Published in Ther Adv Chronic Dis on May 01, 2011
Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). J Nutr (2015) 1.20
C-reactive protein is related to memory and medial temporal brain volume in older adults. Brain Behav Immun (2011) 1.10
Cerebral dysfunction after coronary artery bypass surgery. J Anesth (2013) 0.89
Therapeutic implications of the prostaglandin pathway in Alzheimer's disease. Biochem Pharmacol (2014) 0.85
Inflammation and cognitive functioning in African Americans and Caucasians. Int J Geriatr Psychiatry (2014) 0.80
Chronic adjunction of 1-deoxynojirimycin protects from age-related behavioral and biochemical changes in the SAMP8 mice. Age (Dordr) (2015) 0.79
Genetic variation and cognitive dysfunction in opioid-treated patients with cancer. Brain Behav (2016) 0.76
Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study. Eur J Nutr (2016) 0.76
The Relation between canine cognitive dysfunction and age-related brain lesions. J Vet Med Sci (2016) 0.75
The Immunomodulatory Effects of Plant Extracts and Plant Secondary Metabolites on Chronic Neuroinflammation and Cognitive Aging: A Mechanistic and Empirical Review. Front Pharmacol (2017) 0.75
Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer's-Like Mouse Model. Biomed Res Int (2016) 0.75
Monocyte Activation is Associated with Worse Cognitive Performance in Virologically Suppressed HIV-Infected Women. J Infect Dis (2016) 0.75
Effects of Moderate Aerobic Exercise on Cognitive Abilities and Redox State Biomarkers in Older Adults. Oxid Med Cell Longev (2016) 0.75
Relationship between inflammation and oxidative stress and cognitive decline in the institutionalized elderly. Oxid Med Cell Longev (2015) 0.75
Aerobic Activity in the Healthy Elderly Is Associated with Larger Plasticity in Memory Related Brain Structures and Lower Systemic Inflammation. Front Aging Neurosci (2016) 0.75
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner. Nat Commun (2017) 0.75
The processing-speed theory of adult age differences in cognition. Psychol Rev (1996) 15.76
Inflammatory blockade restores adult hippocampal neurogenesis. Science (2003) 10.14
Caloric restriction delays disease onset and mortality in rhesus monkeys. Science (2009) 9.84
Risk factors for functional status decline in community-living elderly people: a systematic literature review. Soc Sci Med (1999) 9.17
Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med (2006) 6.15
The role of executive function and attention in gait. Mov Disord (2008) 5.03
Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol (2010) 5.03
Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc (1999) 4.84
Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry (2001) 4.70
Top-down suppression deficit underlies working memory impairment in normal aging. Nat Neurosci (2005) 4.68
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab (2010) 4.11
Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study. JAMA (2000) 3.99
Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J (2005) 3.84
Central mechanisms of motor skill learning. Curr Opin Neurobiol (2002) 3.84
Systemic inflammation and disease progression in Alzheimer disease. Neurology (2009) 3.79
A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology (2005) 3.78
Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke (2000) 3.74
IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A (2008) 3.19
Under-recruitment and nonselective recruitment: dissociable neural mechanisms associated with aging. Neuron (2002) 3.18
Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology (2007) 3.12
Fundamental components of attention. Annu Rev Neurosci (2007) 3.03
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology (2007) 3.02
Inflammatory processes in Alzheimer's disease. J Neuroimmunol (2007) 2.91
Influence of executive function on locomotor function: divided attention increases gait variability in Alzheimer's disease. J Am Geriatr Soc (2003) 2.87
Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol Psychiatry (2003) 2.77
A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study. Neurology (2000) 2.76
Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project. Arterioscler Thromb Vasc Biol (1997) 2.76
Depressive symptoms and cognitive decline in a community population of older persons. J Neurol Neurosurg Psychiatry (2004) 2.67
Elevated levels of interleukin-6 in unstable angina. Circulation (1996) 2.66
Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol Psychiatry (2008) 2.66
Frontal circuitry degradation marks healthy adult aging: Evidence from diffusion tensor imaging. Neuroimage (2005) 2.55
Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial. Neurology (2007) 2.54
Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J Neuroinflammation (2008) 2.53
Depression, inflammation, and incident cardiovascular disease in women with suspected coronary ischemia: the National Heart, Lung, and Blood Institute-sponsored WISE study. J Am Coll Cardiol (2007) 2.49
Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J Neurosci (2002) 2.45
The role of inflammation in Alzheimer's disease. Int J Biochem Cell Biol (2005) 2.39
Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol Aging (2006) 2.37
Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology (2009) 2.32
Association of interleukin-6 and other biologic variables with depression in older people living in the community. J Am Geriatr Soc (1999) 2.31
Inflammatory markers and incident mobility limitation in the elderly. J Am Geriatr Soc (2004) 2.29
Tests of executive function predict instrumental activities of daily living in community-dwelling older individuals. Appl Neuropsychol (2002) 2.27
The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J Gerontol A Biol Sci Med Sci (1997) 2.27
Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment. J Neurosci (2010) 2.25
Working memory span and the role of proactive interference. J Exp Psychol Gen (2001) 2.21
Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am J Geriatr Psychiatry (2005) 2.21
Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. J Neurosci (2008) 2.21
Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology (2010) 2.21
Serum inflammatory proteins and cognitive decline in older persons. Neurology (2005) 2.11
Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome. Cancer (2005) 2.09
Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biol Psychiatry (2005) 2.06
Inflammatory processes in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry (2003) 2.04
Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci (2009) 2.02
Executive function, more than global cognition, predicts functional decline and mortality in elderly women. J Gerontol A Biol Sci Med Sci (2007) 1.97
Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol (2008) 1.94
Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci U S A (2006) 1.92
Systemic markers of inflammation and cognitive decline in old age. J Am Geriatr Soc (2007) 1.91
Inflammatory markers in late-life depression: results from a population-based study. J Affect Disord (2007) 1.89
A prospective evaluation of the directionality of the depression-inflammation relationship. Brain Behav Immun (2009) 1.88
Executive dysfunction in geriatric depression. Am J Psychiatry (2002) 1.85
Dissociating prefrontal and hippocampal function in episodic memory encoding. Nature (1997) 1.84
Cognitive status and incident disability in older Mexican Americans: findings from the Hispanic established population for the epidemiological study of the elderly. Ethn Dis (2004) 1.83
Age-related differences in the functional connectivity of the hippocampus during memory encoding. Hippocampus (2003) 1.83
Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun (2008) 1.82
Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation. J Neurosci (1998) 1.80
The age-related attenuation in long-term potentiation is associated with microglial activation. J Neurochem (2006) 1.76
Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats. Neurobiol Aging (2009) 1.72
Neuroinflammation and cognitive function in aged mice following minor surgery. Exp Gerontol (2008) 1.68
A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study. Alzheimer Dis Assoc Disord (2008) 1.63
Microglia in the aging brain. J Neuropathol Exp Neurol (2006) 1.60
The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Crit Care (2010) 1.59
Local neuroinflammation and the progression of Alzheimer's disease. J Neurovirol (2002) 1.59
Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J Clin Psychiatry (2006) 1.57
Inflammation and Alzheimer's disease pathogenesis. Neurobiol Aging (1997) 1.56
Cognitive functioning as a predictor of functional disability in later life. Am J Geriatr Psychiatry (2006) 1.55
