Published in Mol Cell on October 09, 2009
The essence of senescence. Genes Dev (2010) 8.21
Aging, cellular senescence, and cancer. Annu Rev Physiol (2012) 5.08
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature (2013) 3.46
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol (2010) 3.29
The role of senescent cells in ageing. Nature (2014) 3.03
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol (2011) 2.69
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell (2011) 2.40
Pleiotropic actions of estrogen: a mitochondrial matter. Physiol Genomics (2012) 2.07
Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol (2011) 1.98
Progeria syndromes and ageing: what is the connection? Nat Rev Mol Cell Biol (2010) 1.93
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev (2013) 1.78
Human regulatory T cells induce T-lymphocyte senescence. Blood (2012) 1.70
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) (2012) 1.57
Death by transposition - the enemy within? Bioessays (2013) 1.53
p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A (2012) 1.41
Lysosome-mediated processing of chromatin in senescence. J Cell Biol (2013) 1.38
Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell (2010) 1.33
Autophagy and cancer. Cold Spring Harb Perspect Biol (2012) 1.30
A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev (2011) 1.30
Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res (2011) 1.29
The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci (2013) 1.28
Activation of nuclear factor-kappa B signalling promotes cellular senescence. Oncogene (2011) 1.23
NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog (2011) 1.23
Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell (2012) 1.08
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer. Br J Cancer (2011) 1.08
From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence. Liver Cancer (2013) 1.05
Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. Cell Div (2010) 1.05
Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths. Aging (Albany NY) (2010) 1.03
Early-onset aging and defective DNA damage response in Cdc14b-deficient mice. Mol Cell Biol (2011) 1.00
Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells. PLoS One (2013) 1.00
Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Mol Cell Biol (2011) 1.00
The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis. Nat Commun (2014) 1.00
CPEB control of NF-kappaB nuclear localization and interleukin-6 production mediates cellular senescence. Mol Cell Biol (2011) 0.98
A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging. Age (Dordr) (2014) 0.98
p35 is required for CDK5 activation in cellular senescence. J Biol Chem (2010) 0.96
ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer. Oncogene (2015) 0.95
Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis. PLoS One (2013) 0.95
BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss. Mol Cell Biol (2013) 0.95
A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. PLoS One (2010) 0.95
Bisphosphonates induce senescence in normal human oral keratinocytes. J Dent Res (2011) 0.95
Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress. Blood (2012) 0.93
Modulation of the autophagy pathway by human tumor viruses. Semin Cancer Biol (2013) 0.93
DPY30 regulates pathways in cellular senescence through ID protein expression. EMBO J (2013) 0.92
3'UTR elements inhibit Ras-induced C/EBPβ post-translational activation and senescence in tumour cells. EMBO J (2011) 0.91
Telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers. PLoS One (2012) 0.91
Senescence from G2 arrest, revisited. Cell Cycle (2015) 0.89
Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice. Arterioscler Thromb Vasc Biol (2011) 0.89
Senescence at a glance. J Cell Sci (2013) 0.88
MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation. Biochem Biophys Res Commun (2012) 0.88
Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex. PLoS Pathog (2014) 0.87
Deciphering the role of nuclear factor-κB in cellular senescence. Aging (Albany NY) (2011) 0.87
Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging. Dev Cell (2015) 0.86
α-Fucosidase as a novel convenient biomarker for cellular senescence. Cell Cycle (2013) 0.86
Characterization of cellular senescence mechanisms in human corneal endothelial cells. Aging Cell (2011) 0.86
From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence. Cell Metab (2016) 0.86
Therapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic disease. Oxid Med Cell Longev (2012) 0.85
Cellular senescence and the aging brain. Exp Gerontol (2014) 0.85
Kinetics of the cell biological changes occurring in the progression of DNA damage-induced senescence. Mol Cells (2011) 0.83
Inflammation Perturbs the IL-7 Axis, Promoting Senescence and Exhaustion that Broadly Characterize Immune Failure in Treated HIV Infection. J Acquir Immune Defic Syndr (2016) 0.82
Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth. Oncotarget (2014) 0.82
Lessons from senescence: Chromatin maintenance in non-proliferating cells. Biochim Biophys Acta (2011) 0.82
Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence. EMBO J (2011) 0.82
Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid. Int J Mol Sci (2014) 0.82
Epigenetic rejuvenation. Genes Cells (2012) 0.82
Human gingival fibroblasts display a non-fibrotic phenotype distinct from skin fibroblasts in three-dimensional cultures. PLoS One (2014) 0.82
Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs. J Gerontol A Biol Sci Med Sci (2015) 0.81
p63 supports aerobic respiration through hexokinase II. Proc Natl Acad Sci U S A (2015) 0.81
A stress-induced cellular aging model with postnatal neural stem cells. Cell Death Dis (2014) 0.81
Signalling the end of the line. Nat Cell Biol (2012) 0.80
Exploiting tumor cell senescence in anticancer therapy. BMB Rep (2014) 0.80
Redox control of senescence and age-related disease. Redox Biol (2016) 0.79
Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy. Small GTPases (2011) 0.79
The Intricate Interplay between Mechanisms Underlying Aging and Cancer. Aging Dis (2014) 0.79
Radiation-Induced Bystander Response: Mechanism and Clinical Implications. Adv Wound Care (New Rochelle) (2014) 0.79
Caveolae control the anti-inflammatory phenotype of senescent endothelial cells. Aging Cell (2014) 0.79
Quantitative nucleolar proteomics reveals nuclear re-organization during stress- induced senescence in mouse fibroblast. BMC Cell Biol (2011) 0.79
Multiple facets of p53 in senescence induction and maintenance. Cancer Sci (2016) 0.79
SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation. PLoS One (2015) 0.78
MicroRNAs as molecular classifiers for cancer. Cell Cycle (2011) 0.78
Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia. Proc Natl Acad Sci U S A (2009) 0.78
Chromatin: a molecular interface between cancer and aging. Curr Opin Genet Dev (2010) 0.78
Cytokines shape chemotherapy-induced and 'bystander' senescence. Aging (Albany NY) (2010) 0.78
SNP55, a new functional polymorphism of MDM2-P2 promoter, contributes to allele-specific expression of MDM2 in endometrial cancers. BMC Med Genet (2015) 0.77
An Arf-Egr-C/EBPβ pathway linked to ras-induced senescence and cancer. Mol Cell Biol (2014) 0.77
Long-term quiescent fibroblast cells transit into senescence. PLoS One (2014) 0.77
Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence. Onco Targets Ther (2013) 0.77
Bach1 deficiency and accompanying overexpression of heme oxygenase-1 do not influence aging or tumorigenesis in mice. Oxid Med Cell Longev (2014) 0.77
Bioelectrical regulation of cell cycle and the planarian model system. Biochim Biophys Acta (2015) 0.77
Stress induced premature senescence: a new culprit in ovarian tumorigenesis? Indian J Med Res (2014) 0.77
Comparison of liver oncogenic potential among human RAS isoforms. Oncotarget (2016) 0.76
The ER stress regulator Bip mediates cadmium-induced autophagy and neuronal senescence. Sci Rep (2016) 0.76
Role of miR-182 in response to oxidative stress in the cell fate of human fallopian tube epithelial cells. Oncotarget (2015) 0.76
Postmyocardial infarct remodeling and heart failure: potential contributions from pro- and antiaging factors. Cardiol Res Pract (2011) 0.76
Research progress on the negative factors of corneal endothelial cells proliferation. Int J Ophthalmol (2012) 0.76
Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging. Front Immunol (2016) 0.75
Drug-induced premature senescence model in human dental follicle stem cells. Oncotarget (2016) 0.75
Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxide. Cold Spring Harb Mol Case Stud (2017) 0.75
EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells. Cell Death Dis (2016) 0.75
Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells. Sci Rep (2017) 0.75
Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway. Cell Death Dis (2016) 0.75