biochem (2008) 1.37

17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J Clin Invest (1994) 1.37

Gender differences in skin: a review of the literature. Gend Med (2007) 1.37

Role of free radicals in aging and disease. Ann N Y Acad Sci (1992) 1.34

Senescence-associated beta-galactosidase histochemistry for the primate eye. Invest Ophthalmol Vis Sci (1999) 1.32

Mitochondrial oxidative stress and mammalian healthspan. Mech Ageing Dev (2010) 1.29

Mitochondrial mechanisms of estrogen neuroprotection. Biochim Biophys Acta (2009) 1.25

Bioenergetic origins of complexity and disease. Cold Spring Harb Symp Quant Biol (2011) 1.19

Cellular senescence, ageing and disease. Age (Dordr) (2008) 1.17

Mitochondrial DNA damage and its consequences for mitochondrial gene expression. Biochim Biophys Acta (2012) 1.12

Females live longer than males: role of oxidative stress. Curr Pharm Des (2011) 1.12

Novel mechanisms for estrogen-induced neuroprotection. Exp Biol Med (Maywood) (2006) 1.09

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue. Aging Cell (2010) 1.09

Menopausal hormone therapy and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev (2009) 1.07

Mitochondrial estrogen receptors--new insights into specific functions. Trends Endocrinol Metab (2007) 1.06

Ethanol impairs estrogen receptor signaling resulting in accelerated activation of senescence pathways, whereas estradiol attenuates the effects of ethanol in osteoblasts. J Bone Miner Res (2009) 1.05

Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications. Biochim Biophys Acta (2005) 0.99

Skin aging and menopause : implications for treatment. Am J Clin Dermatol (2003) 0.95

Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging. Front Endocrinol (Lausanne) (2012) 0.95

Menopause: an evolutionary perspective. Exp Gerontol (1994) 0.94

Role of wild-type estrogen receptor-beta in mitochondrial cytoprotection of cultured normal male and female human lens epithelial cells. Am J Physiol Endocrinol Metab (2008) 0.94

Estrogen and the regulation of mitochondrial structure and function in the brain. J Steroid Biochem Mol Biol (2012) 0.92

Estrogen, mitochondria, and growth of cancer and non-cancer cells. J Carcinog (2005) 0.90

Sex steroids and cutaneous wound healing: the contrasting influences of estrogens and androgens. Climacteric (2007) 0.89

Estrogen receptor beta is a novel therapeutic target for photoaging. Mol Pharmacol (2010) 0.89

Estrogen reduces angiotensin II-induced acceleration of senescence in endothelial progenitor cells. Hypertens Res (2005) 0.87

17beta-estradiol enhances the production of granulocyte-macrophage colony-stimulating factor in human keratinocytes. J Invest Dermatol (2004) 0.81

Menopause and related problems. Minerva Med (2007) 0.81