Chronic unpredictable stress exacerbates lipopolysaccharide-induced activation of nuclear factor-kappaB in the frontal cortex and hippocampus via glucocorticoid secretion. J Neurosci (2006) 1.55
Prefrontal deficits in attention and inhibitory control with aging. Cereb Cortex (1997) 1.55
The significance of neuroinflammation in understanding Alzheimer's disease. J Neural Transm (Vienna) (2006) 1.55
The functional roles of prefrontal cortex in episodic memory. I. Encoding. Brain (1998) 1.54
The fate of cognition in very old age: six-year longitudinal findings in the Berlin Aging Study (BASE). Psychol Aging (2003) 1.53
Cognitive efficiency is associated with endogenous cytokine levels in patients with chronic hepatitis C. J Neuroimmunol (2010) 1.52
Normal rates of cognitive change in successful aging: the freedom house study. J Int Neuropsychol Soc (2005) 1.50
The neuroinflammatory hypothesis of delirium. Acta Neuropathol (2010) 1.49
Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism. J Neuroinflammation (2008) 1.46
Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc Natl Acad Sci U S A (1997) 1.46
Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse. BMC Genomics (2009) 1.46
Cognitive decline and markers of inflammation and hemostasis: the Edinburgh Artery Study. J Am Geriatr Soc (2007) 1.46
Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function. Neurobiol Aging (2010) 1.45
Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration. J Neuroinflammation (2008) 1.45
Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation (2008) 1.43
Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol Aging (2010) 1.42
Cytokines and acute phase response in delirium. J Psychosom Res (2007) 1.42
Memory function in normal aging. Acta Neurol Scand Suppl (2003) 1.42
Cytokines and C-reactive protein production in hip-fracture-operated elderly patients. J Gerontol A Biol Sci Med Sci (2007) 1.38
Cognitive impairment as a strong predictor of incident disability in specific ADL-IADL tasks among community-dwelling elders: the Azuchi Study. Gerontologist (2005) 1.37
Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun (2009) 1.36
N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psychiatry Neurosci (2011) 1.35
Changes in depression and physical decline in older adults: a longitudinal perspective. J Affect Disord (2000) 1.35
The effects of aging on layer 1 in area 46 of prefrontal cortex in the rhesus monkey. Cereb Cortex (1998) 1.34
Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers. Psychosom Med (2006) 1.34
C-reactive protein, vitamin D deficiency, and slow gait speed. J Am Geriatr Soc (2013) 1.40
Stress-induced increases in hypothalamic IL-1: a systematic analysis of multiple stressor paradigms. Brain Res Bull (2005) 1.27
Behavioral responses during the forced swim test are not affected by anti-inflammatory agents or acute illness induced by lipopolysaccharide. Behav Brain Res (2004) 1.13
Cognitive-behavioral therapy for chronic low back pain in older persons: a preliminary study. Pain Med (2003) 1.12
Risk factors for disability subtypes in older persons. J Am Geriatr Soc (2009) 1.07
Maternal separation with early weaning: a novel mouse model of early life neglect. BMC Neurosci (2010) 0.99
Longitudinal association between self-rated health and timed gait among older persons. J Gerontol B Psychol Sci Soc Sci (2009) 0.93
Association between angina and treatment satisfaction after myocardial infarction. J Gen Intern Med (2007) 0.90
cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Proc Natl Acad Sci U S A (2014) 0.85
Neuroanatomical changes in a mouse model of early life neglect. Brain Struct Funct (2011) 0.84
Use of antithrombotic medications among elderly ischemic stroke patients. Circ Cardiovasc Qual Outcomes (2010) 0.83
Depressive symptoms and physical performance in the lifestyle interventions and independence for elders pilot study. J Am Geriatr Soc (2011) 0.83
Plasma beta amyloid level and depression in older adults. J Gerontol A Biol Sci Med Sci (2012) 0.83
Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits. Dev Psychopathol (2012) 0.83
Protracted increases in core body temperature and interleukin-1 following acute administration of lipopolysaccharide: implications for the stress response. Physiol Behav (2005) 0.83
Brief prenatal ethanol exposure alters behavioral sensitivity to the kappa opioid receptor agonist (U62,066E) and antagonist (Nor-BNI) and reduces kappa opioid receptor expression. Alcohol Clin Exp Res (2014) 0.79